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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neoplastic Processes (8):
Recent article
Neoplastic Processes
Khirurgiia ()6 2011
Abstract
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Abstract
We provide a mathematical model that begins to address this challenge. We model tumors as a discrete time branching process that starts with a single driver mutation and proceeds as each new driver mutation leads to a slightly increased rate of clonal expansion. Using the model, we observe tremendou...
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PMID: 20876136
PDF is available here.
PDF is available here.
Abstract
Accumulating lines of experimental evidence have revealed that the malignant transformation of multipotent tissue-resident adult stem/progenitor cells into cancer stem/progenitor cells endowed with a high self-renewal capacity and aberrant multilineage differentiation potential may be at origin of t...
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PMID: 20552555
PDF is available here.
PDF is available here.
Abstract
We report here that mice living in an enriched housing environment show reduced tumor growth and increased remission. We found this effect in melanoma and colon cancer models, and that it was not caused by physical activity alone. Serum from animals held in an enriched environment (EE) inhibited can...
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PMID: 20603014
PDF is available here.
PDF is available here.
Abstract
This study evaluated a biodegradable drug delivery system for local cancer radiotherapy consisting of a thermally sensitive elastin-like polypeptide (ELP) conjugated to a therapeutic radionuclide. Two ELPs (49 kDa) were synthesized using genetic engineering to test the hypothesis that injectable biop...
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PMID: 20117157
PDF is available here.
PDF is available here.
Thrombosis Research (125 Suppl 2) 2010
Abstract
We postulate that the TF pathway may play an important role in formation of the vascular niche for tumour initiating CSCs, through its procoagulant and signalling effects. Therapeutic blockade of these mechanisms could hamper tumour initiation processes, which are dependent on CSCs and participate i...
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PMID: 20434004
PDF is available here.
PDF is available here.
Neurosurgical FOCUS (28)4 2010
Molecular pathogenesis of craniopharyngioma: switching from a surgical approach to a biological one.
Abstract
Craniopharyngioma has long been considered a benign tumor because of its pathological aspect. This primordial view of craniopharyngioma fit with the primitive treatment attempts based on blind resection of the tumor each time it recurred. The limits of this management strategy were proven early by t...
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PMID: 20367353
PDF is available here.
PDF is available here.
Abstract
Cystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied and reviewed in the literature. Over the last 20 years, however, proteins containing cystatin domains but lacking protease inhibitory activities have been identified, and most likely more will be described...
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PMID: 20173285
PDF is available here.
PDF is available here.
Embo Molecular Medicine (1)6-7 2009
Abstract
Recent advances in our understanding of the molecular pathways that govern the association of inflammation with organ fibrosis and cancer point to the epithelial to mesenchymal transition (EMT) as the common link in the progression of these devastating diseases. The EMT is a crucial...
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PMID: 20049734
PDF is available here.
PDF is available here.
Abstract
We address questions regarding the definitions of pathologic response, as well as the current literature regarding the meaning of pathologic response for some common tumor types. We explore some of the potential confounding effects that may explain the frequent discordance between tumor response and...
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PMID: 19326170
PDF is available here.
PDF is available here.
Abstract
Cells within tissues are continuously exposed to physical forces including hydrostatic pressure, shear stress, and compression and tension forces. Cells dynamically adapt to force by modifying their behaviour and remodelling their microenvironment. They also sense these forces through mechanorecepto...
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PMID: 19165226
PDF is available here.
PDF is available here.
BMC Cancer (9)1 2009
Abstract
Total Src-induced cellular tyrosine phosphorylation as well as the number of phosphotyrosyl substrates was higher in suspension versus adherent cultures. Although the total level of Src-induced cellular phosphorylation was similar in FAK+/+ and FAK-/- backgrounds, the phosphorylation of some substra...
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PMID: 19138410
PDF is available here.
PDF is available here.
BMC Cancer (9)1 2009
Abstract
All stage 4s patients underwent spontaneous remission, only 48% stage 4 patients survived despite combined modality therapy. Stage 4 tumours were 90% near-diploid/tetraploid, 44% MYCN amplified, 77% had 1p LOH (50% 1p36), 23% 11q and/or 14q LOH (27%) and 47% had 17q gain. Stage 4s were 90% near-trip...
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PMID: 19192278
PDF is available here.
PDF is available here.
Abstract
Abstract
We study the interplay between these two conflicting components of cancer dynamics using two types of tissue architecture. Both mean field and multicompartment models are studied. It is shown that tissue architecture affects the pattern of cancer dynamics and that unstable cancers spontaneously orga...
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PMID: 18534628
PDF is available here.
PDF is available here.
Abstract
We demonstrated that increased expression of a splice variant of the Kruppel-like factor 6 (KLF6) tumor suppressor gene, known as KLF6-SV1, in tumors from men after prostatectomy predicted markedly poorer survival and disease recurrence profiles. Analysis of tumor samples revealed that KLF6-SV1 leve...
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PMID: 18596922
PDF is available here.
PDF is available here.
Abstract
Tissue pieces transfected with both adenoviral-cyclooxygenase-2 and adenoviral-vascular endothelial growth factor-A continued to grow up to 30 days postimplantation. The number of proliferating and apoptotic cells, as well as the expression of smooth muscle actin, desmin, vimentin, estrogen receptor...
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PMID: 18468574
PDF is available here.
PDF is available here.
Abstract
We found progressive karyotypic changes from simple to complex in chHES-3, one of the hESC lines established in our laboratory, during a long-term suboptimal culture. We further compared chHES-3 cells at different karyotypic stages in cell surface markers, in vivo differentiation, cell cycle, apopto...
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PMID: 18470900
PDF is available here.
PDF is available here.
Abstract
Aberrant protein tyrosine phosphorylation resulting from the altered activity of protein tyrosine phosphatases (PTPs) is increasingly being implicated in the genesis and progression of human cancer. Accumulating evidence indicates that the dysregulated expression of members of the phosphatase of reg...
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PMID: 18224294
PDF is available here.
PDF is available here.
Abstract
We summarize studies that support the role of integrins in translational control, especially at the initiation step, and discuss the various mechanisms by which integrins regulate the recruitment of translational machinery. This review also examines the hypothesis that integrins contribute to variou...
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PMID: 18300291
PDF is available here.
PDF is available here.
Abstract
We studied hamartomatous polyps for the expression of an early preneoplastic colorectal neoplasia risk marker also found in familial adenomatous polyposis patients. Retrospective, genetic, and hospital archival tissue immunohistochemistry using Adnab-9, a premalignant marker often found in Paneth-li...
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PMID: 17934846
PDF is available here.
PDF is available here.
Abstract
Abstract
We have investigated the role of Rac1 in colorectal tumor progression by genetic modification of the human colorectal adenocarcinoma cell line SW620 to either overexpress Rac1 or lack Rac1 expression. Tumor behavior was studied by orthotopic injection of stably modified cell lines into the cecal wal...
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PMID: 18165265
PDF is available here.
PDF is available here.
Abstract
Epigenetic, modifications of DNA and histones, i.e. heritable alterations in gene expression that do not involve changes in DNA sequences, are known to be involved in disease. Two important epigenetic changes that contribute to disease are abnormal methylation patterns of DNA and modifications of hi...
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PMID: 18078446
PDF is available here.
PDF is available here.
Abstract
Inflammation in the intestine is a well-known risk factor for neoplastic changes in the mucosa. In fact, it has been shown that long-standing ulcerative colitis and colonic Crohn's disease have a significantly increased risk for developing colorectal cancer, although the estimates vary widely betwee...
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PMID: 17309075
PDF is available here.
PDF is available here.
Abstract
We have now tested three models to determine the role of inappropriate expression of Ptn in breast cancer. Mouse mammary tumor virus (MMTV) promoter-driven Ptn expressed in MMTV-polyoma virus middle T antigen (PyMT)-Ptn mouse breast cancers was first shown to induce rapid growth of morphologically i...
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PMID: 17578909
PDF is available here.
PDF is available here.
Abstract
The unique ability of tumour cells to proliferate indefinitely is crucial to neoplastic progression as it allows these cells to express the aggressive properties of cancer without the censure of physiological ageing. This is in contrast to normal somatic cells which are subject to a "mitotic clock,"...
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PMID: 19105326
PDF is available here.
PDF is available here.
Archives of Dermatology (143)2 2007
Abstract
Medical Hypotheses (68)3 2007
Abstract
Laboratory Investigation (86)12 2006
Abstract
There is a growing body of evidence that supports the idea that malignant tumors are initiated and maintained by a population of tumor cells that share similar biologic properties to normal adult stem cells. This model, the cancer stem cell (CSC) hypothesis, is based on the observation that tumors,...
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PMID: 17075578
PDF is available here.
PDF is available here.
Future Oncology (2)6 2006
Abstract
Invasion and metastasis are the most lethal characteristics of cancer and the leading causes of cancer-related death. Transforming growth factor (TGF)-beta is a multifunctional cytokine that normally functions to prevent the uncontrolled proliferation of epithelial, endothelial and hematopoietic cel...
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PMID: 17155901
PDF is available here.
PDF is available here.
Abstract
Smoking causes a variety of adverse effects on organs that have no direct contact with the smoke itself such as the liver. It induces three major adverse effects on the liver: direct or indirect toxic effects, immunological effects and oncogenic effects. Smoking yields chemical substances with cytot...
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PMID: 17036378
PDF is available here.
PDF is available here.
Hereditas (Beijing) (28)7 2006
Abstract
DNA methylation is a kind of epigenetic modification in human genome. Both hypermethylation of tumor suppressor gene or DNA repair gene and hypomethylation of repetitious DNA are closely related to different kinds of tumors. Loss of imprinting can also cause tumorigenesis. The recent study confirmed...
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PMID: 16825178
PDF is available here.
PDF is available here.
FASEB Journal (20)8 2006
Abstract
We discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1, the role of the GPI anchor in Thy-1 localization to lipid rafts and signaling, and regulation of Thy-1 expression. Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles...
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PMID: 16770003
PDF is available here.
PDF is available here.
Abstract
In recent years, several functional molecules specifically expressed and localized in lymphatic endothelial cells, such as 5'-nucleotidase, lymphatic vessel endothelial receptor-1, vascular endothelial growth factor receptor-3, podoplanin and Prox-1, have been identified. The discovery of the lympha...
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PMID: 16800291
PDF is available here.
PDF is available here.
Abstract
We have proposed the following based upon the malignant potential of SCC variants, separating them into categories of low (< or = 2% metastatic rate), intermediate (3-10%), high (greater than 10%), and indeterminate behavior. Low-risk SCCs include SCC arising in actinic keratosis, HPV-associated SCC...
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PMID: 16630176
PDF is available here.
PDF is available here.
Abstract
We have proposed the following based upon the malignant potential of SCC variants, separating them into categories of low (< or = 2% metastatic rate), intermediate (3-10%), high (greater than 10%), and indeterminate behavior. Low-risk SCCs include SCC arising in actinic keratosis, HPV-associated SCC...
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PMID: 16466506
PDF is available here.
PDF is available here.
Abstract
Breast Disease (26) 2006
Abstract
Metastasis is the most lethal attribute of cancer cells and clinical decisions regarding treatment are based largely upon the likelihood of developing metastases. However, improvements in detection as well as recent experimental data have raised questions about the most appropriate definition of a m...
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PMID: 17473362
PDF is available here.
PDF is available here.
Hormone Research (65)6 2006
Abstract
The term 'uncoupling protein' was originally used for the mitochondrial membrane protein UCP1, which is uniquely present in mitochondria of brown adipocytes, thermogenic cells that regulate body temperature in small rodents, hibernators and mammalian newborns. In these cells, UCP1 acts as a proton c...
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PMID: 16641553
PDF is available here.
PDF is available here.
Abstract
In bladder cancer, variations in clinical course and treatment outcomes support the concept that the condition may comprise a compendium of different types of tumor diathesis with unique, albeit interrelated, pathways of development. This concept and the schema of developmental pathways of bladder c...
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PMID: 16194710
PDF is available here.
PDF is available here.
Abstract
A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation, invasion, haematogenous metastasis and angiogenesis, and increased understanding of these roles sets the stage for developing pharmaceutical...
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PMID: 16069816
PDF is available here.
PDF is available here.
Oncology (Basel) (69 Suppl 1) 2005
Abstract
Abstract
SUMMARY. Esophageal cancer is one of the most deadly forms of gastrointestinal cancer with a mortality rate exceeding 90%. The major risk factors for esophageal adenocarcinoma are gastroesophageal reflux disease (GERD) and its sequela, Barrett's esophagus. GERD commonly leads to esophagitis. In a mi...
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PMID: 16053481
PDF is available here.
PDF is available here.
Cancer Treatment Reviews (30)7 2004
Abstract
We propose that inhibitors of the mevalonate pathway are particularly effective when administered in combination with other drugs. Therefore, the mechanisms and effects of combined therapy of statins or farnesyltransferase inhibitors with chemotherapeutics, biphosphonates, non-steroidal anti-inflamm...
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PMID: 15531395
PDF is available here.
PDF is available here.
Melanoma Research (14)4 2004
Abstract
We analysed 385 SN biopsies. The SN identification rate was 87.2% using preoperative lymphoscintigraphy and blue dye, 93.9% using preoperative lymphoscintigraphy, blue dye and different probes, and 100% using preoperative lymphoscintigraphy, blue dye and a computer-assisted probe with adjustable col...
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PMID: 15305163
PDF is available here.
PDF is available here.
Abstract
We will summarize molecular and functional aspects of adrenal tumorigenesis and highlight some prospects for future clinical applications....
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PMID: 15241730
PDF is available here.
PDF is available here.
Abstract
We have recently found altered expression of catalase in IGFBP-2-overexpressing tumor cells, thus implicating IGFBP-2 in influencing intracellular peroxide levels. However, since transgenic mice with IGF-II or IGFBP-2 overexpression in the adrenal gland do not show an increased frequency of adrenal...
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PMID: 15241731
PDF is available here.
PDF is available here.
Abstract
Acta Neurochirurgica (146)5 2004
Abstract
Pre- and postoperative tumour volumes, and the involvement of more than one lobe were strongly associated with worse outcome. Preoperative tumour volume was the strongest predictor of OS (p<0.01) and the only predictor of MT (p<0.05). The absolute and relative volumes of tumour removed by surgery we...
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PMID: 15118879
PDF is available here.
PDF is available here.
Abstract
Abstract
We report this case with "multifocal solitary fibrous tumors of the pleura," which recurred at different sites in the left pleura at different time intervals over a span of 25 years, finally exhibiting features of malignant transformation. This patient was first seen in 1978, when she was 58 years o...
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PMID: 15160981
PDF is available here.
PDF is available here.
Asian Journal of Surgery (27)2 2004
Abstract
In vitro growth of hybrid clones was significantly delayed compared to parental cells. This was paralleled by a significantly lower rate of promoting invasive carcinoma in nude mice and a longer latency with hybrid cells compared with parental tumour cells. Hybrid clones showed significant suppressi...
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PMID: 15140658
PDF is available here.
PDF is available here.
Abstract
The dissemination of positron emission tomography (PET) technology has enabled a functional approach to the evaluation of lung cancer that complements the anatomic assessment provided by chest radiography, computed tomography (CT) scanning, and magnetic resonance imaging. PET has excellent sensitivi...
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PMID: 14697158
PDF is available here.
PDF is available here.
British Journal of Cancer (89)12 2003
Abstract
High-intensity focused ultrasound (HIFU) is a noninvasive treatment that induces complete coagulative necrosis of a tumour at depth through the intact skin. This study was to explore the possibility of using HIFU for the treatment of patients with localised breast cancer in a controlled clinical tri...
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PMID: 14676799
PDF is available here.
PDF is available here.
Abstract
Abstract
In this paper, the evolution of a tumour cord after treatment is investigated by extensive numerical simulations on the basis of a mathematical model developed by Bertuzzi et al. (submitted). The model is formulated in cylindrical symmetry adopting the continuum approach, and takes into account the...
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PMID: 12909255
PDF is available here.
PDF is available here.
Journal of Surgical Research (113)1 2003
Abstract
We have shown for the first time that human cancer cells exhibit differential responses to treatment with leptin, depending upon organ of derivation. Both leptin and leptin antagonism have potential efficacy in cancer therapy, based on cellular origin. Further studies are warranted and ongoing....
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PMID: 12943810
PDF is available here.
PDF is available here.
Abstract
Clinical Otolaryngology (28)2 2003
Abstract
We have assessed the clinical growth index as an indicator of tumour growth rate in 50 patients with a vestibular schwannoma. Clinical growth index was calculated by measuring the length of history and dividing it by the maximum tumour diameter. Total tumour volumes were also measured from all MRI e...
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PMID: 12680824
PDF is available here.
PDF is available here.