Abstract
We bring this 'bottom-up' approach alongside the current NGS-driven genetic study of genetic variations and disease aetiology. We describe experimental and computational techniques for assessing genetic variants and their deleterious effects on protein structure and function....
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PMID: 21350909
PDF is available here.
Abstract
Several linacs with integrated kilovoltage (kV) imaging have been developed for delivery of image guided radiation therapy (IGRT). High geometric accuracy and coincidence of kV imaging systems and megavoltage (MV) beam delivery are essential for successful image guidance. A geometric...
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PMID: 21776767
PDF is available here.
Abstract
A method is described for gathering and distributing radiation exposure data from X-ray-based imaging procedures such as CT, angiography, fluoroscopy, mammography and digital X-ray systems with integrated generators. The data are recorded in a standard format as a DICOM dose object and are managed in...
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PMID: 21491199
PDF is available here.
Benjamin F Crabtree,
Sabrina M Chase,
Christopher G Wise,
Gordon D Schiff,
Laura A Schmidt,
Jeanette R Goyzueta,
Rebecca A Malouin,
Susan M C Payne,
Michael T Quinn,
Paul A Nutting,
William L Miller and
Carlos Roberto Jaén
Abstract
The patient-centered medical home (PCMH) has become a widely cited solution to the deficiencies in primary care delivery in the United States. To achieve the magnitude of change being called for in primary care, quality improvement interventions must focus on whole-system redesign, and not just isol...
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PMID: 21079525
PDF is available here.
Abstract
Biomedical systems involve a large number of entities and intricate interactions between these. Their direct analysis is, therefore, difficult, and it is often necessary to rely on computational models. These models require significant resources and parallel computing solutions. These approaches are...
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PMID: 21431578
PDF is available here.
Abstract
Disease surveillance for hepatitis C in the United States is limited by the occult nature of many of these infections, the large volume of cases, and limited public health resources. Through a series of discrete processes, the Massachusetts Department of Public Health modified its su...
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PMID: 21337927
PDF is available here.
Abstract
The evolution of the national and European legislation has progressively transformed the working environments into organized environments. Specific models for its management are being proposed, which should be integrated into general management strategies. In the case of hospitals this integration sh...
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PMID: 21468157
PDF is available here.
Abstract
The heightened focus on health information technology deployment, specifically the electronic health record, has magnified the need for the knowledge and skills of informaticians. The clinical informatician is frequently confused with system analyst and project management roles. In this article, the...
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PMID: 21157241
PDF is available here.
Abstract
An integrated communication network, SurgON, has been developed to enable a surgeon to control multiple operating room systems and devices and monitor data streams from diverse sources via a single console. The system also enables the surgeon to grant access and control to remote observers and partic...
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PMID: 21335768
PDF is available here.
Abstract
We propose a wireless hybrid navigation device that integrates miniature inertial sensors and electromagnetic sensing units, for tracking instruments both inside and outside the human-body. The proposed system is free of the constraints of line-of-sight or entangling sensor wires. The main functiona...
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PMID: 21335843
PDF is available here.
Joseph T JT Samosky,
Pete P Allen,
Steve S Boronyak,
Barton B Branstetter,
Steven S Hein,
Mark M Juhas,
Douglas A DA Nelson,
Steven S Orebaugh,
Rohan R Pinto,
Adam A Smelko,
Mitch M Thompson and
Robert A RA Weaver
Abstract
Our design uses tangible (physical) interfaces to simulate surface anatomy, haptic feedback during needle insertion, mechatronic display of muscle twitch corresponding to the specific nerve stimulated, and visual and haptic feedback for the injection syringe. The twitch response is calculated incorp...
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PMID: 21335855
PDF is available here.
Abstract
The Revolutionizing Prosthetics 2009 program conducted by the Defense Advanced Research Projects Agency (DARPA) has resulted in a Virtual Integration Environment (VIE) that provides a common development platform for researchers and clinicians that design, model and build prosthetic limbs and then int...
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PMID: 21335889
PDF is available here.
Abstract
We present the initial steps for the creation of an integrated platform for the provision of a series of eHealth tools and services to both citizens and travelers in isolated areas of the southeast Mediterranean, and on board ships travelling across it. The platform was created through an INTERREG I...
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PMID: 21649924
PDF is available here.
Abstract
We aimed to identify novel sRNAs and sORFs in Shigella, the principal etiologic agents of bacillary dysentery.
We identified 64 sRNAs in Shigella, which were experimentally validated in other bacteria based on sequence conservation. We employed computer-based and tiling array-based m...
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PMID: 21483688
PDF is available here.
Abstract
We have employed a novel approach for the identification of functionally important microRNA (miRNA)-target interactions, integrating miRNA, transcriptome and proteome profiles and advanced in silico analysis using the FAME algorithm. Since miRNAs play a crucial role in the inner ear, demonstrated by...
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PMID: 21483685
PDF is available here.
Abstract
We first predicted a potential cell cycle related gene set. Using Gene Ontology (GO) function annotation as a benchmark, we demonstrated that the prediction by combining microarray and E-MAP data is generally >50% more accurate in identifying co-functional gene pairs than the prediction using either...
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PMID: 21689484
PDF is available here.
Abstract
The inpatient medication delivery system used at a large regional acute care hospital in the Midwest had become antiquated and inefficient. The existing 24-hr medication cart-fill exchange process with delivery to the patients' bedside did not always provide ordered medications to the nursing units w...
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PMID: 21385276
PDF is available here.
Abstract
We emphasize that both Directives are frameworks on which many other directives are linked but that they need to be fully and seamlessly integrated to give a land to open sea system of assessment and management. Hence, by taking account of the experience gained in the WFD implementation, together wi...
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PMID: 20965524
PDF is available here.
Abstract
The desire to make microfluidic technology more accessible to the biological research community has led to the notion of "modular microfluidics", where users can build a fluidic system using a toolkit of building blocks. This paper applies a modular approach for performing droplet-based screening, i...
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PMID: 20717617
PDF is available here.
Abstract
We grew HeLa cells and HUVECs to confluency on separate substrates and then joined the two substrates. A microfluidic device was then assembled onto the substrates and a cell coculture was initiated with controlled perfusion of the medium. When the medium flow was directed from the HeLa side to the...
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PMID: 20563348
PDF is available here.
Abstract
We present here methods and related instrumentation to remove these limitations by combining the advantages of MSL processing with laser micromachining using a CO(2) laser ablation system. This system is applied to both the dense integration of layer-layer interconnects and the direct writing of mic...
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PMID: 20539896
PDF is available here.
Abstract
The authors demonstrated that their integrated photoacoustic imaging and HIFU system has the potential for contrast imaging with gold nanorods with possible diagnosis and treatment of solid tumors....
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PMID: 20964197
PDF is available here.
Abstract
This paper describes 'PathGrid'--an analysis and data integration system, developed initially to meet the demands in the analysis of medical microscopy imaging data. An overview of the current system is given, describing the techniques used in developing the data handling infrastructure and the anal...
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PMID: 20643686
PDF is available here.
Abstract
This article describes a Washington State-based Systems Change Pilot Project in which the chronic care model and the model for improvement were used as tools to promote tobacco cessation-related changes within a health care system. Three diverse sites participated in the pilot. Site...
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PMID: 19129434
PDF is available here.
Abstract
The enantioselective reduction of methyl benzoylformate to (R)-methyl mandelate, an important pharmaceutical intermediate and a versatile resolving agent, was investigated in this study. After minimizing the reaction-specific constraints (constraints dependent on the nature of the su...
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PMID: 20033429
PDF is available here.
Abstract
We present an on-chip arrayed waveguide grating (AWG) sensor based on the confocal arrangement of two AWGs, one acting as focusing illuminator and one as signal collector. The chip can be close to, or in direct contact with, a sample, e.g., biological tissue, without the need of external optics. The...
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PMID: 20717442
PDF is available here.
Abstract
As part of a larger evaluation study, 20 members of staff in a Faculty of Health were interviewed about the impact of service user and carer involvement on learning and teaching. A qualitative approach was adopted and semi-structured interviews were used to explore current levels of involvement, bar...
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PMID: 19959262
PDF is available here.
Abstract
We identified the Ikaros gene from 14 vertebrate genomes and found Ikaros existed in all kinds of vertebrate including fish, amphibians, birds and mammals. Moreover, except rat and Xenopus tropicalis Ikaros proteins, which lack the first C2H2-type 1 Zinc finger region, all identified Ikaros proteins...
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PMID: 20596648
PDF is available here.
Abstract
We have developed an interferometric synthetic aperture incoherent imaging system at 94 GHz, in which a high-power electronic millimeter wave source (Gunn Oscillator) is integrated with a continuous-wave terahertz (THz) photomixing detection system to achieve a high signal-to-noise ratio. Imaging of...
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PMID: 20648115
PDF is available here.
Abstract
We have developed an efficient method for fusing liquid reagents into glass ampoules, which are then sealed into a centrifugally operated cartridge. For on-demand reagent release, the ampoules are disrupted through the flexible lid of the cartridge. Upon centrifugation, 98.7 microL out of 100 microL...
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PMID: 20480115
PDF is available here.
Abstract
We have demonstrated hybrid integrated PDMS microfluidic systems with fused silica capillaries. The hybrid integrated PDMS microfluidics and silica capillary (iPSC) modules exhibit a novel architecture and method for leakage free CE sample injection merely requiring a single high voltage source and...
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PMID: 20480112
PDF is available here.
Abstract
Gaseous microemboli (GME) remain a challenge for cardiopulmonary bypass procedures in adult as well as pediatric cardiac surgery patients. The present study tested the effectiveness of a new adult membrane oxygenator in models both with and without an integrated arterial filter to evaluate GME trapp...
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PMID: 20648898
PDF is available here.
Abstract
Diabetes and hypertension have become very common perhaps because of increasingly busy lifestyles, unhealthy eating habits, and a highly competitive workplace. The rapid advancement of mobile communication technologies offers innumerable opportunities for the development of software and hardware app...
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PMID: 20575728
PDF is available here.
Abstract
We studied the networking infrastructure of the hospital and its available image generation devices, we subsequently carried out a series of measurements during the transmissions, which allowed us to analyze the behavior of the system with different network schemes and connection speeds. The results...
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PMID: 20575731
PDF is available here.
Abstract
Despite previous efforts and expenditure of tremendous resources on creating and simulating disaster response scenarios, true disaster response, specifically for healthcare, has been inadequate. In addition, none of the >200 local and statewide telemedicine programs in the United States has ever res...
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PMID: 20575732
PDF is available here.
Abstract
We conducted a study of three elements, namely (1) teleconsultations, (2) academic activities, and (3) education. We carried out our study from three perspectives: the teleconsultant, telemedicine academic activities, and telemedicine education. In this article, we also show our recent achievement i...
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PMID: 20575733
PDF is available here.
Abstract
Our research clearly documents the increased adoption of electronic medical records in U.S. hospitals from 2005 to 2007. This is important because the electronic medical record provides an opportunity for integration of patient information and improvements in efficiency and quality of care across a...
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PMID: 20503611
PDF is available here.
Abstract
Based on its experience with implementing a virtual central business office, UMMS recommends the following steps to ensure the success of such an initiative: Define the process flow for the organization's day-today revenue cycle operations prior to implementation. Then select best practices and mile...
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PMID: 20533675
PDF is available here.
Abstract
We investigate how radiological assessments of humans and wildlife can be integrated with special consideration given to the recent outputs of the ICRP. We highlight how assumptions about the location of the exposed population of humans and wildlife, and the selection of appropriate benchmarks for d...
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PMID: 20530865
PDF is available here.
Abstract
Stroke is a leading cause of death and long-term severe disability. A major difficulty facing stroke care provision in the UK is the lack of service integration between the many authorities, professionals and stakeholders involved in the process. The objective of this article is to describe a prototy...
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PMID: 20573645
PDF is available here.
Abstract
A novel approach for regulated bioanalytical sample preparation has been developed to combine multiple types of extraction techniques into one integrated and automated sample-preparation suite that pairs a graphical user interface with the Hamilton Microlab(®) STAR robotic liquid ha...
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PMID: 21083206
PDF is available here.
Abstract
We demonstrate the promise of this technology for integrated low power and low cost optical gas sensing. A room temperature ethanol vapor sensor is demonstrated using a ZnO nanoparticle film as a coating on an SOI micro-ring resonator of 5 microm in radius. The local coating on the ring resonators i...
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PMID: 20589047
PDF is available here.