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Carcinoma, Ductal, Breast (0):
Recent article
Carcinoma, Ductal, Breast
New England Journal of Medicine (365)13 2011
Abstract
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New England Journal of Medicine (364)23 2011
Abstract
Abstract
We have used laser capture microdissection (LCM) to isolate microvessels from clinical samples of invasive ductal carcinoma (IDC), the most common form of malignant breast cancer, and from patient-matched adjacent nonmalignant tissue. This approach eliminates many of the problems associated with the...
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PMID: 21401208
PDF is available here.
PDF is available here.
Clinical Breast Cancer (11)1 2011
Abstract
We present an unusual case of radiation-induced morphea (RIM) that occurred after accelerated partial breast irradiation (APBI) using intracavitary Contura brachytherapy. A 65-year-old white woman was treated for stage IIA invasive ductal carcinoma of the left breast with APBI to a dose of 34 Gy in...
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PMID: 21421525
PDF is available here.
PDF is available here.
American Surgeon (77)2 2011
Abstract
American Surgeon (77)2 2011
Abstract
Journal of Neurosurgery (113 Suppl) 2010
Abstract
The goal of this study was to analyze prognostic factors for local tumor control and survival and indications for initial treatment with the Gamma Knife in patients with up to 10 metastatic brain tumors from primary breast cancer.
Outcomes were retrospectively reviewed in 101 women with a total of 6...
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PMID: 21121788
PDF is available here.
PDF is available here.
Abstract
Abstract
Health care disparities have been documented in rural populations. The authors hypothesized that breast cancer patients in urban counties would have higher rates of postmastectomy breast reconstruction relative to patients in surrounding near-metro and rural counties.
The authors used the Surveillan...
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PMID: 21124121
PDF is available here.
PDF is available here.
Abstract
Plastic surgeons routinely submit breast capsulectomy surgical specimens for pathologic evaluation. However, clinically significant findings are rarely identified. In an effort to reduce health care costs and the unnecessary use of hospital resources, this study reviews the efficacy of submitting br...
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PMID: 21124126
PDF is available here.
PDF is available here.
Abstract
We have recently encountered in our consultation practice 4 cases of invasive breast carcinoma (confirmed by clinical findings and other immunophenotypic features) that showed unequivocal tumor cell expression of TTF-1. However, the frequency with which TTF-1 expression is observed in breast carcino...
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PMID: 21107096
PDF is available here.
PDF is available here.
Abstract
The majority of patients with cancer use some form of complementary or alternative medicine. External qigong treatment (EQT), classified as a bioenergy therapy, is one such approach that patients combine with conventional medicine or, in some cases, use in place of conventional medic...
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PMID: 21106615
PDF is available here.
PDF is available here.
Abstract
We report a case of recurrent breast cancer with solitary lung metastasis that has shown no recurrence with treatment by trastuzumab alone after partial resection of the right lung upper lobe. A 56-year-old woman, who presented with left breast cancer, underwent quadrantectomy and axillar lymph node...
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PMID: 21160267
PDF is available here.
PDF is available here.
Abstract
We report a 69-year-old woman with breast cancer who was effectively treated with letrozole as a second-line therapy after becoming resistant to anastrozole. Her chief complaint at presentation was back pain. Physical examination and imaging studies showed a left breast tumor with skin invasion, mul...
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PMID: 21160269
PDF is available here.
PDF is available here.
Abstract
We report a case of multi-drug-resistant breast cancer with liver metastases which completely responded and improved the quality of life (QOL)by S-1 monotherapy. The patient was a 53-year-old woman, who was diagnosed as breast cancer with invasive chest wall, cervical lymph node metastases, multiple...
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PMID: 21160266
PDF is available here.
PDF is available here.
Abstract
A 53-year-old woman with left breast tumor was diagnosed as bilateral breast cancer(left; T3N3M0, Stage III C/right; T2N0M0, Stage II )in our hospital, both of which were revealed as invasive ductal carcinoma shown to be ER-negative, PgR negative and HER2-positive by core needle biopsy. In December...
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PMID: 21160270
PDF is available here.
PDF is available here.
Abstract
We have noticed that some breast carcinomas showing lymphatic spread but lacking histologic features of IMPC have occasional tumor cell clusters reminiscent of those of IMPC without the characteristic prominent retraction artifact. To study the clinicopathologic significance of such features, we pro...
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PMID: 20975342
PDF is available here.
PDF is available here.
Abstract
Our comprehensive database of 2175 consecutive patients with invasive breast cancer diagnosed during the period 1992-2009 served for the analysis. Several potential factors associated with lobular carcinoma as compared with ductal carcinoma were evaluated.
During this period, a 2.4-f...
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PMID: 21243872
PDF is available here.
PDF is available here.
Acta Radiologica (51)9 2010
Abstract
Enhancement characteristics of breast lesions are regarded as a major criterion for their differential diagnosis in dynamic breast MRI (bMRI). However, ductal carcinoma in situ (DCIS) exhibits a highly heterogeneous enhancement pattern when kinetic analysis is performed conventionally by manual plac...
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PMID: 20942728
PDF is available here.
PDF is available here.
Cancer Research (70)21 2010
Abstract
We conducted 14 independent quantitative proteomics experiments comparing pooled plasma samples collected from 420 estrogen receptor-positive (ER(+)) breast cancer patients ≤17 months before their diagnosis and matched controls. Based on the more than 3.4 million tandem mass spectra collected in t...
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PMID: 20959476
PDF is available here.
PDF is available here.
Abstract
This article reviews laboratory and epidemiological research into the endocrine disruptive effects of components of personal care products, namely, phthalate esters, parabens, ultraviolet (UV) filters, polycyclic musks, and antimicrobials. High doses of phthalates in utero can produce “phthal...
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PMID: 20932229
PDF is available here.
PDF is available here.
Abstract
The first patient was a 59-year-old woman who was diagnosed with invasive scirrhous carcinoma. The tumor was estrogen receptor (ER)-positive, progesterone receptor (PgR)-positive, and human epidermal growth factor receptor 2 (HER2)-positive. The patient was treated with adjuvant chemotherapy and end...
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PMID: 21084819
PDF is available here.
PDF is available here.
British Journal of Cancer (103)8 2010
Abstract
The BRCA2 gene is responsible for a high number of hereditary breast and ovarian cancers, and studies of the BRCA2 biological functions are limited by the lack of models that resemble the patient's tumour features. The aim of this study was to establish and characterise a new human breast carcinoma...
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PMID: 20877358
PDF is available here.
PDF is available here.
British Journal of Cancer (103)8 2010
Abstract
We have identified acute phase proteins and the complement system as part of the early host response to epirubicin/docetaxel chemotherapy. As complement C3 cleavage correlates with the efficacy of docetaxel/epirubicin-based chemotherapy, it has the potential as an easily accessible predictive biomar...
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PMID: 20877360
PDF is available here.
PDF is available here.
Abstract
We contribute further data by analysing breast cancer incidence rates from the Hamburg Cancer Registry, Germany, for the time period 1991-2006 and HT use data from a large case-control study conducted in the Hamburg region. At first we determined whether there is a decline in breast cancer incidence...
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PMID: 20705533
PDF is available here.
PDF is available here.
Abstract
We identified PASH in 80 patients. Median follow-up was 3.71 years (range, 0.45-9.42). Age ranged from 12 to 65 (median, 45) and 95% were female. Lesions were palpable in 56% and found on imaging in the remainder. Core biopsy was performed in 65 of 80 patients (81%), which confirmed a diagnosis of P...
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PMID: 20708765
PDF is available here.
PDF is available here.
Abstract
Time to treatment significantly increased over the study time period (mean of 21.8 days in 1998, 31.3 days in 2003, 41.1 days in 2008). In 2008, the only study year in which MRI was routinely used, patients with an MRI had a longer median time to treatment of 43 days versus 32 days for those who did...
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PMID: 20708761
PDF is available here.
PDF is available here.
American Surgeon (76)10 2010
Abstract
We hypothesize that the incidence of axillary recurrence in patients who do not undergo CLND for micrometastases is low, and CLND is not necessary for locoregional control. We performed a retrospective chart review of patients with invasive breast carcinoma and micrometastases detected on SLNB. The...
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PMID: 21105616
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)5 2010
Abstract
We scrutinized the 2 genetic polymorphisms in exons of DNMT1 that may influence the activity of DNMT1. Our research subjects consisted of 305 patients with IDC and 314 age-matched healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. Data...
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PMID: 20920981
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)5 2010
Abstract
Our results demonstrated the prognostic relevance of BM DTCs assessed by a multimarker mRNA panel consisting of TWIST1, CK19, and hMAM in operable breast cancer patients....
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PMID: 20920982
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Our results suggested SLC34A2 to be involved in the development of breast cancer; this gene may therefore be a novel marker for the detection of breast cancer and act as a target gene in therapeutic strategies....
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PMID: 21036732
PDF is available here.
PDF is available here.
Journal of Pathology (222)1 2010
Abstract
We subjected a series of grade- and molecular subtype-matched TCs and IDC-NSTs and molecular subtype-matched TCs and classic ILCs to genome-wide gene expression profiling using oligonucleotide microarrays. Unsupervised and supervised analysis revealed that TCs are similar at the transcriptomic level...
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PMID: 20593406
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Metastatic tumours of the stomach have been reported to result from various types of cancer. Among them, gastric metastasis from breast cancer has been recognised in 0.3-18% patients (1-4). Here, a rare case of metastatic gastric tumour derived from breast carcinoma is reported. Gastric endoscopy co...
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PMID: 20944157
PDF is available here.
PDF is available here.
Future Oncology (6)9 2010
Abstract
We describe three cases with extensively pretreated advanced breast cancer developing intramedullary spinal cord metastases two of whom were receiving trastuzumab, one of whom was a male. As therapeutic advances increase overall survival for patients with metastatic breast cancer, patterns of diseas...
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PMID: 20919834
PDF is available here.
PDF is available here.
Endocrine Pathology (21)3 2010
Abstract
We describe, a 74-year-old woman, presented with a 2 months' history of lower abdominal pain and episodic intestinal subocclusion due to a complex pelvic mass. The mass consisted predominantly of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that ha...
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PMID: 20532676
PDF is available here.
PDF is available here.
Oncology Reports (24)3 2010
Abstract
Cancer development involves the destruction of tight junctions, deprivation of cell polarity, and increased cell mobility. Claudin 16 (CLDN16) is a tight junction protein and plays important roles in the maintenance of cell polarity, cellular arrangement, adhesion, paracellular transport, and ionic...
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PMID: 20664984
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)6 2010
Abstract
We evaluated whether mammary tumor progression in tumor-bearing rats lifetime exposed to SPI is associated with deregulated progesterone receptor (PR) isoform expression. In histologically normal mammary glands of rats with invasive ductal carcinoma lesions, PR-A protein levels were higher for SPI-...
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PMID: 20661826
PDF is available here.
PDF is available here.
Molecular Oncology (4)4 2010
Abstract
We studied gene expression patterns of 31 pure DCIS, 36 pure invasive cancers and 42 cases of mixed diagnosis (invasive cancer with an in situ component) using Agilent Whole Human Genome Oligo Microarrays 44k. Six normal breast tissue samples were also included as controls. qRT-PCR was used for vali...
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PMID: 20663721
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to clarify the frequency of malignancy and the histopathological characteristics of the lesions in patients undergoing magnetic resonance imaging (MRI)-guided vacuum-assisted biopsy (VAB).
A retrospective review of 100 consecutive patients wi...
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PMID: 20799018
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to clarify the frequency of malignancy and the histopathological characteristics of the lesions in patients undergoing magnetic resonance imaging (MRI)-guided vacuum-assisted biopsy (VAB).
A retrospective review of 100 consecutive patients wi...
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PMID: 20799018
PDF is available here.
PDF is available here.
Abstract
Fourteen directors of breast imaging courses met on behalf of the German Society of Radiology to discuss the actual standards of the diagnosis of masses. Open questions on the fields of mammography, breast ultrasound and breast MRI were elucidated by a presentation of one of the 14 panel members, fo...
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PMID: 20544579
PDF is available here.
PDF is available here.
Cellular Signalling (22)9 2010
Abstract
We explored the crosstalk between cell survival (phosphatidylinositol 3-kinase (PI3K)/Akt) and mitogenic (Ras/Raf/MEK/extracellular signal-regulated kinase (ERK)) signaling pathways activated by an epidermal growth factor (EGF) and analyzed their sensitivity to small molecule inhibitors in the PI3K-...
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PMID: 20471474
PDF is available here.
PDF is available here.
Academic Radiology (17)8 2010
Abstract
A composite index, the Tissue Optical Index (TOI), showed a significant ( approximately 50%) decrease over the nearly 18 weeks of chemotherapy. Tumor response was sensitive to the type of chemotherapy agent, and functional indices fluctuated in a manner consistent with dynamic tumor physiology. Fina...
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PMID: 20542448
PDF is available here.
PDF is available here.
Tumor Biology (31)4 2010
Abstract
We determined a methylation profile of tumor-related genes in serum of sporadic breast cancer (SBC). The multigene methylation was examined by methylation-specific polymerase chain reaction assay in serum of 50 SBCs and 50 paired nontumors, and CIMP+ was defined as having three genes that are concor...
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PMID: 20490964
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
Our results suggest that DHEA treatment can reduce body weight gain and protects against DMBA-induced mammary tumor development in the obese Zucker rat model....
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PMID: 20596621
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We evaluated local recurrence, toxicity rate and cosmetic outcome in 72 patients treated with high-dose-rate (HDR) brachytherapy after breast conserving surgery. HDR brachytherapy was administered: i) as partial breast irradiation (PBI) in 64 patients with low-risk early stage breast cancer, enrolle...
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PMID: 20596628
PDF is available here.
PDF is available here.
Life Sciences (87)3-4 2010
Abstract
The frequency of tumor hypermethylation was 27% in BRCA1, 32% in MGMT and 25% in GSTP1 and correlated with methylation of these genes in paired serum DNA. Immunohistochemical analysis showed no detectable expression of BRCA1 and MGMT in 51/89 (57%) and 35/89 (39%) tumors, respectively. MGMT promoter...
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PMID: 20470789
PDF is available here.
PDF is available here.
Abstract
Initial efficacy and toxicity using 3D-CRT to deliver APBI appears comparable to other experiences with similar follow-up. However, additional patients, further follow-up, and mature Phase III data are needed to evaluate the extent of application, limitations, and value of this particular form of AP...
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PMID: 19910132
PDF is available here.
PDF is available here.
Abstract
Whole-brain radiotherapy of occult brain metastases in HER2-positive breast cancer patients with visceral dissemination produces a three-fold decrease in cerebral deaths but does not prolong survival.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 19932944
PDF is available here.
PDF is available here.
Abstract
We present the case of a 49-year-old woman with a past medical history of invasive ductal breast carcinoma 13 years ago, and who was recently diagnosed as having a low-grade adenosquamous carcinoma in the same breast. Genetic analysis of blood DNA revealed a BRCA1 mutation. To our knowledge, BRCA1 m...
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PMID: 20189727
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (28)23 2010
Abstract
While the mortality associated with ductal carcinoma in situ (DCIS) is minimal, the risk of ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) is relatively high. Radiation therapy (RT) and antiestrogen agents reduce the risk of IBTR and are considered standard treatmen...
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PMID: 20625132
PDF is available here.
PDF is available here.
Abstract
The biopsy rate of 536 lesions categorized as BI-RADS 4 was 75% (403 of 536). Malignancy was found in 95 of 460 patients; or a PPV of 21%, PPVs for subcategories 4A, 4B and 4C, were 9%, 21% and 57%, respectively. The most common malignancy was invasive ductal carcinoma (67%). Patients with advanced...
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PMID: 20649064
PDF is available here.
PDF is available here.
Abstract
We earlier evaluated the relationship of 653 triple negative breast cancers (TNBC) with basal immunophenotypic expression by using antibodies to basal cytokeratins (CK5/6, CK14, CK17, 34betaE12), p63, smooth muscle actin (SMA), epidermal growth factor receptor, and CD117, and found that a triple pan...
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PMID: 20495445
PDF is available here.
PDF is available here.
Abstract
About one-tenth of solid DCIS diagnosed in core biopsies in the past may represent LCIS variants. These show a 25% upgrade to invasive lobular carcinoma in surgical excision. The distinction of an LCIS variant from DCIS is important because of its implications for radiation therapy, although it may...
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PMID: 20586632
PDF is available here.
PDF is available here.
Breast Cancer (17)3 2010
Abstract
ATX every 28 days for four cycles is associated with a modest activity (low pCR rate) in the neoadjuvant setting of LABC....
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PMID: 19551465
PDF is available here.
PDF is available here.
Annals of Oncology (21)7 2010
Abstract
We investigated the safety of the combination of sunitinib and paclitaxel in an exploratory study of patients with locally advanced or MBC.
Patients received oral sunitinib 25 mg/day (with escalation to 37.5 mg/day as tolerated) on a continuous daily dosing schedule and paclitaxel 90...
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PMID: 20032126
PDF is available here.
PDF is available here.
Clinical Chemistry (56)7 2010
Abstract
CEA and CA 15.3 are useful prognostic factors in NP and NN breast cancer patients. CEA >7.5 microg/L is associated with a high probability of subclinical metastases....
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PMID: 20472825
PDF is available here.
PDF is available here.
Abstract
British Journal of Cancer (103)1 2010
Abstract
Pathological features associated with ipsilateral recurrence in univariate analysis included high cytonuclear grade, larger lesion size, growth pattern, presence of necrosis or chronic inflammation, incompleteness (or uncertainty of completeness) of excision and smaller margin width. Receipt of post...
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PMID: 20517310
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)24 2010
Abstract
To evaluate the concordance of human epidermal growth factor receptor 2 (HER2) gene amplification in invasive breast cancer by the techniques of fluorescence in situ hybridization (FISH) and silver-enhanced in situ hybridization (SISH).
A prospective study of 63 invasive breast cancer specimens exci...
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PMID: 20979875
PDF is available here.
PDF is available here.