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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Chemistry, Pharmaceutical (1):
Recent article
Chemistry, Pharmaceutical
Abstract
The purpose of the study was to develop a simple, versatile HPLC method for the identification and quantification of praziquantel and ivermectin (in Equimax) or praziquantel and abamectin (in Abamitel Plus). A satisfactory separation was obtained using the Supelcosil LC-ABZ+ column in gradient system...
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PMID: 21796928
PDF is available here.
PDF is available here.
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Abstract
The present investigation outlays the host-guest penetration of hydrophobic selective Cox-II chemopreventive agent, celecoxib (CXB), with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) using inclusion complexation phenomena. Phase solubility studies conducted at 37 degrees C and 25 degrees C revealed t...
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PMID: 21796941
PDF is available here.
PDF is available here.
Abstract
In the present study, the possible interactions between celecoxib and some excipients (colloidal silicon dioxide (Aerosil), microcrystalline cellulose (Avicel PH 102), lactose anhydrous, magnesium stearate, cross-povidone and talc) were evaluated by examining the pure drug or drug-excipient powder mi...
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PMID: 21648198
PDF is available here.
PDF is available here.
Abstract
Abstract
Since the early findings on the protective effects of fluoride present in drinking water upon caries incidence and prevalence, intensive research has been conducted in order to determine the benefits, safety, as well as the cost-effectiveness of other modalities of fluoride delivery....
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PMID: 21701195
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to investigate the effects of alkalizers in dissolution rate and crystal structure of valsartan (VAL) in Poloxamer 407 (POX)-based solid dispersions (SD). VAL, a poorly-water soluble drug was selected as a model drug because of its low solubility at low pH. The POX-based...
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PMID: 21720034
PDF is available here.
PDF is available here.
Abstract
To study the preparation of xiong-bing microemulsion (XB ME) and its quality evaluation.
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PMID: 21506410
PDF is available here.
PDF is available here.
Abstract
We describe the three-tier enterprise software architecture, key data structures that enable a wide variety of design scenarios and workflows, major technical challenges encountered and solved, and lessons learned during its development and deployment throughout its production cycles. In addition, P...
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PMID: 20981530
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)4 2011
Abstract
The market of generic drugs has been greatly developing during the last 15 years in various European Union (EU) member states, mainly in the Mediterranean area, including non-EU countries, i.e., in the Middle East. This has required a more detailed support from EMA (European Medicines Agency) as guid...
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PMID: 21650079
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)4 2011
Abstract
The present study was performed to compare the bioavailability of two perindopril erbumine (CAS 107133-36-8) 4 mg tablet formulations (test formulation and reference formulation). This study was a randomized, single-blind, two-period, two-sequence cross-over study which included 20 healthy adult male...
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PMID: 21650082
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)7 2011
Abstract
Trimetazidine (CAS 5011-34-7) is an effective and well-tolerated antianginal drug that possesses protective properties against ischemia-induced heart injury. The relative bioavailability and pharmacokinetic characteristics of two modified release formulations of 35 mg trimetazidine,...
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PMID: 21899207
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
A sensitive and specific liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) method was developed and validated for the identification and quantification of voriconazole (VRC, CAS 137234-62-9) in human plasma. Following liquid-liquid extraction, VRC and lorata...
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PMID: 21428249
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
Two bioequivalence studies were carried out in healthy volunteers in order to compare the rate and extent of absorption of two dosage forms (film-coated tablet and orodispersible tablet) of oral olanzapine (CAS 132539-06-1) 10 mg test formulations and the respective brand formulation...
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PMID: 21428240
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
A randomized, two-treatment and two-way crossover study on twelve healthy Indian male subjects was conducted to assess the bioequivalence of two tablet formulations containing 20 mg of rimonabant (CAS 158681-13-1). Both of the formulations were administered orally as a single dose wi...
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PMID: 21428241
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
Dermal absorption of mucopolysaccharide polysulfate (MPS, the active ingredient of Hirudoid") in human and minipig was investigated by using 14C-labeled MPS. Three types of human and minipig skin samples were used: intact, dried and tape-stripped. At 24 h after application of 14C-MPS...
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PMID: 21428242
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
Bacterial vaginosis (BV) and vaginal candidiasis (VC) are usually managed with topical antibiotics. This study compared the efficacy of a thymol + eugenol vaginal douche (SD) (CAS nr. thymol: 89-83-8 and eugenol: 97-53-0), with econazole (CAS 27220-47-9) in VC and metronidazole (CAS...
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PMID: 21428248
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
The present study has been designed to investigate the pharmacokinetic parameters of the novel trioxane antimalarial 97-78 (US Patent 6316493 B1, 2001) in male and female rats after single oral and intravenous administration. The pharmacokinetic profile of 97-78 was investigated in t...
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PMID: 21428247
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)3 2011
Abstract
Eplerenone (CAS 107724-20-9) prevents the binding of aldosterone, a key hormone in the renin-angiotensin-aldosterone-system (RAAS), which is involved in the regulation of blood pressure and the pathophysiology of cardiovascular disease and is indicated, in addition to standard therapy including beta-...
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PMID: 21528639
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)3 2011
Abstract
The pharmacokinetics and relative bioavailability/bioequivalence of two formulations of mosapride citrate (CAS 112885-42-4) were assessed in this study. The study was conducted in 20 healthy Chinese male volunteers according to an open, randomized, single-blind, 2-way crossover study design with a wa...
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PMID: 21528641
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)3 2011
Abstract
The present study was designed to determine the pharmacokinetic profiles of a once-daily formulation of tacrolimus (CAS 104987-11-3; TAC-once) in patients before and after introduction of renal transplantation. Pharmacokinetic parameters for tacrolimus were almost comparable among patients receiving...
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PMID: 21528645
PDF is available here.
PDF is available here.
Abstract
This chapter reviews the evidence for "specific" pharmacokinetics playing a role in currently marketed drugs intended to treat lower urinary tract (LUT) symptoms. Principles of drug targeting include intrinsic properties of drugs or organs as well as drug formulations to modify drug release or to cre...
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PMID: 21290231
PDF is available here.
PDF is available here.
Abstract
This pharmacokinetic (PK) study was designed to investigate the maximum intranasal insulin dose that could be achieved by repeated doses in a single nostril of a nasal spray of recombinant regular human insulin 1% in combination with cyclopentadecalactone (CPE-215) 2%, a compound tha...
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PMID: 21303633
PDF is available here.
PDF is available here.
Abstract
We outline key PK concepts relevant to PD, and then consider real-life experiments to illustrate the importance to the medicinal chemist of data obtained by PKPD. Useful assumptions and potential pitfalls are described, providing a holistic view of the plethora of determinants behind in vitro-in viv...
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PMID: 21320067
PDF is available here.
PDF is available here.
Abstract
Metabolic activation of new chemical entities to reactive intermediates is routinely monitored in drug discovery and development. Reactive intermediates may bind to cellular macromolecules such as proteins, DNA and may eventually lead to cell death via necrosis, apoptosis or oxidativ...
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PMID: 21320068
PDF is available here.
PDF is available here.
Abstract
To compare the subjective effects of oxymorphone extended release (OM-ER) versus oxycodone controlled release (OC-CR).
Randomized, double-blind, crossover study.
Inpatient unit.
Healthy, nondependent recreational opioid users....
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PMID: 21823549
PDF is available here.
PDF is available here.