Abstract
The 23rd Congress of the European College of Neuropsychopharmacology (ECNP), held in Amsterdam, included topics covering new therapeutic developments in the field of neuropsychopharmacology. This conference report highlights selected presentations on potential psychotropic drug targets, the relation...
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PMID: 21046518
PDF is available here.
Abstract
The development of geriatric psychopharmacology was built on advances in geriatric psychiatry nosology and clinical pharmacology and on increased investment in aging research by the National Institute of Mental Health and by academic institutions. Application of the US Food and Drug Administration's...
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PMID: 21114947
PDF is available here.
Abstract
This article describes several examples where the development of drugs and devices for use in psychiatry followed from initial serendipitous observations. The potential psychotropic properties of chlorpromazine (Thorazine(®)) were first noted in surgical patients when the drug was being investigate...
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PMID: 20873698
PDF is available here.
Abstract
We retrieved information about articles from 15 journals included in the Pharmacology and Pharmacy category of the Journal Citation Reports database for a 21-year period (1987 to 2007). There were 37540 articles which about 52% were represented by 3 journals. About 70% of psychology publications wer...
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PMID: 20480716
PDF is available here.
Abstract
The purpose of this integrative review is to facilitate social work practitioners' understanding of how psychotropic drug harms are assessed in clinical trials and to make specific suggestions for social workers' increased involvement in detecting drug harms in their clients. The authors undertook a...
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PMID: 20408352
PDF is available here.
Abstract
In line with their vast expansion over the last few decades, the brain sciences -- including neurobiology, psychopharmacology, biological psychiatry, and brain imaging -- are becoming increasingly prominent in a variety of cultural formations, from self-help guides and the arts to advertising and pu...
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PMID: 20514752
PDF is available here.
Abstract
We have applied these techniques to investigate the anti-tumor effect of NSAIDs, isolate novel genes specifically expressed in rheumatoid arthritis, and analyze gene expression profiles in mesenchymal stem cells. Recently, we have developed a novel system of quantitative PCR for detection of BDNF mR...
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PMID: 20030190
PDF is available here.
Abstract
Medical presentations can be enhanced by systematically collecting audience feedback. This is readily accomplished with polling systems, called audience response systems. Several systems are now available that are small, inexpensive, and can be readily integrated into standard powerpoint presentatio...
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PMID: 19890234
PDF is available here.
Abstract
Chirality, the concept of nonsuperimposable mirror images, is a fundamental property of biological systems and can be observed on a molecular, cellular, or organism level. Stereoisomer compounds possess the same molecular and structural formula, but they differ in their three-dimensional configurati...
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PMID: 19681517
PDF is available here.
Abstract
Rates of prescriptions for very young children have increased notably in the last 20 years. These changes have occurred in the context of increasing attention to early childhood mental health, availability of medications perceived to be safer than older medications, application of th...
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PMID: 19486849
PDF is available here.
Abstract
Clinical work--psychotherapy, assessment, consultation, or research--with emotionally ill children and adolescents is challenging, complex, and exceedingly rewarding. Psychiatrists must remain mindful of children's vulnerabilities but also remain respectful of their rights, regardles...
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PMID: 19486811
PDF is available here.
Abstract
We suggest that they may have unanticipated effects upon the care of patients with mental illness. Certainly, the philosophical issues surrounding free will are of tremendous consequence to persons who commit crimes while suffering severe symptoms of mental illness. In addition, the opening up of a...
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PMID: 19486824
PDF is available here.
Abstract
Schizophrenia is a clinical syndrome of variable, but profoundly disruptive, psychopathology that involves cognition, emotion, perception and other aspects of behavior The Remission in Schizophrenia Working Group (RSWG) has defined criteria for symptomatic remission based on achieving and maintainin...
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PMID: 19662777
PDF is available here.
Abstract
Medical education in psychopharmacology can be designed according to modern principles of adult learning. The goal is to go beyond merely exposing learners to novel content, to the documentation that learning has occurred and that behaviors have changed, namely the upgrading of skills in clinical pr...
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PMID: 19407729
PDF is available here.
Abstract
The lowest discriminated dosage is influenced by the criterion of discriminative control that is employed and is higher than the absolute threshold at which discrimination entirely disappears. Threshold estimations closer to absolute threshold can be obtained when criteria are employed that are more...
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PMID: 19082992
PDF is available here.
Abstract
Various sedative drugs cause a discriminable decrease in the function of the CNS. Different types of sedatives can be discriminated from each other. Indole and phenylethylamine hallucinogens have potent discriminative stimulus properties, which are related to the actions of biogenic amine neurotrans...
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PMID: 18712362
PDF is available here.
Abstract
There are important differences in discriminative stimulus properties both between and within atypical and typical antipsychotics and across species. While low-dose clozapine discrimination in rats appears to provide a more sensitive behavioral assay for distinguishing atypical from typical antipsyc...
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PMID: 18795269
PDF is available here.
Abstract
PRO and cocaine exhibited cross-substitution, but their stimulus effects were antagonized differentially by prazosin. PRO (and its optical isomers) can exert a stimulus effect that is based, at least in part, on increased alpha(1)-adrenoceptor activity. PRO might be better characterized as an adreno...
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PMID: 18795268
PDF is available here.
Abstract
Beginning this month and appearing periodically in future columns, "Trends in Psychopharmacology" will cover a new concept and hot topic in the field, namely, that of "multifunctional drugs." The concept is presented in overview here. Future installments will cover specific drugs in greater depth. M...
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PMID: 19238121
PDF is available here.
Abstract
Neuroscience is a rapidly developing area of science which has benefitted from the blurring of interdisciplinary boundaries. This was apparent in the range of papers presented at this year's Neuroscience Ireland Conference, held in Galway during August 2008. The event was attended by academics, post...
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PMID: 19143651
PDF is available here.
Abstract
Abstract The practice patterns of US psychiatrists have changed over the last two decades, favoring brief clinical encounters and a primary emphasis on pharmacologic care. The main focus of this paper is to illustrate the relevance of psychodynamic principles to prescribing practices. Psychodynamic...
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PMID: 19591561
PDF is available here.
Abstract
Issues relating to informed consent and ethics in paediatric psychopharmacology limit research in this population. Children vary in their levels of cognitive development, and presence of psychiatric disorder may further impair their ability to give informed consent. In decisional impairment subjects...
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PMID: 19287054
PDF is available here.
Abstract
I analyze risks and limits of the current psychopharmacology and how both are promoting a new social interpretation of health concept. Besides, I show how such interpretation can be detected in four issues related to safety, equality, psychiatrization of human condition, and autonomy. In the conclus...
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PMID: 19507923
PDF is available here.
Abstract
Anxiety disorders frequently affect the general population and have a lifetime prevalence ranging from 13.6% to 28.8%. This paper reviews full articles dealing with the pharmacological treatments of generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), panic disorder (PD) and post...
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PMID: 19636172
PDF is available here.
Abstract
I noted 5 years ago, 'Unless steps are taken soon to undertake a comprehensive restoration of our system, the profound advances in bio-medical research so rapidly accruing today may never be effectively transformed into meaningful advances in health care for society.' I remain perplexed and frustrat...
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PMID: 19079067
PDF is available here.
Abstract
The author has reviewed bipolar disorder-relevant abstracts from the July 2008 Munich CINP (Collegium Internationale Neuro-Psychopharmacologicum) meeting. Seven abstracts are summarized, focusing on the psychopharmacologic treatment of bipolar depression, the neuropsychological effects of psychotrop...
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PMID: 18980737
PDF is available here.
Abstract
We grow. Informed by hermeneutic phenomenology, psychiatry's first priority is to suspend the prejudices that come with being a medical doctor in order to hear what the patient is saying. To this end, psychiatry can begin to understand the patient not as a static, material body with a clearly define...
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PMID: 18633696
PDF is available here.
Abstract
The review focuses on ethical issues surrounding the use of propranolol to treat or prevent posttraumatic stress disorder, issues concerning the capacity of the mentally ill to give informed consent to medical treatment and the potential social implications of cognitive enhancers and other intervent...
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PMID: 18852564
PDF is available here.
Abstract
The literature on pharmacological interventions suggests changes in prescribing patterns for some substance classes owing to regulatory authorities' warnings. For most of the commonly used medications in children and adolescents no sound database about efficacy and safety is available and knowledge...
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PMID: 18852568
PDF is available here.
Abstract
Recent studies have revealed the prevalence of antipsychotic polytherapy (defined as the use of more than one antipsychotic; up to 45.7%), less conservative antipsychotic use (defined as the use of more than 1000 mg/day chlorpromazine equivalents; up to 17.9%) and depot antipsychotic use (up to 15.3...
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PMID: 18852575
PDF is available here.
Abstract
The contributions of Joseph V. Brady to behavioral pharmacology span more than 50 years and range from early studies using the Estes-Skinner (conditioned emotional response) procedure to examine drug effects and various physiological processes in experimental animals to the implementation of mobile...
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PMID: 19070344
PDF is available here.
Abstract
Two naturally occurring tropane alkaloids, anisodamine and scopolamine, structurally dissimilar in one OH group, are well established as muscarinic acetylcholine receptor (mAChR) antagonists in clinic and basic research. However, experimental evidence for central effects of anisodamine is limited an...
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PMID: 18672024
PDF is available here.