Abstract
There is increasing clinical, imaging and neurophatological evidence that amyotrophic lateral sclerosis (ALS) represents a multisystem neurodegenerative disease. Neurodegeneration is not restricted to motor neurons, but also includes parts of the brain other than the motor cortex, especially the pref...
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PMID: 21412715
PDF is available here.
Abstract
The most important challenge of ALS remains finding biomarkers. Clinical features remain of key importance in the diagnosis and for follow up. Neurophysiology remains difficult to use in clinical trials. Neuroimaging have some utility for upper motor neuron integrity and function. Among proteins and...
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PMID: 21412714
PDF is available here.
Author(s) unavailable
Abstract
In the review one of actual problems of psychophysiology in studying a phenomenon of integration of mechanisms of regulation of state of a brain and features of the organization is discussed by a brain of cognitive activity. Basic value of results of long-term researches of academician N.P. Bechterev...
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PMID: 21950093
PDF is available here.
Abstract
Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disorder clinically characterized by various combinations of cerebellar ataxia, choreoathetosis, myoclonus, epilepsy, dementia, and psychiatric symptoms. The most striking clinical features of DRPLA are the co...
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PMID: 21827919
PDF is available here.
Abstract
HD is a complex illness, with a broad clinical picture that begins years before clear motor onset and evolves over decades to a terminal state of extreme disability. It challenges the resources of families and communities and the skills of medical and ancillary health care providers. A broader unders...
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PMID: 21496568
PDF is available here.
Abstract
Noninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that they enable one to study the effects of g...
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PMID: 20103503
PDF is available here.
Abstract
Noninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that they enable one to study the effects of g...
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PMID: 20103503
PDF is available here.
Abstract
Noninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that they enable one to study the effects of g...
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PMID: 20103503
PDF is available here.
Abstract
Normal sensory experience rarely presents us with isolated bars, gratings, or other stimuli that have shaped our knowledge of sensory representations. Instead, typical input adheres to certain statistical regularities, which make it 'natural' and cannot be adequately modeled by linear superposition...
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PMID: 20434327
PDF is available here.
Abstract
We describe a new implantation technique, which combines the biocompatibility of titanium, a high carrying capacity with a minimal skull footprint, and a decreased chance of infection, all in a relatively inexpensive package. This technique utilizes an in-house fabricated 'Nesting Platform' (NP), mo...
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PMID: 20153370
PDF is available here.
Abstract
I propose a hypothesis that may resolve this puzzle. A growing body of evidence suggests that memory formation involves epigenetic mechanisms that regulate patterns of gene expression. Therefore, it is conceivable that the process of memory consolidation may include the synthesis of novel proteins t...
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PMID: 20378956
PDF is available here.
Abstract
We develop a nonparametric estimator of the response latency based on repeated stimulations. A simulation study is provided to show how the estimator behaves with an increasing number of observations and for different rates of spontaneous and evoked spikes. Our nonparametric approach requires very f...
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PMID: 20235823
PDF is available here.
Abstract
We provide a statistical framework for the conditioning test pulse paradigm which also serves as a system identification tool for quadratic or second order Volterra systems. A nonparametric spectral domain based methodology is proposed for the quadratic system identification. It is shown that by car...
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PMID: 19958783
PDF is available here.
Abstract
We first applied it to a system of two coupled Rössler attractors under varying levels of coupling with small frequency mismatch. The application of these analytical techniques to intracranially recorded brain signals provides a means for assessing how complex oscillatory behavior in the brain evol...
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PMID: 19900477
PDF is available here.
Abstract
We present a simple and cost-effective method to quantitatively measure the optokinetic response (OKR) of individual adult zebrafish and medaka, which can be used to characterize visual capabilities of adult fish. This method can be applied to any fish species of similar size.
(c) 2009 Elsevier B.V....
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PMID: 19900474
PDF is available here.
Abstract
We propose a method of utilizing additional information derived from the same extracellular recording to generate a more comprehensive picture of neuronal functional organization. This analysis is based on the relationship between the oscillatory activity of single neurons and their neighboring neur...
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PMID: 19900473
PDF is available here.
Abstract
The changing use of the clock metaphor serves as a helpful contrast medium to highlight the different concepts of the body-soul-system between 1450 and 1750. This article first relates to the social, political and philosophical functions of the horologium. Then it outlines the different fields of di...
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PMID: 20499617
PDF is available here.
Abstract
Insects have extremely sensitive systems of olfaction. These systems have been explored as potential sensors for odourants associated with forensics, medicine, security, and agriculture application. Most sensors based on insect olfaction utilize associative learning to "program" the...
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PMID: 21415881
PDF is available here.
Abstract
We conducted this study to clarify the impact of the procedure of stapling anastomosis on postoperative anal function.
Twenty-five cases with sigmoid colon cancer underwent potentially curative sigmoid colectomy with stapling anastomosis (ST group) and 20 cases with hand-sewn anastomosis (non-ST gro...
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PMID: 20689294
PDF is available here.
Abstract
We illustrate this view by investigating whether a non-reductionist physicalist position, which postulates that the 'mental' supervenes on the 'physical' without being reducible to it, is compatible with the results of research on alterations in the brain during psychotherapy.
A non-reductionist phy...
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PMID: 20623451
PDF is available here.
Abstract
We review what is known about the development of multisensory integration, with a focus on the circuitry and experiential antecedents of its development in the model system of the multisensory (i.e., deep) layers of the superior colliculus. Of particular interest here are two sets of experimental ob...
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PMID: 19345256
PDF is available here.
Abstract
We do this by developing further and generalizing the "synaptic decoding" approach of Sen et al. (1996). Given the spike times in a train and the observed overall response, we use least-squares minimization to construct the best estimated response and at the same time best estimates of the elementar...
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PMID: 19695289
PDF is available here.
Abstract
We demonstrate that prolonged periods of axon separation from targets and Schwann cell denervation eliminate regenerative capacity in the peripheral nervous system (PNS). A substantial delay of 4 weeks for all regenerating axons to cross a site of repair of sectioned nerve contributes to the long pe...
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PMID: 20014648
PDF is available here.
Abstract
We describe the use of these dyes to visualize neural activity. Although the protocols described here concern spinal networks in culture or an intact in vitro preparation, they can be, and have been, widely used in other parts of the nervous system....
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PMID: 19802815
PDF is available here.
Epilepsia (50 Suppl 9) 2009
Abstract
Cortical malformations are highly epileptogenic lesions associated with complex, unanticipated, and often aberrant electrophysiologic and functional relationships. These relationships are inextricably linked to widespread cortical networks subserving eloquent functions, particularly language and mot...
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PMID: 19761450
PDF is available here.
Abstract
Researchers have found, in studies carried out over several years, that many passengers and crew, following their recent flights in commercial jet aeroplanes, have become unwell, with a range of symptoms in common. This condition, which has not yet been officially recognised, is called Aerotoxic Syn...
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PMID: 19891417
PDF is available here.
Abstract
The ability of the human hand to perform complex sensorimotor tasks such as tactile exploration and grasping is based on 1. exact encoding of somatosensory information by cutaneous mechanoreceptors, 2. elaborated processing of afferent signals in somatosensory relay stations and cortex fields, 3. ra...
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PMID: 19685383
PDF is available here.
Abstract
The patient was diagnosed with a clinically relevant T6-T7 disc herniation and underwent successful surgical decompression resulting in electrophysiological improvements. CONCLUSION: This unique case highlights the value of electrophysiology in the evaluation of a complex spinal disorder in a patien...
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PMID: 19525827
PDF is available here.
Abstract
Friedreich ataxia is the most frequent hereditary ataxia, with an estimated prevalence of 3-4 cases per 100,000 individuals. This autosomal-recessive neurodegenerative disease is characterized by progressive gait and limb ataxia, dysarthria, lower-limb areflexia, decreased vibration sense, muscular...
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PMID: 19347027
PDF is available here.
Abstract
The electrical induction of seizures with a therapeutic aim began in 1938, but the history of electric currents to relieve mental illness began 2 centuries earlier with the pioneering work of the Italian Giovanni Aldini and the American Benjamin Franklin.These early experiments are described demonst...
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PMID: 19209070
PDF is available here.
Abstract
We describe an algorithm to obtain a specific form of such a coarse-graining from data, and illustrate its operation using a simulated dynamical system. We then apply the method to an electroencephalographic recording, where we are able to identify macrostates from the physiological data that corres...
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PMID: 19335006
PDF is available here.
Abstract
The new discipline system was brought forward as follows: (1) Definition: neurorestoratology was a sub-discipline of neuroscience which studies neural regeneration, neural structural repair of replacement, neuroplasticity and neuromodulation. The core purpose was to promote neural functional recover...
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PMID: 19366156
PDF is available here.
Abstract
We discuss recent research about pulp tests that determine the vitality of the tooth and clinically accepted pulp testers. A pain response to hot, cold or an electric pulp tester indicates the vitality of only a tooth's pulpal sensory supply; the response does not give any idea about the state of th...
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PMID: 19267966
PDF is available here.
Abstract
The available English and other major Western European language literature was reviewed to assess the stage of development of experimental epileptology prior to the end of the 19th Century. The relevant investigations had been carried out in animals of various species employing a number of methods o...
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PMID: 19055496
PDF is available here.
Abstract
We evaluated the hypothesis that synergies are reflected in common input to different contributing muscles, and investigated modulations in motor unit (MU) synchronization of homologous muscles during a rhythmic balance task. If common input is related to muscle synergies, the resultant MU synchroni...
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PMID: 19175407
PDF is available here.
Abstract
These results support a model of both episodic and persistent neurobiologic components of LLD. The altered functional connectivity,perhaps due to vascular damage to frontal white matter, appears to be persistent. Further, at least some of the prefrontal hypoactivity (in the right dLPFC) seems to be...
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PMID: 19001356
PDF is available here.
Abstract
We overview empirical evidence illustrating the dynamics of adaptive movement behavior in a range of multi-articular actions including kicking, throwing, hitting and balancing. We model the emergence of creativity and the diversity of neurobiological action in the meta-stable region of self organisi...
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PMID: 19061544
PDF is available here.
Abstract
The indicated level of evidence for diagnostic lumbar, cervical, and thoracic facet joint nerve blocks is Level I or II-1. The indicated evidence is Level II-2 for lumbar and cervical discography, whereas it is Level II-3 for thoracic provocation discography. The evidence for diagnostic sacroiliac j...
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PMID: 19668292
PDF is available here.
Abstract
Claude Bernard was one of the founder of the Société de Biologie created in 1849. He actively took part to it from its very beginning by presenting various communications and several important memoirs. Epistemological thoughts found in these memoirs lead to the methodological chapters introducing...
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PMID: 19833070
PDF is available here.
Abstract
Long lasting polemics about the mechanisms of the action of curare took place at the Société de Biologie over thirty years. After a period during which poisoning protocols were developed on various animal species, where Claude Bernard, Vulpian and their colleagues were involved, German electrophys...
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PMID: 19833069
PDF is available here.
Abstract
Andrew Newberg, MD, is an associate professor in the Department of Radiology, Division of Nuclear Medicine, at the Hospital of the University of Pennsylvania, Philadelphia, with secondary appointments in the Departments of Psychiatry and Religious Studies. He is actively involved in neuroimaging res...
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PMID: 20671335
PDF is available here.
Abstract
We simply do not know enough about the physical world of matter at this time but eventually perhaps discoveries about the nature of matter may solve the problem. But as of now, the implication of this impasse is that the introspective data of consciousness are ontologically subjective, pointing to t...
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PMID: 19591564
PDF is available here.
Abstract
This paper will address the use of animal models as a vital constituent of 'life science in the making' by focussing on the 'sensibility trials' conducted by the Swiss physiologist Albrecht von Haller (1708-1777). Haller was a pioneering figure in the early days of neurophysiological research, being...
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PMID: 20108702
PDF is available here.
Abstract
Surgical or interventional neurophysiology is a term commonly used to refer to a large number of neurosurgical procedures involving the brain, cranial nerves, spinal cord and peripheral nervous system which, to be efficient and safe, demand specific neurophysiological know-how. As a result of the de...
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PMID: 20412727
PDF is available here.
Abstract
The child prodigy Marie-Jean-Pierre Flourens received his medical degree at Montpellier when aged 19. As a young promising physician Flourens was asked to investigate Gall's controversial views on cerebral localization. To test Gall's assertions, Flourens developed ablation as a procedure to explore...
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PMID: 19295220
PDF is available here.