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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Pharmacology, Clinical (0):
Recent article
Pharmacology, Clinical
Clinical Pharmacology and Therapeutics (89 Suppl 1) 2011
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British Journal of Clinical Pharmacology (70 Suppl 1) 2010
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Population-based modeling is now considered superior to older, more traditional modeling methods. Nonlinear mixed-effect modeling - a commonly used population-based modeling approach - estimates intraindividual and interindividual variability, limits the influence of outlying samples and individuals...
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PMID: 20610985
PDF is available here.
PDF is available here.
Abstract
POCD has emerged as a new concern for anesthesiologists and their older patients. Several recent studies indicate that POCD is common after noncardiac surgery, with an incidence approaching 30-40% at discharge, although this incidence declines at 3 months. Some data suggest that POCD imparts risk fo...
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PMID: 20489604
PDF is available here.
PDF is available here.
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We describe briefly the contributions of pharmacometrics and the specific goals of the Task Force....
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PMID: 20648032
PDF is available here.
PDF is available here.
Abstract
YAKUGAKU ZASSHI (130)5 2010
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Pharmacogenomics (11)4 2010
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Membrane transporters are major determinants of the absorption, distribution and elimination of many of the most commonly used drugs. In the past decade, the field of membrane transporter pharmacogenomics has undergone enormous growth. In particular, functional genomic and clinical studies have prov...
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PMID: 20350125
PDF is available here.
PDF is available here.
The Lancet (375)9712 2010
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The HPS provides a novel educational format to teach essential information regarding opioid pharmacology for the management of acute postoperative pain. The HPS provides a realistic format to teach the pharmacology of acute opioid side effects and the management of acute and life-threatening side ef...
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PMID: 20481177
PDF is available here.
PDF is available here.
Pharmacogenomics (11)1 2010
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While no genome-wide pharmacogenetics study has yet been published, the field of pharmacogenetics is moving towards exploratory, large-scale analyses of the interaction between genetic variation and drug treatment. The Drug Metabolizing Enzymes and Transporters (DMET) platform offers a standardized...
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PMID: 20017675
PDF is available here.
PDF is available here.
BMC Pharmacology (10 Suppl 1) 2010
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Clinical Medicine (9)5 2009
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Clinical Medicine (9)5 2009
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Objective. To establish a clinically relevant list with explicit criteria for pharmacologically inappropriate prescriptions in general practice for elderly people ≥70 years. Design. A three-round Delphi process for validating the clinical relevance of suggested criteria (n = 37) for i...
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PMID: 19462339
PDF is available here.
PDF is available here.
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Drug-drug interaction studies are important building blocks in drug development to understand the perceived risk of a purported interaction due to the differing clinical pharmacology attributes of the co-administered drugs. Two case studies are presented that justify the importance of evaluating the...
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PMID: 19280517
PDF is available here.
PDF is available here.
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Pharmacogenomics (10)7 2009
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The conference 'Biobanking in Pharmacogenetics' was held on the 23rd and 24th of April 2009 in London, UK. The conference was organized by the European Federation for Pharmaceutical Sciences European Research Network on Pharmacogenetics/Pharmacogenomics. The European Association for Clinical Pharmac...
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PMID: 19604088
PDF is available here.
PDF is available here.
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European Heart Journal (30)9 2009
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Pharmacy World & Science (31)2 2009
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Naunyn-Schmiedebergs Archives of Pharmacology (379 Suppl 1)s1 2009
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Vnitrni lekarstvi (55)4 2009
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The basic method of pharmaceutical care is the maximization of benefits (instructions, how to use the drug correctly, how to support the patient's compliance, change in lifestyle) and the minimization of risks (to look for risk signals and to help resolve them; to resolve them directly with the OTC...
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PMID: 19449755
PDF is available here.
PDF is available here.
Abstract
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Students in Rijeka were significantly more satisfied with their traditional lecture-based course. Only 56% of Zagreb students and 54% of students from Rijeka felt confident about their prescription-writing skills. Only 8% of Zagreb and none of Rijeka students had written more than six prescriptions...
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PMID: 19083211
PDF is available here.
PDF is available here.
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The first integrase inhibitor licensed to treat HIV-1 infection was approved in late 2007, more than a decade after the introduction of the first inhibitors of the HIV-1 reverse transcriptase and protease. The unique biochemical and molecular mechanism of action of this novel class of antiretroviral...
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PMID: 18928385
PDF is available here.
PDF is available here.
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Microbicides, substances applied topically to prevent sexual HIV infection, are needed to empower receptive sexual partners with effective prevention methods. Several large microbicide trials, however, failed to demonstrate efficacy, thus motivating a reevaluation of the current microbicide developm...
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PMID: 19006450
PDF is available here.
PDF is available here.
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The development of novel drugs falls into two completely different categories: truly novel drugs and drugs that can be considered as improvements of further advanced and eventually marketed drugs. The risk of failure and the reason for failure by these two classes of compounds obviously are very dif...
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PMID: 19236259
PDF is available here.
PDF is available here.
Lakartidningen (106)9 2009
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Paediatric Drugs (11)1 2009
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Paediatric Drugs (11)1 2009
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A paradigm change is taking place from protecting children against clinical research to protecting them through research. It is based on a better scientific understanding of the child's physiology, on the increasing potential of biomedical interventions, and on an evolving conviction of children's r...
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PMID: 19127957
PDF is available here.
PDF is available here.
Paediatric Drugs (11)1 2009
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The vast majority of drugs prescribed for children have not been approved by regulatory agencies for the pediatric age group and, in many cases, have not been studied appropriately. In July 2008, at a meeting of pediatric pharmacologists from over 30 countries and 5 continents in Toronto, ON, Canada...
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PMID: 19127940
PDF is available here.
PDF is available here.
Paediatric Drugs (11)1 2009
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Canada has a long tradition of undertaking research and training in pediatric clinical pharmacology, and has one of the longest continuous enterprises in this field in the world. Training in pediatric clinical pharmacology in Canada is nationally accredited and rigorous. Canada has the largest numbe...
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PMID: 19127954
PDF is available here.
PDF is available here.
Paediatric Drugs (11)1 2009
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Established in 1979, the Toronto Program in Pediatric Pharmacology has trained pediatricians and pharmacists from over 30 countries and five continents. Within the training guidelines of the Royal College of Physicians and Surgeons of Canada, the philosophy of the program is tailoring the goals to m...
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PMID: 19127958
PDF is available here.
PDF is available here.
Paediatric Drugs (11)1 2009
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In recent years there has been a rapid and marked increase in global recognition of the need for better medicines for children, with various initiatives being implemented at global and regional levels. These exciting developments are matched by recognition of the need to build greater capacity in th...
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PMID: 19127959
PDF is available here.
PDF is available here.
Paediatric Drugs (11)1 2009
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Developmental pharmacology is a science that does not start at birth, but rather preconceptionally. However, training for obstetricians, perinatologists, and neonatologists in this field is almost nonexistent. The novel Summer Institute in Maternal-Fetal Pharmacology is presented, with preliminary i...
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PMID: 19127962
PDF is available here.
PDF is available here.
Abstract
After a single dose, lithium, usually given as carbonate, reaches a peak plasma concentration at 1.0-2.0 hours for standard-release dosage forms, and 4-5 hours for sustained-release forms. Its bioavailability is 80-100%, its total clearance 10-40 mL/min and its elimination half-life is 18-36 hours....
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PMID: 19374461
PDF is available here.
PDF is available here.
BMC Pharmacology (9 Suppl 2) 2009
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Genetic factors have been suggested depending on the drug, to account for 20 to 95 % of the variability in drug disposition and effects. Pharmacogenetics is defined as the study of interindividual variations in DNA sequence related to drug disposition or drug action that can influence clinical respo...
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PMID: 20232787
PDF is available here.
PDF is available here.
Clinical Pharmacology and Therapeutics (85 Suppl 1) 2009
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Pharmacotherapy (28)12 2008
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The 2007 Accreditation Council for Pharmacy Education (ACPE) Accreditation Standards and Guidelines for the Professional Program in Pharmacy delineate new expectations for experiential education within curricula and include guidance on the development and conduct of Pharmacy Practice Experiences. Th...
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PMID: 19025437
PDF is available here.
PDF is available here.
Pharmacotherapy (28)12 2008
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Drug development is a lengthy, costly, and complex process, with clinical trials essential for characterizing dosing, safety, and efficacy in treated populations. After regulatory approval, aggressive marketing ensures that most drugs are used by a broad spectrum of ages, genders, races, and ethnic...
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PMID: 19008903
PDF is available here.
PDF is available here.
Journal of Nursing Education (47)11 2008
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High-fidelity patient simulations provide unique learning opportunities in undergraduate pharmacology. Every year, adverse drug events in the clinical setting affect thousands of patients. Pharmacology content is often taught independently without a clinical application component. Students have diff...
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PMID: 19010051
PDF is available here.
PDF is available here.
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Evidence is presented which supports the conclusion that the hormetic dose-response model is the most common and fundamental in the biological and biomedical sciences, being highly generalizable across biological model, endpoint measured and chemical class and physical agent. The paper provides a br...
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PMID: 18662293
PDF is available here.
PDF is available here.
Abstract
Clinical pharmacology assumes that deductions can be made about the concentrations of drugs from a knowledge of the pharmacokinetic parameters in an individual; and that the effects are related to the measured concentration. Post-mortem changes render the assumptions of clinical pharmacology largely...
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PMID: 18637886
PDF is available here.
PDF is available here.
Abstract
The irrational prescribing of drugs seems to be a general problem in medical practice, occasionally leading to serious consequences. In order to improve the drug prescribing performance of medical students, a compulsory context-learning pharmacotherapy module was implemented in 1998 in the medical c...
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PMID: 19238657
PDF is available here.
PDF is available here.
Abstract
We start to address the overwhelming mandate and the unfortunate shortage of qualified investigators in the field (both physicians and non-physicians)....
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PMID: 19238658
PDF is available here.
PDF is available here.
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The purpose of this mini review is to discuss the use of physiologically-based drug absorption modeling to guide the formulation development. Following an introduction to drug absorption modeling, this article focuses on the preclinical formulation development. Case studies are presented, where the...
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PMID: 18751901
PDF is available here.
PDF is available here.
Abstract
During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and BioSim, the major European Network of Excellence on Systems Biology, held a challenging conference on the use of mathematical models in the drug development process. More precisely, the purpose o...
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PMID: 18602464
PDF is available here.
PDF is available here.
Abstract