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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Genetic Research (1):
Recent article
Genetic Research
Annals of Internal Medicine (154)6 2011
Abstract
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Abstract
Human biobanks, and genetic research databases, as referred to by the Organisation for Economic Co-operation and Development (OECD), are essential tools for modern biomedical research. Biobanks may consist in collections created in clinical diagnosis (such as pathology tissue samples in hospitals) o...
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PMID: 20949382
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
Genetics in Medicine (12)10 2010
Abstract
Abstract
We summarize the literature on MZ twins discordant for Mendelian inherited disorders and chromosomal abnormalities. A systematic literature search for English articles on discordant MZ twin pairs was performed in Web of Science and PubMed. A total number of 2,016 publications were retrieved and revi...
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PMID: 20468073
PDF is available here.
PDF is available here.
Abstract
To describe the utility of twin studies for attention-deficit/hyperactivity disorder (ADHD) research and demonstrate their potential for the identification of alternative phenotypes suitable for genomewide association, developmental risk assessment, treatment response, and intervention targets.
Brie...
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PMID: 20732624
PDF is available here.
PDF is available here.
Abstract
We used DNA microarrays to explore the historical ideo-plastic faculty of therapeutic hypnosis. We documented how to measure changes in activity or experience-dependent gene expression over relatively brief time periods (1 hour and 24 hours) following a single intervention of therapeutic hypnosis (a...
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PMID: 20718241
PDF is available here.
PDF is available here.
Abstract
We used data from birth years 2000 to 2005 from 32 surveillance programs of the International Clearinghouse for Birth Defects Surveillance and Research. We computed the adjusted observed versus expected ratio (aOE) of DS birth prevalence among women 25-44 years old. The aOE ratio was close to unity...
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PMID: 20578135
PDF is available here.
PDF is available here.
Abstract
Arguments for public involvement in science and technology are often based on ideas of developing a more capable public and the assumed effects this may have for science. However, such a relationship is yet to be sufficiently explored and recent work indicates that a more involved public may have co...
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PMID: 20977179
PDF is available here.
PDF is available here.
Abstract
We conducted a qualitative research study with in-depth interviews of ethnocultural community leaders (e.g., members of the Canadian Parliament, school commissioners) on their perspectives concerning population specific genomics research and biobanks. An equal partnership model where public is not o...
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PMID: 20977184
PDF is available here.
PDF is available here.
Nature Neuroscience (13)7 2010
Abstract
All research on human subjects requires their informed consent. Obtaining valid consent from isolated minorities can be particularly challenging, but scientists need to avoid the temptingly easy way out, so as to prevent further exclusion of these vulnerable populations from biomedical research.
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PMID: 20581808
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (28)18 2010
Abstract
Abstract
We derive explicit Mendelian models (in which the genetic architecture relies on one or two large-effect loci), and compare them with classical polygenic models. With simulations, we show that the models are accurate and powerful enough to provide useful estimates from realistic experimental designs...
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PMID: 20036681
PDF is available here.
PDF is available here.
Genetics in Medicine (12)2 2010
Abstract
African Americans were less likely to give a blood sample, when compared with whites (21% vs. 13%, P < 0.05). After controlling for "trust," this difference was no longer statistically significant (17% vs. 13%, P = 0.27). Those who had given samples were more likely to express willingness to partici...
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PMID: 20098329
PDF is available here.
PDF is available here.
Abstract
Abstract
Canadian journal of cardiovascular nursing = Journal canadien en soins infirmiers cardio-vasculaires (20)1 2010
Abstract
We discuss the ambiguous distinction between genetic research and clinical genetics, particularly for Mendelian diseases with high recurrence risk, high morbidity and/or mortality and the possible amelioration of such diseases by screening or treatment. We use arrhythmogenic right ventricular cardio...
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PMID: 20301857
PDF is available here.
PDF is available here.
Abstract
This chapter gives an educational overview of: * The origins and evolution of bioinformatics from its beginning where it was a discipline mainly oriented towards the resolution of problems in biology to the present where it shows a clear interest on the field of translational research in medicine. *...
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PMID: 20407170
PDF is available here.
PDF is available here.
Genome Biology (11)5 2010
Abstract
Genetic studies have identified more than 150 autoimmune loci, and next-generation sequencing will identify more. Is it time to make human the model organism for autoimmune research?
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PMID: 20441610
PDF is available here.
PDF is available here.
Maternal attitudes toward DNA collection for gene-environment studies: a qualitative research study.
Abstract
To assess attitudes toward DNA collection in an epidemiological study, focus groups were assembled in September 2007 with mothers who had participated in a case-control study of birth defects. Each recruited mother previously had completed an interview and had received a mailed kit containing cytobr...
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PMID: 19839045
PDF is available here.
PDF is available here.
Abstract
Abstract
Psychiatric Genetics (19)4 2009
Abstract
The National Institute of Mental Health's effort to rectify the underrepresentation of American Blacks in the genetic studies of psychiatric disorders has met with mixed success. This study was designed to understand some of the barriers to recruitment.
Men and women, who were of Black, White or His...
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PMID: 19593860
PDF is available here.
PDF is available here.
Genetics in Medicine (11)7 2009
Abstract
The authors describe the rationale and initial development of a new collaborative initiative, the Genomic Applications in Practice and Prevention Network. The network convened by the Centers for Disease Control and Prevention and the National Institutes of Health includes multiple stakeholders from...
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PMID: 19471162
PDF is available here.
PDF is available here.
Abstract
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence, the abilit...
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PMID: 19217256
PDF is available here.
PDF is available here.
Abstract
Employed adults valued future genetic testing as being important to their well-being and strongly preferred reconsenting for future use of stored tissue. These data provide a baseline to measure potential changes in workers' attitudes since the passage of the U.S. Genetic Information Nondiscriminati...
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PMID: 19405873
PDF is available here.
PDF is available here.
Abstract
Changes in the clinical research enterprise to involve practicing psychiatrists in gathering evidence in real-world settings are truly exciting. The CAPTN breaks important ground as a PBRN in psychiatry. The authors anticipate that more practical clinical trials will come. These chan...
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PMID: 19486819
PDF is available here.
PDF is available here.
Abstract
This article highlights major results of a study into the ethical norms and rules governing biobanks. After describing the methodology, the findings regarding four topics are presented: (1) the ownership of human biological samples held in biobanks; (2) the regulation of researchers' use of samples...
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PMID: 19623818
PDF is available here.
PDF is available here.
Abstract
We reviewed the literature and evaluated the advantages and difficulties of psychiatric genetic studies in the Brazilian population. CONCLUSION: The Brazilian population is one of the most heterogeneous populations in the world, formed mainly by the admixture between European, African and Native Ame...
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PMID: 19578689
PDF is available here.
PDF is available here.
Psychiatric Genetics (19)2 2009
Abstract
This qualitative research examined the ethical concerns regarding the psychosocial issues, research design and implementation, and application of psychiatric genetic research on substance use disorders (SUD) from multiple perspectives.
A literature review of the bioethics literature related to psych...
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PMID: 19668113
PDF is available here.
PDF is available here.
Annals of Internal Medicine (150)3 2009
Abstract
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information into the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the abili...
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PMID: 19189911
PDF is available here.
PDF is available here.
Medicina Clínica (132)4 2009
Abstract
Abstract
Abstract
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We explore the computational and ethical challenges that emanate from the intersection of bioinformatics and healthcare informatics research. We describe the current situation of the EHR and its capabilities to store clinical and genetic data and then discuss the Genetic Information Nondiscriminatio...
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PMID: 20169020
PDF is available here.
PDF is available here.
Abstract
Abstract
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability...
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PMID: 19189221
PDF is available here.
PDF is available here.
Abstract
We epidemiologists, as a collective of researchers, should leave behind the decision-oriented, inference-denying cult of statistical 'significance' adduced by Neyman and Pearson, and in its stead we should embrace the Fisherian culture of focusing on the production of statistical evidence, for use i...
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PMID: 18941905
PDF is available here.
PDF is available here.
Hastings Center Report (39)1 2009
Abstract
Hastings Center Report (39)1 2009
Abstract
Abstract
Health Affairs (28)3 2009
Abstract
Abstract
Genetic research in exercise science has produced a lot of data including the ability to draw a human exercise gene map. However, progress at the genetic level has been slow because gene-based association studies are not powerful enough to detect multiple small but cumulative gene effects. In future...
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PMID: 19696516
PDF is available here.
PDF is available here.
Abstract
A fairly large number of psychiatric disorders, namely about 30 to 85%, can be inherited. In addition, the non-shared environment has a considerable influence on the phenotype. The influence of the shared environment seems to have only a limited influence or it is totally absent. The results of quan...
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PMID: 19760565
PDF is available here.
PDF is available here.
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft fur Sozialpadiatrie und Deutsche Gesellschaft fur Kinderheilkunde (28)1 2009
Abstract
Abstract
1911 saw the beginning of decisive developments in psychiatric genetic research. During that year, two expert papers dealing with the application of the Mendelian Theory were published in Germany and in the United States. Only a decade after the "rediscovery" of the Mendelian Laws simultaneous effor...
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PMID: 19831248
PDF is available here.
PDF is available here.
Psychiatry (72)2 2009
Abstract
With increasing emphasis on understanding genetic contribution to disease, inclusion of all racial and ethnic groups in molecular genetic research is necessary to ensure parity in distribution of research benefits. Blacks are underrepresented in large-scale genetic studies of psychiatric disorders....
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PMID: 19614555
PDF is available here.
PDF is available here.
Abstract
The author demonstrates own research data and literature review to justify a necessity of wider genetic research in evaluating influence of chemicals on workers' sexual function.
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PMID: 19943535
PDF is available here.
PDF is available here.
Abstract
Community-based approaches may enhance representation of minorities in genomics-related research crucial to eliminating health disparities....
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PMID: 19824292
PDF is available here.
PDF is available here.
Abstract
I argue here that both those who claim that particular types of human-nonhuman chimera research threaten human dignity and those who argue that such threat does not exist fail to make their case. I first introduce some of the arguments that have been offered supporting the claim that the creation of...
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PMID: 19143408
PDF is available here.
PDF is available here.
Health Data Management (16)12 2008
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Genetics in Medicine (10)11 2008
Abstract
Most respondents (84%) supported the study, and 60% would participate. Returning research results (odds ratio = 1.6, 95% confidence interval 1.3-1.8) and increasing compensation from $50 to $200 (odds ratio = 1.5, 95% confidence interval 1.2-1.7) were associated with increased willingness to partici...
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PMID: 19011407
PDF is available here.
PDF is available here.
Abstract
Critical Care Medicine (36)10 2008
Abstract
Abstract
Abstract
Our study suggests that enrollment by surrogate authorization into stroke genetic research is often not approved by IRBs, and even when allowed is frequently not used. For disorders like stroke, this situation has significant implications for scientific validity....
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PMID: 18658034
PDF is available here.
PDF is available here.