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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Pharmacogenetics (1):
Recent article
Pharmacogenetics
Abstract
A large number of genetic polymorphisms have been reported in the genes that mediate the metabolism, transport and pharmacological activity of doxorubicin. The clinical significance of these is still undergoing evaluation. AREAS COVERED: Doxorubicin is a widely used anticancer drug in the treatment...
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PMID: 21919804
PDF is available here.
PDF is available here.
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Abstract
Personalized medicine is a broad and rapidly advancing field of health care that is informed by each person's unique clinical, genetic, genomic, and environmental information. Personalized medicine depends on multidisciplinary health care teams and integrated technologies (e.g., clin...
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PMID: 21721939
PDF is available here.
PDF is available here.
Missouri medicine (108)4 2011
Abstract
We now are at the cusp of yet another such overhaul with the protease inhibitors about to be introduced into the market....
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PMID: 21905441
PDF is available here.
PDF is available here.
Abstract
We report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences...
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PMID: 21886157
PDF is available here.
PDF is available here.
Abstract
Tamoxifen is metabolized by cytochrome P450s, with an important role for CYP2D6. Recently, we demonstrated in 80 patients that CYP2C19*2 is associated with increased survival in breast cancer patients using tamoxifen. Here, we aimed to confirm this in a large group of 499 patients.
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PMID: 21830868
PDF is available here.
PDF is available here.
Abstract
Type 2 diabetes mellitus (T2DM) is an increasingly prevalent disease. Several classes of drugs are currently available to treat T2DM patients; however, clinical response to these drugs often exhibits significant variation among individuals. For the oral antidiabetic drug classes of sulfonylureas, non...
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PMID: 21843065
PDF is available here.
PDF is available here.
Abstract
Weight gain is an important side effect of antipsychotic drugs. Since the high interindividual difference in weight gain suggests that genetic factors play a role in this weight gain, studies have tried to identify these factors. Most of these studies were carried out in the past few years and focuss...
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PMID: 21843067
PDF is available here.
PDF is available here.
Abstract
Abstract
Efavirenz plasma concentration-time data obtained from 29 HIV-1-infected, treatment-naïve patients were merged with previously reported data from 32 adult healthy subjects. The model identified sex and HIV/AIDS disease as statistically significant categorical predictors of efavirenz pharmacokinetic...
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PMID: 21740076
PDF is available here.
PDF is available here.
Abstract
We have recently reported the remarkable clinical outcome of a patient with advanced, gemcitabine-resistant, pancreatic cancer who was later treated with DNA damaging agents, on the basis of the observation of significant activity of this class of drugs against a personalized tumorgraft generated fr...
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PMID: 21673092
PDF is available here.
PDF is available here.
Abstract
Molecular reductionism has failed to deliver the broad-based therapeutic insights that were initially hoped for. Simple reductionism is now being replaced by so-called "systems biology." This is a poorly defined approach and/or discipline with some versions of it relying excessively...
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PMID: 21636568
PDF is available here.
PDF is available here.
Psychiatry Research (187)1-2 2011
Abstract
Dopamine D2 receptors, encoded by DRD2, play a role in regulating serum prolactin concentration. Single nucleotide polymorphisms (SNPs), rs2734842(C), rs6275(T), and rs6279(C) located within DRD2, have been shown to be associated with prolactin increase in olanzapine/fluoxetine combination (OFC)-trea...
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PMID: 21095016
PDF is available here.
PDF is available here.
Abstract
The 4-anilinoquinazolines (gefitinib, erlotinib and lapatinib) are members of a class of potent and selective inhibitors of the human epidermal growth factor receptor (HER) family of tyrosine kinases that have been developed to treat patients with tumours with defined genetic alterat...
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PMID: 21553932
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Duloxetine, a potent reuptake inhibitor of serotonin (5-HT) and norepinephrine, is effective for the treatment of major depressive disorder, diabetic neuropathic pain, stress urinary incontinence, generalized anxiety disorder and fibromyalgia. Duloxetine achieves a maximum plasma concentration (C(max...
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PMID: 21366359
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)12 2011
Abstract
We sought to prevent carbamazepine-induced SJS-TEN by using HLA-B*1502 screening to prospectively identify subjects at genetic risk for the condition.
From 23 hospitals in Taiwan, we recruited 4877 candidate subjects who had not taken carbamazepine. We genotyped DNA purified from the...
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PMID: 21428768
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to investigate the effects of polymorphisms in CYP3A5*3, CYP3AP1, and MDR1, and of haplotype, on plasma levels of tacrolimus in Chinese patients after renal transplantation, and to assess the relationship between polymorphisms and the variability of concentration/dose of...
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PMID: 21436775
PDF is available here.
PDF is available here.
Abstract
A substantial proportion of patients with rheumatoid arthritis do not respond to tumor necrosis factor blocking therapy. Results of a large genome-wide association study demonstrate evidence of novel genetic factors that determine response to treatment, which could provide a basis fo...
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PMID: 21304506
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (131)2 2011
Abstract
We established a research group in 2006 with professionals of pharmacogenomics, dermatologists, ophthalmologists and psychiatrists to explore genetic biomarkers associated with Japanese SJS/TEN patients. To date, we have collected more than 100 Japanese SJS/TEN patients through participating institu...
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PMID: 21297371
PDF is available here.
PDF is available here.
Lakartidningen (108)22-23 2011
Abstract
British Journal of Nutrition (105)1 2011
Abstract
Inter-individual response differences to vitamin D and Ca supplementation may be under genetic control through vitamin D and oestrogen receptor genes, which may influence their absorption and/or metabolism. Metabolomic studies on blood and urine from subjects supplemented with Ca and vitamin D revea...
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PMID: 20727239
PDF is available here.
PDF is available here.
Abstract
Our goal was to identify candidate polymorphisms that could influence overall survival (OS) in advanced non-small cell lung cancer (NSCLC) patients treated with carboplatin (CBDCA) and paclitaxel (PTX).
Chemotherapy-naïve stage IIIB or IV NSCLC patients treated with CBDCA (area unde...
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PMID: 21079520
PDF is available here.
PDF is available here.
Pharmocoepigenetics: a new approach to predicting individual drug responses and targeting new drugs.
Abstract
Epigenetics is the study of heritable changes in genes and gene expression that do not involve DNA nucleotide sequences. Epigenetic modifications include DNA methylation, several forms of histone modifications, and microRNA expression. Because of its dynamic nature, epigenetics provi...
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PMID: 21602587
PDF is available here.
PDF is available here.
Abstract
Psychiatry Research (188)1 2011
Abstract
We did not find evidence supporting any of such associations....
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PMID: 21168919
PDF is available here.
PDF is available here.
Journal of Hepatology (54)6 2011
Abstract
The rs2858996/rs707889 polymorphisms in the HFE gene may be associated with reversible ALT elevation in pazopanib-treated patients with RCC.
Copyright © 2010. Published by Elsevier B.V....
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PMID: 21145803
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Abstract
Pharmacogenetic testing is used to uncover genetic causes for variations in drug response. Documentation of the method's usefulness in a clinical setting is scarce. The aim of the study was to systematically categorize the experience from routine CYP2D6 genotyping in a diagnostic laboratory.
All sam...
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PMID: 21109842
PDF is available here.
PDF is available here.
Abstract
We have identified a gene, which may contribute to genetic variability in MTX response in JIA, and established as proof of principle that genes that are differentially expressed at mRNA level after drug administration may also be good candidates for genetic analysis....
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PMID: 20827233
PDF is available here.
PDF is available here.
Acta Oncologica (49)8 2010
Abstract
Identification of the genetic basis of variable treatment response, prognosis and survival in cancer patients (i.e. personalized medicine) is an important aim in current medicine. Millions of genetic variations exist in the human genome, some of which are already found to be directly involved in var...
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PMID: 20670087
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
We present here some of the techniques aimed at the identification of structural DNA variations. We present afterwards some examples of the role that play polymorphic constitutive variations of the genome in the occurrence of cancer (molecular epidemiology) and the activity of anticancer drugs (phar...
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PMID: 21115419
PDF is available here.
PDF is available here.
Abstract
We retrospectively studied 51 Japanese adults with colorectal cancer who had received oxaliplatin-based chemotherapy to explore the pharmacogenetic association between oxaliplatin-induced neuropathy and polymorphisms of the excision repair cross-complementation Group 1 (ERCC1) and glutathione-S-tran...
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PMID: 20979931
PDF is available here.
PDF is available here.
B M B Reports (43)10 2010
Abstract
We know as disease". Accordingly, the traditional methods of medicine are not always best for all patients. Over the last decade, the study of genomes and their derivatives (RNA, protein and metabolite) has rapidly advanced to the point that genomic research now serves as the basis for many medical...
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PMID: 21034525
PDF is available here.
PDF is available here.
Abstract
Abstract
Adverse drug reactions are recognized as a significant public health issue. Pharmacogenetics (PGx) provides a potential means of preventing some adverse drug reactions by predicting the optimal medication dose for an individual; however, PGx is rarely used in clinical practice. Thus far, there have...
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PMID: 20813335
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)8 2010
Abstract
I enrolled 16 patients; 700 mg/m was defined as pemetrexed recommended dose. Thirteen serious adverse events were reported; the most common grade 3/4 toxicities were haematologic (10 of 13, 76.9%). Phase II enrolled 73 patients, 69 qualified for safety and 68 for efficacy analysis; 65 for pharmacoge...
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PMID: 20634689
PDF is available here.
PDF is available here.
Abstract
We summarize the possible role of cytochrome P450 (CYP) enzymes in drug-induced interstitial lung disease.
The CYP enzyme family plays an important role in the metabolism of all sorts of ingested, injected or inhaled xenobiotic substances. Although the liver is considered to be the major metabolism...
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PMID: 20592596
PDF is available here.
PDF is available here.
Abstract
We review: the current knowledge on the clinical and genetic determinants of warfarin dosing and summarize how such determinants have been incorporated in clinical practice; the main pharmacogenetics-based predictive models and their performance; and the potential clinical role of recently developed...
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PMID: 20473166
PDF is available here.
PDF is available here.
Abstract
In North America warfarin is the current standard for oral anticoagulation therapy in the treatment and/or prophylaxis of different thrombotic conditions. In daily clinical practice a significant proportion of patients on long-term warfarin therapy fail to stabilize within their target therapeutic r...
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PMID: 20601874
PDF is available here.
PDF is available here.
Abstract
We earlier reported a significant association between the cytochrome P450 2D6 (CYP2D6) genotype and the clinical outcome in 282 Japanese breast cancer patients receiving tamoxifen monotherapy. Although many research groups have provided evidence indicating the CYP2D6 genotype as one of the strongest...
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PMID: 20574415
PDF is available here.
PDF is available here.
Abstract
The aim of the study is to improve our understanding of the worldwide allele frequency distribution of four genetic polymorphisms known to influence warfarin dosing (VKORC1 rs9923231, CYP2C9 rs1799853, CYP2C9 rs1057910 and CYP4F2 rs2108622). These four polymorphisms were genotyped in the Human Genom...
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PMID: 20555338
PDF is available here.
PDF is available here.
Abstract
Bulletin du cancer (97)8 2010
Abstract
We still need predictive factors of treatment and /or prognosis factors specific of each patient. Regarding hormonal therapy, expression of hormone receptors is essential, but not sufficient to accurately predict response to treatment for all patients. To date, numerous data have identified differen...
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PMID: 20605764
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We developed a population pharmacokinetic (PPK) model of S-1 including the cytochrome P450 (CYP) 2A6 genotype and then used this PPK model to assess the influence of the CYP2A6 genotype on PK parameters of S-1 and the relationship between toxicity and the individual maximum concentrations (Cmax) or...
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PMID: 20596643
PDF is available here.
PDF is available here.
Abstract
Medical Journal of Australia (193)2 2010
Abstract
Genomic research can link specific molecular genetic information with specific diseases. Implications of genomic medicine in general practice include developments in screening and diagnosis, predicting disease prognosis, and optimising preventive and therapeutic care. As users or co-producers of gen...
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PMID: 20642421
PDF is available here.
PDF is available here.
Abstract
Colorectal cancer (CCR), which is one of the most common causes of cancer, has benefited from the major advances in the understanding of the intracellular signaling pathways implicated in the initiation, growing and local and metastasis dissemination of tumor, which have occurred during the 20 past...
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PMID: 20637356
PDF is available here.
PDF is available here.
Abstract
Abstract
When applying the IWPC pharmacogenetic algorithm to our cohort of patients, the percentage of patients within 1 mg/d of the therapeutic warfarin dose increases from 54% to 63% using clinical factors only, or from 38% using a fixed-dose approach. CYP4F2 adds 4% to the fraction of the variability in d...
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PMID: 20442691
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Pediatric acute lymphoblastic leukemia (ALL) represents one of the best examples of progress in disease treatment and improved outcome based in part upon the incorporation of the principles of pharmacogenomics. Throughout the past several decades, clinical scientists have co...
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PMID: 20429672
PDF is available here.
PDF is available here.
Abstract
We evaluated if OXT and OXT receptor (OXTR) genes might play a role in the symptom severity and clozapine treatment response in schizophrenia subjects. The rs2740204 variant in the OXT gene was significantly associated with treatment response (after 1000 permutations p=0.042) and nominally associate...
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PMID: 20196918
PDF is available here.
PDF is available here.
Abstract
Warfarin genotyping reduced the risk of hospitalization in outpatients initiating warfarin. (The Clinical and Economic Impact of Pharmacogenomic Testing of Warfarin Therapy in Typical Community Practice Settings [MHSMayoWarf1]; NCT00830570).
Copyright (c) 2010 American College of Cardiology Foundat...
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PMID: 20381283
PDF is available here.
PDF is available here.
Abstract
Biological Psychiatry (67)11 2010
Abstract
Previously, described associations between polymorphisms in candidate genes and antidepressant treatment response were not replicated in this study. This result may suggest that previous associations are specific to serotonin reuptake inhibitors.
Copyright 2010 Society of Biological Psychiatry. Publ...
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PMID: 20110084
PDF is available here.
PDF is available here.
Abstract
Physicians at early adopting departments of psychiatry endorsed the clinical utility of pharmacogenetic testing and the use of some patient safeguards, but showed a lack of consensus about other safeguards and risks.
2010 Physicians Postgraduate Press, Inc....
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PMID: 20361898
PDF is available here.
PDF is available here.
Psychiatria Danubina (22)2 2010
Abstract
The concept of personalized drug therapy on the basis of genetic investigations has become a major issue in psychopharmacology. Pharmacogenetic studies have focused on polymorphisms in liver cytochrome P450 isoenzymes that metabolize many antidepressant and antipsychotic medications. The most signif...
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PMID: 20562776
PDF is available here.
PDF is available here.
Psychiatria Danubina (22)2 2010
Abstract
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal co...
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PMID: 20562760
PDF is available here.
PDF is available here.
Psychiatria Danubina (22)2 2010
Abstract
Antipsychotics are the lodestar in the treatment of schizophrenia despite the variability of the therapeutic response and drug-induced adverse effects (especially extrapyramidal symptoms, gain weight, and metabolic disturbances). More and more data are supporting the notion that genetic factors - as...
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PMID: 20562775
PDF is available here.
PDF is available here.