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Electrophysiology (1):
Recent article
Electrophysiology
Developmental Cell (21)4 2011
Abstract
We use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of s...
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PMID: 21944720
PDF is available here.
PDF is available here.
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Abstract
Abstract
We found that action potentials were intrinsically generated by immature IHCs of altricial rodents and that apical IHCs showed bursting activity as opposed to more sustained firing in basal cells. We show that the efferent neurotransmitter acetylcholine fine-tunes the IHC's resting membrane potentia...
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PMID: 21572434
PDF is available here.
PDF is available here.
Abstract
We present data on patients with syncope due to paroxysmal atrioventricular (AV) block unexplainable in terms of currently known mechanisms.
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PMID: 21570228
PDF is available here.
PDF is available here.
Endocrinology (152)4 2011
Abstract
We used the slice preparation from female guinea pigs to study the endogenous conductances and the effects of leptin on kisspeptin neurons. We targeted the arcuate kisspeptin neurons using visualized-patch whole-cell recording and identified kisspeptin neurons using immuocytochemical staining for ki...
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PMID: 21285322
PDF is available here.
PDF is available here.
Abstract
These results suggest a role for Ca(2+)-activated K(+) channels in human articular chondrocytes, leading to hyperpolarization as a consequence of K(+) efflux through these channels. These channels could have a role in the articular chondrocyte's response to a hyperosmotic challenge and matrix metabo...
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PMID: 21460408
PDF is available here.
PDF is available here.
Abstract
We describe the establishment of procedures to direct the differentiation of human embryonic stem cells and human induced pluripotent stem cells into forebrain neurons that are capable of forming synaptic connections. In addition, HEK293T cells expressing Neuroligin (NLGN) 3 and NLGN4, but not those...
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PMID: 21278334
PDF is available here.
PDF is available here.
Abstract
We use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiographical judgments, and arithmetic processing. We found a heterogeneous profile of PMC responses in functional, spatial, and temporal domains. Although the majo...
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PMID: 21282630
PDF is available here.
PDF is available here.
Abstract
We clarified a unique molecular convergence of DGLα, CB(1), and MGL at specific inhibitory synapses in the basal nucleus (BA), but not lateral nucleus, of the basolateral amygdala. The synapses, termed invaginating synapses, consisted of conventional symmetrical contact and unique perisynaptic inva...
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PMID: 21282604
PDF is available here.
PDF is available here.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] (Chapter 6) 2011
Abstract
Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electroph...
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PMID: 21207366
PDF is available here.
PDF is available here.
Abstract
We measured prefrontal cortical synaptic plasticity and working memory function in NR2B overexpressing transgenic mice. In vitro electrophysiological data showed that overexpression of NR2B specifically in the forebrain region resulted in enhancement of prefrontal cortical long-term potentiation (LT...
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PMID: 21655294
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated that the absence of beta-arrestin 2 (beta-arr2) augments the constitutive coupling of mu receptors to voltage-activated Ca2+ channels in primary afferent dorsal root ganglion neurons from beta-arr2-/- mice. We used this in vitro approach to characterize neutral competitive...
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PMID: 21486473
PDF is available here.
PDF is available here.
Abstract
We report that short-term synaptic plasticity and long-term potentiation (LTP) are impaired and that the severity of impairment is correlated with the size of the CAG repeat. Remarkably, the deficits in LTP and short-term plasticity are reversed in the presence of a D(1) dopamine receptor agonist (S...
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PMID: 21282937
PDF is available here.
PDF is available here.
Abstract
We characterize the specificity of the octenol receptor neuron in the yellow fever mosquito, Aedes aegypti (L.), in vivo using single cell recordings. The octenol neuron is exquisitely sensitive to (R)-(-)-1-octen-3-ol; comparable responses to (S)-(+)-1-octen-3-ol were elicited only at stimulus dose...
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PMID: 21738794
PDF is available here.
PDF is available here.
Abstract
We investigate the feasibility of using MEAs to record from skeletal myotubes derived from primary myoblasts as a way of introducing a third electrogenic cell type and expanding the potential end applications for MEA-based biosensors. We find that the extracellular action potentials (EAPs) produced...
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PMID: 21574266
PDF is available here.
PDF is available here.
Abstract
Oscillatory activity can be widely recorded in the cortex and basal ganglia. This activity may play a role not only in the physiology of movement, perception and cognition, but also in the pathophysiology of psychiatric and neurological diseases like schizophrenia or Parkinson's disease. Ketamine adm...
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PMID: 21829443
PDF is available here.
PDF is available here.
Abstract
We look at the relationship between the pattern of brain damage and spatial memory deficits in two chronic models of TLE (lithium-pilocarpine, LIP and kainic acid, KA) from two different rat strains (Wistar and Sprague-Dawley) using the Morris water maze and the elevated plus maze in combination wit...
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PMID: 21829459
PDF is available here.
PDF is available here.
Abstract
We discuss how these characteristic features of excitatory propagation in the IC play functional roles in transmitting neural excitation arising from the limbic structures to the frontal and orbital cortices....
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PMID: 21708315
PDF is available here.
PDF is available here.
Abstract
Abstract
Sporadic adult-onset ataxia of unknown etiology (SAOA) denotes the non-hereditary degenerative adult-onset ataxia disorders that are distinct from multiple system atrophy (MSA). Rather than being a defined disease entity, SAOA has to be regarded as a group of disorders of unknown etiology that are de...
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PMID: 21827893
PDF is available here.
PDF is available here.
Abstract
Chronic influence of metals on an organism differs from their sharp toxic action. In some exposed to long chronic metals influence people appear chronic inflammatory diseases, including oncological, on a background of neurologic symptoms develop. Today the overwhelming majority of the population is m...
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PMID: 21950091
PDF is available here.
PDF is available here.
Revue Neurologique (167)1 2011
Abstract
This review focuses on the main aspects of positive and differential diagnosis of carpal tunnel syndrome (CTS) in different clinical situations encountered in daily practice.
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PMID: 21190705
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)3 2011
Abstract
We show that H4IIE liver cells express all three types of IP₃ receptor, but only type 1 and to a lesser extent type 3, but not type 2, participate in the activation of CRAC current (I(CRAC)), while type 1 and type 2, but not type 3, participate in observed Ca²+ release in response to receptor sti...
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PMID: 21182823
PDF is available here.
PDF is available here.
Journal of Clinical Psychiatry (71)suppl 2 2010
Abstract
Psychobiologic evidence and psychosocial functioning in patients with schizoaffective disorder suggest that the disease may be a distinct disorder, a variant of schizophrenia or affective disorders, the comorbidity of schizophrenia and a mood disorder, or an intermediate disorder on a spectrum that...
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PMID: 21190647
PDF is available here.
PDF is available here.
Abstract
We previously established a novel assay method based on cardiac field potential as an endpoint. However, cardiac specificity of this field potential is not yet clarified, because beating cells have not been rigorously evaluated as skeletal or cardiomyocyte. Here, we investigated the relationships be...
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PMID: 21139340
PDF is available here.
PDF is available here.
Abstract
We utilized a combination of computational methodologies in order to construct a structural model for the Na(+)/H(+) antiporter from the gram-negative bacterium Vibrio parahaemolyticus. We explored its overall architecture by computational means and validated its stability and robustness. This prote...
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PMID: 21107625
PDF is available here.
PDF is available here.
NeuroImage (53)2 2010
Abstract
We propose a biological cortical column model, at an intermediate mesoscopic scale, in order to better understand and interpret biological sources of voltage-sensitive dye imaging signal (VSD signal). To perform a quantitative analysis of the relative contributions to the VSD signal, a detailed comp...
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PMID: 20600993
PDF is available here.
PDF is available here.
Abstract
Airborne metal-containing particles represent a known source of health risk but the role of nano-sized particles in the pathogenicity of dust has been recognized only recently. As a model of inhalational exposure to manganese, adult male Wistar rats were treated with a suspension of MnO(2) nanoparti...
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PMID: 20863568
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We characterized the molecular complex of the melatonin MT₁ receptor, which directly and constitutively couples to G(i) proteins and the regulator of G-protein signalling (RGS) 20. The molecular organization of the ternary MT₁/G(i)/RGS20 complex was monitored in its basal and activated state by...
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PMID: 20859254
PDF is available here.
PDF is available here.
Current Eye Research (35)11 2010
Abstract
Our results indicate that more RCS-ON-RBCs survived in the central retinal area near cone clusters, potentially as a result of ectopic neuritis. Meanwhile the surviving RCS-ON-RBCs remained immature and had no normal electrophysiological characteristics....
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PMID: 20958189
PDF is available here.
PDF is available here.
Brain research (1354) 2010
Abstract
We investigated the effect of various in vitro-aged Abeta(1-42) oligomer solutions on the perforant pathway-evoked field potentials in the ventral hippocampal dentate gyrus in vivo. Firstly, Abeta oligomer solutions (1 microl, 200 microM) which had been aggregated in vitro for 0, 24 or 72h were inje...
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PMID: 20659435
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)10 2010
Abstract
We aimed to evaluate the potential of tissue-engineered nerve grafts created from acellular allogenic nerve tissues combined with autologous bone marrow stromal cells (BMSCs) for repairing large peripheral nerve lesions. In a rhesus monkey model, a 2.5-cm-long gap was created in the radial nerve, fo...
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PMID: 20701436
PDF is available here.
PDF is available here.
Abstract
We investigated the capacity of oestrogen receptor β ligand treatment to affect callosal axon demyelination and stimulate endogenous myelination in chronic experimental autoimmune encephalomyelitis using electrophysiology, electron microscopy, immunohistochemistry and tract-tracing methods. Oestrog...
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PMID: 20858739
PDF is available here.
PDF is available here.
Neuroreport (21)13 2010
Abstract
We examined the effect of 2'-3'-O-(4-benzoylbenzoyl)-adenosine-5'-triphosphate (Bz-ATP), a P2X7 receptor agonist, on action potential-independent glutamate release from nerve terminals attached to mechanically isolated immature hilar neurons. Bz-ATP increased spontaneous excitatory postsynaptic curr...
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PMID: 20639779
PDF is available here.
PDF is available here.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (368)1925 2010
Abstract
We discuss the use of a parametric modelling toolkit, called Nimrod, that makes it possible both to explore model behaviour as parameters are changed and also to tune parameters by optimizing model output. Importantly, Nimrod leverages computers on the Grid, accelerating experiments by using availab...
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PMID: 20643684
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2010)9 2010
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810637
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2010)9 2010
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810636
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2010)9 2010
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810634
PDF is available here.
PDF is available here.
Abstract
These results suggested that PLGA filled with OECs is a significant alternative to conventional autograft in repairing peripheral nerve defects, and OECs are potential seed cells for peripheral nerve tissue engineering.
(c) 2010 Wiley Periodicals, Inc....
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PMID: 20336740
PDF is available here.
PDF is available here.
Abstract
Human pluripotential stem cells including both embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) possess self-renewing potency and pluripotentency and can differentiate into virtually any somatic cell type. These features are a distinct advantage for the generati...
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PMID: 20214558
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810633
PDF is available here.
PDF is available here.
Neuropsychologia (48)11 2010
Abstract
We recorded Electroencephalograms (EEGs) during a cued Continuous Performance Task (CPT) to investigate lifespan differences in the efficiency of response conflict processing under conditions that put high demands on the ability to suppress a prepotent response. Previous evidence indicates that chil...
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PMID: 20638396
PDF is available here.
PDF is available here.
Abstract
This study describes the morphology and function of the antennal sensilla in two gall midge species, Contarinia nasturtii and Mayetiola destructor, where multi-component sex pheromones have been identified. Both species possess sensilla trichodea, s. coeloconica, s. chaetica and s. circumfila. Sensi...
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PMID: 20416312
PDF is available here.
PDF is available here.
Abstract
We recorded EAG responses of two parasitoid species with different degrees of host specificity, Microplitis croceipes (specialist) and Cotesia marginiventris (generalist), to a wide array of odor stimuli including compounds representing green leaf volatiles (GLVs), herbivore-induced plant volatiles...
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PMID: 20371248
PDF is available here.
PDF is available here.
Methods in Molecular Biology (583)583 2010
Abstract
We discuss the sensitivity of the system with regard to the impedance sensor and describe the optical setup. The relevant parameters related to the experimental setup and sample preparation are discussed. The use of dielectrophoretic forces for particle manipulation is presented as a simple enabling...
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PMID: 19763464
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
We observed that curcumin inhibits Panc28 and L3.6pL pancreatic cancer cell and tumor growth in nude mice bearing L3.6pL cells as xenografts. In addition, curcumin decreased expression of p50 and p65 proteins and NFkappaB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription f...
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PMID: 20538607
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
We postulated that CRMP-2 levels affects the actions of LCM on VGSCs. CRMP-2 labeling by LCM analogs was competitively displaced by excess LCM in rat brain lysates. Manipulation of CRMP-2 levels in the neuronal model system CAD cells affected slow inactivation of VGSCs without any effects on other v...
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PMID: 20538611
PDF is available here.
PDF is available here.
Abstract
INTRODUCTION: The giant fiber system (GFS) of Drosophila is a well-characterized neuronal circuit that mediates the escape response in the fly. It is one of the few adult neural circuits from which electrophysiological recordings can be made routinely. This protocol describes a simple procedure for...
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PMID: 20647357
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)8 2010
Abstract
We used a controlled cortical impact (CCI) model in rats to examine post-traumatic changes in neocortical excitability. Neocortical slices were prepared from rats at 7-9 days (week 1) and 14-16 days (week 2) after CCI injury. By week 2, we observed a substantial gray matter lesion with a cavity that...
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PMID: 20504156
PDF is available here.
PDF is available here.
Abstract
We established a compendium of functional correlates between changes in membrane potential and the dynamic discharge properties of these sensory neurons as a result of the controlled recruitment of I(h) using the current clamp technique. 3. Two robust responses were observed in response to hyperpola...
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PMID: 20456426
PDF is available here.
PDF is available here.
Abstract
Desert locusts show extreme phenotypic plasticity and can change reversibly between two phases that differ radically in morphology, physiology and behaviour. Solitarious locusts are cryptic in appearance and behaviour, walking slowly with the body held close to the ground. Gregarious locusts are con...
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PMID: 20416321
PDF is available here.
PDF is available here.
Abstract
We suggest that neurons of a second visual pathway, via the accessory medulla and posterior optic tubercle, also provide polarization information to the central complex. Intracellular recordings show that two types of neuron in this posterior pathway are sensitive to polarized light. One cell type c...
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PMID: 20488187
PDF is available here.
PDF is available here.
Abstract
We investigate, for the first time, the neuronal composition of the locust HG, as well as its motor output. We identify rhythmic patterns endogenous to the isolated HG, demonstrating the presence of a central pattern-generating network. Our findings suggest interactions between the HG and FG rhythm-...
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PMID: 20417216
PDF is available here.
PDF is available here.
Abstract
We have discovered that SD-like events occur in the CNS of an invertebrate model, Locusta migratoria. Locusts enter comas in response to stress during which neural and muscular systems shut down until the stress is removed, and this is believed to be an adaptive strategy to survive extreme environme...
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PMID: 20361971
PDF is available here.
PDF is available here.
NeuroImage (51)4 2010
Abstract
Functional magnetic resonance imaging (fMRI) techniques highlight cerebral vascular responses which are coupled to changes in neural activation. However, two major difficulties arise when employing these techniques in animal studies. First is the disturbance of cerebral blood flow due to anaesthesia...
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PMID: 20304075
PDF is available here.
PDF is available here.
NeuroImage (51)4 2010
Abstract
We attempt to address this question by separately examining BOLD responses during reversal learning driven by reward and during reversal learning driven by punishment. We demonstrate simultaneous valence-specific and valence-nonspecific signals in the striatum, with the posterior dorsal striatum res...
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PMID: 20303408
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)28 2010
Abstract
We explored the presence and intraterminal distribution of CaMKII within these terminals. Here we show that (1) unlike other proteins, both CaMKII labeling and distribution were highly variable between contiguous contacts, and (2) CaMKII was not restricted to the periphery of the terminals, in which...
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PMID: 20631177
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)28 2010
Abstract
We undertook a forward genetic screen in zebrafish (Danio rerio) to identify mutants exhibiting abnormal touch-evoked behaviors, despite the presence of sensory neurons and peripheral neurites. One family, subsequently named touché, was found to harbor a recessive mutation which produced offspring...
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PMID: 20631165
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)28 2010
Abstract
We inactivated specific olivary subdivisions in six male cats with a glutamate receptor blocker. Olivary inactivation eliminates Purkinje cell complex spikes, which results in a high rate of Purkinje cell simple spike discharge. The increased simple spike discharge inhibits output from connected reg...
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PMID: 20631170
PDF is available here.
PDF is available here.
Abstract
We report the hematologic and invasive electrophysiologic management of a 12-year-old boy with mild hemophilia A (factor VIII deficiency) and atrioventricular nodal reentrant tachycardia. Thoughtful preparation with detailed input from the patient's comprehensive hemophilia center combined with vigi...
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PMID: 20505535
PDF is available here.
PDF is available here.