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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
physiology (5):
Recent article
physiology
Biochemical Pharmacology (82)11 2011
Abstract
We analyzed the effects of IFN-α2b and TGF-β1 treatments on Wnt/β-catenin pathway, Smads proteins levels, β-catenin/TCF4/Smads interaction and proliferation and apoptotic death in HepG2/C3A and Huh7 cell lines. IFN-α2b and TGF-β1 attenuated Wnt/β-catenin signal by decreasing β-catenin and Fr...
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PMID: 21843516
PDF is available here.
PDF is available here.
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Abstract
We have discovered that other cellular stressors are integrated with glucocorticoid signaling through a new hormone-independent phosphorylation site, Ser134, on the human glucocorticoid receptor (GR). Ser134 phosphorylation is induced by a variety of stress-activating stimuli in a p38 mitogen-activa...
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PMID: 21930780
PDF is available here.
PDF is available here.
Journal of Neurochemistry (119)5 2011
Abstract
We have used neuroblastoma cells expressing NDM29 at its basal level (Mock cells) or at 5.4-fold higher levels (S1 cells) to investigate whether a functional differentiation correlates with morphological and biochemical development induced by NDM29 expression. First, analyzing the expression of spec...
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PMID: 21933186
PDF is available here.
PDF is available here.
Journal of Neurochemistry (119)5 2011
Abstract
We have investigated presenilin (PS)-dependent secretase-mediated processing of nectins in PS1 KO cells and primary hippocampal neurons. The loss of PS1/γ-secretase activity delayed the processing of nectin-1 and caused the accumulation of its full-length and C-terminal fragments. Over-expression o...
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PMID: 21910732
PDF is available here.
PDF is available here.
Abstract
We summarize the current knowledge on the mechanisms underlying the transition of the intestinal mucosa during the neonatal period leading to the establishment of a stable, life-long host-microbial homeostasis. The environmental exposure and microbial colonization during the neonatal period, and als...
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PMID: 21952827
PDF is available here.
PDF is available here.
Development (138)21 2011
Abstract
We demonstrate that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB receptors, controls Schwann cell migration in addition to its previously known roles in proliferation and myelination. Chimera analyses indicate that ErbB receptors are required in all migrating Schwann cells, and...
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PMID: 21965611
PDF is available here.
PDF is available here.
Abstract
We studied the effect of exercise training on islet and β-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted...
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PMID: 21810930
PDF is available here.
PDF is available here.
Abstract
We found that high-fat diet (HFD) feeding strikingly promoted daytime rather than nighttime caloric intake in mice, leading to feeding circadian arrhythmicity. Using scheduled feeding with a defined amount of daily HFD intake, we found that an increase in the ratio of daytime to nighttime feeding pr...
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PMID: 21828335
PDF is available here.
PDF is available here.
Abstract
We concluded that GES pulse width increases had the largest effect on VMH neuronal activity, and these effects were paralleled by pulse width-dependent reductions in food intake and body weight. Lengthening pulse width beyond the range used in prior clinical studies may be critical to making GES a v...
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PMID: 21852365
PDF is available here.
PDF is available here.
Transplantation (92)8 2011
Abstract
We examined 10 stable kidney transplant patients (mean estimated glomerular filtration rate 51±10 mL/min/1.73 m(2)) who received cinacalcet daily for persistent hyperparathyroidism. Urine specimens were collected at baseline and every 2 hr for a total study period of 6 hr after ingestion of 30 mg c...
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PMID: 21876476
PDF is available here.
PDF is available here.
Abstract
We show that implanted vascular networks anastomose with host vessels through a previously unidentified process of "wrapping and tapping" between the engrafted endothelial cells (ECs) and the host vasculature. At the host-implant interface, implanted ECs first wrap around nearby host vessels and the...
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PMID: 21835951
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that RegIIIγ, a secreted antibacterial lectin, is essential for maintaining a ~50-micrometer zone that physically separates the microbiota from the small intestinal epithelial surface. Loss of host-bacterial segregation in RegIIIγ(-/-) mice was coupled to increased bacterial colonization o...
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PMID: 21998396
PDF is available here.
PDF is available here.
Abstract
We depleted the intestinal microbiota of mice with antibiotics before inoculation with poliovirus, an enteric virus. Antibiotic-treated mice were less susceptible to poliovirus disease and supported minimal viral replication in the intestine. Exposure to bacteria or their N-acetylglucosamine-contain...
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PMID: 21998395
PDF is available here.
PDF is available here.
Abstract
We describe a synthetic genetic circuit that couples cell density and motility. This system enabled programmed Escherichia coli cells to form periodic stripes of high and low cell densities sequentially and autonomously. Theoretical and experimental analyses reveal that the spatial structure arises...
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PMID: 21998392
PDF is available here.
PDF is available here.
Abstract
Abstract
We report that early gamma oscillations (EGOs) enable precise spatiotemporal thalamocortical synchronization in the neonatal rat whisker sensory system. Driven by a thalamic gamma oscillator and initially independent of cortical inhibition, EGOs synchronize neurons in a single thalamic barreloid and...
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PMID: 21998388
PDF is available here.
PDF is available here.
Abstract
Abstract
We developed a nuclear magnetic resonance approach that enabled direct detection of structural elements within the intact leader (712-nucleotide dimer) that are critical for genome packaging. Residues spanning the gag start codon (AUG) form a hairpin in the monomeric leader and base pair with residu...
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PMID: 21998393
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of s...
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PMID: 21944720
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We show that Fgf8 and Sema3f, produced by early dental epithelium, respectively, attract and repulse mesenchymal cells, which cause them to pack tightly together during mouse tooth development. Resulting mechanical compaction-induced changes in cell shape induce odontogenic transcription factors (Pa...
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PMID: 21924961
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We generated and characterized Atxn1L(-/-) and Atxn1(-/-); Atxn1L(-/-) mice. Atxn1L(-/-) mice have hydrocephalus, omphalocele, and lung alveolarization defects. These phenotypes are more penetrant and severe in Atxn1(-/-); Atxn1L(-/-) mice, suggesting that ATXN1 and ATXN1L are functionally redundan...
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PMID: 22014525
PDF is available here.
PDF is available here.
Abstract
We show that platelet-derived growth factor receptor (Pdgfr) signalling controls age-dependent β-cell proliferation in mouse and human pancreatic islets. With age, declining β-cell Pdgfr levels were accompanied by reductions in β-cell enhancer of zeste homologue 2 (Ezh2) levels and β-cell replic...
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PMID: 21993628
PDF is available here.
PDF is available here.
Abstract
We show, in humans and rhesus monkeys, that a transcortical pathway through primary motor cortex (M1) resolves this ambiguity during fast feedback control. We demonstrate that single M1 neurons of behaving monkeys can integrate shoulder and elbow motion information into motor commands that appropria...
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PMID: 21964335
PDF is available here.
PDF is available here.
Abstract
Abstract
We observed a false-positive case in which plakoglobin signal was reduced in a patient initially believed to have ARVC but who actually had cardiac sarcoidosis. Sarcoidosis can masquerade clinically as ARVC but has not been previously associated with altered desmosomal proteins.
We o...
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PMID: 21859801
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)10 2011
Abstract
The quest for synthetic materials to repair load-bearing bone lost because of trauma, cancer, or congenital bone defects requires the development of porous, high-performance scaffolds with exceptional mechanical strength. However, the low mechanical strength of porous bioactive ceram...
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PMID: 21745606
PDF is available here.
PDF is available here.
Abstract
We measured the effect of variations in scaffold stiffness on the expression of extracellular matrix molecules specific to the NP (proteoglycans and collagen) by native NP cells. We prepared sample discs of different concentrations of alginate (1%-6%) by two different methods, diffusion and in situ...
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PMID: 21783128
PDF is available here.
PDF is available here.
Abstract
Tissue engineering promises to restore tissue and organ function following injury or failure by creating functional and transplantable artificial tissues. The development of artificial tissues with dimensions that exceed the diffusion limit (1-2 mm) will require nutrients and oxygen...
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PMID: 21892744
PDF is available here.
PDF is available here.
Otology & Neurotology (32)8 2011
Abstract
To establish a tissue engineering therapy for the treatment of large tympanic membrane perforation (TMP) without the need for conventional surgical therapy.
Randomized control trial.
General hospital.
A total of 63 chronic TMPs were ran...
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PMID: 21897328
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)10 2011
Abstract
These results correlate with measurements of the mechanical properties of the scaffolds, since both the ultimate tensile strength and tensile modulus of the cell seeded scaffolds had increased by the end of the culture period. This experiment demonstrates that porcine and avian collagen could be use...
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PMID: 21723967
PDF is available here.
PDF is available here.
Abstract
We constructed rad50 alleles encoding truncations of the coiled-coil domain to determine which Mre11 complex functions required the full length of the coils. These mutations abolished telomere maintenance and meiotic double-strand break (DSB) formation, and severely impaired homologous recombination...
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PMID: 21892167
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)14 2011
Abstract
Endocrinology (152)10 2011
Abstract
We characterized to which GRE GR binds in the rat hippocampus. Using a position-specific scoring matrix, we identified evolutionary-conserved putative GREs from a microarray based set of hippocampal target genes. Using chromatin immunoprecipitation, we were able to confirm GR binding to 15 out of a...
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PMID: 21846803
PDF is available here.
PDF is available here.
Journal of Surgical Research (170)2 2011
Abstract
We report the generation of hepatocyte-like cells derived from hES cells.
Hepatic endoderm cells were generated by adding activin A for 5 d- to 1-d-old embryoid bodies formed from hES cells. The hepatic endoderm cells were cocultured with mitomycin treated 3T3-J2 feeder cells....
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PMID: 21816427
PDF is available here.
PDF is available here.
Journal of Surgical Research (170)2 2011
Abstract
We induced POLF by combining extended left hepatectomy and ischemia of the small liver remnant of 150 min duration. Subsequently, the remnant liver parenchyma was reperfused and the animals were closely monitored for 24 h.
Twelve Landrace pigs (weight 25-30 kg) were randomly assigned...
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PMID: 21816413
PDF is available here.
PDF is available here.
Abstract
We show that the combined action of Isw1 and Chd1 nucleosome-spacing enzymes is required to maintain this organization. In the absence of these enzymes, regular positioning of the majority of nucleosomes is lost. Exceptions include the region upstream of the promoter, the +1 nucleosome, and a subset...
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PMID: 21940898
PDF is available here.
PDF is available here.
The Lancet (378)9797 2011
Abstract
New England Journal of Medicine (365)13 2011
Abstract
Molecular Cell (43)6 2011
Abstract
We describe 31 dominant-negative, secreted variant isoforms of receptor tyrosine kinases (RTKs) that are produced by activation of intronic poly(A) sites. We show that blocking U1-snRNP can activate IPA, indicating a larger role for U1-snRNP in RNA surveillance. Moreover, we report the development o...
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PMID: 21925381
PDF is available here.
PDF is available here.
Molecular Cell (43)6 2011
Abstract
RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory...
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PMID: 21925380
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
Biomacromolecules (12)9 2011
Abstract
The final goal of the present study was the development of a 3-D chitosan dressing that would shorten the healing time of skin wounds by stimulating migration, invasion, and proliferation of the relevant cutaneous resident cells. Three-dimensional chitosan nanofibrillar scaffolds pro...
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PMID: 21761871
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
I and elastin was significantly up-regulated when compared with TCPS control, whereas collagen III was down-regulated on PHBV fibers and 2-D film after 14 days in culture. The less ductile PHBV 2-D films showed higher levels of elastin expression. Furthermore, the PHBV fibers in the presence and abs...
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PMID: 21800891
PDF is available here.
PDF is available here.
Science Signaling (4)190 2011
Abstract
We show that protein arginine methylation limits the ERK1/2 signal elicited by particular growth factors in different cell types from various species. We found that this restriction in ERK1/2 phosphorylation depended on methylation of RAF proteins by protein arginine methyltransferase 5 (PRMT5). PRM...
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PMID: 21917714
PDF is available here.
PDF is available here.
Abstract
We describe a protocol to differentiate murine Tol-DCs from bone marrow precursors in vitro. Importantly, Tol-DCs actively suppress T cells stimulated with immunogenic allogeneic DCs. Indeed, Tol-DCs generated using this approach can be useful in studying and characterising the immunoregulatory path...
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PMID: 20941609
PDF is available here.
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We previously showed that adenoviral-delivered overexpression of an endogenous inhibitor, the tissue inhibitor of metalloproteinases-3 (TIMP-3), significantly retarded intimal thickening in short-term autologous porcine arteriovenous interposition grafts (28 days). However, it is essential to determ...
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PMID: 21911803
PDF is available here.
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We performed a cell trafficking experiment, which demonstrated significantly greater recruitment of bone marrow cells to the ischemic myocardium in the double-knockdown group. Fluorescence-activated cell sorting showed significantly higher activation of endogenous c-kit(+) cardiac progenitor cells....
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PMID: 21911818
PDF is available here.
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We used bioinformatics analysis and experimental validation assays to show that Bim, a critical apoptotic activator, is an important target gene of the microRNA cocktail, which collectively can bind to the 3'UTR region of Bim and suppress its expression.
We have demonstrated that a m...
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PMID: 21911815
PDF is available here.
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We investigated the effect of epidermal growth factor-like domain 7 (Egfl7) on nuclear factor-κB activation, intercellular adhesion molecule-1 expression, and neutrophil adhesion to human coronary artery endothelial cells after calcineurin-inhibition-induced injury.
Human coronary e...
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PMID: 21911813
PDF is available here.
PDF is available here.
Abstract
We recently characterized the interaction between the intraviral domains of envelope glycoproteins (Gn and Gc) and ribonucleoprotein (RNP) of Puumala and Tula hantaviruses (genus Hantavirus, family Bunyaviridae). Herein we report a direct interaction between spike-forming glycoprotein and nucleic ac...
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PMID: 21807393
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)37 2011
Abstract
We used functional multineuron calcium imaging to monitor the spike outputs from thousands of CA1 neurons in response to the stimulation of two independent sites of the dentate gyrus in rat hippocampal networks ex vivo. Only pyramidal cells were analyzed based on post hoc immunostaining. Some CA1 py...
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PMID: 21917800
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)37 2011
Abstract
We used two-photon RuBi-Glutamate uncaging to optically map how the largest population of cortical interneurons, the parvalbumin-positive cells (PV+), are connected to pyramidal cells (PCs) in mouse neocortex. We found locally dense connectivity from PV+ interneurons onto PCs across cortical areas a...
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PMID: 21917809
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)37 2011
Abstract
We contrasted the connection patterns of parvalbumin-immunoreactive cells in two functionally distinct cortical regions: the tonotopic, narrowly frequency-tuned module [central narrow band (cNB)] of cat central primary auditory cortex (AI) and the nontonotopic, broadly tuned second auditory field (A...
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PMID: 21917816
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)37 2011
Abstract
We found that many Wnt-signaling genes were dynamically regulated, with an immediate decrease, followed by an eventual normalization during memory consolidation. This rapid decrease in Wnt mRNA was confirmed with individual quantitative PCR and in situ hybridization. We then manipulated Wnt signalin...
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PMID: 21917789
PDF is available here.
PDF is available here.
Life Sciences (89)11-12 2011
Abstract
We used activated EL-4 murine T-lymphoma cells, which produce interleukin (IL)-4 and IL-5, but not interferon (IFN)-γ, as T(H)2 cell-like cells and treated them with PMA+cAMP to investigate the effects of shikonin on T(H)2 cytokines, transcriptional factors, and the related mitogen-activated protei...
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PMID: 21806999
PDF is available here.
PDF is available here.