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Neoplastic Processes (8)
Articles on Neoplastic Processes
Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm.
[Antioxidant protection as a component of anesthetic management cancer patients].
Accumulation of driver and passenger mutations during tumor progression.
We provide a mathematical model that begins to address this challenge. We model tumors as a discrete time branching process that starts with a single driver mutation and proceeds as each new driver mutation leads to a slightly increased rate of clonal expansion. Using the model, we observe tremendou...
New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recu...
Accumulating lines of experimental evidence have revealed that the malignant transformation of multipotent tissue-resident adult stem/progenitor cells into cancer stem/progenitor cells endowed with a high self-renewal capacity and aberrant multilineage differentiation potential may be at origin of t...
Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition.
We report here that mice living in an enriched housing environment show reduced tumor growth and increased remission. We found this effect in melanoma and colon cancer models, and that it was not caused by physical activity alone. Serum from animals held in an enriched environment (EE) inhibited can...
Monitoring tumor response to therapy with 18F-FLT PET.
Injectable intratumoral depot of thermally responsive polypeptide@?radionuclide conjugates delays tumor progression in a mouse model
This study evaluated a biodegradable drug delivery system for local cancer radiotherapy consisting of a thermally sensitive elastin-like polypeptide (ELP) conjugated to a therapeutic radionuclide. Two ELPs (49 kDa) were synthesized using genetic engineering to test the hypothesis that injectable bio...
Role of the tissue factor pathway in the biology of tumor initiating cells
We postulate that the TF pathway may play an important role in formation of the vascular niche for tumour initiating CSCs, through its procoagulant and signalling effects. Therapeutic blockade of these mechanisms could hamper tumour initiation processes, which are dependent on CSCs and participate i...
Molecular pathogenesis of craniopharyngioma: switching from a surgical approach to a biological one.
Craniopharyngioma has long been considered a benign tumor because of its pathological aspect. This primordial view of craniopharyngioma fit with the primitive treatment attempts based on blind resection of the tumor each time it recurred. The limits of this management strategy were proven early by t...
Cystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied and reviewed in the literature. Over the last 20 years, however, proteins containing cystatin domains but lacking protease inhibitory activities have been identified, and most likely more will be described...