Author(s) unavailable
Abstract
Data on interactions between the paradoxical sleep (PS) and thermoregulation under thermo-comfortable and extreme conditions (in high and low temperatures, forced and spontaneous fasting, acclimation to cold and acclimation to natural winter conditions) are reviewed. The hypothesis of the PS role in...
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PMID: 21786641
PDF is available here.
Abstract
We speculate that TICAM-1, TICAM-2 and TIRAP might have co-evolved with the TLR3/22 antivirus signaling, the LPS-specific TLR4 signaling and the Gram-positive bacteria-induced TLR2 signaling pathways, respectively. Our results are valuable contributions to the understanding of TICAM/TIRAP evolutiona...
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PMID: 21362440
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Abstract
I will present evidence of neoplasia and invasive malignancy, as well as tumor immunity in invertebrates and nonmammalian vertebrates. I will also present a comparative and evolutionary view of the complex interactions between neoplasia and the host immune system. Overall, I wish to go beyond the to...
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PMID: 20553753
PDF is available here.
Abstract
We demonstrated the expression of genes encoding thyrostimulin and sex steroidogenic enzymes by an in situ hybridization technique. Here, we discuss the evolution of hormones and reproductive functions in the neuroendocrine control system of chordates....
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PMID: 21558187
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Abstract
We have used lampreys to investigate the possibility that embryonic midline signaling systems have been a driving force for the evolution of the forebrain in vertebrates. We have focused on Sonic Hedgehog/Hedgehog (Shh/Hh) signaling. In this article, we first review and summarize our recent work on...
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PMID: 21558191
PDF is available here.
Abstract
We provide an overview of existing and ongoing comparative studies of the role of the cerebellum in primate behavior. In particular, we discuss evidence that great apes show greater cerebellar relative size than monkeys and that such interspecific difference is mainly explained by growth of the late...
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PMID: 19926082
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Abstract
We review the evidence for the presence of sleep states in non-mammalian species including zebrafish (Danio rerio), fruitflies (Drosophila melanogaster) and roundworms (Caenorhabditis elegans). We describe conserved sleep-regulatory molecular pathways with a focus on cAMP and epidermal growth factor...
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PMID: 18538867
PDF is available here.
Abstract
Computational model for airflow through the upper airway of a horse was developed. Previous flow models for human airway do not hold true for horses due to significant differences in anatomy and the high Reynolds number of flow in the equine airway. Moreover, models that simulate the entire respirat...
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PMID: 18532860
PDF is available here.
Abstract
The natriuretic peptide (NP) family is a seemingly ubiquitous sodium and volume reducing endocrine system of predominantly cardiac origin. Members of the NP system include ANP, BNP, CNP, VNP, their guanylate cyclase (GC)-linked receptors (NPR-A and NPR-B), and clearance receptor (NPR-C). Through the...
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PMID: 18472099
PDF is available here.
Abstract
While traditional measures (e.g., maximum range of motion) grossly detected asymmetries due to bracing, these new analyses identified significant regions of asymmetry. Knee-bracing affected the knee during mid-swing, but also increased ankle asymmetry during both terminal stance and mid-swing and hi...
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PMID: 18242805
PDF is available here.
Abstract
This review uses the current morphological evidence to evaluate the facial morphology of the hypothetical last common ancestor (LCA) of the chimpanzee/bonobo (panin) and human (hominin) lineages. Some of the problems involved in reconstructing ancestral morphologies so close to the formation of a li...
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PMID: 18380866
PDF is available here.
Abstract
Corticosteroids are important mediators of homeostasis and stress, and exert their effects via two transcription-factor receptors, mineralocorticoid receptor (MR) and glucocorticoid receptor (GR). Both receptors are expressed in the brain in a region-specific manner, and regulate neuroendocrine and...
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PMID: 17916381
PDF is available here.
Abstract
We discuss placental proteomics by describing existing studies, pointing out their strengths and weaknesses. In so doing, we strive to inform investigators interested in this area of research about the current gap between hyperbolic promises and realities. Additionally, we discuss the utility of pro...
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PMID: 18222537
PDF is available here.
Abstract
The genomes of over a dozen placental mammal species are now publicly available. These genome sequences have the potential to provide insight into the development and evolution of the placenta. In particular, the variable anatomy of the placenta has likely been affected by natural selection on the g...
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PMID: 18155141
PDF is available here.
Abstract
We explore the extent of dietary niche separation amongst these taxa using stable isotope (13C/12C, 18O/16O) and trace-element (Sr, Ba, Ca) analyses of fossil tooth enamel. In particular we searched for evidence of subtle niche separation between the more closely related, morphologically similar tax...
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PMID: 17941102
PDF is available here.
Abstract
Since the time of Muybridge and Marey in the last half of the nineteenth century, studies of animal movement have relied on some form of high-speed or stop-action imaging to permit analysis of appendage and body motion. In the past ten years, the advent of megapixel-resolution high-speed digital ima...
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PMID: 17883331
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Abstract
Research and teaching activities are of Academician A.N. Severtsov are briefly considered. His scientific heritage is shown to be based on the extensive comparative morphological data on lower vertebrates. The concepts of phylembriogenesis and biological progress elaborated by A.N. Severtsov did not...
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PMID: 18669300
PDF is available here.
Abstract
These results indicate that modern spotted hyenas and plains zebras exhibit mainly size variation between regions, with southern African samples possessing statistically larger craniodental metrics than eastern African samples. Comparison of fossil and modern samples reveals that the fossil assembla...
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PMID: 17915290
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Abstract
Although mortality and longevity are inherently biological phenomena, their study has historically been the purview of demography and the actuarial sciences. An infusion of biological thinking into these disciplines transforms demography into biodemography and provides expectations and coherency to...
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PMID: 17986573
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Abstract
I illustrate, using three examples, the broad range of avenues along which zebrafish can inform us about motor systems. The examples include efforts to understand the functional organization and evolution of spinal interneurons, the role of mutants in informing us about motor dysfunction and human d...
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PMID: 17024661
PDF is available here.
Abstract
Insulin induces protein accretion by stimulating protein synthesis and inhibiting proteolysis. However, the mechanisms of regulation of protein metabolism by insulin are complex and still not completely understood. The use of approaches combining hyperinsulinemic clamp and isotopic methods, or measu...
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PMID: 16876379
PDF is available here.
Abstract
We determined that the Y. enterocolitica rovA (rovA(Yent)) promoter is weaker than the Y. pseudotuberculosis promoter. However, despite the missing H-NS/RovA binding site in the rovA(Yent) promoter, H-NS and RovA are still involved in the regulation of rovA(Yent). DNA binding studies suggest that H-...
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PMID: 17573476
PDF is available here.
Abstract
We investigate the distribution of Latin American comparative biochemistry and physiology across subject areas and systematic groups. Our study focuses on papers published over the last decade (1997-2006) in four leading topical journals. Brazil dominates the production of papers, followed by Argent...
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PMID: 17428716
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Abstract
We felt that it was important to critically discuss the state of comparative biochemistry and physiology in this country. Our study is based on data collected from the ISI Web-of-Science. We analyzed publication trends through time, availability of novel approaches and techniques, patterns of collab...
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PMID: 17321770
PDF is available here.
Abstract
We can exploit even a small proportion of the rich and varied experimental data currently available, significant insights into clinically important aspects of human physiology will follow. To achieve this requires the integration of data from disparate sources into a common framework. Extrapolation...
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PMID: 17449822
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Abstract
Our research group has argued for the redefinition of integrative physiology as the investigation of gene function in an organotypic context in the intact animal. Implicit in this definition is the use of transgenics and reverse genetics to manipulate gene function in a cell-specific manner; this in...
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PMID: 17449829
PDF is available here.
Abstract
Successful reconstruction of any aspect of human evolution ideally requires broad-based comparisons with other primates, as recognition of general principles provides a more reliable foundation for inference. Indeed, in many cases it is necessary to conduct comparisons with other placental mammals t...
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PMID: 18046752
PDF is available here.
Abstract
These results show that marsupials differ markedly from placental mammals in the relationships of cranial integration, phylogeny, and diet, which may be related to the accelerated development of the masticatory apparatus in marsupials....
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PMID: 17912372
PDF is available here.
Abstract
We investigated the motion of the single ossicle found in the middle ears of four different species of birds. In the avian middle ear, the off centre attachment of the extracolumella to the tympanic membrane and the flexion of the joint between the extracolumella and columella results in rocking of...
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PMID: 16923318
PDF is available here.
Abstract
Substantial advances have been made in recent years in the understanding of the genetic basis of behavior in "simpler" organisms, especially the mouse and the fruit fly Drosophila. The authors examine the degree of similarity between the genetic underpinnings of psychiatric illness and genetic influ...
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PMID: 17012675
PDF is available here.
Abstract
We show that Drierite has an affinity for CO(2) when new and completely anhydrous, and therefore it has an adverse effect on the washout characteristics of this gas. Exposing the Drierite to room air reduces this CO(2) affinity, and a 2-min exposure at 20 degrees Celsius and 50% relative humidity is...
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PMID: 16927244
PDF is available here.
Abstract
We must guard against fractionation of effort and purpose. Increasingly available molecular methods are seductive in encouraging work on model species and in employing these species in place of more appropriate comparative models. Concomitantly, the comparative approach is reaching out beyond the in...
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PMID: 16555181
PDF is available here.
Abstract
Evolutionary physiology is the emerging physiological discipline. Unlike environmental physiology or ecophysiology, whose definitions have long been made quite clear, evolutionary physiology has a broader scope of objectives, and its definition lacks a concise treatise. This paper presents the argum...
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PMID: 16555182
PDF is available here.
Abstract
We accumulate information about physiological function in the field, we are often forced to reconsider established paradigms: hibernating bears may contract their muscles to maintain strength and tone, testosterone levels in male stonechats maintaining territories in winter are exceptionally low, wi...
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PMID: 16555183
PDF is available here.
Abstract
The purpose of this symposium was to examine how foraging physiology is studied in the field across a diversity of species and habitats. While field studies are constrained by the relatively poor ability to control the experiment, the natural variability in both the environment and animal behavior p...
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PMID: 16555184
PDF is available here.
Abstract
We present an overview of research findings presented at a session of the Third International Conference of Comparative Physiology and Biochemistry. We hope such a synthesis will stimulate new directions in research that address biological responses to environmental change. In this context, we belie...
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PMID: 16555186
PDF is available here.
Abstract
Emerging technologies in genomics (e.g., cDNA library screening, DNA arrays), proteomics (e.g., two-dimensional gel electrophoresis and mass-spectroscopy fingerprinting), and metabolic regulation (e.g., elucidating protein-protein binding associations or signal transduction pathways) offer powerful...
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PMID: 16555191
PDF is available here.
Abstract
Superfast muscles of vertebrates power sound production. The fastest, the swimbladder muscle of toadfish, generates mechanical power at frequencies in excess of 200 Hz. To operate at these frequencies, the speed of relaxation has had to increase approximately 50-fold. This increase is accomplished b...
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PMID: 16460271
PDF is available here.
Abstract
These results suggest that functional demands placed on the limbs during ontogeny have a strong impact on the development of limb mass distribution patterns....
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PMID: 16011842
PDF is available here.
Abstract
This review explores the emergence of Comparative Medicine in the late 19th Century as 'the medicine of the future', its failure to realise these expectations during the 20th century as it became increasingly equated with laboratory animal models of human disease, and explains why there is now an un...
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PMID: 15985379
PDF is available here.
Abstract
Every field of biology has its assumptions, but when they grow to be dogma, they can become constraining. This essay presents data-based challenges to several prominent assumptions of developmental physiologists. The ubiquity of allometry is such an assumption, yet animal development is characterize...
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PMID: 15921940
PDF is available here.