Abstract
Our patient underwent a rigorous chemotherapeutic regimen followed by peripheral blood stem cell transplant, and as of August 2010, (17 months after initial diagnosis), the patient has had no recurrence....
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PMID: 21117517
PDF is available here.
Abstract
We report two Chinese patients, one with chronic lymphocytic leukemia and the other with thymoma. Both of them initially presented with severe oral erosion with lichenoid features that resisted all the regular therapy. The routine histology was not typical in both patients, with features of liquefac...
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PMID: 20657859
PDF is available here.
Abstract
We present a case in which a 25-year-old, Hispanic woman presented with seizures, memory loss, and unusual behavioral changes. The woman had a teratoma removed 2 months earlier. Because of the time course, a paraneoplastic syndrome was initially considered unlikely. Brain imaging, electroencephalogr...
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PMID: 20731268
PDF is available here.
Abstract
We report two unique patients with adenocarcinoma of the lung associated with tumor fever, necrotic liver metastases and granulocyte-colony stimulating factor (G-CSF) driven leukocytosis....
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PMID: 20806616
PDF is available here.
Abstract
Less than 1% of the lung cancer patients developed HPO as a paraneoplastic manifestation. Males, heavy smokers, and advanced disease predominated in lung cancer patients with HPO. The symptoms and bone scintigram findings of HPO improved in half of the patients on treating the lung cancer....
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PMID: 20453688
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Abstract
A 52-year-old woman with advanced non-small cell lung cancer was admitted to our hospital with melena and palpable purpura which appeared on her lower legs. She had been taking gefitinib for about 2 months before admission. A skin biopsy revealed leukocytoclastic vasculitis in the superficial dermis...
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PMID: 20684219
PDF is available here.
Abstract
We present a boy with recurrent episodes of paraneoplastic cerebellar ataxia associated with a ganglioneuroma. A 20-month-old boy developed the first episode of cerebellar ataxia after nonspecific respiratory tract infections. During this episode he showed a wide gait and truncal ataxia with intenti...
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PMID: 20666137
PDF is available here.
Abstract
Paraneoplastic dermatoses are a heterogeneous group of skin disorders that manifest an underlying internal malignancy. Early recognition of these cutaneous hallmarks offers an opportunity for early diagnosis, treatment of the internal malignancy and monitoring for tumor recurrence. The 9 most common...
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PMID: 20723267
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Abstract
We report a case of paraneoplastic neurological syndrome with anti-neuronal antibodies, namely anti-Hu and anti-GluR epsilon 2 antibodies in sera. A 72-year-old male had a transient history of eye movement disorder and sensory neuropathy, which improved spontaneously. Two years later, he was admitte...
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PMID: 20681263
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Abstract
A total of 9 of 55 patients were diagnosed with paraneoplastic myositis. FDG uptake was positive in 7 patients (1 false-positive), negative in 44 patients (3 false-negative), and inconclusive in 4 patients. Positive and negative predictive values of FDG-PET/CT for the diagnosis of cancer were 85.7%...
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PMID: 20569766
PDF is available here.
Abstract
This 11-year-old boy presented with a rare case of Castleman syndrome caused by a clear cell meningioma manifesting as persistent fever of unknown origin, 2 years after glomerulonephritis. Laboratory investigation of the patient showed an increased inflammatory reaction, as well as e...
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PMID: 20515337
PDF is available here.
Abstract
A 53-year-old woman with chief complaints of vomiting and constipation was given a diagnosis of ileus and admitted to a local hospital. The origin of the ileus was unknown despite intensive examinations. However, her chest X-ray film and CT showed left hilar and mediastinal lymphadenopathy. Her pro-...
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PMID: 20608088
PDF is available here.
Abstract
Paraneoplastic syndrome is defined as tumor-associated symptoms and signs not related to the physical effects of primary or metastatic tumors. The mechanisms of this syndrome include the production of bioactive soluble factors by tumor cells and autoimmune diseases elicited by the immune responses a...
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PMID: 20567097
PDF is available here.
Abstract
Paraneoplastic osteoarthropathy includes various forms of arthritis syndrome which probably relates to immune mechanisms, and much more often hypertrophic osteoarthropathy(HOA). HOA is often accompanied with primary lung cancer, malignant pleural mesothelioma, chronic pulmonary diseases, cyanotic co...
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PMID: 20567102
PDF is available here.
Abstract
We review clinical syndromes, associated imaging and laboratory findings. While most reports arise from adult populations, children and adolescents are also concerned as evidenced by increasing observations. Early recognition is mandatory, since early immunomodulatory treatment appears to be related...
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PMID: 20499581
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Abstract
We report a case of penile SCC involving a change in the patient's mental status along with hypercalcemia and leukocytosis; all three conditions resolved after the tumor was excised. We also discuss the possible factors contributing to hypercalcemia, leukocytosis and change in mental status in SCC....
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PMID: 20375950
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Abstract
We reviewed the literature over the last 15 years and located 6 additional cases. In 9 of 12 reported patients an unusual physical finding such as splenomegaly or lymphadenopathy was noted at the time of diagnosis, and in the entire group, the malignancy occurred within a mean of 12 months. It is le...
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PMID: 20057323
PDF is available here.
Abstract
We sought to evaluate factors influencing long-term survival in 19 patients with primary neuroendocrine tumours of the thymus.
From January 1990 to December 2004, 19 patients (14 males, 5 females; mean age 48.6 years) were surgically treated for a primary neuroendocrine tumour of the...
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PMID: 19954997
PDF is available here.
Abstract
I chimeric anti-CD20 antibody that has shown efficacy in chronic lymphocytic leukemia (CLL), both as a single agent and in combination with traditional chemotherapies. The modest activity demonstrated in early studies evaluating rituximab in relapsed CLL was improved with higher doses or more dose-i...
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PMID: 20350663
PDF is available here.
Abstract
We describe the first reported case, in an 82-year-old man, of erythrocytosis caused by an erythropoietin (EPO)-producing thymic carcinoma. The patient underwent computed tomography-guided fine-needle aspiration of a 6-cm anterior mediastinal mass, and histological findings revealed thymic squamous...
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PMID: 20179983
PDF is available here.
Abstract
Skin serves as a window to the wellbeing and disease in a person. The recognition of cutaneous markers of endocrine neoplasia can allow for the early diagnosis of tumors, for early treatment and ultimately prevention of morbidity and mortality secondary to malignancy. The following review outlines t...
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PMID: 20467397
PDF is available here.
Abstract
Anti-NMDA-receptor encephalitis is a severe and considerably underdiagnosed form of encephalitis with characteristic clinical features including psychiatric symptoms, decreased levels of consciousness, hypoventilation, epileptic seizures, autonomic dysfunction and dyskinesias. Most patients are prim...
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PMID: 20119656
PDF is available here.
Abstract
We present a case of paraneoplastic Raynaud's phenomenon in a patient with non-small-cell lung cancer that was associated with significant morbidity, involved a multidisciplinary approach, and eventually responded to a specialized intervention (i.e., iloprost trometamol).
Copyright (c) 2010 U.S. Can...
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PMID: 20199852
PDF is available here.
Abstract
We report two cases of hypercalcemia-hyperleucocytosis paraneoplastic syndrome complicating cutaneous squamous cell carcinoma. CASE REPORTS: The first patient, a 50-year-old man, suffering for hidradenitis suppurativa for the past 20 years, was admitted for squamous cell carcinoma. Laboratory findin...
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PMID: 20167400
PDF is available here.
Abstract
These results indicate that development of osteomalacia in this patient was related to the maxillary tumor, which overexpressed FGF23.
Copyright 2010 Mosby, Inc. All rights reserved....
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PMID: 20219587
PDF is available here.
Abstract
A paraneoplastic syndrome is defined as a group of symptoms that develop when substances released by some cancer cells disrupt the normal function of the surrounding cells and tissue. Paraneoplastic renal syndromes are diseases that indirectly compromise tubular and glomerular function by electrolyt...
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PMID: 20228504
PDF is available here.
Abstract
We suggest that sclerodermiform syndrome be included in the systemic sclerosis classification.
Copyright 2010 SPLF. Published by Elsevier Masson SAS. All rights reserved....
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PMID: 20359618
PDF is available here.
Abstract
We report a 77-year-old woman affected by pancreatic carcinoma with-eruptive disseminated porokeratosis (EDP). We reviewed published cases of EDP developing suddenly or within a few months and found a total of 16 patients, 6 with internal malignancies of the liver or gastrointestinal tract. These fi...
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PMID: 20408516
PDF is available here.
Abstract
We report a 74-year-old man in whom small cell carcinoma of lung (SCLC) was diagnosed during a presentation with GBS. Treatment with chemotherapy for SCLC and intravenous immunoglobulins led to complete neurological recovery and tumor regression....
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PMID: 20175250
PDF is available here.
Abstract
We report here the case of an 80-year-old woman who presented a secondary Raynaud's phenomenon. First-line investigations remained negative. A mammography was performed and revealed breast cancer. Raynaud's phenomenon disappeared after treatment of the breast carcinoma and did not recur during the 2...
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PMID: 19959302
PDF is available here.
Abstract
HISTORY: A 65-year-old female was admitted with fever of unknown origin. DIAGNOSTIC PROCEDURES: Abdominal computed tomography showed a solid mass (7.5 cm in diameter) with central fluid, located in the right lobe of the liver. Fine-needle aspiration cytology was unremarkable. Further work-up procedu...
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PMID: 20127606
PDF is available here.
Abstract
We present a case of a 44-year-old male with pyoderma gangrenosum (PG) presenting simultaneously with diagnosis of acute leukemia. His skin disease was stabilized with corticosteroids and most lesions cleared after chemotherapy-induced remission of the malignancy, but the largest lesion remained nec...
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PMID: 20373596
PDF is available here.
Abstract
We present two cases of a bronchopulmonary tumor with paraneoplastic nephrotic syndrome as initial manifestation. After surgical resection of the tumor, regression of the nephrotic syndrome occurred.
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PMID: 20690522
PDF is available here.
Abstract
The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The revi...
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PMID: 20036861
PDF is available here.
Abstract
We report a case of multiple periocular xanthogranulomas arising in a 43 year old man with chronic lymphocytic leukaemia. This case supports the emerging hypothesis that both juvenile and adult xanthogranulomas may share an association with an underlying haematological malignancy. Also highlighted i...
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PMID: 19919911
PDF is available here.
Abstract
We describe the paraneoplastic thromboembolic syndrome in venous and arterial (coronary, cerebral, peripheral) systems and in the heart (paraneoplastic endocarditis). We emphasise that the syndrome may signal presence of an occult malignant disease that, at that time, might be treatable.
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PMID: 20184112
PDF is available here.