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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neuropharmacology (0):
Recent article
Neuropharmacology
Behavioural Pharmacology (22 E-Suppl) 2011
Abstract
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Neuropharmacology (60)7-8 2011
Abstract
Abstract
The 23rd Congress of the European College of Neuropsychopharmacology (ECNP), held in Amsterdam, included topics covering new therapeutic developments in the field of neuropsychopharmacology. This conference report highlights selected presentations on potential psychotropic drug targets, the relation...
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PMID: 21046518
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Abstract
Bergamot (Citrus bergamia, Risso) is a fruit most knowledgeable for its essential oil (BEO) used in aromatherapy to minimize symptoms of stress-induced anxiety and mild mood disorders and cancer pain though the rational basis for such applications awaits to be discovered. The behavioural and EEG spe...
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PMID: 20093169
PDF is available here.
PDF is available here.
Abstract
Operant self-administration procedures are used to assess the neural basis of ethanol-seeking behavior under a wide range of experimental conditions. In general, rats do not spontaneously self-administer ethanol in pharmacologically meaningful amounts. This unit provides a step-by-step guide for tra...
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PMID: 20373508
PDF is available here.
PDF is available here.
Abstract
Journal of Neuroscience (30)4 2010
Abstract
We asked what combination of potencies in these three modes of TRPV1 activation corresponds to the lowest potency of a TRPV1 antagonist to cause hyperthermia. We studied hyperthermic responses of rats, mice, and guinea pigs to eight TRPV1 antagonists with different pharmacological profiles and used...
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PMID: 20107070
PDF is available here.
PDF is available here.
Abstract
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia (115)1-2 2010
Abstract
Our main studies on cerebrovascular and brain microanatomical changes occurring in SHR and their sensitivity to pharmacological interventions are summarized....
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PMID: 21072984
PDF is available here.
PDF is available here.
Metabolic Brain Disease (24)4 2009
Abstract
Abstract
We have applied these techniques to investigate the anti-tumor effect of NSAIDs, isolate novel genes specifically expressed in rheumatoid arthritis, and analyze gene expression profiles in mesenchymal stem cells. Recently, we have developed a novel system of quantitative PCR for detection of BDNF mR...
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PMID: 20030190
PDF is available here.
PDF is available here.
Schizophrenia Bulletin (35)4 2009
Abstract
We discuss how the 3 modulators regulate learning within the striatum and how their dysfunction may lead to delusional thinking....
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PMID: 19487337
PDF is available here.
PDF is available here.
European Neuropsychopharmacology (19 Suppl 1) 2009
Abstract
Abstract
We examined the effects of acute and repeated dosing with two antipsychotics, haloperidol and clozapine, and Delta(9)-tetrahydrocannabinol [Experiments 1 and 2, respectively] in adolescent rats of both sexes that differed in shipping status (i.e., shipped from a commercial breeder at weaning or bred...
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PMID: 19041390
PDF is available here.
PDF is available here.
Neuropsychopharmacology (34)1 2009
Abstract
Neuropsychopharmacology (34)1 2009
Abstract
I noted 5 years ago, 'Unless steps are taken soon to undertake a comprehensive restoration of our system, the profound advances in bio-medical research so rapidly accruing today may never be effectively transformed into meaningful advances in health care for society.' I remain perplexed and frustrat...
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PMID: 19079067
PDF is available here.
PDF is available here.
Abstract
Neuropharmacology (55)6 2008
Abstract
We discuss the current capabilities of, and future potential for phMRI to address fundamental questions in serotonergic research using animal models. Firstly we review existing literature on the application of phMRI to the serotonergic system by exploring 3 broad research themes: (i) the functional...
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PMID: 18789342
PDF is available here.
PDF is available here.
Neuroscience Letters (443)3 2008
Abstract
Two naturally occurring tropane alkaloids, anisodamine and scopolamine, structurally dissimilar in one OH group, are well established as muscarinic acetylcholine receptor (mAChR) antagonists in clinic and basic research. However, experimental evidence for central effects of anisodamine is limited an...
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PMID: 18672024
PDF is available here.
PDF is available here.
Abstract
We compared the effects of mode of delivery of neuroactive agents and the effects of dimethyl sulfoxide (DMSO), a vehicle for dissolving neuroactive agents, on locomotor-like activity in vitro. By superfusion, d-glutamate (0.3-0.9 mM) produced robust walking-like activity at superfusion rates 10-25...
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PMID: 18692523
PDF is available here.
PDF is available here.
Lancet Neurology (7)9 2008
Abstract
Abstract
The vasoconstrictor substance named serotonin was identified as 5-hydroxytryptamine (5-HT) by Maurice Rapport in 1949. In 1951, Rapport gave Gaddum samples of 5-HT substance allowing him to develop a bioassay to both detect and measure the amine. Gaddum and colleagues rapidly identified 5-HT in brai...
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PMID: 18516072
PDF is available here.
PDF is available here.
European Neuropsychopharmacology (18 Suppl 4) 2008
Abstract
Abstract
The aim of the study was to evaluate the use of imaging in the development of neuropharmacological drugs. All New Drug Applications (NDAs) approved from 1995 through 2004 in the Division of Neuropharmacological Drug Products at the Food and Drug Administration were surveyed for imaging studies. Imag...
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PMID: 18563070
PDF is available here.
PDF is available here.
Abstract
It seems that the well investigated khat alkaloids have many features similar to amphetamines; however there is a need for a more thorough examination of khat itself in well designed in vitro, animal and human studies with a range of comparator drugs before confirming the claim that khat is a "natur...
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PMID: 18561890
PDF is available here.
PDF is available here.
Seminars in Neurology (28)3 2008
Abstract
The advent of multiple new antiepileptic drugs (AEDs) in the past 15 years has provided new options for clinicians treating patients with epilepsy, but has also created a need for guidelines in AED use. For selection of the most appropriate AED, the neurologist must know the pharmacological properti...
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PMID: 18777477
PDF is available here.
PDF is available here.
International Journal of Neuropsychopharmacology (11 Suppl1) 2008
Abstract
Abstract
Abstract
Abstract
We present here the concept of a virtual archive, spatially referenced over a simplified 3D brain map and accessible over the Internet. A simple prototype (available at http://aquatics.crs4.it/neuropsydat3d) has been realized using current Web-based virtual reality standards and technologies. It ill...
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PMID: 18262677
PDF is available here.
PDF is available here.
Neuropsychopharmacology (33)6 2008
Abstract
We report the pharmacological and neurochemical characterization of two novel and selective 5-HT6 receptor agonists. WAY-181187 and WAY-208466 possess high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (WAY-181187: EC50=6.6 nM, Emax...
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PMID: 17625499
PDF is available here.
PDF is available here.
Abstract
Thirty years of clinical investigation of patients with prion disease has resulted in little progress in either defining or evaluating potential treatments. Disease course and treatment of all patients must be evaluated within a structured framework, preferably within randomized controlled trials....
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PMID: 18391159
PDF is available here.
PDF is available here.
Abstract
Ten new antiepileptic drugs have been developed in the last two decades, making selection of optimal therapy complex; they have not been shown to have better efficacy but generally seem to be better tolerated. Newer antiepileptic drugs offer new opportunities to patients who have not had a favorable...
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PMID: 18317275
PDF is available here.
PDF is available here.
Abstract
We examined further the one-trial tolerance by performing a factor analysis of the exploratory behavior of rats injected with saline before both trials as well as an immunohistochemistry study for quantification of Fos expression in encephalic structures after these sessions. Factor analysis of all...
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PMID: 18190969
PDF is available here.
PDF is available here.
European Neuropsychopharmacology (18 Suppl 1) 2008
Abstract
Abstract
Personalized medicine is still in its infancy concerning drug development in neuropsychopharmacology. Adequate biomarkers with clinical relevance to drug response and/or tolerability and safety largely remain to be identified. Possibly, this kind of personalized medicine will first gain clinical rel...
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PMID: 18344043
PDF is available here.
PDF is available here.
Abstract
I would like to review recent progress in the research fields of neuropharmacology in China....
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PMID: 18240016
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
This article assesses pain within the context of the dose response. A substantial number of studies indicate that the dose response for pain-related endpoints is commonly biphasic, being independent of the type of biological model employed, endpoint measured, or agent tested. The quantitative feature...
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PMID: 18709566
PDF is available here.
PDF is available here.
Abstract
We survey Dr. Calabrese's findings, illustrate the somewhat provocative premise of hormesis, and posit that while evidence suggests that amplification of low-dose effects are operative in neural systems, it is equally important to consider observations and claims of hormesis in greater detail, and f...
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PMID: 18709570
PDF is available here.
PDF is available here.
Abstract
Hormesis is defined operationally as responses of cells or organisms to an exogenous or intrinsic factor (chemical, temperature, psychological challenge, etc.) in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses. The compendium of...
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PMID: 18709572
PDF is available here.
PDF is available here.
Revista de Neurologia (46)11 2008
Abstract
Abstract
Current Medicinal Chemistry (15)24 2008
Abstract
The identification and characterization of potential pharmacological targets in neurology and psychiatry is a fundamental problem at the intersection between medicinal chemistry and the neurosciences. Exciting new techniques in proteomics and genomics have fostered rapid progress, opening numerous q...
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PMID: 18855673
PDF is available here.
PDF is available here.
Abstract
The treatment of mania starts with a correct diagnosis and elementary measures to prevent risks for the patient, relatives, and others. Sometimes, compulsory admission and treatment may be required for a few days. Patients with psychotic or mixed mania may be more difficult to treat. At the present...
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PMID: 18689287
PDF is available here.
PDF is available here.
Abstract
Basic scientific advances in understanding the neuropsychobiology of bipolar disorder have given us a multitude of opportunities to explore and exploit new avenues of therapeutics. Pharmacotherapeutic approaches include: neuropeptides (agonists such as thyrotropin-releasing hormone and antagonists s...
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PMID: 18689289
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Through the rapid progress in neuropharmacology it seems to become possible to effectively improve our cognitive capacities and emotional states by easily applicable means. Moreover, deep-brain stimulation may allow an effective therapeutic option for those neurological and psychiatric diseases whic...
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PMID: 18058664
PDF is available here.
PDF is available here.
Abstract
The present study was aimed to characterize the type of conotoxin present in Conus parvatus. (CP) belongs to family conidae, through neuro-pharmacological activities of the crude venom extract on some of the CNS animal experiment using mice as animal model. The effects of CP on CNS were studied, by...
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PMID: 19090294
PDF is available here.
PDF is available here.
Abstract
This review of traumatic brain injury encompasses its impact on society, pathophysiology, and rehabilitative management. Topics include mild traumatic brain injury, outcomes, prognosis, cognitive rehabilitation, behavioral management, and neurologic and medical complications. Emphasis is placed on c...
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PMID: 17967360
PDF is available here.
PDF is available here.
European Neuropsychopharmacology (17 Suppl 4) 2007
Abstract
Abstract
Abstract
Behavioural Pharmacology (18 Suppl 1) 2007
Abstract
Abstract
A beam-walking apparatus has been evaluated for its ability to detect motor impairments in mice acutely treated with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg, s.c., single or double administration). Mice subjected to MPTP lesioning showed deficits in m...
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PMID: 17498809
PDF is available here.
PDF is available here.
Abstract
An unavoidable consequence of enzymatic dispersion of sensory neurons from intact ganglia is loss of the axon and thus the ability to classify afferent fiber type based upon conduction velocity (CV). An intact rat nodose ganglion preparation was used to randomly sample neurons (n=76) using the patch...
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PMID: 17512602
PDF is available here.
PDF is available here.
Abstract
Fast-scan cyclic voltammetry in conjunction with carbon fiber microelectrode has been used to study dopamine (DA) release and uptake mechanisms in rat brains because of the smaller size of the electrode and the subsecond resolution. Current voltammetry data were analyzed by a DA kinetic model assumi...
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PMID: 17498808
PDF is available here.
PDF is available here.
Abstract
We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural...
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PMID: 17499854
PDF is available here.
PDF is available here.