Karsten Suhre,
So-Youn Shin,
Ann-Kristin Petersen,
Robert P Mohney,
David Meredith,
Brigitte Wägele,
Elisabeth Altmaier,
CARDIoGRAM,
Panos Deloukas,
Jeanette Erdmann,
Elin Grundberg,
Christopher J Hammond,
Martin Hrabé de Angelis,
Gabi Kastenmüller,
Anna Köttgen,
Florian Kronenberg,
Massimo Mangino,
Christa Meisinger,
Thomas Meitinger,
Hans-Werner Mewes,
Michael V Milburn,
Cornelia Prehn,
Johannes Raffler,
Janina S Ried,
Werner Römisch-Margl,
Nilesh J Samani,
Kerrin S Small,
H-Erich Wichmann,
Guangju Zhai,
Thomas Illig,
Tim D Spector,
Jerzy Adamski,
Nicole Soranzo,
Christian Gieger,
Themistocles L Assimes,
Panos Deloukas,
Jeanette Erdmann,
Hilma Holm,
Sekar Kathiresan,
Inke R König,
Ruth McPherson,
Muredach P Reilly,
Robert Roberts,
Nilesh J Samani,
Heribert Schunkert and
Alexandre F R Stewart
Abstract
We report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences...
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PMID: 21886157
PDF is available here.
Abstract
Update of the 2004 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for bladder cancer.
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PMID: 21844550
PDF is available here.
Abstract
OVERVIEW: This article describes the findings and limitations of the major research thus far on hormone therapy, particularly that of the Women's Health Initiative; examines practice recommendations; clarifies common terminology related to menopause and hormone therapy; and provides...
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PMID: 21613919
PDF is available here.
Abstract
The comparative study of vertebrate brains is inherently dependent upon access to a sufficient number of species and specimens to perform meaningful comparisons. Although many studies rely on compiling published information, continued specimen collection, in addition to more extensiv...
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PMID: 21599690
PDF is available here.
Abstract
The Zagreb Collection of developing and adult human brains was founded in 1974 by Ivica Kostović and consists of 1,278 developing and adult human brains, including 610 fetal, 317 children, and 359 adult brains. It is one of the largest collections of developing human brains. The col...
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PMID: 21599691
PDF is available here.
Abstract
We address concerns raised in this issue by Bretzner et al. (2011) by explaining the rationale for including subjects with subacute, neurologically complete spinal cord injuries in the Phase 1 trial of GRNOPC1. We also present elements of the informed consent process that minimize the likelihood of...
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PMID: 21549322
PDF is available here.
Abstract
We present an overview of the most important open access applications and their functionality. The main part of the paper is devoted to the major problems with which all such applications have to deal. The first problem is terminology processing, i.e., recognizing biomedical terms and identifying th...
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PMID: 18592194
PDF is available here.
Abstract
General practitioners are asked to implement new tools or approaches often without attention being paid to whether these are acceptable, feasible and effective in the primary care context. Cardiovascular absolute risk (CVAR) assessment is recommended in clinical practice guidelines and assessment too...
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PMID: 21597551
PDF is available here.
Abstract
The epidemic of human immunodeficiency virus in Zambia has led to a dramatic rise in the incidence of human herpesvirus-8 (HHV-8)-associated Kaposi's sarcoma in both adults and children. However, there is a paucity of knowledge about the routes of HHV-8 transmission to young children. The Zambia Chil...
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PMID: 21447476
PDF is available here.
Abstract
We have real problems, for example, how to protect privacy concerning specimens gathered from patients. Therefore, there have been many kinds of rules or guidelines established recently. Although we tend to strictly follow these guidelines, it is not always clear which guidelines should be applied t...
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PMID: 21626879
PDF is available here.
Abstract
We conclude that in spite of the improving profit-margins, the vaccine market remains vulnerable and insecure. Vaccines are permeated by society, even more so than pharmaceutics that are used to cure or alleviate illnesses. Radical changes in financial conditions with promises of a more profitable m...
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PMID: 21560548
PDF is available here.
Abstract
We give an overview of the actual role of proteomic technologies in the study of pancreatic cancers (PCs). We describe PC proteomics on the basis of sample origins, i.e. tissues, body fluids, and PC cell lines. As regards PC tissues, we report the identification of a number of candidate biomarkers o...
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PMID: 21229586
PDF is available here.
Abstract
We give an overview of the actual role of proteomic technologies in the study of pancreatic cancers (PCs). We describe PC proteomics on the basis of sample origins, i.e. tissues, body fluids, and PC cell lines. As regards PC tissues, we report the identification of a number of candidate biomarkers o...
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PMID: 21229586
PDF is available here.
Abstract
Regenerative medicine seeks to repair or replace damaged tissues or organs, with the goal to fully restore structure and function without the formation of scar tissue. Cell based therapies are promising new therapeutic approaches in regenerative medicine. By using mesenchymal stem ce...
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PMID: 21251219
PDF is available here.
Abstract
To review the literature on infectious diseases and meteorological and climate change risk factors in the New Zealand context and to describe a tentative research agenda for future work.
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PMID: 21905452
PDF is available here.
Abstract
Josef Armin Knapp (1843-1899) as Austrian botanist was interested in development of botanical knowledge of Austro-Hungarian Monarchy--his maternal country. Monarchy, during the long regency of emperor Franz Josef I, was multinational, very much diversified geographically territory. T...
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PMID: 21936457
PDF is available here.
Abstract
Global health research often involves North-South partnerships. However, these types of partnerships present particular challenges. The aim of this study is to examine these challenges from the perspectives of those involved in order to formulate ideas for further discussion and acti...
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PMID: 21612053
PDF is available here.
Abstract
The objective of this study was to identify racial differences in willingness to participate in a population with previous exposure to clinical research. A survey instrument was administered to community-dwelling whites and African Americans who were voluntarily receiving a lay research and health ed...
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PMID: 21526582
PDF is available here.
Manuel M De-La-Llata-Romero,
Armando A Castorena-Maldonado,
María M Corsi-Cabrera,
Manuel M Díaz,
Reyes R Haro-Valencia,
Alejandro A Jiménez-Genchi,
María Sonia MS Meza-Vargas,
Rogelio R Pérez-Padilla,
Oscar O Próspero-García,
Margarita M Reyes-Zúñiga,
Luis L Torre-Bouscoulet,
Matilde M Valencia-Flores and
Javier J Velázquez-Moctezuma
Abstract
We will continue to commit resources only on the attention of its effects and not on prevention, making the impact on the economy and quality of life of patients with sleep disorders, much higher than in developed countries. It is necessary to build a program of medical care to incorporate the Sleep...
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PMID: 21585014
PDF is available here.
Abstract
The major breakthroughs achieved in nanotechnologies open new avenues in the field of healthcare--aid to diagnosis, upgrading medical treatment efficacy, development of regenerative medicine--but they are also associated with risks, hence the increasing need of legislation. So far ve...
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PMID: 21850972
PDF is available here.