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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Genetics, Population (0):
Recent article
Genetics, Population
Abstract
We analysed the genetic diversity and structure of Mongolian sheep in China. These animals belong to a traditional local breed with high production, extensive adaption, early maturity and roughage resistance. For this purpose, 26 microsatellites were genotyped for five Mongolian sheep populations. T...
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PMID: 21906110
PDF is available here.
PDF is available here.
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Abstract
We know Arabidopsis suecica and Arabidopsis kamchatica as fully stabilized allopolyploid species. Both species evolved during Pleistocene glaciation and deglaciation cycles in Fennoscandinavia and the amphi-Beringian region, respectively. These hybrid studies were conducted either on a phylogeograph...
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PMID: 21825128
PDF is available here.
PDF is available here.
Abstract
Abstract
We determined the susceptibility to bovine tuberculosis (bTB), and the prevalence of antibody to feline viruses of native lions, and compared the findings with those from translocated outbred lions and their offspring. Antibodies to feline herpesvirus, feline calicivirus, feline parvovirus, and feli...
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PMID: 21719814
PDF is available here.
PDF is available here.
Abstract
Mitochondrial DNA (mtDNA) and Y-DNA analysis have been widely used to predict ancestral origin. Genetic anthropologists predict that human civilizations may have originated in central Africa one to two million years previously. Primary iron overload is not a common diagnosis among indigenous people o...
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PMID: 21766093
PDF is available here.
PDF is available here.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Universita di Napoli, Secondo ateneo (75)2 2011
Abstract
The phenotypic expression of COPD consists of pulmonary emphysema and chronic bronchitis. An imprecise phenotypic definition may result in inconsistencies among genetic studies regarding COPD pathogenesis. Endothelin-1 gene polymorphisms have been linked to increased susceptibility of COPD developmen...
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PMID: 21932697
PDF is available here.
PDF is available here.
Abstract
There used to be a broad split within the experimental genetics research community between those who did mechanistic research using homozygous laboratory strains and those who studied patterns of genetic variation in wild populations. The former benefited from the advantage of reproducible experiment...
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PMID: 21546546
PDF is available here.
PDF is available here.
Abstract
All the 20 studied molecular markers were found to be polymorphic in both the tribal population groups and showed similarities with respect to allele frequencies, with a low coefficient of gene differentiation (G(ST)) value. Moreover, sharing and distribution patterns of haplotypes of the β-globin...
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PMID: 21486165
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)4 2011
Abstract
We carried out the high density limited genome scanning to the HLA class III region about 58 kb in Ningxia population (case 300 and control 385). In this study, 33 SNPs in LTA were genotyped in Ningxia population. We analyzed these SNPs and the haplotypes covering LTA. Only the distribution of TCC h...
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PMID: 21482522
PDF is available here.
PDF is available here.
Abstract
Our data revealed high diversity values in the two populations, in agreement with other Andean studies. The comparisons with the available literature for both sets of markers indicated that the central Andean area is relatively homogeneous. For mtDNA, the Aymaras seemed to have been more isolated th...
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PMID: 21469069
PDF is available here.
PDF is available here.
Abstract
We provide new approaches to calculate the parameters used in the frequency surveying method: a maximum likelihood estimation of the regression parameters (r(1), r(2), s(1) and s(2)) and a revised Frequency Surveying framework with variable binning and a database preprocessing to take the population...
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PMID: 21094108
PDF is available here.
PDF is available here.
Abstract
Cytochrome P450 (CYP) 2C9 is responsible for the metabolism of a number of widely used drugs such as oral anticoagulants, oral antidiabetics and non-steroidal anti-inflammatory drugs. The CYP2C9 is a genetically polymorphic enzyme. The most common allele is CYP2C9*1, while CYP2C9*2 a...
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PMID: 21371265
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)2 2011
Abstract
We determined the frequencies of HLA-Alus (i.e., AluMICB, AluTF, AluHJ, AluHG, and AluHF) in Zhuang and Yugu ethnic populations at first. Then, combined with HLA genotyping data, we studied associations between HLA-Alus and HLA-A alleles in Zhuang, Yugu, Bulang, Dai, and Hani ethnic populations. Our...
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PMID: 21377970
PDF is available here.
PDF is available here.
Mutation Research (708)1-2 2011
Abstract
We analyzed the occurrence of germline slippage mutations in the hypervariable pentanucleotide microsatellite locus HrU10 across six species of swallow (Aves: Hirundinidae). These species exhibit marked differences in the length range of the microsatellite, as well as differences in the intensity of...
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PMID: 21291898
PDF is available here.
PDF is available here.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (28)1 2011
Abstract
To investigate the polymorphisms of 9 non-DNA combined index system (CODIS) short tandem repeats (STRs), i.e., D7S3048, D8S1132, D11S2368, D2S1772, D6S1043, D13S325, D12S391, GATA198B05, D18S1364 in Hebei Han population, and evaluate the usage of them in paternity testing.
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PMID: 21287521
PDF is available here.
PDF is available here.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (28)1 2011
Abstract
To analyze the allele frequencies and polymorphism of human leukocyte antigens (HLA) -A, B, Cw, DRB1 and DQB1 between donors-recipients on high-resolution typing; and to analyze the matching and mismatching proportion between donors and recipients.
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PMID: 21287519
PDF is available here.
PDF is available here.
Abstract
We present a Sumatran orang-utan draft genome assembly and short read sequence data from five Sumatran and five Bornean orang-utan genomes. Our analyses reveal that, compared to other primates, the orang-utan genome has many unique features. Structural evolution of the orang-utan genome has proceede...
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PMID: 21270892
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)1 2011
Abstract
I (mtDNA-COI) gene was used to investigate the intraspecific genetic subdivision among 12 geographical populations of Gampsocleis sedakovii distributed in Jilin, Liaoning, Inner Mongolia, Hebei, and Sichuan provinces, China. As for the 626 bp mtDNA-COI sequences of 36 individuals, 29 haplotypes and...
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PMID: 21377962
PDF is available here.
PDF is available here.
Abstract
The light brown apple moth (LBAM), Epiphyas postvittana (Walker), is native to Australia but invaded England, New Zealand, and Hawaii more than 100 years ago. In temperate climates, LBAM can be a major agricultural pest. In 2006 LBAM was discovered in California, instigating eradication efforts and q...
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PMID: 21298019
PDF is available here.
PDF is available here.
Abstract
Callitropsis guadalupensis (Guadalupe cypress) is endemic to Guadalupe Island, Mexico, where it is the dominant species of the only forest. The species has suffered declining numbers following the introduction of goats to the island over 150 years ago. Callitropsis guadalupensis is closely related to...
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PMID: 21283771
PDF is available here.
PDF is available here.
Abstract
We report a large-scale genetic analysis of human variation in the Iban population from the Malaysian state of Sarawak in northwestern Borneo, located in the center of ISEA. Genome-wide single-nucleotide polymorphism (SNP) markers analyzed here suggest that the Iban exhibit greatest genetic similari...
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PMID: 21305013
PDF is available here.
PDF is available here.
Abstract
I compare the phylogeographic patterns revealed through the maternally inherited mitochondrial COI region and the paternally inherited 7(th) intron region of the Dby gene on the Y-chromosome in eight common Neotropical bat species. These species are diverse and include members of two families from t...
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PMID: 21814545
PDF is available here.
PDF is available here.
Abstract
Genome-wide studies have shown that polymorphisms on chromosome 4q25, 16q22 and 1q21 correlate with atrial fibrillation (AF). However, the distribution of these polymorphisms differs significantly among populations.
To test the polymorphisms on chromosome 4q25, 16q22...
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PMID: 21760908
PDF is available here.
PDF is available here.
Abstract
We conducted a genome-wide association study (GWAS) in 250 KD patients and 446 controls in a Han Chinese population residing in Taiwan, and further validated our findings in an independent Han Chinese cohort of 208 cases and 366 controls. The most strongly associated single-nucleotide polymorphisms...
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PMID: 21326860
PDF is available here.
PDF is available here.
Abstract
This review is focused on the role of genetic factors in etiology and pathogenesis of thrombophilia in adults and children. Their knowledge permits to elucidate the main causes of this pathology and choose adequate measures for its prevention.
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PMID: 21786606
PDF is available here.
PDF is available here.
BMC Medical Genetics (12)1 2011
Abstract
Crohn's disease (CD) has the highest prevalence among individuals of Ashkenazi Jewish (AJ) descent compared to non-Jewish Caucasian populations (NJ). We evaluated a set of well-established CD-susceptibility variants to determine if they can explain the increased CD risk in the AJ population.
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PMID: 21548950
PDF is available here.
PDF is available here.
Abstract
Abstract
We used genome-wide SNP data from 15,257 parent-offspring pairs to construct the first recombination maps based on directly observed recombinations with a resolution that is effective down to 10 kilobases (kb). Comparing male and female maps reveals that about 15% of hotspots in one sex are specific...
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PMID: 20981099
PDF is available here.
PDF is available here.
Abstract
Parasitology (137)13 2010
Abstract
We used 12 microsatellite markers developed for Leishmania braziliensis to genotype 28 strains of the main species of the Leishmania guyanensis complex (i.e. L. guyanensis and L. panamensis) collected in Ecuador and Peru. The important heterozygote deficits observed in these populations are similar...
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PMID: 20609264
PDF is available here.
PDF is available here.
Legal Medicine (12)6 2010
Abstract
We also compared the allele frequencies from this population with other populations in the same geographic vicinity.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved....
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PMID: 20863737
PDF is available here.
PDF is available here.
Legal Medicine (12)6 2010
Abstract
The genetic profiles for 15 autosomal microsatellite loci were analyzed in a Tamil population from Southern India to study the genetic diversities and relatedness of this population with other national and global populations. Statistical analyses of the data revealed all loci were within Hardy-Weinb...
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PMID: 20813574
PDF is available here.
PDF is available here.
Fertility and Sterility (94)6 2010
Abstract
We adapted a method that allows the identification of X chromosome copy number by quantitative real-time polymerase chain reaction (PCR) in a short amount of time. It may be used for sex and aneuploidy involving X chromosome large population screening tests.
Copyright © 2010 American Society for Re...
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PMID: 20493475
PDF is available here.
PDF is available here.
Abstract
We provide a mathematical model that begins to address this challenge. We model tumors as a discrete time branching process that starts with a single driver mutation and proceeds as each new driver mutation leads to a slightly increased rate of clonal expansion. Using the model, we observe tremendou...
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PMID: 20876136
PDF is available here.
PDF is available here.
Abstract
Abstract
Journal of Fish Biology (77)5 2010
Abstract
These results indicate that populations of G. macrocephalus in the north-western Pacific are genetically subdivided and represent evolutionary lineages that should be managed individually.
© 2010 The Authors. Journal compilation © 2010 The Fisheries Society of the British Isles....
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PMID: 21039491
PDF is available here.
PDF is available here.
Journal of Fish Biology (77)5 2010
Abstract
Examination of the genetic structure of the vairone Telestes souffia based on 10 nuclear markers (microsatellites) revealed little-to-moderate genetic differentiation between geographically adjacent populations in the eastern part of Lake Constance in central Europe. Results emphasize the critically...
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PMID: 21039497
PDF is available here.
PDF is available here.
Abstract
We sampled 296 individuals from 13 worldwide populations that are not covered by previous studies. By combining these samples with a data set from our laboratory and the HapMap II samples, we assembled a final dataset of ~250,000 SNPs in 850 individuals from 40 populations. With more uniform samplin...
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PMID: 20643205
PDF is available here.
PDF is available here.
Abstract
We sequenced multiple alleles of the eater gene from an African and a North American population of D. melanogaster and found signatures of a partial selective sweep in North America that is localized around the second intron. This pattern is consistent with local adaptation to novel selective pressu...
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PMID: 20444883
PDF is available here.
PDF is available here.
Tracing the Austronesian footprint in Mainland Southeast Asia: a perspective from mitochondrial DNA.
Abstract
We have analyzed mitochondrial DNA (mtDNA) control-region and coding-region sequence variations in 168 Cham and 139 Kinh individuals from Vietnam. Around 77% and 95% matrilineal components in the Chams and the Kinhs, respectively, could be assigned into the defined mtDNA haplogroups. Additionally, t...
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PMID: 20513740
PDF is available here.
PDF is available here.
Abstract
We scanned all available shotgun genome sequence data from laboratory lines of P. falciparum and chose six loci with more than five single nucleotide polymorphisms per kilobase (including PF10_0348) for in-depth frequency-based analyses in a Kenyan population (allele sample sizes >50 for each locus)...
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PMID: 20457586
PDF is available here.
PDF is available here.
Abstract
To investigate diversity of mitochondrial gene pool of Tatars inhabiting the territory of the middle Volga River basin, 197 individuals from two populations representing Kazan Tatars and Mishars were subjected for analysis of mitochondrial DNA (mtDNA) control region variation. In addition, 73 mitoch...
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PMID: 20457583
PDF is available here.
PDF is available here.
Abstract
We conclude that the large noncoding-DNA content of the V. carteri genomes is best explained by the mutational-hazard hypothesis and speculate that the shift from unicellular to multicellular life in the ancestor that gave rise to V. carteri contributed to a low V. carteri population size and thus a...
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PMID: 20430860
PDF is available here.
PDF is available here.
Abstract
We investigated the weight development over a period of 11 years in a case-control study, consisting of 1,632 cases (BMI≥35 kg/m (2)) and 3,379 normal weight controls (BMI 20-24.9 kg/m (2)) from a Norwegian population based cohort, the HUNT study. Subjects were aged 20-80 at baseline, 25% men and...
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PMID: 20373279
PDF is available here.
PDF is available here.
Abstract
We investigated the spatial genetic structure and genetic diversity of 161 individuals of K. septentrionalis collected from five natural populations using AFLP molecular markers. Within-population genetic variation was measured, with percentage of polymorphic bands (PPB) ranged from 63% to 87%, whil...
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PMID: 20661630
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)10 2010
Abstract
These results indicate the maintenance of chromosome frequency of the distribution of inversions XL1 and 3R (in longitude) and 2R1 (in latitude). The inversion frequency distribution in the examined part of the areal have been preserved for a long time....
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PMID: 21254547
PDF is available here.
PDF is available here.
Clinical Cancer Research (16)21 2010
Abstract
The tumor suppressor p53 plays a crucial role in maintaining genomic stability and tumor prevention. Mdm2, Mdm4, and Hausp are all critical regulators of the p53 protein. Despite the importance of the p53 pathway in prostate cancer development and progression, little is known about the association of...
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PMID: 20855462
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (325)1-2 2010
Abstract
We screened the polymorphisms in the 5'-UTR (c.-18G>T, c.-23A>G, c.-45G>A and c.-53G>C) and c.977C>G (Ser326Cys) in exon 7 of hOGG1 gene. A case-control study indicated that c.-23A/G heterozygote was markedly associated with diabetes (P=0.004, OR=2.648, 95%CI=1.355-5.176) and with an increased level...
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PMID: 20562008
PDF is available here.
PDF is available here.
Abstract
We derive a coalescent dual process for a related class of continuous-time Moran models with viability selection. In these models, individuals can give birth to multiple offspring whose survival depends on both the parental genotype and the brood size. This extends the dual process construction for...
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PMID: 20685218
PDF is available here.
PDF is available here.
Nature Genetics (42)9 2010
Abstract
Two genome-wide association studies for meningococcal disease and tuberculosis identify new loci associated with susceptibility to these infectious diseases. They highlight a role for the acquired and innate immune systems in host control of several human pathogens and demonstrate th...
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PMID: 20802473
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (16)9 2010
Abstract
This molecular genetics study was conducted in Karachi, Pakistan from 2004 to 2006 to provide guidelines for prenatal diagnosis programmes in the country. Blood samples of patients with beta-thalassaemia minor (n=200) and beta-thalassaemia major (n=150) were collected from hospitals, transfusion cen...
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PMID: 21218725
PDF is available here.
PDF is available here.
Abstract
We provide a historical perspective, review AIM panels and software packages, and discuss recent successes and unexpected insights into human diseases that exhibit disparate rates across human populations....
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PMID: 20594047
PDF is available here.
PDF is available here.
Legal Medicine (12)5 2010
Abstract
Fifteen autosomal STR loci included in AmpFlSTR NGM kit were analyzed in 154 unrelated individuals from Poland. This multiplex kit enables simultaneous amplification of 10 standard STR loci included in AmpFlSTR SGM Plus kit (D3S1358, vWA, D16S539, D2S1338, D8S1179, D19S433, TH01, FGA, D21S11 and D18...
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PMID: 20624686
PDF is available here.
PDF is available here.
Theory in Biosciences (129)2-3 2010
Abstract
We have the freedom, especially in optimization models, to test approaches both realistic and outright speculative, from the biological point of view. In this article, we discuss different common evolutionary algorithm models, and then present some alternatives of interest. These include biologicall...
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PMID: 20532997
PDF is available here.
PDF is available here.
Theory in Biosciences (129)2-3 2010
Abstract
We celebrate Charles Darwin's second centenary, and 150 years since the publication of 'The Origin of Species'. After so many years, what has changed in the way we understand Evolution? Obviously we have now a full understanding of the mechanisms underlying heritability. Many molecular tools are ava...
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PMID: 20502983
PDF is available here.
PDF is available here.
Theory in Biosciences (129)2-3 2010
Abstract
We review attempts to investigate tempo and mode of evolution using present-day species since the introduction of the theory of punctuated equilibrium in 1972. We discuss advantages, disadvantages, and prospects of using neontological data, methodological advances, and the findings of some recent st...
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PMID: 20514523
PDF is available here.
PDF is available here.
Theory in Biosciences (129)2-3 2010
Abstract
Adaptation to a new environment (as well as its underlying mechanisms) is one of the most important topics in Evolutionary Biology. Understanding the adaptive process of natural populations to captivity is essential not only in general evolutionary studies but also in conservation programmes. Since...
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PMID: 20532673
PDF is available here.
PDF is available here.