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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neoplasm Invasiveness (1):
Recent article
Neoplasm Invasiveness
Abstract
We reviewed the slides of patients with clinical stage I nonseminomatous germ cell testicular tumors who underwent retroperitoneal lymph node dissection to evaluate the concordance between original and reviewed vascular invasion status, and other histological correlates.
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PMID: 21849196
PDF is available here.
PDF is available here.
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Abstract
We report that MT4-MMP is displayed on the cell surface as a mixed population of monomeric, dimeric, and oligomeric forms. Sucrose gradient fractionation demonstrated that these forms of MT4-MMP are all present in lipid rafts. Mutational and computational analyses revealed that Cys(564), which is pr...
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PMID: 21828052
PDF is available here.
PDF is available here.
Abstract
We demonstrate that neutrophils accumulate in the lung prior to the arrival of metastatic cells in mouse models of breast cancer. Tumor-entrained neutrophils (TENs) inhibit metastatic seeding in the lungs by generating H(2)O(2) and tumor secreted CCL2 is a critical mediator of optimal antimetastatic...
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PMID: 21907922
PDF is available here.
PDF is available here.
Brain research (1411) 2011
Abstract
We show MMP-9 overexpression conferred a poor prognosis in 163 GBM patients. Furthermore, MMP-9 specific miRNA expression profile (14 positively and 31 negatively correlated miRNAs with MMP-9) was established via miRNA microarrays in 60 GBM samples. Among them, two miRNAs: miR-885-5p and miR-491-5p,...
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PMID: 21831363
PDF is available here.
PDF is available here.
British Journal of Cancer (105)6 2011
Abstract
We found that miR-874 was significantly reduced in cancer cells. We focused on the functional significance of miR-874 in cancer cells and identification of miR-874-regulated novel cancer networks in MSSCC.
We used PCR-based methods to investigate the downregulated miRNAs in clinical...
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PMID: 21847129
PDF is available here.
PDF is available here.
Abstract
We are therefore at a juncture where a reduction of LR may be achieved by tumor resection with wide margins, but data regarding optimal margin width are conflicting and the risk/benefit balance of tumorectomy with wide margins has not been demonstrated. A randomized trial of reexcision for close mar...
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PMID: 22010383
PDF is available here.
PDF is available here.
Dental update (38)7 2011
Abstract
A case of a 66-year-old man, who was referred to the Oral Medicine service with persistent oral ulceration and widespread cutaneous rash is presented. Laboratory investigations confirmed a diagnosis of epitheliotropic, CD8-positive, cytotoxic, T-cell lymphoma. CLINICAL RELEVANCE: Ora...
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PMID: 22046907
PDF is available here.
PDF is available here.
Abstract
We hypothesized that these observations may be explained by a second MIF-like ligand, and we considered a probable candidate to be the protein encoded by the homologous, D-dopachrome tautomerase (D-DT) gene. We show that recombinant D-DT protein binds CD74 with high affinity, leading to activation o...
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PMID: 21817065
PDF is available here.
PDF is available here.
Abstract
Previous studies reported that CD10 positive Colorectal Cancer Cells (CRC) characterized by deeply invasive neoplasia.
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PMID: 21834477
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)32-34 2011
Abstract
Abstract
We have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors.
To investigate whether IMP3 can be used as a new biomarker to predict the recurrence and overall survival of patients with meningiomas.
One hundred seven patients w...
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PMID: 21809995
PDF is available here.
PDF is available here.
Abstract
We demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the an...
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PMID: 21741598
PDF is available here.
PDF is available here.
Abstract
To assess the value of endothelin-1 (ET-1) expression in predicting extracapsular extension (ECE) in clinically localized prostate cancer (PCa).
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PMID: 21091977
PDF is available here.
PDF is available here.
Abstract
To investigate the in vitro effects and the primary mechanisms of Changweiqing (, CWQ) on antimetastasis and antiinvasion of hypoxic colon carcinoma cells. In addition, to provide experimental evidence for the Chinese medicinal theory of "strengthening the body's resistance to elimin...
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PMID: 21725877
PDF is available here.
PDF is available here.
Abstract
Oral Oncology (47)9 2011
Abstract
We showed that some growth factors are produced in higher levels by tumor-associated myofibroblasts compared to tumor-associated fibroblasts, including activin A. Myofibroblast-conditioned media containing activin A significantly increased OSCC cell proliferation and tumor volume, whereas down-regul...
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PMID: 21727023
PDF is available here.
PDF is available here.
Abstract
We have developed tools for IHC of RREB1 protein isoform-specific amplification of RREB1 mRNA and selective knockdown of RREB1 isoforms and use these to provide new information by characterizing RREB1 expression in bladder and prostate cancer cell lines and human tissue samples. Previously described...
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PMID: 21703425
PDF is available here.
PDF is available here.
Abstract
We performed gene expression analysis and found that the level of P-cadherin was higher in tissue from liver metastases of colon cancer than in the corresponding primary colon cancer tissues. IHC analysis also showed that P-cadherin expression was significantly higher in liver metastases than in pai...
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PMID: 21703417
PDF is available here.
PDF is available here.
Abstract
We evaluated our long-term experience with chemoradiation therapy (CRT) for bladder preservation....
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PMID: 21616918
PDF is available here.
PDF is available here.
Abstract
This study aimed to evaluate the relationship between expression of LGR8, VEGF, MMP-2, MMP-9, fascin-1 and cortactin with clinicopathological parameters in hepatocellular carcinoma (HCC). The six biomarkers were investigated immunohistochemically using tissue microarrays of 93 HCC sp...
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PMID: 21789898
PDF is available here.
PDF is available here.
Abstract
We aimed at investigating the role of CCND1 G870A in both bladder cancer and UTUC in Taiwanese cohorts. The CCND1 G870A genotypes of 171 (101 bladder cancer and 70 UTUC) patients and 243 control subjects were determined by PCR-RFLP and their correlation with clinical and histopathological data was e...
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PMID: 21789902
PDF is available here.
PDF is available here.
Abstract
We assessed the role of CD44(hi)/CD24(lo) cells and pathways that regulate them, in an experimental model of brain metastasis. Notch signaling (mediated by γ-secretase) has been shown to contribute to maintenance of the cancer stem cell (CSC) phenotype. Cells sorted for a reduced stem-like phenotyp...
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PMID: 21665937
PDF is available here.
PDF is available here.
Presse Medicale (40)11 2011
Abstract
Twenty cases were collected. The mean age was 61.25 years. Skin invasion by tumor was found in all patients, and it was the reason for consultation. It was a cutaneous involvement at the nipple and areola (17 cases) and at the periareolar skin (three cases). The clinical appearance of skin involveme...
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PMID: 21684107
PDF is available here.
PDF is available here.
Abstract
Downstaging by neoadjuvant chemotherapy improves the survival of patients with muscle-invasive bladder cancer. In salvage setting, gemcitabine plus cisplatin has demonstrated an efficacy similar to that of methotrexate, vinblastine, doxorubicin and cisplatin with less toxicity. Therefore, the applica...
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PMID: 21665907
PDF is available here.
PDF is available here.
Abstract
We report studies of the in vivo invasion of head and neck squamous cell carcinoma (HNSCC) cells in response to applied gradients of a growth factor [epidermal growth factor (EGF)] and a chemokine (CXCL12), using orthotopic floor-of-mouth models. Analysis of the invading cells indicated that >75% of...
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PMID: 21641405
PDF is available here.
PDF is available here.
Abstract
We examined tissues from human oral squamous cell carcinoma (OSCC) for SLPI expression in parallel with proteases associated with tumor progression and evaluated their relationships using tumor cell lines. Significantly decreased SLPI was detected in OSCC compared to normal oral epithelium. Furtherm...
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PMID: 21641406
PDF is available here.
PDF is available here.
Abstract
We explored the potential mechanism of CuB in murine B16F10 melanoma cells. Anti-proliferation and anti-invasion effects were assessed in cultured cells, and in vivo anti-tumor activity was evaluated in a murine subcutaneous melanoma model. Flow cytometry was adopted to analyze cell cycle distributi...
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PMID: 21642275
PDF is available here.
PDF is available here.
Abstract
We developed a novel mouse xenograft model of PDAC metastasis to expedite testing of candidate genes associated with the disease. Human PDAC cell lines BxPC-3, MiaPaCa-2, and Panc-1 stably expressing luciferase were generated and introduced by intracardiac injections into immunodeficient mice to mod...
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PMID: 21636682
PDF is available here.
PDF is available here.
Abstract
We report here the regulation of members of the NR4A family of nuclear receptors by the BRAF-MEK-ERK cascade in melanoma cells. Expression profiling of melanoma cells in which both the NR4A1 and NR4A2 family members have been down-regulated by siRNA revealed alterations in genes associated with prol...
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PMID: 21362156
PDF is available here.
PDF is available here.
Abstract
The ideal treatment of patients with "borderline resectable pancreatic tumors (BRTs)" needs to be established. Current protocols advise neoadjuvant chemo(radio)therapy, although some patients may appear to have BRT on preoperative imaging and a complete resection may be achieved with...
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PMID: 21669578
PDF is available here.
PDF is available here.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia (83)2 2011
Abstract
A 78-year-old male presented complaining voiding low urinary tract symptoms associated to genital weightiness over the past few years. Grossly the lesion was only interesting the scrotum, for an about 7.5 kg mass. The scrotum was minimally tender, with an intact skin bereft of erythe...
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PMID: 21826882
PDF is available here.
PDF is available here.
Abstract
We organized a radical operation even though the node status was classified to cStage IV, because ipsilateral axillary lymph nodes may be regarded as regional nodes for tumors invading the chest wall. Right upper lobectomy and chest wall resection were performed, and the ipsilateral hilar, mediastin...
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PMID: 21677493
PDF is available here.
PDF is available here.
Abstract
A 46-year-old man with Crohn's disease was referred to our hospital. In 2007, abdominal pain accompanied by redness and swelling of the right lower quadrant developed. A small bowel series and computed tomography of the abdomen revealed a stricture in the terminal ileum, suggesting a penetration of t...
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PMID: 21677498
PDF is available here.
PDF is available here.
Abstract
We considered that curative resection was not possible and performed temporary colostomy for fecal diversion. After colostomy, he was treated with neoadjuvant chemoradiotherapy(NACRT)for down staging. The radiation therapy was delivered with 45 Gy(1. 8 Gy/fraction; 5 days/week×5 weeks), and the con...
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PMID: 21677500
PDF is available here.
PDF is available here.
Abstract
We report a bladder cancer case with multiple metastases which were controlled by low-dose UFT. At the same time, the chemosensitivity of 5-FU combined with uracylor 5-chloro-2, 4-dihydroxypyridine(CDHP). Four invasive bladder cancer cell lines were evaluated with a collagen gel droplet embedded dru...
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PMID: 21677502
PDF is available here.
PDF is available here.
Abstract
This study evaluates the prognostic significance of [18F]-fluoro-2-deoxyglucose positron emission tomography/computed tomography findings according to histological subtypes in patients with completely resected non-small cell lung cancer.
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PMID: 21613306
PDF is available here.
PDF is available here.
Abstract
HER2/neu status in breast cancer is determined by immunohistochemical analysis and/or fluorescence in situ hybridization (FISH). Previous studies have found widely varying sensitivities and specificities for anti-HER2/neu antibodies, including recently developed rabbit monoclonal antibodies. The curr...
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PMID: 21571957
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We investigate the mechanisms by which ETS fusions mediate their effects, and find that the product of the predominant ETS gene fusion, TMPRSS2:ERG, interacts in a DNA-independent manner with the enzyme poly (ADP-ribose) polymerase 1 (PARP1) and the catalytic subunit of DNA protein kinase (DNA-PKcs)...
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PMID: 21575865
PDF is available here.
PDF is available here.
Abstract
We investigated the importance of EPLIN, a cytoskeletal associated protein implicated in cancer, in clinical prostate cancer and its role in the PC-3 prostate cancer cell line (ATCC™).
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PMID: 21600601
PDF is available here.
PDF is available here.
Abstract
La Tunisie medicale (89)5 2011
Abstract
Abstract
We tested the correlation between methylation remodeling pervasiveness and malignant biological features. A methyl deviation index (MDI) was calculated for each lesion relative to terminal ductal-lobular unit baseline, and group comparisons revealed that high-grade and short-survival estrogen recept...
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PMID: 21641572
PDF is available here.
PDF is available here.
Abstract
Few cases of adenoid cystic carcinoma of the scalp have been described in the literature. Herein, we report a new case illustrating the difficulties of diagnosis and treatment of this rare form of tumour.
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PMID: 21570568
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1813)5 2011
Abstract
We have previously demonstrated that Cyclosporin A (CsA) affects glioblastoma invasion in organotypic brain slices and tumorigenicity in mice. Here we show that CsA impairs migration and invasion of human glioblastoma cells by downregulation of Akt phosphorylation. Interference with PI-3K/Akt signal...
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PMID: 21276823
PDF is available here.
PDF is available here.
Abstract
Intravascular large B-cell lymphoma (IVLBCL) is a distinct disease entity of non-Hodgkin lymphoma which is characterized in the current WHO classification by the selective growth of tumour cells in the lumina of small vessels of various organs. This rare disease entity has a high inc...
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PMID: 21515926
PDF is available here.
PDF is available here.
Abstract
Oral Oncology (47)7 2011
Abstract
Vascular invasion and lymph node metastasis have been used as histopathological prognosticators of cancers including oral squamous cell carcinoma (OSCC). In addition to metastatic potential via blood vessels, tumor-induced angiogenesis might also be associated with prognosis. However...
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PMID: 21602095
PDF is available here.
PDF is available here.
Abstract
Lung adenocarcinoma invasion and metastasis arises from autocrine and paracrine signaling events between tumor epithelial cells and the stromal microenvironment that is mediated in part by transforming growth factor-β (TGF-β) signaling. The copper-dependent amine oxidase lysyl oxidase (LOX) plays a...
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PMID: 21523732
PDF is available here.
PDF is available here.
Abstract
An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay syst...
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PMID: 21500849
PDF is available here.
PDF is available here.
Abstract
We show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival. CCL18 released by breast TAMs promotes the invasiveness of cancer cells by triggering integrin clustering and enhancing their adherence to extra...
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PMID: 21481794
PDF is available here.
PDF is available here.
Abstract
We report the synthesis and pharmacological characterization of ATX inhibitors based on the 4-tetradecanoylaminobenzylphosphonic acid scaffold, which was previously found to lack sufficient stability in cellular systems. The new 4-substituted benzylphosphonic acid and 6-substituted naphthalen-2-ylme...
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PMID: 21465666
PDF is available here.
PDF is available here.
Abstract
We report the observation of a 69-year-old woman with known cholelithiasis, admitted for biliary colic. CT scan highlighted a thick-walled gallbladder harboring a tumor invading segments IV and V of the liver. The patient underwent cholecystectomy associated with bisegmental hepatic resection. Patho...
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PMID: 21497148
PDF is available here.
PDF is available here.
Abstract
The aim of the present study is to investigate whether severe postoperative complications following elective colorectal surgery increase local recurrence or distant metastasis rate.
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PMID: 21504856
PDF is available here.
PDF is available here.
Abstract
We evaluated immunohistochemical Lgr5 expression in 31 distant metastases and in primary tumor compartments with relevance for metastasizing, comprising 89 colorectal carcinomas. Lgr5 expression was seen in 51.6% of distant metastases. 12.9%, 14.8% and 26.7% of primary tumors with histologically con...
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PMID: 21577318
PDF is available here.
PDF is available here.
Abstract
We reviewed a total of 320 consecutive patients with stage I adenocarcinoma who underwent complete resections with systematic node dissections from January 2004 to December 2006 at the National Cancer Center Hospital East.
A statistically significant difference was observed in recurr...
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PMID: 21325977
PDF is available here.
PDF is available here.
Abstract
We reviewed a total of 320 consecutive patients with stage I adenocarcinoma who underwent complete resections with systematic node dissections from January 2004 to December 2006 at the National Cancer Center Hospital East.
A statistically significant difference was observed in recurr...
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PMID: 21325977
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of two different inhibitors of MAPK signaling in proliferative and invasive melanoma cell cultures with various mutations in the MAPK pathway. Proliferative melanoma cells were more susceptible to pathway inhibition than invasive phenotype cells, irrespective of BRAF muta...
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PMID: 21176117
PDF is available here.
PDF is available here.
Abstract
KAI1/CD82 has been reported to attenuate the process of metastases in a variety of tumors; however, its mechanism of action in invasion has not been fully elucidated. The present study aimed to investigate the importance of KAI1 in invasion and its correlation with activation of sphingosine kinase (S...
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PMID: 21459729
PDF is available here.
PDF is available here.
Abstract
To compare microvascular invasion (McVI) with parameters defined by the Milan criteria in predicting tumor recurrence and overall survival (OS) in patients with surgical resection (SR) for hepatocellular carcinoma (HCC).
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PMID: 21527845
PDF is available here.
PDF is available here.
Oral Oncology (47)5 2011
Abstract
We retrospectively reviewed pathologic specimens and MRI findings of 114 patients who were diagnosed with squamous cell carcinoma of the oral cavity and oropharynx. Invasion depths were evaluated in pathologic specimens and by MRI. The mean histologic and MRI invasion depths were 13.57 ± 8.476 and...
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PMID: 21459662
PDF is available here.
PDF is available here.