Abstract
We believe is one of the longest and largest prospective studies assessing the development of bone sarcoma in individuals exposed to ionizing radiation, it appears that the development of radiation-induced bone sarcoma may be associated with exposure to much lower doses of ionizing radiation than ha...
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PMID: 21984980
PDF is available here.
Abstract
Cancer induction after radiation therapy is known as a severe side effect. It is therefore of interest to predict the probability of second cancer appearance for the patient to be treated including breast cancer.
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PMID: 21651799
PDF is available here.
Abstract
Risks to health from large-scale atmospheric nuclear weapons testing are still relatively unknown. A sample of 85,000 deciduous teeth collected from Americans born during the bomb-testing years assessed risk by in vivo measurement of residual strontium-90 (Sr-90) concentrations, usin...
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PMID: 21319726
PDF is available here.
Abstract
We recommend delayed autologous reconstruction after completion of radiotherapy....
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PMID: 20697311
PDF is available here.
Abstract
The increasing incidence of radiation-induced sarcoma (RIS) has become a significant problem that can limit long-term survival. The objective of the current study was to analyze the clinicopathologic characteristics, treatment outcomes, and prognostic factors of RIS after radiotherap...
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PMID: 20715161
PDF is available here.
Abstract
Our goal was to identify the most effective strategy for decreasing radiation exposure while retaining the benefits of computerized imaging. Based on a literature review and our trauma registry, the mortality risk of untreated injuries was compared with that of patients who received treatment of inj...
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PMID: 21140695
PDF is available here.
Abstract
We analysed the incidence of second primary intracranial tumours in patients with pituitary adenomas treated with radiotherapy compared to the risk of patients not exposed to irradiation and to the general population.
This retrospective cohort study includes 298 patients with pituitary adenomas that...
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PMID: 20429723
PDF is available here.
Abstract
We found lung cancer mortality to be significantly increased among underground miners. Uranium mining took place from early in the 1950s to 1990, and the Grants Uranium Mill operated from 1958-1990. The present study evaluates cancer mortality during 1950-2004 and cancer incidence during 1982-2004 a...
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PMID: 20954862
PDF is available here.
Abstract
Vitamin D deficiency is an established risk factor for rickets in children and osteomalacia in adults; and is associated with an increased risk of osteoporosis and fractures. Several studies have found a beneficial role of vitamin D on both incidence and prognosis for other diseases, e.g. cancer, bu...
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PMID: 20882079
PDF is available here.
Abstract
We review current findings on how sunlight-generated UVR generates DNA damage, inflammation, and immune suppression, thus leading to melanoma....
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PMID: 20623386
PDF is available here.
Abstract
Pregnant women are at risk of exposure to nonionizing and ionizing radiation resulting from necessary medical procedures, workplace exposure, and diagnostic or therapeutic interventions before the pregnancy is known. Nonionizing radiation includes microwave, ultrasound, radio frequency, and electrom...
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PMID: 20822083
PDF is available here.
Abstract
The average cumulative exposure in underground workers was 32 kBq year/m(3) (65 working level months (WLM)), experienced over 14.6 years. The excess RR (ERR) per kBq year/m(3) was 0.046 (95% CI 0.015 to 0.077; 0.022 ERR/WLM). Confounding by quartz may affect these results but appears to account only...
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PMID: 20647379
PDF is available here.
Abstract
Crystalline silica, a known carcinogen, probably affects lung cancer risk in iron ore miners. The main implication of the results is for interpretation of the dose-response curve for radon and lung cancer in underground iron ore miners. Since exposure to radon and quartz is often correlated, quartz...
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PMID: 20519746
PDF is available here.
Abstract
We investigated in vivo differential effects of gamma-rays and HZE ions on intestinal tumorigenesis using two different murine models, ApcMin/+ and Apc1638N/+. We showed that gamma- and/or HZE exposure significantly enhances development and progression of intestinal tumors in a mutant-line-specific...
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PMID: 20490531
PDF is available here.
Abstract
In the present paper, analysis of solid cancer mortality and incidence risk after radiation exposure in the Techa River Cohort in the Southern Urals region of Russia is described. Residents along the Techa River received protracted exposure to ionizing radiation in the 1950s due to the releases of r...
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PMID: 20461395
PDF is available here.
Jean A McDougall,
Ritsu Sakata,
Hiromi Sugiyama,
Eric Grant,
Scott Davis,
Nobuo Nishi,
Midori Soda,
Yukiko Shimizu,
Yoshimi Tatsukawa,
Fumiyoshi Kasagi,
Akihiko Suyama,
Phillip Ross,
Kenneth J Kopecky and
Christopher I Li
Abstract
We examined the risk of breast cancer in atomic bomb survivors to investigate whether women exposed to radiation between menarche and first birth had a higher risk of radiogenic breast cancer than women exposed at the same age but outside this interval.
Women (n = 30,113) were classi...
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PMID: 20570914
PDF is available here.
Vladimir Drozdovitch,
Valeri Khrouch,
Evaldas Maceika,
Irina Zvonova,
Oleg Vlasov,
Angelica Bratilova,
Yury Gavrilin,
Guennadi Goulko,
Masaharu Hoshi,
Ausrele Kesminiene,
Sergey Shinkarev,
Vanessa Tenet,
Elisabeth Cardis and
André Bouville
Abstract
A population-based case-control study of thyroid cancer was carried out in contaminated regions of Belarus and Russia among persons who were exposed during childhood and adolescence to fallout from the Chernobyl accident. For each study subject, individual thyroid doses were reconstructed for the fo...
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PMID: 20539120
PDF is available here.
F F Faletra,
I D'Angeli,
C Klersy,
M Averaimo,
J Klimusina,
E Pasotti,
G B Pedrazzini,
M Curti,
C Carraro,
R Diliberto,
T Moccetti and
A Auricchio
Abstract
This study provided an estimate of the LAR of cancer in middle-aged patients of both sexes after a single diagnostic CTCA, providing an easy-to-read table....
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PMID: 20538668
PDF is available here.
Abstract
The median age was 16 years. Sixty-three percent of patients had undifferentiated tumors. Sixty-six percent had locally advanced tumor. With a median follow-up of 107 months, one patient presented a local relapse, 24 patients developed distant metastases with a median delay of 7 months. The 5 years...
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PMID: 20347607
PDF is available here.
Abstract
We have attempted to identify why the results for the AECL cohort were so discrepant and had such a remarkable influence on the 15-country risk estimate. When considering the issues associated with data on the AECL cohorts and their handling, we noted a striking feature: a major change in outcome of...
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PMID: 20530869
PDF is available here.
Abstract
Computed tomography (CT) has been recognised as the most widely used imaging technique in both adults and children, owing to technological developments, especially with the recent innovations in multislice CT. This has resulted in an increase in the use of CT examinations in children younger than 15...
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PMID: 20658103
PDF is available here.
Abstract
This paper revisits three major accidents that occurred in South America. The main purpose of this review is to analyze the long term health and other effects of accidental exposures to ionizing radiation in order to extract lessons from these radiological emergencies that might be useful for avoidi...
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PMID: 20445396
PDF is available here.
Abstract
We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be susceptible to melanoma induction by ultraviolet A (UVA) and visible light. Whereas ultraviolet B (UVB) irradiation of neonates yielded high f...
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PMID: 20439744
PDF is available here.
Abstract
We reveal a previously uncharacterized gene FATS through a genome-wide approach and demonstrate its essential role in regulating the abundance of p21 in surveillance of genome integrity. A large exon coding the NH2-terminal domain of FATS, deleted in spontaneous mouse lymphomas, is much more frequen...
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PMID: 20154723
PDF is available here.
Abstract
We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma. Given the risk of post-radiation secondary primaries in breast cancer patients, long-term s...
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PMID: 20526547
PDF is available here.
Abstract
A total of 87 cancers occurred in the cohort between 1980 and 2006: 33 leukemia, 13 lymphoma, 10 brain tumors, and 31 other tumors. The standardized incidence ratio (SIR) for all cancers was 0.99 (95 % CI: 0.79 1.22). A dose-response relationship was not observed for all cancers, leukemia and lympho...
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PMID: 20234999
PDF is available here.
Abstract
We present the first reported case of synchronous radiation-induced orbital meningioma and cavernomas of the cerebellum and bilateral basal ganglia, presenting 16 years after ionizing radiation therapy for parietal anaplastic ependymoma, at the age of five. This case again underscores the risks of r...
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PMID: 20491803
PDF is available here.
Abstract
Experiments were conducted to assay whether monoenergetic neutron-induced genetic damage in parental germline cells can give rise to development of cancer in the offspring. Seven-week-old C3H male mice were irradiated with monoenergetic neutrons with energy levels of 0.2 or 0.6 MeV at doses of 0, 50...
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PMID: 20372851
PDF is available here.
Abstract
This type of analysis allows an assessment of gene expression changes that are associated with a physical mechanism. These genes and chromosomal regions are potential markers for radiation-induced PTC....
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PMID: 19725780
PDF is available here.
Abstract
We have examined childhood leukaemia incidence in 11 large-scale cancer registries in three continents for which data were available at least as early as 1962. We found no evidence of a wave of excess cases corresponding to the peak of radioactive fallout from atmospheric weapons testing. The absenc...
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PMID: 20309707
PDF is available here.
Abstract
The treatment-related second cancer risks in organs outside the primary beam due to 3D-CRT and IMRT is small. New risk assessment techniques need to be investigated to address the concern of radiation-induced second cancers from prostate treatments, particularly focusing on risks to organs inside th...
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PMID: 20527532
PDF is available here.
Abstract
The histologic diagnosis revealed sarcoma that was immunoreactive to vimentin and focally to S100 and O13 antibodies. Radiation-induced sarcoma should be suspected in patients who have received radiation treatment previously and present with new neurologic symptoms and signs in the irradiated area....
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PMID: 20375775
PDF is available here.
Tara O Henderson,
Alison Amsterdam,
Smita Bhatia,
Melissa M Hudson,
Anna T Meadows,
Joseph P Neglia,
Lisa R Diller,
Louis S Constine,
Robert A Smith,
Martin C Mahoney,
Elizabeth A Morris,
Leslie L Montgomery,
Wendy Landier,
Stephanie M Smith,
Leslie L Robison and
Kevin C Oeffinger
Abstract
BACKGROUND: Women treated with therapeutic chest radiation may develop breast cancer. PURPOSE: To summarize breast cancer risk and breast cancer surveillance in women after chest radiation for pediatric or young adult cancer. DATA SOURCES: Studies from MEDLINE, EMBASE, the Cochrane Library, and CINA...
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PMID: 20368650
PDF is available here.
Abstract
A complete assessment of late effects of X-ray diagnostics should take into account that radiation sensitivity varies considerably for the different ages at exposure and, furthermore, that not only malignant diseases but also benign neoplasms are induced which also may lead to severe detriment of th...
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PMID: 19551621
PDF is available here.
Abstract
The 10-fold variability in the observed toxicity ratio for different tumour endpoints shows that tissue sensitivity is a more important determinant of relative toxicity than radiation quality. The use of single radiation-weighting (w(R)) factors for radiation risk prediction and for radiological pro...
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PMID: 20353340
PDF is available here.
Jonine L Bernstein,
Robert W Haile,
Marilyn Stovall,
John D Boice,
Roy E Shore,
Bryan Langholz,
Duncan C Thomas,
Leslie Bernstein,
Charles F Lynch,
Jorgen H Olsen,
Kathleen E Malone,
Lene Mellemkjaer,
Anne-Lise Borresen-Dale,
Barry S Rosenstein,
Sharon N Teraoka,
Anh T Diep,
Susan A Smith,
Marinela Capanu,
Anne S Reiner,
Xiaolin Liang,
Richard A Gatti,
Patrick Concannon and
WECARE Study Collaborative Group
Abstract
Women who carry rare deleterious ATM missense variants and who are treated with radiation may have an elevated risk of developing contralateral breast cancer. However, the rarity of these deleterious missense variants in human populations implies that ATM mutations could account for only a small por...
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PMID: 20305132
PDF is available here.
Abstract
: Exposure to low-to-moderate doses of ionizing radiation appears to increase the risk of thyroid PMCs, even when exposure occurs during adulthood. Cancer 2010. (c) 2010 American Cancer Society....
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PMID: 20120034
PDF is available here.
Abstract
We analyzed 84 patients with mild to severe primary cutaneous melanoma treated between 1990 and 2007. Slides containing surgical specimens were analyzed, and new slides were made from archived paraffin sections when necessary.
The melanoma incidence was higher in areas of sun exposure, with lesions...
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PMID: 20360915
PDF is available here.
Abstract
We discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms....
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PMID: 19942715
PDF is available here.
Abstract
Osteosarcoma can develop secondary to malignant transformation within a preexisting benign bone lesion, such as Paget disease, osteonecrosis, fibrous dysplasia, and chronic infection, or it can arise in previously irradiated areas. This article presents the case of a 36-year-old woman who was affect...
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PMID: 20186080
PDF is available here.
Abstract
RIJOS developed at 3 to 14 years following radiotherapy. Four patients had tumors in the maxilla and 3 in the mandible. Five tumors were osteoblastic, with 1 osteolytic and 1 mixed lesions. Osteoid tumor matrix mineralization was identified in 6 subjects. Periosteal reaction was demonstrated in 6 ca...
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PMID: 20219593
PDF is available here.
Abstract
The honokiol-pretreated group exhibited a 45% reduction in tumor multiplicity as compared to the control group. Mechanistic studies showed the possible involvement of caspase-3, caspase-8, caspase-9, poly (ADP-ribose) polymerase (PARP) and p53 activation (p<0.05) leading to the induction of DNA frag...
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PMID: 20392996
PDF is available here.