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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Endometrial Neoplasms (2):
Recent article
Endometrial Neoplasms
Abstract
Providing accurate estimates of cancer risks is a major challenge in the clinical management of Lynch syndrome.
To estimate the age-specific cumulative risks of developing various tumors using a large series of families with mutations of the MLH1, MSH2, and MSH6 genes...
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PMID: 21642682
PDF is available here.
PDF is available here.
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Abstract
Abstract
Abstract
Endometrial serous carcinomas constitute no more than 10% of endometrial adenocarcinomas, but frequently present at an advanced stage and have a significantly worse prognosis than the more common low-grade and intermediate-grade endometrioid adenocarcinomas. The neoplasm's potential for rapid tumor...
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PMID: 21164282
PDF is available here.
PDF is available here.
Abstract
We compared the expression profiles of 723 human miRNAs from 14 cases of EEC, 10 cases of CAH, and 10 normal proliferative endometria controls using Agilent Human miRNA arrays following RNA extraction from formalin-fixed paraffin-embedded (FFPE) tissues. The expression of 4 dysregulated miRNAs was v...
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PMID: 21897839
PDF is available here.
PDF is available here.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer (186) 2011
Abstract
We will discuss the evidence for an association of physical activity with gynecologic cancers including those of the endometrium, ovaries, and cervix. Cancers of the endometrium and ovaries have a strong hormonal etiology (Risch 1998; Kaaks et al. 2002; Lukanova and Kaaks 2005), and physical activit...
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PMID: 21113764
PDF is available here.
PDF is available here.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer (186) 2011
Abstract
Gynecologic oncology involves the study of preinvasive disease and cancers of the vulva, vagina, cervix, uterus, ovaries, and gestational trophoblastic disease. Endometrial cancer is the most common of the pelvic malignancies however, ovarian cancer is the most lethal. The other gynecologic cancers...
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PMID: 21113770
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (50)1 2011
Abstract
We examine the role of CYP17 gene in endometrial carcinogenesis. Immunohistochemistry staining of endometrial carcinoma and corresponding uninvolved tissues showed that CYP17 is upregulated in endometrial cancers (15 of 24, 62.5%). To understand the functional significance of this upregulation, we s...
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PMID: 20886547
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (116)6 2010
Abstract
We selected English language studies reporting at least 25 robotic cases compared with laparoscopic or laparotomy cases that also addressed surgical technique, complications, and perioperative outcomes. Patients underwent total hysterectomy, bilateral salpingo-oophorectomy, and lymphadenectomy.
Eigh...
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PMID: 21099613
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (116)6 2010
Abstract
To estimate the conversion rate of attempted laparoscopic staging for primary endometrial adenocarcinoma.
Two hundred thirty-five consecutive patients with primary endometrial adenocarcinoma underwent attempted laparoscopic staging regardless of age, body mass index (BMI, calculated as weight (kg)/[...
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PMID: 21099602
PDF is available here.
PDF is available here.
Bulletin du cancer (97)12 2010
Abstract
Abstract
Dysregulation of phosphatase and tensin homolog (PTEN) and the gene that encodes the p110α catalytic subunit of phosphatidylinositol-3-kinase (PI3K), PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in constitutive act...
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PMID: 20681032
PDF is available here.
PDF is available here.
Abstract
This study evaluated whether progression-free interval (PFI) following primary chemotherapy (PCT) was predictive of overall survival (OS) after second-line chemotherapy in advanced/recurrent endometrial cancer (EC).
This is a pooled analysis of patients who recurred a...
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PMID: 20737572
PDF is available here.
PDF is available here.
Abstract
Myometrial invasion is an independent prognostic parameter of the endometrioid carcinomas which correlates with the risk of metastasis to pelvic and/or paraaortic lymph nodes. Recognition of myometrial invasion is sometimes difficult. In fact, myoinvasion is overdiagnosed in routine practice in as m...
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PMID: 20962622
PDF is available here.
PDF is available here.
Abstract
We believe reflects the intratumoral heterogeneity, should be taken into account when applying DNA ploidy to endometrial carcinoma specimens....
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PMID: 20881853
PDF is available here.
PDF is available here.
Abstract
We report 2 cases of primary endometrial adenocarcinoma, one of mucinous and the other of endometrioid type, with a significant component of signet ring cells. One of the neoplasms arose within adenomyosis. In reporting these cases, we illustrate that the presence of signet ring cells does not precl...
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PMID: 20881852
PDF is available here.
PDF is available here.
Abstract
To determine the sensitivity of MR imaging utilizing diffusion weighted imaging (DWI) in detection of endometrial cancer and to compare the Apparent Diffusion Coefficient (ADC) values of malignant and normal endometrium.
Cross-sectional analytical study.
Radiology Department, Aga Khan University Hos...
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PMID: 21078241
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Disease-free interval after primary treatment predicts prognosis of recurrent endometrial carcinoma.
Abstract
We demonstrate a significantly worse prognosis in cases with early versus late recurrence of resected endometrial carcinomas, irrespective of the type of adjuvant therapy....
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PMID: 21036762
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
We investigated the expression of BAG-1, ERa and PRA isomorphs in endometrioid adenocarcinoma and we correlated them with clinicopathological findings of the tumor. Fresh endometrial tissues were obtained from 33 patients with endometrial carcinoma and 191 paraffin-embedded tissues were analyzed by...
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PMID: 21036726
PDF is available here.
PDF is available here.
Abstract
A 52-year-old woman with recurrent high-grade endometrial stromal sarcoma presented with left hypochondralgia. She had undergone total hysterectomy and bilateral salpingo-oophorectomy for the disease over the past six months, and preferred not to receive additional treatment. The following regimen o...
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PMID: 20948274
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
The patient showed WT1 positivity in 10% of tumour cells and diffusely in the intratumoural endothelial cells of the recurrent disease. After 2 injections, CA125 started to decrease and WT1-specific T-cells increased 2.5-fold. The treatment was feasible and there were no treatment-related side-effec...
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PMID: 20944158
PDF is available here.
PDF is available here.
Abstract
We established four monoclonal 5FU-resistant cell lines from human endometrial adenocarcinoma cells by long-term 5FU-exposure cultures and limiting dilution cultures. The established subclones exhibited 5-25 times greater 5FU-resistance than the parent cells, and showed suppression of 5FU-induced DN...
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PMID: 20664942
PDF is available here.
PDF is available here.
The Lancet (376)9740 2010
Abstract
The Lancet (376)9740 2010
Abstract
The Lancet (376)9740 2010
Abstract
Obstetrics & Gynecology (116)2 Pt 1 2010
Abstract
One thousand four hundred forty-three eligible women were identified. One thousand two hundred one had complex (n=164 no progestin) and 242 had atypical (n=62 no progestin) hyperplasia. During follow-up, a median of 5.3 years (range 8 weeks to 20.8 years), 71 women were diagnosed with endometrial ca...
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PMID: 20664397
PDF is available here.
PDF is available here.
Cancer Research (70)15 2010
Abstract
We examined loss of PAX2 expression, a gene required for embryonic uterine development, during endometrial carcinogenesis. Normal proliferative, EIN, and malignant (endometrial adenocarcinoma) endometrial tissues were immunostained for PTEN and PAX2. Proliferative samples with loss of protein in at...
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PMID: 20631067
PDF is available here.
PDF is available here.
Abstract
The current results indicated that EGFR overexpression may play an important role in reducing sensitivity to progestin treatment in EC. An EGFR tyrosine kinase-specific inhibitor may be useful in the treatment of EC.
Copyright (c) 2010 American Cancer Society....
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PMID: 20564127
PDF is available here.
PDF is available here.
Cancer Letters (294)1 2010
Abstract
We found that TWEAK gene expression was down-regulated and Fn14 gene expression was up-regulated in human endometrial cancer specimens compared with that in normal endometrial specimens; TWEAK acting on Fn14 decreased cell viability by inducing apoptosis through caspase pathways in endometrial cance...
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PMID: 20189297
PDF is available here.
PDF is available here.
Abstract
Our data emphasize the clinical importance of the WHO classification in ESS. It is of utmost importance to establish a proper classification to increase the consistency of data that may be useful for improving clinical and therapeutic management of patients with ESS....
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PMID: 19482859
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
Human endometrial cancer expresses both the known estrogen receptors (ER-alpha and ER-beta). The significance of the relative expression of both ER subtypes in endometrial adenocarcinomas remains to be clarified and the usefulness of the determination of the receptor status in endometrial cancer pat...
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PMID: 20596625
PDF is available here.
PDF is available here.
Abstract
The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of r...
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PMID: 20562188
PDF is available here.
PDF is available here.
Abstract
A nested case-control study, including 830 cases and 992 controls from 7 cohorts, was conducted to evaluate the association of circulating 25-hydroxyvitamin D (25(OH)D), the best indicator of vitamin D status, with risk of endometrial cancer. Matching factors included age at blood do...
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PMID: 20562189
PDF is available here.
PDF is available here.
Abstract
Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentration...
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PMID: 20562191
PDF is available here.
PDF is available here.
Abstract
The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) brought together 10 cohorts to conduct a prospective study of the association between vitamin D status, measured as serum concentrations of 25-hydroxyvitamin D (25(OH)D), and the development of 7 rarer cancer sit...
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PMID: 20562193
PDF is available here.
PDF is available here.
Abstract
The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of r...
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PMID: 20562188
PDF is available here.
PDF is available here.
Abstract
A nested case-control study, including 830 cases and 992 controls from 7 cohorts, was conducted to evaluate the association of circulating 25-hydroxyvitamin D (25(OH)D), the best indicator of vitamin D status, with risk of endometrial cancer. Matching factors included age at blood do...
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PMID: 20562189
PDF is available here.
PDF is available here.
Abstract
Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentration...
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PMID: 20562191
PDF is available here.
PDF is available here.
Abstract
The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) brought together 10 cohorts to conduct a prospective study of the association between vitamin D status, measured as serum concentrations of 25-hydroxyvitamin D (25(OH)D), and the development of 7 rarer cancer sit...
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PMID: 20562193
PDF is available here.
PDF is available here.
Abstract
Endometrial and endocervical adenocarcinomas may seem histologically identical and it can be difficult to determine primary site of origin based on morphology alone. As the distinction is significant and cannot always be made on the basis of clinical findings, various immunohistochemical panels have...
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PMID: 20534993
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (116)1 2010
Abstract
Abnormal uterine bleeding in women older than age 35 years, and certainly in menopausal patients, mandates evaluation, mainly to exclude cancer and hyperplasia, but also to better diagnose the source of the bleeding to appropriately manage the patient. In the past, dilation and curettage was the mai...
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PMID: 20567184
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (116)1 2010
Abstract
We contacted 79 primary investigators to obtain the individual patient data of their reported studies, of which 13 could provide data. Data on 2,896 patients, of which 259 had carcinoma, were included. Several approaches were used in the analyses of the acquired data. First, we performed receiver op...
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PMID: 20567183
PDF is available here.
PDF is available here.
Abstract
Abstract
During carcinogenesis, loss of intracellular cohesion is observed among cancer cells with altered expression of such adhesion molecules as E-cadherin and beta-catenin, and aberrant expression and cellular location of intercellular gap junction proteins-connexins. The aim of this study was to evaluat...
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PMID: 20567150
PDF is available here.
PDF is available here.
Abstract
We selected 180 endometrial carcinomas of SC, EC, or CCC type. No mixed carcinomas were included in the study. We chose the following immunohistochemical markers, estrogen receptor (ER), insulin-like growth factor 2 mRNA-binding protein 3 (IMP3), p16, p53, progesterone receptor (PR), and phosphatase...
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PMID: 20567148
PDF is available here.
PDF is available here.
Abstract
We report on a case of a primary low-grade endometrial stromal sarcoma (ESS) that progressed to a secondary high-grade ESS. In the secondary tumor, the immunohistochemical profile and focal tumor cell proliferation pattern suggested that this tumor was not truly undifferentiated, but possessed featu...
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PMID: 20567152
PDF is available here.
PDF is available here.
Abstract
This study assessed the feasibility of F-18-fluorodeoxyglucose positron-emission tomography ((18)F-FDG PET) in the post-therapy surveillance for patients with endometrial cancer showing no evidence of disease (NED). From April 1997 to June 2007, 127 patients with endometrial cancer showing NED were...
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PMID: 20592894
PDF is available here.
PDF is available here.
British Journal of Cancer (103)1 2010
Abstract
Seven cohort studies, including 1,511,661 participants and 6086 endometrial cancer cases, were included in the dose-response random-effect meta-regression model. Compared with non-drinkers, women drinking less than 1 drink of alcohol (13 g of ethanol) per day had a lower risk for endometrial cancer;...
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PMID: 20485288
PDF is available here.
PDF is available here.
Analytical Biochemistry (401)2 2010
Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors.
Abstract
We were able to determine the first measurements of binding affinity for specific Wnt interactions. This study shows that purified Wnt3a, Wnt7a, and Wnt5a have different binding specificities for Fzds and SFRPs.
Copyright (c) 2010 Elsevier Inc. All rights reserved....
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PMID: 20227380
PDF is available here.
PDF is available here.
Revue medicale suisse (6)252 2010
Abstract
A clear relationship between diabetes and cancer has been demonstrated. An increased incidence of several cancers is observed in diabetic patients, notably pancreatic, hepatic, colo-rectal, breast, urinary tract and endometrial cancer. By contrast a decreased incidence of prostate ca...
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PMID: 20614754
PDF is available here.
PDF is available here.
Abstract
Endometrial cancer has an miRNA profile distinct from normal endometrium, even in patients with stage IA grade 1 tumors. This miRNA cancer profile was able to correctly assign a specimen as a malignancy with a sensitivity of 92%. Overexpressed miRNAs were predicted to target PTEN, and transfection o...
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PMID: 20400061
PDF is available here.
PDF is available here.
Abstract
[F]FDG PET/CT could correctly detect primary tumor in 29 of the 32 high-risk patients, with a sensitivity of 90.6%. The overall [F]FDG PET/CT patient-based sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 57.1, 100.0, 100.0, 86.4, and 88.5%, respective...
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PMID: 20168262
PDF is available here.
PDF is available here.
Medical Oncology (27)2 2010
Abstract
We confirmed that 5-azadC treatment resulted in growth inhibition, G(2) arrest, and cell apoptosis in human endometrial cancer cell lines. Furthermore, the data obtained by real-time PCR and Western blotting analysis demonstrated that the expression of hMLH1 was up-regulated by 5-azadC treatment in...
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PMID: 19306077
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
Neither OHT nor fulvestrant inhibited cell growth, nor did they induce apoptosis. Gefitinib, everolimus and perifosine inhibited proliferation in all cell lines. Only perifosine induced apoptosis. In PTEN-positive HEC1A cells, combined treatment of gefitinib plus OHT showed increased antiproliferati...
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PMID: 20651347
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
In 2005-2008, a total of 196 patients with EC and known cytological results underwent surgery. Positive cytological results (C+) were obtained in 11 patients (5.6%). The rate of C+ in patients without hysteroscopy was 18.2% (n=4) and in patients after one and two hysteroscopies, 1.9% (n=2) and 7.1%...
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PMID: 20651403
PDF is available here.
PDF is available here.
Acta Oncologica (49)5 2010
Abstract
A substantial reduction of cervical cancer incidence followed the introduction of population-based screening in the 1970s and was also accompanied by a modest improvement in survival. Incidence trends in cancer of corpus uteri varied between the countries but the survival increased by around 20 perc...
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PMID: 20307243
PDF is available here.
PDF is available here.
Abstract
From the total group of 144 patients, 122 were included for survival analysis. We found 15 (12.3%) patients with recurrence of the disease. Mean age was 64,5 (34-88) years. Immunohistologic expression was p53 positive in 29 (23.8%), bcl-2 positive in 87 (71.3%), c-erbB-2 positive in 34 (27.9%), Ki-6...
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PMID: 20731299
PDF is available here.
PDF is available here.
Abstract
Based on hysterosopy, 31 (72.1%) patients were classified as G1, G2 7 (16.3%) and G3 5 (11.6%) respective. In grade 1 the concordance rate was 77.4% of cases, in grade 2 it was in 14.3% of cases and in grade 3 it was in 80.0% of cases. In hysterosocpy samples the p53 expression was found in 23 (53.5...
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PMID: 20731294
PDF is available here.
PDF is available here.
Abstract
Our study suggest that tested cytokines (HGFs) can be clinically useful in diagnostic of endometrial cancer patients. M-CSF can be clinically useful in differentiation of endometrial cancer and myoma uteri. Furthermore SCF and M-CSF showed usefulness in primary diagnostic of cancer uteri, especially...
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PMID: 20568396
PDF is available here.
PDF is available here.
Modern Pathology (23)5 2010
Abstract
We showed that PIK3CA and p53 alterations in uterine endometrial carcinomas correlate with poor prognosis. However, the contribution of phosphatidylinositol 3-kinase (PI3K) -AKT deregulation to endometrial carcinogenesis is not completely understood. The purpose of this study was to analyze alterati...
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PMID: 20173732
PDF is available here.
PDF is available here.