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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neoplasms by Histologic Type (14):
- Neoplasms, Plasma Cell
- Neoplasms, Complex and Mixed
- Neoplasms, Nerve Tissue
- Lymphoma
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Glandular and Epithelial
- Neoplasms, Gonadal Tissue
- Nevi and Melanomas
- Neoplasms, Connective and Soft Tissue
- Histiocytic Disorders, Malignant
- Neoplasms, Vascular Tissue
- Lymphatic Vessel Tumors
- Odontogenic Tumors
- Leukemia
Recent article
Neoplasms by Histologic Type
Abstract
We designated FAM107B as heat shock-inducible tumor small protein (HITS) and studied its expression and functional properties in cancer. HITS is an 18-kDa nuclear protein expressed in a variety of tissues including stomach, colon, lung and lymphoid organs. In human gastric and colorectal cancers and...
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PMID: 20664927
PDF is available here.
PDF is available here.
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Abstract
We don't have information as to which is the actual plasma level of vitamin C that can produce tumor shrinkage. We don't have consistent information either regarding what is the clinical dose necessary to yield therapeutic plasma levels. In view of this lack of data after trials which have included...
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PMID: 20799507
PDF is available here.
PDF is available here.
Nature Protocols (5)8 2010
Abstract
We have developed a multivalent nanoparticle platform based on the cowpea mosaic virus (CPMV) that facilitates particle labeling at high density with fluorescent dyes and other functional groups. Compared with other technologies, CPMV-based viral nanoparticles are particularly suited for long-term i...
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PMID: 20671724
PDF is available here.
PDF is available here.
Abstract
Accumulating lines of experimental evidence have revealed that the malignant transformation of multipotent tissue-resident adult stem/progenitor cells into cancer stem/progenitor cells endowed with a high self-renewal capacity and aberrant multilineage differentiation potential may be at origin of t...
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PMID: 20552555
PDF is available here.
PDF is available here.
Abstract
We summarize SRC biology and how it has been applied to the clinical development of SRC inhibitors. The status of SRC inhibitors, including dasatinib, saracatinib, and bosutinib, which are in phase 1, 2, and 3 trials, is highlighted....
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PMID: 20689754
PDF is available here.
PDF is available here.
Abstract
This study showed that children undergoing treatment of all types of cancer have a significantly lower body cell mass and a significantly higher fat mass than do healthy controls. Nutritional support is suggested for all children undergoing treatment of cancer....
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PMID: 20484453
PDF is available here.
PDF is available here.
Abstract
We show that a disruption of the JmjC domain of dUTX results in a growth advantage for mutant cells over adjacent wild-type tissue due to increased proliferation. The growth advantage of dUTX mutant tissue is caused, at least in part, by increased Notch activity, demonstrating that dUTX is a Notch a...
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PMID: 20212086
PDF is available here.
PDF is available here.
Oncology Reports (23)5 2010
Abstract
We used immunohistochemistry to investigate the expression of TK-1 and TS in various types of cancer. TK-1 and TS expression was markedly different between cancer types. High TK-1 expression was detected prominently in gastrointestinal adenocarcinomas and esophageal and uterine squamous cell carcino...
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PMID: 20372850
PDF is available here.
PDF is available here.
Thrombosis Research (125 Suppl 2) 2010
Abstract
The relation of cancer to thromboembolism has been described since the mid 1800s. Different studies in animal and in vitro models have confirmed the link between the haemostatic system and both tumor stroma formation and metastasis. Although the mechanisms of warfarin effects on cancer are not eluci...
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PMID: 20433986
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (337)1-2 2010
Abstract
We studied the expression of HMGB1 protein in malignant human tumors of different differentiation level and in tumor metastasis. In all tumor tissues, the protein level is elevated. In moderately differentiated carcinomas, the localization of the protein is perinuclear, while in the low differentiat...
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PMID: 19876719
PDF is available here.
PDF is available here.
Future Oncology (6)4 2010
Abstract
We propose future oncology interventions with the concept of integrative cancer therapy....
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PMID: 20373871
PDF is available here.
PDF is available here.
Abstract
Minichromosome maintenance (MCM) proteins are essential for the process of DNA replication, functioning as license components for the S-phase of cell-cycle initiation and further exerting weak helicase activity to unwind DNA from its supercoiled state at replication forks. The requirement for MCM pr...
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PMID: 20054807
PDF is available here.
PDF is available here.
Abstract
Claudins are tight junction proteins that are critical for the sealing of cellular sheets and controlling paracellular ion flux. The claudin family of proteins is composed of at least 24 closely related transmembrane proteins, most of them are well characterized at the gene and protein levels. The c...
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PMID: 19924644
PDF is available here.
PDF is available here.
Abstract
Erythropoietin (Epo) may be considered as an endogenous stimulator of vessel growth during tumor progression through an autocrine and/or paracrine loop. The vascular effects of Epo would be relevant in tumor angiogenesis and the negative effect of Epo on tumor growth may be aggravated by its angioge...
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PMID: 19886790
PDF is available here.
PDF is available here.
Abstract
We now present a novel approach for in vivo detection of beta-galactosidase using optical imaging to detect light emission following administration of the chemiluminescent 1,2-dioxetane substrate Galacto-Light PlusTM.
B-gal activity was visualized in stably transfected human MCF7-lac...
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PMID: 20700459
PDF is available here.
PDF is available here.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (51)2 2010
Abstract
Matrix metalloproteinases (MMPs) have a great variability that provides a complex intervention in pathophysiological conditions. MMPs roles in pathology may be grouped into the following main types: (1) tissue destruction, as in cancer invasion and metastasis, rheumatoid arthritis, osteoarthritis, d...
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PMID: 20495735
PDF is available here.
PDF is available here.
Abstract
In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at the National Institute of Radiological Science (NIRS), Japan. Among several types of ion species, carbon ions were chosen for cancer therapy because they were judged to have the most optimal properties in term...
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PMID: 20508375
PDF is available here.
PDF is available here.
Abstract
We offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions t...
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PMID: 20184390
PDF is available here.
PDF is available here.
Abstract
We review the literature to date on various regulatory functions of osteoactivin, as well as its discovery, structure, expression, and function in different tissues and cells. The transcriptional regulation of osteoactivin and its mechanism of action in normal and diseased conditions with special em...
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PMID: 21395506
PDF is available here.
PDF is available here.
Abstract
We report the implementation of a genotyping and validation algorithm that enables robust tumor mutation profiling in the clinical setting.
We developed and implemented an optimized mutation profiling platform ("OncoMap") to interrogate approximately 400 mutations in 33 known oncogen...
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PMID: 19924296
PDF is available here.
PDF is available here.
Veterinary Pathology (46)4 2009
Abstract
Neoplastic diseases in prosimians have been sporadically reported in the literature. To provide a comprehensive review of prosimian neoplasia, a retrospective evaluation of neoplasia in a large captive prosimian colony and an extensive literature review were performed. Primates that belong to the Or...
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PMID: 19276064
PDF is available here.
PDF is available here.
Abstract
A retrospective analysis of benign tumours seen in children aged 0-14 years over a 10-year period (1993-2002) was carried out in Benin City Nigeria, in order to determine the various histological types of such tumours. A total of 76 cases were seen during the study period, out of which 32 occurred i...
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PMID: 20175425
PDF is available here.
PDF is available here.
Croatian Medical Journal (50)3 2009
Abstract
Profiles obtained using the Identifiler system were generally more complete, but showed 3-fold higher levels of instability (86%) than those obtained using PowerPlex 16 (27%). Instances of genetic instability were distributed throughout all loci in both multiplex STR systems. CONCLUSION: After havin...
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PMID: 19480018
PDF is available here.
PDF is available here.
Abstract
Including 5 Gy of C-ion and 8 Gy of gamma-rays, which did not inhibit the primary tumor growth, all doses used in this study inhibited lung metastasis significantly. Pathologic findings showed no difference among the metastatic tumor nodules in the nonirradiated, C-ion-irradiated, and gamma-ray-irra...
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PMID: 19362239
PDF is available here.
PDF is available here.
Abstract
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell mig...
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PMID: 19224455
PDF is available here.
PDF is available here.
Abstract
We analyzed FAK mRNA expression in normal, invasive and metastatic human tissues and demonstrated through Northern blot analysis that normal tissues had very low levels of FAK mRNA while primary and metastatic tumors significantly overexpressed FAK. We also demonstrated and confirmed FAK overexpress...
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PMID: 19224453
PDF is available here.
PDF is available here.
Abstract
Osteoprotegerin (OPG) is a soluble tumor necrosis factor receptor family member, which potently inhibits RANKL-mediated osteoclastogenesis. Numerous constructs have been created for therapeutic purposes in which the heparin-binding and death homology domains of OPG were removed and the remaining pep...
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PMID: 19011755
PDF is available here.
PDF is available here.
Molecular Neurobiology (39)1 2009
Abstract
We discuss the importance and role of NFI in these processes in the context of several CNS systems including the neocortex, hippocampus, cerebellum, and spinal cord at both cellular and molecular levels....
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PMID: 19058033
PDF is available here.
PDF is available here.
Abstract
The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved transcription factors that are found in diverse organisms that range from flatworms to humans. These factors are expressed within, and play pivotal developmental roles in, cell populations that give rise to the head...
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PMID: 18989625
PDF is available here.
PDF is available here.
Abstract
We provide an exhaustive review of the many faces of semaphorins both during developmental, regulatory and pathological processes. Indeed, because of their crucial fundamental roles, the semaphorins and their receptors represent important targets for the development of drugs directed at a variety of...
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PMID: 18953684
PDF is available here.
PDF is available here.
Abstract
I and ERalpha-positive tumors. Women in the highest quartiles of weight, BMI, waist- and hip circumference and body fat percentage were all associated with tumors of ductal type, Grade II, low Ki67 index, HER2 negativity and low expression of the oncogene cyclin D1. Obesity was further associated wi...
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PMID: 18798278
PDF is available here.
PDF is available here.
Gaceta medica de Mexico (145)1 2009
Abstract
It is well-known that there are different tumor-type-dependent metastatic patterns. For example, in carcinomas metastatic spread is preferentially via the lymphatic system by which they reach regional lymph nodes through pre-existent afferent lymph vessels and/or newly formed lymph capillaries; whil...
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PMID: 19256411
PDF is available here.
PDF is available here.
Przeglad lekarski (66)10 2009
Abstract
Tumour suppressor gene TP53 is a subject of frequent lesions and mutations in a majority of cancer types that is followed by its dysfunction in regulation of cell proliferation, apoptosin and DNA repair. Mutation profile reflects the presence of mutagen-vulnerable sites (including tobacco smoke carc...
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PMID: 20301891
PDF is available here.
PDF is available here.
Acta Oncologica (48)1 2009
Abstract
About half of the 202 cases (93 malignant and 8 benign) should have been reported, which translates into an additional 1 579 malignant cases (95% CI 1 349-1 808), or 3.7% of the cases reported in 1998. The crude incidence rate for males and females combined would increase from 493 per 100,000 to 511...
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PMID: 18767000
PDF is available here.
PDF is available here.
Abstract
Preoperative UCG increases the risk of early surgical complications in DPN....
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PMID: 20550863
PDF is available here.
PDF is available here.
Abstract
The haloacetonitriles (HANs) exist in drinking water exclusively as byproducts of disinfection. HANs are found in drinking water more often, and in higher concentrations, when surface water is treated by chloramination. Human exposure occurs through consumption of finished drinking water; oral and d...
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PMID: 19253036
PDF is available here.
PDF is available here.
International Journal of Cancer (123)11 2008
Abstract
We summarize the latest reports on decorin and related molecules that are relevant to cancer and bring forward the idea of decorin as an anticancer therapeutic and possible prognostic marker for patients affected by various types of tumors. We also discuss the role of lumican and LRIG1, a novel cell...
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PMID: 18798267
PDF is available here.
PDF is available here.
Iubmb Life (60)12 2008
Abstract
Lumican belongs to the family of small leucine-rich repeat proteoglycans. Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of lumican has been cor...
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PMID: 18949819
PDF is available here.
PDF is available here.
Abstract
I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and in various types of malignancies. Different MHC class I abnormalities have been found in solid tumors of d...
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PMID: 18408926
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 20 2008
Abstract
We show that the protein phosphatase PP2A-B' regulatory subunit Widerborst (Wdb), which coimmunoprecipitates with Akt in vivo, selectively modulates levels of activated Akt in the cytoplasm. It alters lipid droplet size and expression of the lipid storage perilipin-like protein LSD2 in the Drosophil...
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PMID: 18827008
PDF is available here.
PDF is available here.
Annals of Oncology (19)10 2008
Abstract
The MTD of trabectedin was 1.1 mg/m(2). Drug-related grade 3 and 4 toxic effects were neutropenia (31%) and elevated transaminases (31%). Six patients responded (one CR, five partial responses), with an overall response rate of 16.7%, and 14 had stable disease (less than a 50% reduction and less tha...
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PMID: 18497430
PDF is available here.
PDF is available here.
Abstract
We investigated the issue using data from a multicentric case-control study conducted in Italy between 1997 and 2007 on 230 cases aged not more than 80 years, with histologically confirmed incident gastric cancer and 547 controls admitted to hospital for acute, non neoplastic conditions. Logistic re...
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PMID: 18567000
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1783)9 2008
Abstract
Lamin B1, a major component of the nuclear lamina, anchors the nucleus to the cytoskeletal cage, and controls nuclear orientation, chromosome positioning and, alongside several enzymes, fundamental nuclear functions. Exposing polyomavirus-transformed rat pyF111 fibroblasts and human cervical carcino...
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PMID: 18439918
PDF is available here.
PDF is available here.
Abstract
We show that JNK/SAPK signaling plays an important role in Wnt-dependent mammary development and malignant transformation. The JNK/SAPK pathway is stimulated in pregnancy-mediated lobulo-alveolar morphogenesis, a process highly dependent on Wnt/beta-catenin signaling. Strong elevations of JNK/SAPK s...
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PMID: 18714362
PDF is available here.
PDF is available here.
Veterinary Pathology (45)5 2008
Abstract
A total of 90 tumors from 85 domestic hamsters (70 Djungarian hamsters and 15 Syrian hamsters) were examined by histology. In the Djungarian hamsters, 64 neoplastic and 11 non-neoplastic lesions were identified, whereas 14 Syrian hamsters showed neoplastic disease, and one showed non-neoplastic dise...
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PMID: 18725472
PDF is available here.
PDF is available here.
Clinical Cancer Research (14)15 2008
Abstract
We identified mutations in 82.4% of cases, the highest VHL gene mutation prevalence reported to date. Analysis of 11 VHL promoter CpG sites revealed that 8.3% of tumors were hypermethylated and all were mutation negative. In total, 91% of ccRCCs exhibited alteration of the gene through genetic or ep...
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PMID: 18676741
PDF is available here.
PDF is available here.
Abstract
EPH receptors and their ephrin ligands constitute the largest sub-family of receptor tyrosine kinases (RTKs) and are components of cell signaling pathways involved in animal development. The ability of the EPH/ephrin guidance system to position cells and modulate cell morphology underlies their vari...
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PMID: 18498077
PDF is available here.
PDF is available here.
Abstract
We have chosen to concentrate our efforts on the structure, function, regulation, and future prospect of RECK in order to provide a new target for prevention and treatment of tumours....
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PMID: 18498076
PDF is available here.
PDF is available here.
Abstract
We examined immune parameters in female rats of two different behavioral types previously shown to have differential glucocorticoid production and life spans. We categorized young female rats according to their behavioral response to novelty (high- or low-locomotion), and compared their glucocortico...
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PMID: 18155400
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)22 2008
Abstract
We used a well established in vitro EMT assay: transforming growth factor-beta-induced EMT in NMuMG murine mammary epithelial cells. We found that members of the miR-200 family, organized as two clusters in the genome, were repressed during EMT. Overexpression of each miRNA individually or as cluste...
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PMID: 18411277
PDF is available here.
PDF is available here.
Abstract
The tyrosine kinase receptor Tie2 was initially identified as a specific vascular growth factor that governed several properties of endothelial cells under both physiological and pathological conditions. It was subsequently found that angiopoietins, the natural ligands of Tie2, modulate Tie2-depende...
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PMID: 18366015
PDF is available here.
PDF is available here.
Pathologie Biologie (56)4 2008
Abstract
There is a strong association between cancer and venous thromboembolism (VTE). Cancer patients have a seven-fold higher risk of developing VTE as compared with noncancer patients. In the year following the diagnosis of cancer, 1.6% of patients will develop a VTE event. VTE is one of the main cause o...
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PMID: 18325691
PDF is available here.
PDF is available here.
Clinical Cancer Research (14)10 2008
Abstract
Tumor-specific alterations in Bcl-B expression may define subsets of nonepithelial and epithelial neoplasms with distinct clinical behaviors....
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PMID: 18483366
PDF is available here.
PDF is available here.
Infection and Immunity (76)5 2008
Abstract
We analyzed intravaginal (ivag) vaccine delivery of live attenuated Salmonella enterica serovar Typhimurium expressing HPV16L1 as a model antigen. Innate immune responses were examined in cervicovaginal tissues by determining gene expression patterns by microarray analysis using nylon membranes impr...
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PMID: 18332214
PDF is available here.
PDF is available here.
Cancer Research (68)9 2008
Abstract
We compared in vitro R1 alpha Delta 6 with wild-type (wt) R1 alpha. We assessed PKA activity and subunit expression, phosphorylation of target molecules, and properties of wt-R1 alpha and mutant (mt) R1 alpha; we observed by confocal microscopy R1 alpha tagged with green fluorescent protein and its...
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PMID: 18451138
PDF is available here.
PDF is available here.
Biochemistry (New York) (73)5 2008
Abstract
Complete and incomplete transitions of epitheliocytes into cells of mesenchymal type, so-called epithelial-mesenchymal transitions (EMT), take place in many types of normal morphogenesis and in epithelial carcinogenesis. Connective tissue cells (fibroblasts) also undergo considerable morphological c...
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PMID: 18605977
PDF is available here.
PDF is available here.
Abstract
Focal Adhesion Kinase is a 119-121 kDa nonreceptor protein kinase widely expressed in various tissues and cell types. Several studies showed that FAK plays an important role in integrin signaling. Once activated by integrin and non-integrin stimuli, it binds and activates several other molecules, su...
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PMID: 18283648
PDF is available here.
PDF is available here.
Abstract
We review the literature with emphasis on the syncytin family and propose that syncytins may represent universal fusogens in primates and rodents, which work together with a number of other proteins to regulate the cell fusion machinery....
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PMID: 18351375
PDF is available here.
PDF is available here.
Cancer Science (99)5 2008
Abstract
We found that proteasome inhibitors prevent translesion replication in human cancer cells but not in normal cells. Three proteasome inhibitors, MG-132, lactacystin, and MG-262, inhibited UV-induced translesion replication in a wide range of cancer cell lines, including HeLa, HGC-27, MCF-7, HepG2, Wi...
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PMID: 18294277
PDF is available here.
PDF is available here.
Nature Genetics (40)5 2008
Abstract
We analyze the enrichment patterns of gene sets associated with embryonic stem (ES) cell identity in the expression profiles of various human tumor types. We find that histologically poorly differentiated tumors show preferential overexpression of genes normally enriched in ES cells, combined with p...
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PMID: 18443585
PDF is available here.
PDF is available here.