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Neoplasms, Hormone-Dependent (0):
Recent article
Neoplasms, Hormone-Dependent
Integrative Biology (3)7 2011
Abstract
We show that, in addition to causing cell death of hormone-refractory prostate cancer cells, PJ also increases cell adhesion and decreases cell migration of the cells that do not die. We hypothesized that PJ does so by stimulating the expression and/or activation of molecules that alter the cytoskel...
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PMID: 21594291
PDF is available here.
PDF is available here.
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Abstract
We have found that signal transducer and activator of transcription 3 (Stat3) activation up-regulates ERβ expression in PC14PE6/AS2 lung cancer cells in a preliminary Affymetrix oligonucleotide array study, and we sought to confirm the findings. In this study, we show that IL-6 induced ERβ mRNA an...
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PMID: 21546410
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the mRNA and protein expression of Klf5, a pro-proliferation transcription factor in breast cancer, was dramatically up-regulated in mouse pregnant and lactating mammary glands. Pg, but not estrogen and prolactin, induced the expression of Krüpple-like factor 5 (KLF5) in multipl...
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PMID: 21566082
PDF is available here.
PDF is available here.
Nature Medicine (17)4 2011
Abstract
Antibody responses to prostate-associated antigens in patients with prostatitis and prostate cancer.
Abstract
We set out to determine whether the evaluation of multiple antigenic targets would allow the identification of a subset of antigens that are common immunologic targets in patients with prostate cancer.
Using a phage immunoblot approach, we evaluated IgG responses in patients with prostate cancer (n...
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PMID: 20632317
PDF is available here.
PDF is available here.
Abstract
Health care disparities have been documented in rural populations. The authors hypothesized that breast cancer patients in urban counties would have higher rates of postmastectomy breast reconstruction relative to patients in surrounding near-metro and rural counties.
The authors used the Surveillan...
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PMID: 21124121
PDF is available here.
PDF is available here.
Abstract
This review describes the pathology, prognosis, current treatment options, and future directions for the management of patients with triple-negative breast cancer. "Triple-negative" tumors lack expression of estrogen and progesterone receptors, and HER2. The subtype comprises some 15% of all breast...
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PMID: 20023571
PDF is available here.
PDF is available here.
Abstract
Steroid hormone receptors (SHR) are crucial regulators of disease and the basis for clinical intervention in cancers. Recent evidence confirms that microRNAs (miRNAs) impact the pathobiology of hormone-regulated malignancies. Therefore, elucidating miRNA regulation of SHR expression and modulation o...
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PMID: 20739888
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)10 2010
Abstract
Androgen-dependent and castration-resistant prostate cancer (PC) is usually sensitive to docetaxel chemotherapy. Nevertheless, docetaxel resistance frequently appears after several cycles of treatment, raising the problem of salvage treatment for docetaxel-resistant PC patients. Although the combina...
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PMID: 20827173
PDF is available here.
PDF is available here.
Abstract
The median follow-up period was 30.1 months; median overall survival, 15.3 months and median progression-free survival, 7.5 months. During follow-up, 37 patients (67.3%) achieved the PSA response, and 5 of 18 (27.8%) patients with measurable disease showed a partial response. Among the 27 patients w...
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PMID: 20587613
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)41 2010
Abstract
MMW Fortschritte der Medizin (152)41 2010
Abstract
MMW Fortschritte der Medizin (152)41 2010
Abstract
Abstract
We have now determined that DHA-mediated up-regulation of SDC-1 induces apoptosis. Bovine serum albumin-bound DHA and exogenous human recombinant SDC-1 ecotodomain were delivered to PC3 and LNCaP cells in the presence or absence of SDC-1 small interfering (si)RNA. In the presence of control siRNA, b...
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PMID: 20927321
PDF is available here.
PDF is available here.
Abstract
We investigated whether vascularization of androgen-sensitive PCa xenografts changed after ADT and whether such therapy affected radiation response. CWR22 xenografts received combinations of ADT by castration (CWR22-cas) and 15 Gy of single-dose irradiation. At a shortest tumor diameter of 8 mm, vas...
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PMID: 20927320
PDF is available here.
PDF is available here.
Bulletin du cancer (97)8 2010
Abstract
We still need predictive factors of treatment and /or prognosis factors specific of each patient. Regarding hormonal therapy, expression of hormone receptors is essential, but not sufficient to accurately predict response to treatment for all patients. To date, numerous data have identified differen...
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PMID: 20605764
PDF is available here.
PDF is available here.
Abstract
We used several methods to assess interactions between PCa and bone stromal cells using three PCa cell lines: PC3, LNCaP, and the LNCaP derivative, C4-2B.
Co-culture of LNCaP and C4-2B cells with bone marrow stromal cell lines, HS27a and HS5, decreased cell number, as did culture with conditioned me...
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PMID: 20665531
PDF is available here.
PDF is available here.
Abstract
These results demonstrate the mechanism of action of these novel titanocene dichloride analogs and their potential use in castrate-independent advanced prostate cancer.
Copyright © 2010 Wiley-Liss, Inc....
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PMID: 20665530
PDF is available here.
PDF is available here.
Abstract
We previously developed a carborane-containing AR antagonist, 3-(12-hydroxymethyl-1,12-dicarba-closo-dodecaborane-1-yl)benzonitrile (BA341), which was more potent than hydroxyflutamide (4) but acted as an agonist toward LNCaP prostate cancer cells expressing T877A AR mutant. Here, we designed and sy...
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PMID: 20521823
PDF is available here.
PDF is available here.
Abstract
CYP17 inhibition is a promising therapy for prostate cancer (PC) because proliferation of 80% of PC depends on androgen stimulation. Introduction of isopropylidene substituents onto the linker of biphenylmethylene 4-pyridines resulted in several strong CYP17 inhibitors, which were more potent and se...
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PMID: 20550118
PDF is available here.
PDF is available here.
Abstract
We have previously identified a K303R ERalpha mutation within the hinge region of ERalpha. This mutation results in an altered posttranslational regulation and increased in vitro growth in the presence of low estrogen concentrations. We sought to determine if cells expressing this mutant ERalpha wou...
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PMID: 19842032
PDF is available here.
PDF is available here.
Abstract
We report that histone deacetylase inhibitor LBH589 (panobinostat) is a potent inhibitor of aromatase expression (with an IC(50) value < 25 nM). LBH589 selectively suppresses human aromatase gene promoters I.3/II, which are preferentially used in breast cancer tissue. Furthermore, using the H295R ce...
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PMID: 20534486
PDF is available here.
PDF is available here.
British Journal of Cancer (102)12 2010
Abstract
Myoglobin mRNA was found in a subset of breast cancer cell lines; in microdissected tumours Mb transcript was markedly upregulated. In all, 71% of tumours displayed Mb protein expression in significant correlation with a positive hormone receptor status and better prognosis. In silico data mining co...
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PMID: 20531416
PDF is available here.
PDF is available here.
American Surgeon (76)6 2010
Abstract
We initiated a breast clinic designed to serve patients regardless of funding status. We analyzed age, race,tumor size, nodal status, estrogen, progesterone, and her-2-neu status. We compared our results to NSABP B-06 (nodal status), B-15 (estrogen, progesterone, and Her-2-neu receptor status), B-18...
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PMID: 20583523
PDF is available here.
PDF is available here.
Abstract
We report that a PIK3CA mutation-associated gene signature (PIK3CA-GS) derived from exon 20 (kinase domain) mutations was able to predict PIK3CA mutation status in two independent datasets, strongly suggesting a characteristic set of gene expression-induced changes. However, in ER+/HER2- BC despite...
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PMID: 20479250
PDF is available here.
PDF is available here.
Harvard Mental Health Letter (26)12 2010
Abstract
Anticancer Research (30)6 2010
Abstract
Cetuximab (100 microg/ml) caused a significant growth inhibition by inducing cell apoptosis in Du145 cells, but not in PC-3 cells. It caused EGFR down-regulation and inhibited EGFR Tyr-845 autophosphorylation in both Du145 and PC-3 cells. However, EGFR phosphorylation at Tyr-1173 and MAPK 44/42 phos...
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PMID: 20651333
PDF is available here.
PDF is available here.
Abstract
These results strongly suggested that the radiation-resistant property may develop with progression of PCa to androgen-independent status. Not only can the LNCaP and C4-2 PCa progression model be applied for investigating androgen-refractory progression, but it can also be used to explore the develo...
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PMID: 20118949
PDF is available here.
PDF is available here.
European Radiology (20)5 2010
Abstract
Triple-negative breast cancers showed a high histological grade. On mammography, triple-negative breast cancers usually presented with a mass (43/87, 49%) or with focal asymmetry (19/87, 22%), and were less associated with calcifications. On ultrasound, the cancers were less frequently seen as non-m...
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PMID: 19898850
PDF is available here.
PDF is available here.
Abstract
Estrogen receptor and PR negativity remained highly variable among hospitals despite use of a single laboratory and tended to be significantly associated with prolonged specimen handling. More studies are needed to confirm these findings....
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PMID: 20367311
PDF is available here.
PDF is available here.
Thrombosis Research (125 Suppl 2) 2010
Abstract
The Breast (19)2 2010
Abstract
Breast cancer in males should be considered a condition biologically different from female breast cancer as a result of factors related to the different hormonal influences, reflected mainly in immunohistochemical differences.
Copyright 2010 Elsevier Ltd. All rights reserved....
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PMID: 20117933
PDF is available here.
PDF is available here.
The Breast (19)2 2010
Abstract
These results highlight differences in expression markers and the pathology of ER-positive tumors detected in younger women, with a notable characteristic being co-expression of HER-2.
Copyright 2010 Elsevier Ltd. All rights reserved....
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PMID: 20117934
PDF is available here.
PDF is available here.
Abstract
Abstract
Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive (18)1 2010
Abstract
In a follow-up a 74-year-old woman with breast cancer (clinical stage T4N1M0 at onset, treatment by surgical resection and tamoxifen) presented a combination of two distinct diseases in the lung: breast cancer metastasis and tuberculosis. A CT scan showed multiple pulmonary nodular lesions and in on...
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PMID: 20424525
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We will highlight microRNAs of potential relevance to endocrine tumors and hormone-dependent cancers. Through this overview of how microRNAs regulate multiple targets and entire pathways, we will provide insight into the potential to develop new molecular microRNA-targeted therapies for endocrine tu...
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PMID: 19843580
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We know that CLU is a single 9-exons gene expressing three protein forms with different sub-cellular localisations and diverse biological functions. Despite the many reports from many research teams on CLU action and its relation to tumourigenesis, contradictions in the data and alternative hypothes...
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PMID: 19903745
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has docu...
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PMID: 19779034
PDF is available here.
PDF is available here.
Clinical Oncology (22)2 2010
Abstract
Thirty-seven (28.4%) patients had rSCC on MRI. The proportion of patients free from neurological deficit at 3, 6, 12, 18 and 24 months was 94, 80, 59 and 43%, respectively, in patients who had rSCC on initial MRI and 97.5, 89, 75 and 63%, respectively, in patients who had no rSCC. A high prostate-sp...
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PMID: 20034772
PDF is available here.
PDF is available here.
Bulletin du cancer (97)3 2010
Abstract
Tamoxifen is a prodrug mainly metabolized by the CY2D6 cytochrome. More than 80 variants of the CYP2D6 gene have been identified. They predict four different enzymatic phenotypes: ultra-rapid metabolizers (UM), extensive metabolizers (EM), intermediate metabolizers (IM) and poor metabolizers (PM). S...
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PMID: 20123649
PDF is available here.
PDF is available here.
Abstract
Forty-four triple negative and 68 controls (triple positive) were eligible for our analysis. BRCA1 promoter methylation was present in 31.8% of triple negative and in 20.6% of triple positive cases. BRCA1 was inactivated (absent BRCA1 m-RNA expression and lack of BRCA1 protein) in 21.4% of tumors wi...
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PMID: 20701084
PDF is available here.
PDF is available here.
Abstract
E2F1 may be a potential prognostic and predictive factor for clinical outcome and therapeutic results following adjuvant chemotherapy in HRNBC patients....
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PMID: 19841979
PDF is available here.
PDF is available here.
Abstract
We have focused on BMP-7 because it is involved in prostate morphogenesis, and its expression is regulated by androgens. The objective of our study was to determine BMP-7 expression in PCa metastases and investigate the effects of BMP-7 on PCa cells. Our results show that BMP-7 is expressed in metas...
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PMID: 20126477
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)1 2010
Abstract
We developed a mouse model system that mimics hormone-dependent postmenopausal breast cancer. In this model, human estrogen receptor-positive (ER+) breast cancer cells (MCF-7) stably transfected with aromatase (MCF-7Ca) are grown as tumors in ovariectomized female nude mice. Using this model, we hav...
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PMID: 20133251
PDF is available here.
PDF is available here.
Abstract
We report here the case of an 80-year-old woman who presented a secondary Raynaud's phenomenon. First-line investigations remained negative. A mammography was performed and revealed breast cancer. Raynaud's phenomenon disappeared after treatment of the breast carcinoma and did not recur during the 2...
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PMID: 19959302
PDF is available here.
PDF is available here.
Abstract
Voprosy onkologii (56)2 2010
Abstract
Abstract
Although docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer in 2004, additional therapies are still required. Prostate cancer is often slow-growing and expresses many tumor-associated antigens, making it a feasible target for immunotherapy. Several therapeuti...
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PMID: 19857185
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Our experience of kalumide (bikalutamide) administration in patients with prostatic cancer agrees with the data of other investigators on a good effect of the drug on quality of life of patients with prostatic cancer.
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PMID: 20891045
PDF is available here.
PDF is available here.
Abstract
We retrospectively compared the risk features and clinical outcome of patients with TN against these with HER2 HR+/- tumours....
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PMID: 20164004
PDF is available here.
PDF is available here.
Abstract
We present two patients with advanced ESS, who had increased levels of p,p-DDE; hexachlorobenzene; PCB 28; PCB 52; PCB 101; PCB 138; PCB 153 and PCB 180 in abdominal adipose tissue. Other xenoestrogens were within expected limits for the non-exposed European population. CONCLUSION: Increased levels...
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PMID: 20349793
PDF is available here.
PDF is available here.
Abstract
Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis.
The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.
A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and...
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PMID: 20878621
PDF is available here.
PDF is available here.
Abstract
We have examined the prognostic value of IGF-II mRNA expression in breast cancer and its relationship to other predictive parameters.
Sixty-eight women with infiltrating ductal carcinoma were given the same treatments including mastectomy and antitumoral therapies and followed up for 5 years.
The ov...
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PMID: 20677165
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that the MT1 receptor is a major transducer of melatonin's actions in the breast, suppressing mammary gland development and mediating the anticancer actions of melatonin through multiple pathways....
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PMID: 20050373
PDF is available here.
PDF is available here.
Minerva endocrinologica (34)4 2009
Abstract
Several cutting-edge strategies are being used to evaluate candidate genetic risk factors for breast cancer. These include linkage analysis for mapping out BRCA1 and BRCA2, mutational screening of candidate risk genes like CHEK2, ATM, BRIP1 and PALB2, which are associated with an intermediate level...
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PMID: 20046159
PDF is available here.
PDF is available here.
Future Oncology (5)9 2009
Abstract
Hormone-refractory prostate cancer is the result of regrowth of prostate cancer cells that have adapted to the hormone-deprived environment of the prostate. The process by which castration-resistant prostate cancer (CRPC) cells are generated appears to be varied. The complex mechanism of hormone res...
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PMID: 19903068
PDF is available here.
PDF is available here.
Future Oncology (5)9 2009
Abstract
Endocrine therapy is a major treatment modality for hormone-dependent breast cancer. It has a relatively low morbidity, and there is evidence that antihormonal treatments have had a significant effect in reducing mortality for breast cancer. Despite this, resistance to endocrine therapy, either prim...
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PMID: 19903069
PDF is available here.
PDF is available here.