Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Toxicology (3):
Recent article
Toxicology
Toxicology Letters (206)1 2011
Abstract
| < More recent | Older article > |
Abstract
With the advent of "-omics" technologies, there has been an explosion of data generation in the field of toxicology, as well as in many others. As new candidate biomarkers of toxicity are being regularly discovered, the next challenge is to validate these observations in a targeted manner. Tradition...
|
PMID: 20972768
PDF is available here.
PDF is available here.
Toxicology In Vitro (24)8 2010
Abstract
Abstract
There are few true international meetings dedicated to covering multiple areas of toxicology. The XII International Congress of Toxicology (IUTOX) held from 19 to 23 July 2010 in Barcelona, Spain is one such meeting. The IUTOX is important as its emphasis is on chemical safety and integrating approa...
|
PMID: 20843280
PDF is available here.
PDF is available here.
Abstract
The public health and environmental communities will face many challenges during the next decade. To identify significant issues that might be addressed as part of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) scientific portfolio, an expert grou...
|
PMID: 20854192
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
These results suggest that the instrument running cost would be fully covered at nationwide emergency and critical care centers if the additional 5,000 NHI points (1 point = 10 yen) for hospital admission, which is approved for advanced emergency and critical care centers, were applicable to all fac...
|
PMID: 20873397
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Humans are unavoidably exposed to a variety of environmental toxicants and combinations thereof, resulting in an increased risk for a number of diseases. The emerging field of toxicoproteomics has been boosted by quantitative and qualitative proteomic technologies and its increasing...
|
PMID: 20175663
PDF is available here.
PDF is available here.
Abstract
High-throughput omics strategies delineate the molecular mechanism of toxicity, predict the toxicity of newer drugs and chemicals, and identify individuals at high risks on the basis of expression patterns of messenger ribonucleic acids, genes, and proteins, and detection of intermed...
|
PMID: 20082572
PDF is available here.
PDF is available here.
Abstract
We provide diverse illustrations of the use of pluripotent stem cells in drug discovery and predictive toxicology, using either human embryonic stem cell lines or iPSC lines....
|
PMID: 20659002
PDF is available here.
PDF is available here.
Bioanalysis (2)8 2010
Abstract
The dried blood spots (DBS) technique has been actively evaluated as plasma replacement for monitoring drug exposure to support drug development in preclinical/clinical pharmacokinetic and toxicokinetic studies. Plasma samples from some of these studies are typically used for metabol...
|
PMID: 21083337
PDF is available here.
PDF is available here.
Abstract
A new open-access online database, E-SovTox, is presented. E-SovTox provides toxicological data for substances relevant to the EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) system, from publicly-available Russian language data sources. The database contains informat...
|
PMID: 20822322
PDF is available here.
PDF is available here.
Abstract
The National Academies' Standing Committee on Use of Emerging Science for Environmental Health Decisions held a meeting (21-22 September 2009 in Washington, DC) titled "Computational Toxicology: From Data to Analyses to Applications." This commentary reflects on the presentations and roundtable disc...
|
PMID: 20483702
PDF is available here.
PDF is available here.
Abstract
Reproductive Toxicology (29)3 2010
Abstract
Diether Neubert, toxicologist, and Hans-Joachim Merker, histopathologist and embryologist, made significant contributions to the field of Developmental and Reproductive Toxicology. They worked under the same roof at the Institute of Toxicology and Embryopharmacology in Berlin, and actively collabora...
|
PMID: 20206254
PDF is available here.
PDF is available here.
Abstract
We conclude that for a mechanistic gene population link in risk management, research is required that includes at least one meaningful end point at each level of organization....
|
PMID: 20459122
PDF is available here.
PDF is available here.
Current Protocols in Toxicology (Chapter 21) 2010
Abstract
The disruption of intestinal barrier leads to the penetration of noxious luminal compounds into the gut wall, causing further damage. This unit describes the assessment of enteric bacteria translocation into the intestinal wall of rats, an established method for the evaluation of bow...
|
PMID: 20967745
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
Abstract
Abstract
This article describes results obtained by testing the European Food Safety Authority-tiered guidance approach for safety assessment of botanicals and botanical preparations intended for use in food supplements. Main conclusions emerging are as follows. (i) Botanical ingredients must...
|
PMID: 19960456
PDF is available here.
PDF is available here.
Abstract
This article describes results obtained by testing the European Food Safety Authority-tiered guidance approach for safety assessment of botanicals and botanical preparations intended for use in food supplements. Main conclusions emerging are as follows. (i) Botanical ingredients must...
|
PMID: 19960456
PDF is available here.
PDF is available here.
Abstract
Computational toxicology employing quantitative structure-activity relationship (QSAR) modeling is an evidence-based predictive method being evaluated by regulatory agencies for risk assessment and scientific decision support for toxicological endpoints of interest such as rodent car...
|
PMID: 20024931
PDF is available here.
PDF is available here.
Abstract
Computational toxicology employing quantitative structure-activity relationship (QSAR) modeling is an evidence-based predictive method being evaluated by regulatory agencies for risk assessment and scientific decision support for toxicological endpoints of interest such as rodent car...
|
PMID: 20024931
PDF is available here.
PDF is available here.
Toxicology In Vitro (24)1 2010
Abstract
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a full regulatory replacement for the Draize Eye Irritation test. However, companies have been using in vitro methods to screen new formulations and in some cases as their primary assessment of eye irri...
|
PMID: 19490935
PDF is available here.
PDF is available here.
Abstract
We describe a case of major but not emergency head and neck surgery on a patient with a massive ossifying fibroma whose preoperative toxicology screen was positive for cocaine. The surgery was completed without complication, and the patient recovered uneventfully. The decision to proceed with surger...
|
PMID: 20155664
PDF is available here.
PDF is available here.
Abstract
Abstract
Hormesis describes dose-response relationships characterized by a reversal of response between low and high doses of chemicals, biological molecules, physical stressors, or other initiators of a response. Acceptance of hormesis as a viable dose-response theory has been limited until recently, in par...
|
PMID: 20448256
PDF is available here.
PDF is available here.
Abstract
We are advocates for our patients. As allergists, we probe patient exposures. Occasionally, our good intentions find us entwined with forensic matters. Unfortunately, we have little formal training in toxicological, epidemiological, or evidence-based medicine methodology when determining exposure-re...
|
PMID: 20167139
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
I review the role that chemistry has played in understanding toxic and medicinal plants. After some introductory remarks, three broad areas are addressed: the role of natural products in understanding plant taxonomy and evolution, recent developments in chemical synthesis, especially efforts to disc...
|
PMID: 20358684
PDF is available here.
PDF is available here.
Abstract
Venomous animals occur in numerous phyla and present a great diversity of taxa, toxins, targets, clinical effects and outcomes. Venomous snakes are the most medically significant group globally and may injure >1.25 million humans annually, with up to 100 000 deaths and many more cases with long-term...
|
PMID: 20358686
PDF is available here.
PDF is available here.
Abstract
This paper reviews procedures for screening, identification and quantification of drugs, poisons and their metabolites in biosamples, and the corresponding work-up procedures. Gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry are mostly used today in analytical toxicol...
|
PMID: 20358688
PDF is available here.
PDF is available here.
Abstract
Using the strictly same parameters (identical two publication years (2004-2005) and identical one-year citation window (2006)), impact factor (IF) 2006 was compared with h-index 2006 for one sample of "pharmacology and pharmacy" journals computed from the ISI Web of Science. For this sample, the IF...
|
PMID: 20478245
PDF is available here.
PDF is available here.
Recenti progressi in medicina (101)7-8 2010
Abstract
Genetic factors could alter drug metabolism and activity and could predict drug toxicity and/or efficacy. Several chemotherapy agents are administered in different schedules for the treatment of different cancer histotypes. The most used drug in the treatment of gastro-intestinal, head and neck and...
|
PMID: 20842953
PDF is available here.
PDF is available here.
Abstract
Abstract
Aviation combustion toxicology is a subspecialty of the field of aerospace toxicology, which is composed of aerospace and toxicology. The term aerospace, that is, the environment extending above and beyond the surface of the Earth, is also used to represent the combined fields of aeronautics and ast...
|
PMID: 20109297
PDF is available here.
PDF is available here.
Neuroendocrinology Letters (31 Suppl 2) 2010
Abstract
Abstract
The study represents an attempt at employing segmental hair analysis in complex poisonings with xenobiotic mixtures of heroine - cocaine - amphetamines in the context of the cause of death as a consequence of complex interaction mechanisms which occurred prior to death. Two cases of complex poisonin...
|
PMID: 21180103
PDF is available here.
PDF is available here.
Abstract
Henry Matthew was appointed a consultant in the Royal Infirmary of Edinburgh in 1955, by which time he was a highly regarded general physician with an interest in cardiology. In 1964 he agreed, almost certainly reluctantly, to head the recently designated Regional Poisoning Treatment Centre, which h...
|
PMID: 20509461
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 2) 2009
Abstract
We are lucky that, in 1899, there was no regulatory toxicology. Adding, for the purpose of this article, a fourth R to the Three Rs, i.e. Realism, three reality-checks are carried out. The first one comes to the conclusion that the tools of toxicology are hardly adequate for the challenges ahead. Th...
|
PMID: 20105011
PDF is available here.
PDF is available here.
Abstract
Considering the need to rapidly screen tens of thousands of anthropogenic compounds, our study shows the feasibility of using combined HTS assays as a novel approach toward obtaining toxicologic data on numerous biological end points. The HTS assay approach is very useful to quickly identify potenti...
|
PMID: 20049205
PDF is available here.
PDF is available here.
Current Protocols in Toxicology (Chapter 12) 2009
Abstract
Intracellular signaling events play fundamental roles in regulating physiological function. In neurons, these include inducing growth and differentiation, secretion, gene expression, and controlling processes associated with learning and memory. All of these processes have in common...
|
PMID: 20960422
PDF is available here.
PDF is available here.
Abstract
With the ever increasing volume of data available to scientists in drug discovery and development, the opportunity to leverage an increasing amount of these data in the assessment of drug safety is clear. The challenge in an environment of increasing data volume is in the structuring and the analysi...
|
PMID: 20017577
PDF is available here.
PDF is available here.
Abstract
We have focused on methodologies that are based on three-dimensional models of small molecules binding to such entities, and discuss the results at the molecular level.
2009 FRAME....
|
PMID: 20017578
PDF is available here.
PDF is available here.
Abstract
For over a decade, the United States Food and Drug Administration (US FDA) has been engaged in the applied research, development, and evaluation of computational toxicology methods used to support the safety evaluation of a diverse set of regulated products. The basis for evaluating computational to...
|
PMID: 20017581
PDF is available here.
PDF is available here.
Abstract
The applicability domain of a (quantitative) structure-activity relationship ([Q]SAR) must be defined, if a model is to be used successfully for toxicity prediction, particularly for regulatory purposes. Previous efforts to set guidelines on the definition of applicability domains have often been bi...
|
PMID: 20017582
PDF is available here.
PDF is available here.
Abstract
Federal Register (74)202 2009
Abstract
The Food and Drug Administration (FDA) is announcing the classification of cardiac allograft gene expression profiling test systems into class II (special controls). The special control that will apply to the device is the guidance document entitled "Class II Special Controls Guidance Document: Card...
|
PMID: 19877379
PDF is available here.
PDF is available here.
Abstract
About 4,000 to 6,000 venomous snakebites occur each year in the United States. Although these envenomations (also known as envenomings) are rarely fatal, about 70 percent require antivenom therapy. Few evidence-based guidelines are available for the management of envenomation. Antivenom therapy is t...
|
PMID: 19835341
PDF is available here.
PDF is available here.
Revista Medica de Chile (137)10 2009
Abstract
A toxicology testing is the search by the laboratory of the possible etiologic agents that can cause poisoning. Given the wide variety of substances that can poison a person, the laboratories should work coordinated with the emergency wards in order to determine the appropriate tests menu and the re...
|
PMID: 20011950
PDF is available here.
PDF is available here.
Abstract
Historically, different approaches have been adopted for comparing and characterizing hazards that can be found in the very complex mixture of substances present in food. In this review a variety of prominent risk assessment models are evaluated in the context of food safety. In their current state o...
|
PMID: 19582642
PDF is available here.
PDF is available here.
Clinical Toxicology (47)7 2009
Abstract
Introduction. The aryl hydrocarbon receptor (AhR) is a cellular signaling molecule infamous for mediating the toxicity of dioxins and related compounds. Aim. The aim of this review is to provide a background of AhR and to examine critically its role in chemical toxicity, in physiologica...
|
PMID: 19640236
PDF is available here.
PDF is available here.
Abstract
The generation to which Boris Pavlovich Belousov (1893-1976) belonged has almost disappeared. The archives hold only a few documents about his life and basically secret research. This article is a brief biography of Belousov and attempts to reconstruct what lay behind his famous discovery of the osc...
|
PMID: 19805897
PDF is available here.
PDF is available here.