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Chemistry, Clinical (0):
Recent article
Chemistry, Clinical
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Collegium Antropologicum (34)1 2010
Abstract
Since 2003 when the international norm for implementation of quality management in medical laboratories (EN ISO 15189, Medical laboratories--Particular requirements for quality and competence) was established and accepted, accreditation has become practical, generally accepted method of quality mana...
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PMID: 20437640
PDF is available here.
PDF is available here.
Abstract
The substantial variability in SCr assays across laboratories necessitates calibration of SCr measures to a common standard. Failing to do so may substantially affect study eligibility and clinical interpretations when they are determined by Cr-based estimates of GFR.
2010 S. Karger AG, Basel....
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PMID: 20389058
PDF is available here.
PDF is available here.
Lakartidningen (107)32-33 2010
Abstract
Abstract
To determine the influence of age, gestational age, gender and methodological protocol on serum 17OHP and cortisol concentrations. 17OHP in non-extracted (NE) and extracted (E) sera was measured by RIA in 319 full-term (FT) (1 d-5 yr) infants, 38 pre-term (PT) and in 19 neonates with classical CAH a...
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PMID: 20432815
PDF is available here.
PDF is available here.
Abstract
Deficiency of insulin-like growth factor-I (IGF-I) results in growth failure. A variety of molecular defects have been found to underlie severe primary IGF-I deficiency (IGFD), in which serum IGF-I concentrations are substantially decreased and fail to respond to GH therapy. Identification of more p...
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PMID: 20432800
PDF is available here.
PDF is available here.
Abstract
Abstract
Serum OPG did not differ between boys and girls or younger and older children. There was no correlation between OPG level and height, weight and BMI percentiles. The level of sRANKL was 3 times higher in males than in females (p < 0.01) and almost 3 times higher in older than younger children (p < 0...
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PMID: 20333868
PDF is available here.
PDF is available here.
Abstract
Serum IGF-I and IGFBP-3 assays are used to monitor rhGH treatment. Some discrepancies in results obtained by means of different assays have been reported. The aim of this study was to establish normal ranges for circulating IGF-I and IGFBP-3 in children and adolescents of Hispanic and Italian origin...
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PMID: 20333872
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (17)11 2009
Abstract
Medical Laboratory Observer (41)11 2009
Abstract
Abstract
The mission of translational research involves difficult tasks to be accomplished for its ultimate goal, i.e., the introduction of novel, effective therapeutic strategies in the clinic to diminish human suffering and cure life-threatening diseases. Translational research (also referred to as transla...
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PMID: 19776705
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (102)3 2009
Abstract
Within each patient treated with vitamin K antagonist (VKA), variation of the international normalised ratio (INR) occurs over the treatment period. The purpose of the present study was to assess INR variation in selected patients on long-term treatment in whom the dose of VKA was not changed. This...
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PMID: 19718481
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (102)3 2009
Abstract
Many primary care laboratories use point-of-care (POC) instruments to monitor patients on anticoagulant treatment. The internal analytical quality control of these instruments is often assessed by analysing lyophilised control materials and/or by sending patient samples to a local hospital laborator...
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PMID: 19718482
PDF is available here.
PDF is available here.
Abstract
In 302 hospitalised children with seizure, about ten percent of 938 tests were abnormal. 27.7 percent of these abnormal results were seen in 1-12-month-old infants. Only 11 percent of abnormal tests (1.3 percent of total tests) might have caused a seizure. Also, 0.2 percent of the results could not...
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PMID: 19710982
PDF is available here.
PDF is available here.
Abstract
Panic values are laboratory test levels suggesting life-threatening conditions of patients. When these values are obtained, clinical doctors must start treatment promptly. However, the definition of panic values varies between laboratories. Herein, the management of panic values (in the field of cli...
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PMID: 19708537
PDF is available here.
PDF is available here.
Abstract
Clinical Chemistry and Laboratory Medicine (47 Suppl 1) 2009
Abstract
Indian Pediatrics (46)5 2009
Abstract
This prospective study was conducted to evaluate the accuracy of transcutaneous bilirubinometry in preterm newborns less than 32 weeks of gestation. Serum bilirubin values measured by direct spectrophotometry were considered as standard, the range was 2.2-12.5 mg/dL. 32 jaundiced infants of less tha...
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PMID: 19179735
PDF is available here.
PDF is available here.
Abstract
Up-converting phosphors promise simpler readout systems with less background at a given signal level than many other popular approaches. (To listen to a podcast about this feature, please go to the Analytical Chemistry website at pubs.acs.org/journal/ancham.).
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PMID: 19368339
PDF is available here.
PDF is available here.
Muscle & Nerve (39)4 2009
Abstract
The objective was to determine the effect of a proposed increase in the upper reference limits of serum creatine kinase (CK) on neuromuscular disease diagnosis. This was a retrospective study of 94 Caucasian subjects (49 women and 45 men) in whom a neuromuscular physician ordered a CK as part of the...
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PMID: 19260057
PDF is available here.
PDF is available here.
Abstract
We demonstrate the correct use of repeated measures ANOVA to prevent or minimize ethical or scientific problems due to its misuse. We also describe the appropriate use of multiple comparison tests for follow-up analysis in repeated measures ANOVA. Finally, we demonstrate the use of repeated measures...
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PMID: 19262072
PDF is available here.
PDF is available here.
Abstract
We compared the IRIS iQ200 Body Fluids Module (Iris Diagnostics, Chatsworth, CA) and the Beckman-Coulter LH750 (Beckman-Coulter, Brea, CA) with manual counts and evaluated the impact of automation on the laboratory if clinically acceptable performance was to be maintained. Automated counts were comp...
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PMID: 19095566
PDF is available here.
PDF is available here.
Abstract
Abstract
We evaluated this method for analytical performance as well as potential interference from gadolinium-containing magnetic contrast agents. With Siemens Chemistry serum and urine controls, 2-levels each, the imprecision for the new method was (n=40 each): within-run and total CV of <2.2 and <3.8%, re...
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PMID: 19927350
PDF is available here.
PDF is available here.
Pediatric Nephrology (24)1 2009
Abstract
We suggest that NIST develop a pediatric SCr standard reference material for use by assay manufacturers to improve accuracy and precision of assays at the low SCr levels observed in most pediatric patients....
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PMID: 18769945
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The present model is a powerful tool for improved characterization of semi-quantitative kits, which makes it possible to evaluate and validate kits and to optimize external quality control....
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PMID: 19499483
PDF is available here.
PDF is available here.
Abstract
To face the economic pressures arising from the current socio-economic conjuncture, hospital laboratories are endangered by an increasing trend towards the outsourcing of clinical laboratory tests to external (mega-) laboratories. This should allow hospitals to meet their economic requirements, but...
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PMID: 19663541
PDF is available here.
PDF is available here.
Abstract
Each clinical laboratory should record errors in a structured manner. A relation database is a useful tool for the recording and extraction of data, as the database can be structured to reflect the workflow at each individual laboratory....
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PMID: 19663542
PDF is available here.
PDF is available here.
Abstract
Clinical laboratory (55)1-2 2009
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The impact factor, originally devised by Eugene Garfield, offsets the advantages of journal size and age, and is a tool often used for the evaluation of journals and scientists, and is considered to provide a reliable trend of basic and clinical research worldwide. Overall, the median impact factor...
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PMID: 19350849
PDF is available here.
PDF is available here.
Abstract
In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 10 years, more t...
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PMID: 19676151
PDF is available here.
PDF is available here.
Abstract
In conclusion, the cobas c 501 module seems to be well-suited for routine use as consolidated workstation. Except for a potential interaction with AMPH, as indicated by the positive DeltaCV, no significant interferences from different reagents could be observed during this study....
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PMID: 19496737
PDF is available here.
PDF is available here.
Abstract
While interpretative commenting is an important laboratory activity, the results of this study suggest that there is room for improvement in the quality of interpretative comments offered by senior laboratory professionals, even for commonly reported results relating to most prevalent and important...
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PMID: 19589106
PDF is available here.
PDF is available here.
Abstract
Abstract
Early observations on the acidity of normal urine by J. B. von Helmont (1527-1644) and on urine content of sulfate, phosphate and carbonate by J. J. Berzelius (1779-1848), followed by the studies of Bence Jones (1813-1878) on the connection between food, nutrition and urine acidity, pointed to the r...
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PMID: 20013742
PDF is available here.
PDF is available here.
Abstract
Tadeusz Reichstein was born in Wloclawek (Poland) into a Polish-Jewish family. His family emigrated to Switzerland, and he was educated in the Technical University of Zurich, becoming an engineer of chemistry. Thus he started his scientific career, firstly in Zurich and later in Basel. In his very b...
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PMID: 20013737
PDF is available here.
PDF is available here.
Abstract
Manufacturers should fully inform laboratories about a calibration change and its clinical impact. Laboratory reports for PSA measurements should indicate the assay's manufacturer and which calibration standard was used to avoid misleading information concerning PCa risk....
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PMID: 19634108
PDF is available here.
PDF is available here.
Abstract
Abstract
Metrology and one of its contributions, metrological traceability represent two fundamental developments for the clinical laboratories. Several international and national institutions take part in these developments. They elaborate recommendations going from concepts to implementation in the clinica...
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PMID: 19297298
PDF is available here.
PDF is available here.
Abstract
Abstract
I were up-graded to N+P II. Grading of ILC provides valuable predictive and prognostic information. The N+P grading system for ILC decreases the element of subjectivity for assessing mitotic activity and appears to be superior to the SBR system in predicting patient survival....
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PMID: 19201737
PDF is available here.
PDF is available here.
Abstract
The Akray Adams HA-8160 HbA1c analyser performed within the target CV of < 2.5% and showed a good correlation with the Cobas Integra 800....
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PMID: 19291916
PDF is available here.
PDF is available here.
Abstract
HbA1c is used for assessing glycaemic control in patients with diabetes. It is also used for treatment goals and as a target for therapeutic intervention. The Direct Control and Complications Trial in the USA showed that HbA1c can be used to predict the risk of complications. Hence, it is important...
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PMID: 19291914
PDF is available here.
PDF is available here.
Abstract
External quality assurance (EQA) schemes are essential for improvement of accuracy, reliability and comparability of results of biochemical genetic tests. ERNDIM (European Research Network for evaluation and improvement of screening, Diagnosis and treatment of Inherited disorders of Metabolism), est...
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PMID: 19016343
PDF is available here.
PDF is available here.
Abstract
Abstract
We have carried out an External Quality Assessment scheme for mutation analysis in phenylketonuria. Each year, three DNA samples with previously characterized genotypes were mailed to participating laboratories. Indications for testing were either confirmation of diagnosis and prediction of disease...
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PMID: 19015950
PDF is available here.
PDF is available here.
Abstract
We devised a questionnaire and compared the responses with the results for performance in the scheme. A trend towards better performance could be demonstrated for those laboratories that regularly use internal quality control (QC) samples in their sample preparation (p = 0.079) and those that partic...
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PMID: 18985434
PDF is available here.
PDF is available here.
Ugeskrift for laeger (170)47 2008
Abstract
Abstract
The upper normal limit of serum alanine aminotransferase level in normal weight and nondiabetics was significantly lower than the total study group (36 versus 45 U/L). Serum alanine aminotransferase level was independently associated with male gender, body mass index, and diabetes mellitus (OR=2.05;...
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PMID: 18976029
PDF is available here.
PDF is available here.
Veterinary Journal (178)2 2008
Abstract
In an attempt to standardise the determination of biological reference values, the International Federation of Clinical Chemistry (IFCC) has published a series of recommendations on developing reference intervals. The IFCC recommends the use of an a priori sampling of at least 120 healthy individual...
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PMID: 17888695
PDF is available here.
PDF is available here.
Abstract
We aligned BCR-ABL values generated by 38 laboratories to an international scale (IS) where a major molecular response (MMR) is 0.1% or less. Alignment was achieved by application of laboratory-specific conversion factors calculated by comparisons performed with patient samples against a reference m...
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PMID: 18684859
PDF is available here.
PDF is available here.
Singapore medical journal (49)10 2008
Abstract
Positivity of HLA-B27 in childhood SSA was only 71.4 percent (50/70). Gender-wise analysis showed that 76.7 percent (46/60) males and 20.0 percent (2/10) of the female patients were HLA-B27 positive. In HLA-B27-positive cases, the sacroiliac, hip, ankle, lower spine and knee joints were more involve...
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PMID: 18946613
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (100)3 2008
Abstract
We report on a multicenter performance evaluation of a new particle-enhanced immunoassay, Innovance D-Dimer. Innovance D-Dimer assay was performed in 1,543 frozen samples from outpatients suspected of DVT and/or PE enrolled in three management studies as well as in a routine clinical practice. Sampl...
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PMID: 18766269
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (100)3 2008
Abstract