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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
genetics (11):
Recent article
genetics
Abstract
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Abstract
Links are well established between both family history of diabetes and reduced birthweight and increased risk of diabetes in adulthood.
1) To investigate the influence of parental history of type 2 diabetes (T2DM) on offspring birthweight and adult offspring glucose t...
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PMID: 21916855
PDF is available here.
PDF is available here.
Abstract
We present the first analysis of age-at-onset in the NIMH LOAD sample that allows for both a multilocus trait model and genetic heterogeneity among the contributing sites, while at the same time accommodating age censoring, effects of known genetic covariates, and full pedigree and marker informatio...
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PMID: 21812099
PDF is available here.
PDF is available here.
Abstract
We experienced a case of a peritoneal dialysis patient with chronic hepatitis C who was successfully treated with PEG-IFN monotherapy. A 50-year old man was undergoing peritoneal dialysis because of diabetic nephropathy. Considering that his HCV genotype was 2, we decided to treat him with PEG-IFN a...
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PMID: 21873827
PDF is available here.
PDF is available here.
Journal of Neurochemistry (119)5 2011
Abstract
We have used neuroblastoma cells expressing NDM29 at its basal level (Mock cells) or at 5.4-fold higher levels (S1 cells) to investigate whether a functional differentiation correlates with morphological and biochemical development induced by NDM29 expression. First, analyzing the expression of spec...
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PMID: 21933186
PDF is available here.
PDF is available here.
Journal of Neurochemistry (119)5 2011
Abstract
We have investigated presenilin (PS)-dependent secretase-mediated processing of nectins in PS1 KO cells and primary hippocampal neurons. The loss of PS1/γ-secretase activity delayed the processing of nectin-1 and caused the accumulation of its full-length and C-terminal fragments. Over-expression o...
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PMID: 21910732
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We show that nuclear factor-κB1 (NF-κB1) is crucial for maintaining the resting state of DCs. Self-antigen-pulsed unstimulated DCs that do not express NF-κB1 were able to activate CD8(+) T lymphocytes and induce autoimmunity. We further show that NF-κB1 negatively regulates the spontaneous produ...
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PMID: 22081022
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We show that nuclear factor-κB1 (NF-κB1) is crucial for maintaining the resting state of DCs. Self-antigen-pulsed unstimulated DCs that do not express NF-κB1 were able to activate CD8(+) T lymphocytes and induce autoimmunity. We further show that NF-κB1 negatively regulates the spontaneous produ...
|
PMID: 22081022
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We show that nuclear factor-κB1 (NF-κB1) is crucial for maintaining the resting state of DCs. Self-antigen-pulsed unstimulated DCs that do not express NF-κB1 were able to activate CD8(+) T lymphocytes and induce autoimmunity. We further show that NF-κB1 negatively regulates the spontaneous produ...
|
PMID: 22081022
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
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PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
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PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We show that nuclear factor-κB1 (NF-κB1) is crucial for maintaining the resting state of DCs. Self-antigen-pulsed unstimulated DCs that do not express NF-κB1 were able to activate CD8(+) T lymphocytes and induce autoimmunity. We further show that NF-κB1 negatively regulates the spontaneous produ...
|
PMID: 22081022
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We show that nuclear factor-κB1 (NF-κB1) is crucial for maintaining the resting state of DCs. Self-antigen-pulsed unstimulated DCs that do not express NF-κB1 were able to activate CD8(+) T lymphocytes and induce autoimmunity. We further show that NF-κB1 negatively regulates the spontaneous produ...
|
PMID: 22081022
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract