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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Pharmacoepidemiology (0):
Recent article
Pharmacoepidemiology
Abstract
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Abstract
Prescription with more than one drug increases the risk of drug-drug interaction (D-DI), therapeutic failure, high pharmacological effect, or adverse events. The objectives of this study were to estimate the frequency of potential drug-drug interactions in prescriptions for hospitalized patients, and...
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PMID: 21717723
PDF is available here.
PDF is available here.
Abstract
Randomized evidence from clinical trials and naturalistic evidence collected from pharmacoepidemiology and pharmacovigilance activities both contribute to the initial and continuous assessment of the benefits and risks of a drug, ie, the balance between therapeutic efficacy and safety risks. Benefit-...
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PMID: 21842615
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)1 2010
Abstract
Abstract
A better understanding of local risk distribution may have implications for response strategies to future introductions of prescription opioids....
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PMID: 20535759
PDF is available here.
PDF is available here.
Abstract
Abstract
We provide examples of how these databases have been used for descriptive drug utilization studies and analytical pharmacoepidemiological studies linking drug exposure to other health registries. Comparisons are facilitated by many similarities among the databases, including data source, content, co...
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PMID: 19961477
PDF is available here.
PDF is available here.
Abstract
Optimizing medication use through the evaluation of Potentially Inappropriate Medications (PIMs) has been the focus of a great deal of research. The Centers for Medicare & Medicaid Services (CMS) has created its own definition of PIMs from a variety of existing criteria and has contracted with each...
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PMID: 20302063
PDF is available here.
PDF is available here.
Abstract
Rare diseases attract very little interest for drug development. To create more favourable conditions, incentives for development (scientific advice, research grants) and marketing of medicines (market exclusivity, regulatory fee reductions) are offered by several orphan legislations. These incentiv...
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PMID: 20824447
PDF is available here.
PDF is available here.
Abstract
Variability in cardiovascular drugs is of great interest because of its high population use, its high expenditure and the availability of strong evidence supporting its use. The aim of this study is to describe variation in dispensation, price and pharmaceutical expenditure for 11 subgroups of cardi...
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PMID: 21141266
PDF is available here.
PDF is available here.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique (17)3 2010
Abstract
Knowledge about safe medication use during pregnancy is limited, yet about two of every three women take at least one prescription medication during pregnancy, furthermore, there is a lack of rigorous studies evaluating birth outcomes associated with in utero exposure to medications. The Medication...
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PMID: 21041866
PDF is available here.
PDF is available here.
Drug Safety (33)1 2010
Abstract
We propose a comprehensive mechanistic classification of adverse drug effects that considers five elements: the Extrinsic chemical species (E) that initiates the effect; the Intrinsic chemical species (I) that it affects; the Distribution (D) of these species in the body; the (physiological or patho...
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PMID: 20000863
PDF is available here.
PDF is available here.
Abstract
We used open source software to build a data management system and an internet application with a Flex client on a Java application server with a MySQL database backend. The application is hosted on Amazon Elastic Compute Cloud. This solution named Phynx supports data management, Web-based display o...
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PMID: 19777533
PDF is available here.
PDF is available here.
Abstract
To estimate the net effect of imperfectly measured highly active antiretroviral therapy on incident acquired immunodeficiency syndrome or death, the authors combined inverse probability-of-treatment-and-censoring weighted estimation of a marginal structural Cox model with regression-calibration metho...
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PMID: 19934191
PDF is available here.
PDF is available here.
Abstract
The sampling methods for the selection of physicians' practices appear to be appropriate. Prescription statistics for several drugs were very similar to available data from the pharmaceutical prescriptions report (Arzneimittelverordnungsreport). The age structures for given diagnoses in Disease Anal...
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PMID: 19825325
PDF is available here.
PDF is available here.
Abstract
Abstract
In total, 20 randomised controlled trials (RCTs) were included in this assessment, mostly of 12-18 weeks duration and comparing one of the technologies added to supportive treatment with supportive treatment alone. Four published economic evaluations were identified. None produced results generalisa...
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PMID: 19863849
PDF is available here.
PDF is available here.
Epidemiology (20)4 2009
Abstract
In typical pharmacoepidemiologic studies, the proposed high-dimensional propensity score resulted in improved effect estimates compared with adjustment limited to predefined covariates, when benchmarked against results expected from randomized trials....
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PMID: 19487948
PDF is available here.
PDF is available here.
Collegium Antropologicum (33)2 2009
Abstract
We concluded that the age may be considered a methodological bias in the presentation of data. Therefore we calculated AED utilization as the age-adjusted prevalence rates (per/1000 inhabitants). For the most commonly prescribed AEDs they were: BARB 1.8 (95% CI 1.6-2.0), CBZ 1.9 (95% CI 1.7-2.1), VP...
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PMID: 19662794
PDF is available here.
PDF is available here.
Clinical Rheumatology (28)4 2009
Abstract
The topic of drug safety has received great attention in recent years. Pharmacoepidemiology is the study of the use and effects of medicines in large populations using epidemiological methods. Pharmacoepidemiologic research can fill the knowledge gaps due to the limitations of existing pharmacovigil...
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PMID: 19190976
PDF is available here.
PDF is available here.
Abstract
Abstract
There were 106,074 births, 1527 ectopic pregnancies and 25,180 terminations of pregnancy. Dispensed medicines were linked to 28.0% of the pregnancy events. Multiple birth pregnancies were 50% more likely to be dispensed a medicine in the first trimester. As parity increased, so did the likelihood of...
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PMID: 19173342
PDF is available here.
PDF is available here.
Pharmacotherapy (29)2 2009
Abstract
The increased availability of electronic medical records and administrative health care databases is adding to the popularity of pharmacoepidemiology and outcomes research studies. Despite their availability, practitioners may be reluctant to use these databases because they lack familiarity with da...
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PMID: 19170584
PDF is available here.
PDF is available here.
Validating a method that deals with missing drug information in the Saskatchewan Drug Plan database.
Abstract
Compared to non-use, the OR of prostate cancer for ever-use of warfarin in the preceding 5 years was 0.91 (95%CI: 0.81-1.02) (without "black-hole") and 0.89 (95%CI: 0.79-1.01) (with "black-hole"). Compared to non-use, cumulative use of 1, 2, 3, and 4 years were associated with ORs of 1.02, 0.94, 0.7...
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PMID: 19090502
PDF is available here.
PDF is available here.
Abstract
The findings suggest that it is possible to estimate the effect of never, current and previous use of HT on breast cancer using prescription data....
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PMID: 19072775
PDF is available here.
PDF is available here.
Chemotherapy (55)4 2009
Abstract
To avoid DDIs, reliable information on all drugs used by each single individual needs to be available at the point of care. Knowledge databases about clinically relevant DDIs must be updated and accurate. To tailor the magic bullet for the individual, new genomic- and proteomic-based knowledge about...
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PMID: 19439942
PDF is available here.
PDF is available here.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique (16)2 2009
Abstract
There are substantial differences between pregnant women insured by the RAMQ-Rx and those insured by private drug insurance plans. However, these differences will most likely limit generalizability, but not internal validity, of studies using data from the RAMQ-Rx database....
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PMID: 19553702
PDF is available here.
PDF is available here.
Drugs & Aging (26)2 2009
Abstract
Use of antidepressants increased from 2003 to 2006, and in each year increased with age, with those > or = 65 years having the greatest use. Differences were seen in the antidepressant most utilized, with the elderly using more tricyclic antidepressants than those who are younger. The utilization of...
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PMID: 19220068
PDF is available here.
PDF is available here.
Drugs & Aging (26)2 2009
Abstract
Among participants with HF, cognitive performance improved in 25% of 1172 participants who received digoxin compared with 16% of remaining patients (p < 0.0001). Among participants without HF, cognition improved in 23% of 2431 patients receiving digoxin compared with 17% of untreated patients (p < 0...
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PMID: 19220067
PDF is available here.
PDF is available here.
Abstract
As a large number of persons are exposed to prescribed psychotropic drugs, their utilisation and impact should be further explored at the population level.
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PMID: 19526741
PDF is available here.
PDF is available here.
Drug Safety (32)1 2009
Abstract
Within the study period there were 56,411 hospitalizations. 2817 patients (5.0%) had >or=1 platelet count below 100x10(9)/L. In 96.3% of these patients, alternative diagnoses for DIT were present, resulting in 103 (0.2%) patients with potential DIT based on platelet measurements. There were 74 patie...
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PMID: 19132806
PDF is available here.
PDF is available here.
Drug Safety (32)10 2009
Abstract
Biopharmaceuticals are important treatment options for a variety of chronic and sometimes life-threatening diseases. Compared with the traditional small molecule drugs, biopharmaceuticals have specific characteristics, which might also influence their safety profile. They have, for example, a comple...
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PMID: 19722725
PDF is available here.
PDF is available here.
Drug Safety (32)10 2009
Abstract
Thirty-two percent (n = 74) of the solicited pharmacies participated in the survey. Only 4.8% of the solicited patients (n = 817) refused to complete the questionnaire distributed by the pharmacy staff. The questionnaire was completed inside the pharmacy by 53.3% of the patients. The other patients...
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PMID: 19722729
PDF is available here.
PDF is available here.
Abstract
With improving socioeconomic conditions, longer life spans have become more common in developing countries-those with a growing economy increasing production, per capita consumption, and income. This has been the case in Brazil. If, on one hand, this phenomenon undoubtedly represents a major social...
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PMID: 19275458
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (15)5 2009
Abstract
We determined the prevalence of adverse drug events (ADEs) in a general teaching hospital in Rabat, Morocco. We performed a 5-day cross-sectional study of hospital departments recruiting inpatients and outpatients. Among the 1390 patients surveyed, 59 (4.2%) experienced at least 1 ADE and for 20 pat...
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PMID: 20214128
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (15)3 2009
Abstract
A cross-sectional study was conducted to determine the extent and pattern of self-medication among adults, to identify their knowledge and practice concerning the purchased drugs and to calculate prescribing and purchaser care indicators. Following WHO methods, 35 pharmacies were randomly selected f...
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PMID: 19731784
PDF is available here.
PDF is available here.
Abstract
The effects of various drugs on serum potassium are highly influenced by comorbidity and comedication. Although the presented model cannot be used to predict potassium in individual patients, we demonstrate that clinical databases could evolve as a powerful tool for industry-independent analysis of...
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PMID: 18614817
PDF is available here.
PDF is available here.
Abstract
Age-related increases in treatment intensity and prevalence, rather than population ageing, drove the increasing treatment intensity with cardiovascular drugs. Increasing treatment prevalence in subgroups was primarily caused by increasing incidence. Due to pharmacoepidemiological disequilibrium, tr...
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PMID: 19032730
PDF is available here.
PDF is available here.
Acta Paediatrica (97)12 2008
Abstract
We outline these sources, together with their strengths and weaknesses. Bradford Hill proposed criteria for assessment of causality of observed associations; we explore their utility in this context. CONCLUSION: Collaborations between clinicians, epidemiologists and clinical pharmacologists, making...
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PMID: 18793295
PDF is available here.
PDF is available here.
Acta Paediatrica (97)12 2008
Abstract
Groups were heterogeneous for GHD, which ranged from partial to severe. For all groups, mean final height corrected for mid-parental height was within the normal Swedish height range. In patients with severe GHD, mean final height was almost identical to mean normal Swedish height. About 16% of pati...
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PMID: 18976357
PDF is available here.
PDF is available here.
Abstract
Participants observed that, with the increasing availability of electronic health data, opportunities have emerged to more accurately characterize and confirm potential safety issues. The gain for public health from a highly coordinated network of population-based databases for active surveillance i...
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PMID: 18823068
PDF is available here.
PDF is available here.
Abstract
Abstract
There are many European healthcare databases providing an enormous potential for pediatric pharmacoepidemiological research. Future research should focus on methods to bring data from different databases together to use the full capacity effectively.
Copyright (c) 2008 John Wiley & Sons, Ltd....
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PMID: 18979461
PDF is available here.
PDF is available here.
Abstract
QT-prolonging drugs were used in a minority of critically ill patients. Prospective evaluation in the ICU environment is necessary to determine whether administration of these agents is associated with adverse cardiac events comparable to those reported in ambulatory patients....
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PMID: 18693297
PDF is available here.
PDF is available here.
Abstract
Abstract
Cisapride was associated with a doubling to tripling of the risk of hospitalization for ventricular arrhythmia, and a nearly eightfold risk in the initial prescription period. Although use of potentially arrhythmogenic CYP3A4 inhibitors was associated with an increased risk, this appears to be due t...
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PMID: 18662288
PDF is available here.
PDF is available here.
Abstract
In-hospital drug incidents cause problems for patients and additional costs for the health system. The variety of terms used to report them leads to disparities in research results and confuses the professionals that report them. This study aimed to review the terms used to describe drug incidents b...
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PMID: 18813672
PDF is available here.
PDF is available here.
Abstract
Applying the legend time method to medicine groups used mainly on a chronic basis revealed good to very good agreement between the two data sources, whereas medicines used as needed showed fair to moderate agreement. When a fixed-time window was applied for analysis, agreement was unchanged for medi...
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PMID: 18468858
PDF is available here.
PDF is available here.
Abstract
The study identified higher use of medicines by women, making them more vulnerable to the harmful effects of polytherapy, such as drug interactions and inadequate use of medicines....
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PMID: 18488101
PDF is available here.
PDF is available here.
Abstract
We undertook a comprehensive review of publications related to the topics ADs, suicide, suicidality, suicidal behaviour and aggression. Based on this comprehensive review we conclude that ADs, including SSRIs, carry a small risk of inducing suicidal thoughts and suicide attempts, in age groups below...
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PMID: 18668279
PDF is available here.
PDF is available here.
Abstract
This retrospective study in Belo Horizonte, Minas Gerais, Brazil, aimed to provide indicators on the sale and consumption of anorexigenic substances. During the first stage, 2,906 of 168,237 prescriptions received by pharmacies in 2003 were analyzed, showing low quality of prescriptions. Projected c...
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PMID: 18709217
PDF is available here.
PDF is available here.
Seminars in Hematology (45)3 2008
Abstract
Pharmacoepidemiology is an important tool for understanding and documenting the relationships between the use of drugs and adverse events. Side effects are an important consideration for clinicians making treatment decisions, and they also figure prominently in action by regulatory agencies. Unlike...
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PMID: 18582625
PDF is available here.
PDF is available here.
Abstract
In French hospitals, pharmacists contribute to preventing DRPs during medication order validation. This study suggests that a few types of drugs and errors constitute a substantial proportion of PIs. Knowledge of the most frequent DRPs could significantly increase the efficiency of clinical PIs....
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PMID: 18559955
PDF is available here.
PDF is available here.
Abstract
Approximately 5.3% of hospital admissions were associated with ADRs. Higher rates were found in elderly patients who are likely to be receiving multiple medications for long-term illnesses. The methods used to detect ADRs are also likely to explain much of the variation in the reported ADR prevalenc...
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PMID: 18594048
PDF is available here.
PDF is available here.
Abstract
Abstract
Medicines are one of the most important health care items for the elderly, who are particularly prone to use multiple drugs with a higher number of adverse reactions. The current study aimed to assess the profile of pharmaceutical consumption by the elderly. A cross-sectional epidemiological study u...
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PMID: 18545769
PDF is available here.
PDF is available here.
Abstract
Abstract
Effect estimates from EPS models by simple LR were generally robust. NN models generally provided the least numerically biased estimates. C was not associated with the magnitude of bias but was with the increased SE....
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PMID: 18311848
PDF is available here.
PDF is available here.
Abstract
There was evidence that the missing blood pressure data were not missing completely at random as subjects with more blood pressure readings tended to have higher recorded values. For statins, the mixed model estimated a change in systolic blood pressure of -3.80 mmHg (99% confidence interval (CI): f...
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PMID: 18265414
PDF is available here.
PDF is available here.
Abstract
This study provides national-level CHP prescription profiles and utilization rates, and documents, for the first time, HF-HF prescription combinations in Chinese medicine (CM) practices in Taiwan. We conclude that more studies are needed to validate the safety and effectiveness of CHP prescriptions....
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PMID: 18481335
PDF is available here.
PDF is available here.