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Microchemistry (0):
Recent article
Microchemistry
Lab On a Chip (10)23 2010
Abstract
We first present three-dimensional microfluidic manipulations utilizing the unconventional gas-liquid interfaces of surface microfluidics, outlined by the micropatterned wetting boundaries (also known as the triple lines). In contrast to the primary linear (resistive) nature of the conventional clos...
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PMID: 20931123
PDF is available here.
PDF is available here.
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Abstract
We developed and validated a Salmonella flagella microagglutination test (SALMATcor) that significantly reduces laboratory requirements of antisera. SALMATcor is based on scaling down, by fivefold, the antigen:antiserum volumes actually required for the reference method: flagella standard tube agglu...
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PMID: 20367066
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
Granulocyte-colony stimulating factor stimulates production and antibacterial function of neutrophiles. Therapy using the recombinant protein drug represents a major step forward in oncology. The protein has not been, however, completely sequenced at the protein level and this formed the rationale o...
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PMID: 19526310
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
Thyrotropin-releasing hormone (TRH) is involved in a wide range of biological responses. It has a central role in the endocrine system and regulates several neurobiological activities. In the present study, a rapid, sensitive and selective liquid chromatography-mass spectrometry method for the ident...
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PMID: 19526311
PDF is available here.
PDF is available here.
Journal of Biochemistry (147)4 2010
Abstract
The activation of receptor tyrosine kinases (RTKs) is tightly regulated through a variety of mechanisms. Kinetic studies show that activation of c-Kit RTK occurs through an inter-molecular autophosphorylation. Phosphopeptide mapping of c-Kit reveals that 14-22 phosphates are added to each mol of wil...
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PMID: 20147452
PDF is available here.
PDF is available here.
Journal of Biochemistry (147)4 2010
Abstract
We have used a proteomic approach to study the protein expression of H. pylori under neutral (pH 7) and acidic (pH 5) conditions. Global protein-expression profiles of H. pylori under acid stress were analysed by two-dimensional polyacrylamide gel electrophoresis (2-DE) followed by liquid chromatogr...
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PMID: 19959503
PDF is available here.
PDF is available here.
Abstract
We confirm these findings in regard to floral pollen, using pollen collected directly from flowers of the known PA plants Senecio jacobaea, S. vernalis, Echium vulgare and pollinia of Phalaenopsis hybrids, and we extend analyses of 1,2-unsaturated PAs and 1,2-unsaturated PANOs to include bee-pollen...
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PMID: 20013884
PDF is available here.
PDF is available here.
Abstract
We confirm these findings in regard to floral pollen, using pollen collected directly from flowers of the known PA plants Senecio jacobaea, S. vernalis, Echium vulgare and pollinia of Phalaenopsis hybrids, and we extend analyses of 1,2-unsaturated PAs and 1,2-unsaturated PANOs to include bee-pollen...
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PMID: 20013884
PDF is available here.
PDF is available here.
Abstract
Abstract
In recent years, intranasal diamorphine (DIM) has been recommended as an alternative to intravenous administration for the treatment of acute-to-severe pain in children. This provides a rapid and less painful route of administration without decreasing the effectiveness of the analgesic properties. A...
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PMID: 20465864
PDF is available here.
PDF is available here.
Abstract
We study the microscopic viscoelastic properties and relaxation dynamics of solutions of a side-chain associative polymer, hydrophobically modified hydroxyethyl cellulose (hmHEC). Dynamic light scattering from small tracer particles suspended in the polymer solutions is used to determine their visco...
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PMID: 20175286
PDF is available here.
PDF is available here.
Abstract
A method for determining all of the six natural vitamin B(6) compounds and pyridoxine-beta-glucoside in urine from humans consuming their usual diet was developed. These compounds were specifically converted with 5 enzymes into a high fluorescent 4-pyridoxolactone which was supersensitively determin...
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PMID: 20651455
PDF is available here.
PDF is available here.
Abstract
We also provide a discussion with pitfalls and alternative techniques adapted to various substrates, including silicone elastomers.
2010 Elsevier Inc. All rights reserved....
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PMID: 20719269
PDF is available here.
PDF is available here.
Methods in Enzymology (475) 2010
Abstract
We present details of the design, construction, and testing of a single-beam optical tweezers apparatus capable of measuring and exerting torque, as well as force, on microfabricated, optically anisotropic particles (an "optical torque wrench"). The control of angular orientation is achieved by rota...
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PMID: 20627165
PDF is available here.
PDF is available here.
Abstract
We developed tubulin purification strategies that allowed sufficient material to be produced for compound-screening projects. Tubulins were polymerized in the presence of compounds using either turbidometric or fluorescence polymerization assays. IC50 and EC50 values were calculated and used to dete...
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PMID: 20466143
PDF is available here.
PDF is available here.
Abstract
To enhance oral absorption of poorly water-soluble daidzein, self-microemulsifying drug delivery system (SMEDDS) composed of oil, surfactant and cosurfactant for oral administration of daidzein was formulated, and its physicochemical properties and pharmacokinetic parameters were evaluated. Solubili...
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PMID: 20460789
PDF is available here.
PDF is available here.
Abstract
A new electrochemical biosensor for the monitoring of ultratrace terbium based on the conformational change of DNA containing a single guanine (G)-rich stretch was described here. The biosensor was fabricated by immobilizing a thiolated DNA containing a single G-rich stretch on the gold surface as p...
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PMID: 19699077
PDF is available here.
PDF is available here.
Applied Optics (48)4 2009
Abstract
We demonstrate standoff detection of several solids, liquids, and gases with single-beam coherent anti-Stokes Raman scattering. This approach utilizes a phase coherent ultrabroad-bandwidth femtosecond laser to probe the fundamental vibrations that constitute a molecule's fingerprint. Characteristic...
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PMID: 19183575
PDF is available here.
PDF is available here.
Analytical Biochemistry (395)1 2009
Abstract
Single nucleotide polymorphism (SNP) analysis of human DNA for the purpose of identification has some promising attributes. The question of approach is critical to the eventual adoption of this technology. The use of a low-volume open array platform was tested with a small selected set of eight SNP...
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PMID: 19646946
PDF is available here.
PDF is available here.
Methods in Molecular Biology (583)583 2009
Abstract
To develop a new generation of drugs, pharmaceutical companies need to be able to synthesise and screen novel chemicals with enhanced speed. New technology that would enable a cost neutral step change in the number of potential drug candidates would provide a distinct competitive advantage. Indeed t...
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PMID: 19763461
PDF is available here.
PDF is available here.
Inorganic Chemistry (48)18 2009
Abstract
A 3D microporous cadmium(II) metal-organic framework based on 1H-tetrazole exhibits strong hydrogen binding with an initial enthalpy of adsorption of 13.3 kJ/mol, due to the smaller pore sizes and the high hydrogen binding affinity of the tetrazolyl-ring-decorated inner surface of the pores.
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PMID: 19702250
PDF is available here.
PDF is available here.
Abstract
We have investigated the adsorption of fibrinogen, bovine serum albumin, and lysozyme on a surface constructed by such a PU in aqueous solution in real time. Our results reveal that the protein resistance of the PUs arises from the hydrated PEG segments instead of microphase separation....
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PMID: 19371047
PDF is available here.
PDF is available here.
Abstract
We present a facile and reproducible method to obtain thermally responsive, monodisperse, fluorescent microgels with diameters smaller than 700 nm based on poly(N-isopropyl acrylamide) (PNIPAM) interpenetrated with poly(thiophene-ethyl buthyl sulfonate) (PTEBS). Changing the temperature and inducing...
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PMID: 19456092
PDF is available here.
PDF is available here.
Abstract
Reversible fluorescence quenching and anti-quenching of CdS quantum dots immobilized in boronic acid-based microgels can be used for the optical detection of glucose.
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PMID: 19597602
PDF is available here.
PDF is available here.
Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering (44)10 2009
Abstract
Our results showed that SPME can be directly applied to soils to provide valuable information on volatile products from organic amendments....
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PMID: 19827492
PDF is available here.
PDF is available here.
Abstract
A sensitive chemiluminescence method based on a luminol-myoglobin system is proposed for the determination of melamine in milk products. It was found that the mixed solutions of melamine and myoglobin could react to form a complex on line, which could greatly inhibit the chemiluminescence intensity...
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PMID: 19334785
PDF is available here.
PDF is available here.
Analytical Biochemistry (389)2 2009
Abstract
We introduce a reagent-free micro pH-stat that can determine absolute enzyme activity without the need for exogenic reagents. This approach employs electrolysis for precise dosing of the requisite acid or base titrant to stat the pH of the sample. The micro pH-stat is based on the rotating sample sy...
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PMID: 19328765
PDF is available here.
PDF is available here.
Analytical Biochemistry (389)2 2009
Abstract
The inhibition of horse serum butyrylcholinesterase (EC 3.1.1.8) by the organophosphorus compound paraoxon (diethyl 4-nitrophenyl phosphate) was studied by flow microcalorimetry at 37 °C in Tris buffer (pH 7.5) using a modification of the kinetic model described by Stojan and coworkers [J. Stojan, V...
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PMID: 19341699
PDF is available here.
PDF is available here.
Abstract
Microcolumn RPLC (microRPLC) is one of the optimum separation modes for shotgun proteomic analysis. To identify as many proteins as possible by MS/MS, the improvement on separation efficiency and peak capacity of muRPLC is indispensable. Although the increase in column length is one of the effective...
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PMID: 19294701
PDF is available here.
PDF is available here.
Chemical Society Reviews (38)4 2009
Abstract
This tutorial review provides an overview of the science of food materials and encapsulation techniques that underpin the development of delivery vehicles for functional food components, nutrients and bioactives. Examples of how the choice of materials, formulation and process affect the structure o...
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PMID: 19421570
PDF is available here.
PDF is available here.
Methods in Molecular Biology (527)527 2009
Abstract
In view of the importance of information transfer mediated throughout the cell by recognition, phosphorylation or dephosphorylation of kinases, their adapters, or substrates, this method was developed. The method provides a potent research tool for rapidly generating and testing these substrates as...
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PMID: 19241019
PDF is available here.
PDF is available here.
Abstract
A sensitive, specific and efficient high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the simultaneous determination of total vincristine and actinomycin-D concentrations in human plasma and an assay for the determination of unbound vincristine are presented. Ele...
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PMID: 19204931
PDF is available here.
PDF is available here.
Abstract
Reactive metabolites are believed to be one of the main reasons for unexpected drug-induced toxicity issues, by forming covalent adducts with cell proteins or DNA. Due to their high reactivity and short lifespan they are not directly detected by traditional analytical methods, but are most tradition...
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PMID: 19224530
PDF is available here.
PDF is available here.
Matrix-free detection of intact ions from proteins in argon-cluster secondary ion mass spectrometry.
Abstract
We have developed SIMS instrumentation in which the primary ions were argon cluster ions having a kinetic energy per atom, controlled down to 1 eV. On applying this instrumentation to several peptides and proteins, the signal intensity of fragment ions was decreased by a factor of 10(2) when the kin...
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PMID: 19173223
PDF is available here.
PDF is available here.
Abstract
We have utilized a sensitive carbon carrier method where a (14)C-deficient compound is added to the HPLC fractions and the composite sample is prepared and analyzed by AMS. Using 50 microL human blood plasma aliquots, we have demonstrated concentration measurements below 20 fM, containing sub-amol a...
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PMID: 19177507
PDF is available here.
PDF is available here.
Abstract
We describe and assign the potential molecular formulae of these doubly charged species, derived from FTICR-MS, and the existence of these species was confirmed via IMS. The parallel application of these powerful techniques enabled the boundaries of the understanding of natural organic matter to be...
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PMID: 19189351
PDF is available here.
PDF is available here.
Abstract
Sociable mice had almost triple the levels of GABA in their mPFC than aggressive or timid mice. No significant differences in aspartate and glutamate levels were found in these three types of individually-housed mice. Forebrain chemistry of group-housed mice did not differ from that of individually-...
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PMID: 19300401
PDF is available here.
PDF is available here.
Carbohydrate Research (344)3 2009
Abstract
This work focuses on the effect of annealing and pressure on microstructures of starch, in particular the crystal structure and crystallinity to further explore the mechanisms of annealing and pressure treatment. Cornstarches with different amylose/amylopectin ratios were used as model materials. Si...
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PMID: 19108818
PDF is available here.
PDF is available here.
Abstract
A simple, low cost and highly sensitive method based on solvent microextraction (SME) for separation/preconcentration and flame atomic absorption spectrometry (FAAS) was proposed for the determination of ultratrace amounts of cadmium in meat and fish samples. The analytical procedure involved the fo...
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PMID: 19138082
PDF is available here.
PDF is available here.
Abstract
Analytical Biochemistry (385)2 2009
Abstract
A nondetergent sulfobetaine (NDSB) was found to improve unfolding reversibility of several proteins by inhibiting heat-induced aggregation. As a consequence, DeltaH(cal)/DeltaH(vH) ratios were also improved to values close to 1 for a two-state unfolding. NDSB is effective in a wide range of pH value...
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PMID: 19059190
PDF is available here.
PDF is available here.
Methods in Molecular Biology (503)503 2009
Abstract
We have developed a new optical label-free sensor called the liquid core optical ring resonator (LCORR). The LCORR integrates optical ring resonator sensors into the microfluidic delivery system by using glass capillaries with a thin wall. The LCORR is capable of performing refractive index detectio...
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PMID: 19151939
PDF is available here.
PDF is available here.
Abstract
The size-dependent chemical and physical properties of nanoparticles inspire the design of unique assays and the use of new detection schemes while also offering the opportunity to vastly improve the results achieved when using traditional signal transduction methods. Herein, the most commonly explo...
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PMID: 20049794
PDF is available here.
PDF is available here.
Abstract
We describe the application of capillary LC-ICP-MS (liquid chromatography-inductively coupled plasma-mass spectrometry) for quantification of phospho-proteins and their phosphorylation degree. Element mass spectrometry is ideally suited for monitor ing and quantification of compounds with heteroelem...
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PMID: 19241015
PDF is available here.
PDF is available here.
Abstract
We describe here a rapid micro (micro)ChIP assay suited for multiple parallel ChIPs from a single chromatin batch from 1,000 cells. The assay is also applicable to a single immunoprecipitation from 100 cells....
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PMID: 19588085
PDF is available here.
PDF is available here.
Abstract
Biodiesel is produced by reacting vegetable oils or animal fats with alcohol in the presence of an alkaline catalyst. The resulting methyl esters, which are the biodiesel fuel, are separated from the by-product glycerin, and then washed with water and dehydrated to produce fuel that must meet standa...
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PMID: 19768629
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
It was found that the fluorescence of Tb(3+)-epinephrine (E) complex can be enhanced by both bovine serum albumin (BSA) and sodium dodecylsulfate (SDS), and stabilized by ascorbic acid (AA). It is considered that the fluorescence enhancement of the Tb(3+)-E-BSA-AA-SDS system originat...
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PMID: 19591244
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
It was found that the fluorescence of Tb(3+)-epinephrine (E) complex can be enhanced by both bovine serum albumin (BSA) and sodium dodecylsulfate (SDS), and stabilized by ascorbic acid (AA). It is considered that the fluorescence enhancement of the Tb(3+)-E-BSA-AA-SDS system originat...
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PMID: 19591244
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
It was found that the fluorescence of Tb(3+)-epinephrine (E) complex can be enhanced by both bovine serum albumin (BSA) and sodium dodecylsulfate (SDS), and stabilized by ascorbic acid (AA). It is considered that the fluorescence enhancement of the Tb(3+)-E-BSA-AA-SDS system originat...
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PMID: 19591244
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
It was found that the fluorescence of Tb(3+)-epinephrine (E) complex can be enhanced by both bovine serum albumin (BSA) and sodium dodecylsulfate (SDS), and stabilized by ascorbic acid (AA). It is considered that the fluorescence enhancement of the Tb(3+)-E-BSA-AA-SDS system originat...
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PMID: 19591244
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
It was found that the fluorescence of Tb(3+)-epinephrine (E) complex can be enhanced by both bovine serum albumin (BSA) and sodium dodecylsulfate (SDS), and stabilized by ascorbic acid (AA). It is considered that the fluorescence enhancement of the Tb(3+)-E-BSA-AA-SDS system originat...
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PMID: 19591244
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
It was found that the fluorescence of Tb(3+)-epinephrine (E) complex can be enhanced by both bovine serum albumin (BSA) and sodium dodecylsulfate (SDS), and stabilized by ascorbic acid (AA). It is considered that the fluorescence enhancement of the Tb(3+)-E-BSA-AA-SDS system originat...
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PMID: 19591244
PDF is available here.
PDF is available here.
Abstract
The extended use of biomass for heat and power production has caused increased operational problems with fouling and high-temperature corrosion in boilers. These problems are mainly related to the presence of alkali chlorides (KCl and NaCl) at high concentrations in the flue gas. The in situ alkali...
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PMID: 19256637
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (54)7-8 2009
Abstract
Rapid testing of pathogen susceptibility to antibiotics is of great practical value for rational chemotherapy of pyoinflammatory deseases and postoperative complications of microbial etiology. The standard microbiological methods, i.e., the disk diffusion method and the method of serial dilutions ar...
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PMID: 20201396
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (134)1 2009
Abstract
Miniaturised liquid/liquid interfaces provide benefits for bioanalytical detection with electrochemical methods. In this work, microporous silicon membranes which can be used for interface miniaturisation were characterized by simulations and experiments. The microporous membranes possessed hexagona...
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PMID: 19082187
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (134)1 2009
Abstract
A highly sensitive and quantitative analysis was performed using a poly(dimethylsiloxane) (PDMS) microwell array in a scanning electrochemical microscopy setup. A microelectrode with a relatively large seal radius was used to cover the top of the cylindrical PDMS microwell (96 pL). The voltammogram...
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PMID: 19082191
PDF is available here.
PDF is available here.
Abstract
An integrated microdevice is developed for the analysis of gene expression in single cells. The system captures a single cell, transcribes and amplifies the mRNA, and quantitatively analyzes the products of interest. The key components of the microdevice include integrated nanoliter metering pumps,...
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PMID: 19075237
PDF is available here.
PDF is available here.
Lab On a Chip (8)12 2008
Abstract
We have designed a microfluidic chip for chemotaxis studies which can use neutrophils isolated on the chip, directly from whole blood. We have tested three different cell adhesion molecules as substrates for neutrophil isolation (P-selectin, E-selectin and fibronectin) and found average capture effi...
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PMID: 19023468
PDF is available here.
PDF is available here.
Lab On a Chip (8)12 2008
Abstract
We report a microvortex manipulator (MVM) that is a passive, scalable system with great potential for the manipulation and separation of particulate samples in microfluidic environments. The movement of particles is determined by a unique combination of helical flow, buoyant, and gravitational force...
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PMID: 19023476
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (112)45 2008
Abstract
The solid state solvation of HCl molecules with small ammonia clusters at an average temperature of 100 K was investigated by on-the-fly molecular dynamics methodology. Structures close to the proton jump from HCl molecule to the ammonia have been further checked with the MP2/aug-cc-pvDZ calculation...
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PMID: 18939785
PDF is available here.
PDF is available here.