Abstract
We will discuss the evidence for an association of physical activity with gynecologic cancers including those of the endometrium, ovaries, and cervix. Cancers of the endometrium and ovaries have a strong hormonal etiology (Risch 1998; Kaaks et al. 2002; Lukanova and Kaaks 2005), and physical activit...
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PMID: 21113764
PDF is available here.
Abstract
Gynecologic oncology involves the study of preinvasive disease and cancers of the vulva, vagina, cervix, uterus, ovaries, and gestational trophoblastic disease. Endometrial cancer is the most common of the pelvic malignancies however, ovarian cancer is the most lethal. The other gynecologic cancers...
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PMID: 21113770
PDF is available here.
Abstract
The congress of Asco made the object of numerous summaries of congress made in the heat of the moment and the Bulletin du Cancer decided to ask to his editorial board, a digested summary, at distance of the congress, to try to sum up the data of the congress which are going to change practice. Of th...
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PMID: 21220230
PDF is available here.
Abstract
We estimated the annual number of new gynecologic cancer cases through 2050; the effects of human papillomavirus (HPV) vaccination was included in cervical cancer estimates. The number of practicing gynecologic oncologists was projected through 2050 using data from the 2005 Society of Gynecologic On...
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PMID: 21099604
PDF is available here.
Abstract
We sought to investigate their impact on normal cells by using Drosophila as a model. We investigated the possible involvement of Drosophila homologue of p53 (Dmp53) and a member of the retinoblastoma binding protein 6 family, known as Snama. On account of its molecular features and experimental evi...
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PMID: 20717003
PDF is available here.
Abstract
We evaluated the percentage of positive cytoplasmic and nuclear staining (focal ≤10%, multifocal=10% to 50%, and diffuse ≥50%) and staining intensity (weak, moderate, and strong). HPV-DNA analysis by polymerase chain reaction was performed on 5 OSCC. Ichthyosis uteri, all UCSCC and 1 OSCC (arisi...
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PMID: 20881863
PDF is available here.
Abstract
I and II have been combined. The number and morphology of the involved nodes have been taken into account, and the bilaterality of positive nodes has been discounted. In cervical cancer Stage 0 has been deleted and substages in Stage IIA have been included. In endometrial cancer Stage IA and IB have...
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PMID: 21117307
PDF is available here.
Abstract
Data from 65 patients were included in the study. The groups were comparable in terms of age, weight, surgical duration, and intraoperative morphine doses. There were no significant differences between the control and treatment groups in the proportion of patients with inadequate analgesia either at...
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PMID: 20547822
PDF is available here.
Abstract
In the design of randomized clinical trials, quality of life (QOL) has become an important component across multiple cancer types. QOL includes the measurement of patient-reported outcomes, mostly described as the physical, social, emotional and functional wellbeing of the patient. These realms of w...
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PMID: 20799874
PDF is available here.
Abstract
We believe that the best way to prevent incisional hernia is to preserve the integrity of the abdominal wall using minimally invasive techniques....
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PMID: 20716270
PDF is available here.
Abstract
Approaches for cervical cancer prevention are changing. Screening still remains the most effective method for cervical cancer prevention. Guidelines are moving to an older group of women to be screened less frequently with combinations of technologies that include biomarkers and cytology. HPV vaccin...
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PMID: 20670593
PDF is available here.
Abstract
Paraneoplastic dermatoses are a heterogeneous group of skin disorders that manifest an underlying internal malignancy. Early recognition of these cutaneous hallmarks offers an opportunity for early diagnosis, treatment of the internal malignancy and monitoring for tumor recurrence. The 9 most common...
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PMID: 20723267
PDF is available here.
A D Beggs,
A R Latchford,
H F A Vasen,
G Moslein,
A Alonso,
S Aretz,
L Bertario,
I Blanco,
S Bülow,
J Burn,
G Capella,
C Colas,
W Friedl,
P Møller,
F J Hes,
H Järvinen,
J-P Mecklin,
F M Nagengast,
Y Parc,
R K S Phillips,
W Hyer,
M Ponz de Leon,
L Renkonen-Sinisalo,
J R Sampson,
A Stormorken,
S Tejpar,
H J W Thomas,
J T Wijnen,
S K Clark and
S V Hodgson
Abstract
Peutz-Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by the development of characteristic polyps throughout the gastrointestinal tract and mucocutaneous pigmentation. The majority of patients that meet the clinical diagnostic criteria have a causative mutation in the ST...
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PMID: 20581245
PDF is available here.
Abstract
Two PMX-DHP treatments were performed on 4 patients, three treatments on 6 patients and four treatments on 1 patient. After the therapy, mean arterial pressure increased (69.45 to 84.09 mm Hg; p < 0.01), heart rate decreased (Ill.73 to77.91 beats/min; p < 0.01), white blood cell count decreased (18,...
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PMID: 20519903
PDF is available here.
Abstract
We have tried to enumerate the primary malignant melanomas at various atypical sites, supported by literature review. Seventeen cases were identified from our records of the past 5 years, which had detailed clinical work-up to exclude a possibility of a metastasis. A clear female predominance with i...
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PMID: 20386135
PDF is available here.
Abstract
A substantial reduction of cervical cancer incidence followed the introduction of population-based screening in the 1970s and was also accompanied by a modest improvement in survival. Incidence trends in cancer of corpus uteri varied between the countries but the survival increased by around 20 perc...
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PMID: 20307243
PDF is available here.
Abstract
Dose-limiting toxicity for the combination of temsirolimus with topotecan was myelosuppression. The regimen may be safe in women who have not previously received radiation, but full doses of each agent could not be administered in combination.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 20347480
PDF is available here.
Abstract
Our results demonstrate that both lovastatin and simvastatin, but not pravastatin, selectively induced cell death in dose- and time-dependent manner in ovarian, endometrial and cervical cancers. Little or no toxicity was observed with any statin on normal cells. Lipophilic statins induced activation...
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PMID: 19432822
PDF is available here.
Abstract
OBJECTIVE: Sexual dysfunctions after surgery for gynaecologic cancer. DESIGN: Review article. SETTING: Department of Gynaecology and Obstetrics, 1st Medical Faculty, Charles University, Prague. METHOD: An overview of published data. CONCLUSION: Sexual functions are the basic part of quality of life....
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PMID: 20731295
PDF is available here.
Abstract
OBJECTIVE: A description of intensity modulated radiation therapy (IMRT) technique and its implementation in the treatment of gynecologic malignancies. SUBJECT: A review article. SETTING: Department of Oncology and Radiotherapy, University Hospital in Hradec Králové. SUBJECT AND METHOD: General ex...
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PMID: 20731296
PDF is available here.
Abstract
We set out to (a) identify all multidimensional HRQoL questionnaires used in studies with women with gynecologic cancer and (b) evaluate their track records in identifying minimal clinically important differences (MCIDs), with a view to making recommendations.
We searched MEDLINE using the term qual...
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PMID: 20442592
PDF is available here.
Abstract
A substantial number of postoperative PEs were occult, and identification of high-risk patients and routine SpO2 level monitoring would reduce the diagnostic delay of PE after gynecologic surgery. Increasing age, longer operation time, and obesity were risks. The use of a perioperative intermittent...
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PMID: 20442591
PDF is available here.
Abstract
This study has used the Delphi technique to identify auditable standards which could be used in the revalidation process of physicians working in the area of gynecological cancer....
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PMID: 20686369
PDF is available here.
Abstract
We conducted four telephone focus groups and five face-to-face focus groups in which a single moderator used the same open-ended questions and discussion facilitation techniques. This comparison was part of a larger study to gain a better understanding of employment experiences after diagnosis of gy...
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PMID: 20142606
PDF is available here.
Abstract
We conducted four telephone focus groups and five face-to-face focus groups in which a single moderator used the same open-ended questions and discussion facilitation techniques. This comparison was part of a larger study to gain a better understanding of employment experiences after diagnosis of gy...
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PMID: 20142606
PDF is available here.
Abstract
We measured the following WB selenium (Se) levels (Se-group vs. control group, U-test): begin RT 64.17+/-13.98 microg/l vs. 64.50+/-14.47 microg/l (p=0.869); mid RT 92.48+/-26.68 microg/l vs. 65.80+/-18.04 microg/l (p<0.001); end RT 93.78+/-25.90 microg/l vs. 64.06+/-17.54 microg/l (p<0.001); 6 week...
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PMID: 20592379
PDF is available here.
Jalid Sehouli,
Guelten Oskay-Oezcelik,
Klaus Pietzner,
Frank Chen,
Alexandra Coumbos,
Silvia Darb-Esfahani,
Beatrix Schuback,
Georg Heinrich,
Christel Kronenberger,
Michael Lorsbach,
Werner Lichtenegger and
Radoslav Chekerov
Abstract
Borderline ovarian tumour (BOT) represents a rare and special tumour entity. Despite a generally favourable prognosis for patients with BOT, the presence of invasive peritoneal implants decreases the survival rate to 30-50%. In contrast to ovarian cancer, only few data exist concerning the current c...
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PMID: 20592364
PDF is available here.
Abstract
We have analysed 297 observations gathered in litterature from 1904 to 2004. The increase in the number of Meigs pseudosyndromes based on diverse associated condition means that we must include under the name Demons syndrome, as he did himself, all tumours of the female genital tract, providing they...
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PMID: 20117886
PDF is available here.
Abstract
The GCLQ effectively distinguished between gynecologic cancer survivors with and those without LLE, with good sensitivity and specificity. The patients, particularly those with LLE, showed high confidence in the GCLQ's ability to detect LLE symptoms.
Copyright (c) 2010 Elsevier Inc. All rights reser...
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PMID: 20163847
PDF is available here.
Abstract
This study shows that GW may have QoL effects for a long time after clearance. The participants were persistently worried about GW recurrence, about being prone to develop ano-genital cancers and about the continual, negative effects on their sex and love lives. The women in particular suffered from...
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PMID: 20385081
PDF is available here.
Abstract
These findings suggest that prevention or treatment of sexual morbidity might foster improved psychological adjustment/QoL. Given the high rates of sexual morbidity in this population and the connection between sexuality and broader psychological adjustment/QoL, there is a clear need for better inte...
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PMID: 20375814
PDF is available here.
Abstract
Among gynecological cancer survivors having undergone pelvic radiotherapy alone or as part of a combined treatment, fecal incontinence is associated with social, psychological, sexual, and functional consequences....
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PMID: 20375813
PDF is available here.
Abstract
We describe the case of a patient with hyperpigmented papules in the skin folds as the only sign of Galli-Galli disease, and we present a review of the literature....
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PMID: 20223160
PDF is available here.
Abstract
An 82-year-old woman was admitted because of progressing cough and dyspnea. Two years prior to admission, she had undergone an operation for extramammary Paget's disease which resected the primary lesion, the left labium majora, and ipsilateral inguinal and obturator lymph nodes. Thoracic images sho...
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PMID: 20387524
PDF is available here.
Abstract
Many benign hyperplastic or reactive processes that occur in the female genital tract may be mistaken for neoplasms both clinically and pathologically. Awareness of the features of such lesions will aid in their correct diagnosis and prevent overtreatment of benign processes....
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PMID: 20196667
PDF is available here.
Abstract
The hypercoagulability status of women with and without gynecologic malignancies was compared using the thromboelastograph coagulation analyzer. Blood specimens from 25 women with newly diagnosed gynecologic malignancies and from 21 age-matched controls were analyzed. Hypercoagulability is defined b...
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PMID: 20083998
PDF is available here.
Abstract
The prevalence of quinacrine exposure was 1.2% among cases and 1.1% among controls. For cervical cancer, analysis of 606 cases (9 exposed) and their 1774 matched controls (18 exposed) produced an odds ratio of 1.44 (95% confidence interval = 0.59-3.48) (adjusted for several covariates including huma...
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PMID: 20160560
PDF is available here.
Abstract
In October 2009, the Advisory Committee on Immunization Practices (ACIP) approved a newly licensed vaccine, Cervarix, directed against human papillomavirus (HPV) to prevent cervical cancer. The ACIP also expanded its recommendations against HPV by giving permission to physicians to v...
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PMID: 20203463
PDF is available here.
Abstract
We retrospectively reviewed the medical records of patients who had diagnosis of pregnancy and adnexal over a period of five years.
The incidence was 0.22%. The mean age was 26 +/- 7.3 years, mean gestational age was 17 +/- 6.6 weeks. The diagnosis was established by ultrasound (USG) in 95% of cases...
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PMID: 20939220
PDF is available here.
Abstract
There is a relative sparsity of research on and resources for individuals with and survivors of gynecologic cancer compared to other cancers. This paper aims to review the current literature related to the challenges this population faces and subsequent support needs. In addition, it discusses futur...
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PMID: 20462067
PDF is available here.
Abstract
In our study population, introduction of the RMI would improve the management of adnexal masses, with a higher percentage of ovarian cancer patients that are operated by a gynecologic oncologist. At the same time, referral of patients with non-invasive (benign and borderline) lesions would be reduce...
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PMID: 19959215
PDF is available here.
Abstract
The response rate was 78.4% (N=29). More than one-third (35.7%) had high levels of emotional exhaustion, the central component of burnout. In the past 6 months, 42.9%, 57.1%, and 28.6% had seriously considered leaving for another position, reducing the number of hours worked, and taking early retire...
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PMID: 19932917
PDF is available here.
Abstract
For the first evaluation, the score for T2WI (4.68 +/- 0.65) was significantly higher than that for CT (3.54 +/- 1.02) or T1WI (3.71 +/- 0.97) (P < 0.01). For the second evaluation, the scores for the localization of FDG accumulation showing that T2WI (2.74 +/- 0.57) provided significantly more addi...
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PMID: 20182843
PDF is available here.
Abstract
We performed a desensitization protocol for platinum infusion in 3 patients who required platinum re-administration after developing HR. Two patients (Case 1 and 2) were treated with the desensitization protocol successfully without developing HR during the subsequent 3 courses. Case 3 tolerated des...
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PMID: 20299757
PDF is available here.
Abstract
In vitro fertilization and embryo cryopreservation is regarded as the only established method for fertility preservation in female cancer patients. However, a possible delay in treatment of the primary disease due to ovarian stimulation, exposure to supraphysiologic estrogen levels induced by ovaria...
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PMID: 20116335
PDF is available here.
Abstract
Gynecologic cancer teams care for women with malignancies of the ovaries, fallopian tubes, uterus, cervix, vagina and vulva. Gynecologic cancer therapies have become increasingly tailored to individual risk factors and are frequently multimodal. Clinical trials are necessary to assess the effectiven...
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PMID: 20157947
PDF is available here.
Abstract
We discuss the background and scientific rationale, related to pertuzumab as it has undergone development for women's cancers. AREAS COVERED IN THIS REVIEW: Pre-clinical and clinical trials, published or presented at national meetings from 1995 to the present, are included in this review. WHAT THE R...
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PMID: 20001562
PDF is available here.
Abstract
Aggressive angiomyxoma must be considered in the differential diagnosis of any female with an asymptomatic perineal mass. A complete margin-free excision should be achieved to avoid recurrence. Long-term follow-up is quite necessary because of the high rate of local recurrence....
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PMID: 20134274
PDF is available here.
Abstract
Survivors of gynecological cancer have generally good long-term QOL, equivalent to healthy controls; however, specific deficits are more prevalent than in women without cancer. Ovarian cancer survivors have good QOL, with few physical symptoms. Psychological distress and sexual impairments exist. No...
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PMID: 19809316
PDF is available here.
Abstract
We can conclude that scoring of gamma-H2AX foci after in vitro irradiation of isolated T-lymphocytes of patients is not predictive for late radiotoxicity. This applies as well to the assessment of the repair kinetics after an HDR dose as to the determination of the number of residual foci after a LD...
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PMID: 20043123
PDF is available here.
Abstract
Despite the prevalence and severe implications of rectovaginal fistula, there is no universally accepted evidence-based approach to surgical management. This article offers a disease-based review of traditional management strategies and highlights the variety of technical approaches...
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PMID: 20109633
PDF is available here.