Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
pharmacology (10):
Recent article
pharmacology
Abstract
We reported that vitamin K₃ (menadione, 2-methyl-1,4-naphthoquinone) (compound 2) inhibits the activity of human mitochondrial DNA polymerase γ (pol γ). In this study, we investigated the inhibitory effects (IEs) of vitamin K3 and its derivatives, such as 1,4-naphthoquinone (compound 1) and 1,2-...
|
PMID: 21837358
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
PDF is available here.