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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Precancerous Conditions (7):
Recent article
Precancerous Conditions
Abstract
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but only rarely within adult benign tissues. The expression of IMP3 in esophageal adenocarcinoma (EAC) and its precursor lesions including distinc...
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PMID: 21809994
PDF is available here.
PDF is available here.
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Abstract
We observed statistically significant co-occurrence of MYC amplification and PI3K-pathway alteration, raising the possibility that these two lesions cooperate in prostate cancer progression. To investigate this, we generated bigenic mice in which both activated human AKT1 and human MYC are expressed...
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PMID: 21394210
PDF is available here.
PDF is available here.
Abstract
Endometrial serous carcinomas constitute no more than 10% of endometrial adenocarcinomas, but frequently present at an advanced stage and have a significantly worse prognosis than the more common low-grade and intermediate-grade endometrioid adenocarcinomas. The neoplasm's potential for rapid tumor...
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PMID: 21164282
PDF is available here.
PDF is available here.
Abstract
We investigated the frequency of PGAs and other lesions in all nonconsultation gastric biopsies and resections (1988 to 2008) diagnosed as AMAG. We further selected cases confirmed as AMAG by immunohistochemical identification of the gastric body (negative gastrin) and linear and nodular enterochrom...
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PMID: 20975338
PDF is available here.
PDF is available here.
PLoS Genetics (6)11 2010
Abstract
We demonstrate that the rs10993994 risk allele is associated with decreased expression of two MSMB isoforms in histologically normal and malignant prostate tissue. In addition, the risk allele is associated with increased expression of five NCOA4 isoforms in histologically normal prostate tissue onl...
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PMID: 21085629
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)44 2010
Abstract
Premalignant disorders of the oral mucosa primarily includes oral leukoplakia. The critical problem is to predict future malignant development. Several markers of malignant development have been suggested, however, possibly the most important is a non-homogeneous clinical appearance. There is no evi...
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PMID: 21044562
PDF is available here.
PDF is available here.
Abstract
We provide evidence that the squamo-oxyntic gap is equivalent to the columnar-lined esophagus. Its presence is a specific and sensitive indicator of reflux and can be used as a cellular criterion to define GERD. The length of the squamo-oxyntic gap provides an accurate assessment of the severity of...
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PMID: 20871393
PDF is available here.
PDF is available here.
Abstract
Performing a stapled ileal pelvic anal anastomosis does not appear to be inferior to mucosectomy and handsewn anastomosis in oncologic outcome, and it seems appropriate in patients with ulcerative colitis associated with coexisting dysplasia or cancer....
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PMID: 20940597
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)9 2010
Abstract
Repeated heating of vegetable oils at high temperatures during cooking is a very common cooking practice. Repeated heating of edible oils can generate a number of compounds, including polycyclic aromatic hydrocarbons (PAH), some of which have been reported to have carcinogenic potential. Consumption...
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PMID: 20687968
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
While no real improvement in the long term survival has been obtained in lung cancer, during this decade a significant improvement in cancer control has been obtained by biology driven targeted therapy as with anti EGFR tyrosine kinase. Two phases can be described in the knowledge of lung cancer bio...
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PMID: 21051316
PDF is available here.
PDF is available here.
British Journal of Cancer (103)9 2010
Abstract
Oral epithelial dysplasia (OED) is a histologically detectable lesion that may progress to carcinoma but there are no accurate markers that predict progression. This study examined the development of carcinoma from oral dysplastic lesions, and the association between abnormal DNA content and progres...
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PMID: 20859287
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (28 Suppl 2) 2010
Abstract
We present the unusual case of a 20-year-old female nonsmoker with severe laryngeal dysplasia managed with endoscopic CO(2) laser resection with frozen-section analysis. We use her case as a platform for discussion of the current evidence surrounding laryngeal dysplasia, particularly etiology and th...
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PMID: 20860544
PDF is available here.
PDF is available here.
Discovery medicine (10)53 2010
Abstract
We focus on changes that, as compared to the 2001 edition, were introduced into the 2008 WHO classification of acute myeloid leukemia (AML) and related precursor neoplasms. The category of AML with recurrent genetic abnormalities was expanded to account for 60% of AML by adding three distinct entiti...
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PMID: 21034669
PDF is available here.
PDF is available here.
Abstract
Prognostication of invasive ampullary adenocarcinomas (AACs) and their stratification into appropriate management categories have been highly challenging owing to a lack of well-established predictive parameters. In colorectal cancers, recent studies have shown that tumor budding confers a worse pro...
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PMID: 20871215
PDF is available here.
PDF is available here.
Abstract
Contradictory results have been reported about the role of interleukin-1B (IL1B) and IL1 receptor antagonist (IL1RN) alleles in gastric carcinogenesis. Here, IL1B and IL1RN polymorphisms were analyzed as genotypes and haplotypes in relation to the presence of atrophic gastritis (AG) and intestinal m...
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PMID: 20631624
PDF is available here.
PDF is available here.
Abstract
Because of delays in diagnosis, oral cancer usually presents for therapy at a late stage. Patients are unaware of having lesions as they are mostly asymptomatic and physicians generally do not examine the mouth sufficiently. People in rural areas or are underserved may not frequently visit the denti...
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PMID: 20738753
PDF is available here.
PDF is available here.
Abstract
We compared the expression of 14 human septin family members in 35 kinds of tumor types with their normal counterparts using the publicly available ONCOMINE microarray database. We found altered expression of most septin members in many kinds of tumors. Significantly, SEPT2, SEPT8, SEPT9, SEPT11 wer...
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PMID: 20195767
PDF is available here.
PDF is available here.
Abstract
Oral precancerous lesions may be solitary or multifocal, the latter being difficult to manage because of extensive field change. The aim of this study was to characterise differences in clinicopathological features, proliferative labelling indexes for cyclin A, cyclin B1, and Ki67, and clinical outc...
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PMID: 19800717
PDF is available here.
PDF is available here.
Abstract
Alcohol is known to be a risk factor for oral precancerous lesions, but evidence has been weakened by subjective estimates of alcohol intake from patients, and confounded by their use of tobacco. Red cell macrocytosis, assessed by calculation of mean corpuscular volume (MCV), may be a useful objecti...
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PMID: 20022150
PDF is available here.
PDF is available here.
Ginekologia polska (81)10 2010
Abstract
Development of primary prevention of cervical cancer in other words a vaccination against selected, oncogenic HPV types, entails an increasing importance of epidemiological studies and prevalence of various types of human papilloma virus. The incidence of HPV varies depending on the geographic locat...
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PMID: 21117301
PDF is available here.
PDF is available here.
Abstract
Periodic surveillance with systematic biopsies is recommended for patients with Barrett's esophagus. Brush cytology has been proposed as a simple inexpensive component of endoscopic surveillance, which may also detect abnormalities prior to detection of histologic abnormalities. The aim of the curre...
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PMID: 20821361
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)10 2010
Abstract
Fluorescent in situ hybridization (FISH) is a valuable tool for detection of chromosome aberrations in clinical practice of malignancies. However, the relatively high false positive and false negative rates of this method complicate its application to analysis of small populations of pathological ce...
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PMID: 21254552
PDF is available here.
PDF is available here.
Abstract
We analyzed changes in QoL in the AIM Dysplasia Trial, a multicenter study of patients with dysplastic Barrett's esophagus who were randomly allocated to RFA therapy or a sham intervention. We developed a 10-item questionnaire to assess the influence of dysplastic Barrett's esophagus on QoL. The que...
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PMID: 20886398
PDF is available here.
PDF is available here.
Human Pathology (41)10 2010
Abstract
We observed a strong correlation between high p53 expression and DNA aneuploidy. This relation was also present at the level of a single nucleus, measured by sequential image cytometry of p53 immunohistochemistry followed by DNA image cytometry on formalin-fixed tissue sections. Similarly, we found...
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PMID: 20656324
PDF is available here.
PDF is available here.
Abstract
We evaluated the promoter hypermethylation of EDNRB and KIF1A and their potential use for risk classification in prospectively collected salivary rinses from patients with premalignant/malignant oral cavity lesions. Quantitative methylation-specific PCR was performed to analyze the methylation statu...
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PMID: 20798208
PDF is available here.
PDF is available here.
Abstract
Erythroplakia is a red mucosal macule with a chronic evolution. It is diagnosed after excluding traumatic, vascular, or inflammatory etiologies. Erythroplakia is rare in the upper aerodigestive tract. It affects middle-aged adults. The main predisposing factors are those of in situ carcinoma. Lesion...
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PMID: 20739037
PDF is available here.
PDF is available here.
Abstract
Abstract
The last WHO expert workgroup recommended abandoning the distinction between potentially malignant lesions and conditions. The term to use is "potentially malignant disorders". Leukoplakia is the most common of these disorders, while erythroplakia is rather rare. The diagnosis is still made by exclu...
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PMID: 20739038
PDF is available here.
PDF is available here.
Optics Express (18)18 2010
Abstract
We developed a ratiometric method capable of estimating total hemoglobin concentration from optically measured diffuse reflectance spectra. The three isosbestic wavelength ratio pairs that best correlated to total hemoglobin concentration independent of saturation and scattering were 545/390, 452/39...
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PMID: 20940771
PDF is available here.
PDF is available here.
Abstract
The fallopian tube has recently emerged as an important site of origin for not only early serous cancer in women with inherited mutations in BRCA1/BRCA2 but as a source of many pelvic serous carcinomas. With this increased attention has come the inevitable need to sort out what epithelial abnormalit...
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PMID: 20733351
PDF is available here.
PDF is available here.
Abstract
We aimed to first investigate the clinical value of combined detection of MG7-Ag and COX-2 (cyclo-oxygenase 2) in prediction of advances in gastric precancerous lesions. Immunohistochemical analysis was used to examine the expression of MG7-Ag and COX-2 in 396 cases of patients with gastric precance...
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PMID: 20446925
PDF is available here.
PDF is available here.
Abstract
Out of 155 initially identified studies, 11 studies, from various countries, fulfilling the inclusion criteria, examined the risk of first-degree relatives developing gastric cancer (n=1500) in comparison with controls (n=2638). For H. pylori prevalence, the pooled odds ratio with 95% confidence int...
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PMID: 20410824
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
P16 protein, absent from all specimens of group 1, was especially noted in group 2 (92.86%) and in group3 (54.55%). Five out of 14 of group 2 cases (35.71%) and 3/11 (27.27%) of group 3 were HPV DNA positive. The HPVs detected were of both high-risk and low-risk genotype. The analysis of the relatio...
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PMID: 20944119
PDF is available here.
PDF is available here.
Abstract
This study was aimed to determine the prevalence of oral mucosal lesions (OML) in patients with diabetes mellitus (DM) and non-diabetic subjects without any oral habits and to investigate the association of DM with oral precancerous lesions.
This cross-sectional study involved 420 diabetic and 420 n...
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PMID: 20488573
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of ellagic acid on colon cancer induced by 1,2-dimethylhydrazine in rats. Male Wistar albino rats were divided into four groups. Group 1 served as control, group 2 rats received ellagic acid 60 mg/kg bodyweight/every day p.o. throughout the experiment. Rats from groups 3 a...
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PMID: 20406206
PDF is available here.
PDF is available here.
Abstract
We have used the comet assay to assess DNA damage in individuals with various disorders of the upper gastrointestinal (GI) tract in a cohort of patients from South India. After thorough clinical, endoscopic, and histopathological evaluation, patients were categorized into cancers, precancers, inflam...
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PMID: 20632893
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)8 2010
Abstract
We used both cell lines and primary cells, which were transformed to be malignant by a retrovirus. Spectral measurements were performed at various post infection stages in parallel with morphological observations. Our results showed gradual and consistent spectral alterations in both cell cultures d...
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PMID: 20526516
PDF is available here.
PDF is available here.
Abstract
Abstract
We found no geographical difference in the incidence of histological subtypes (p = 0.6501), mixed PSCC (p = 0.5937) or HPV-related tumors (p = 0.2505). Geographical variation may be the result of staging variation at clinical presentation or of pathological diagnosis. The identification of similar h...
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PMID: 19578046
PDF is available here.
PDF is available here.
Abstract
Here, we report cytogenetic toxicity to the exposed population by the high lead containing paints from India for the first time. Frequent, high and unregulated use of lead in paints may cause genetic mutation and may accelerate cytogenetic damage which may further lead to different carcinomas in pai...
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PMID: 20300868
PDF is available here.
PDF is available here.
Abstract
Reported incidence rates of oesophageal adenocarcinoma (OAC) in Barrett's oesophagus (BO) vary widely. As the effectiveness of BO surveillance is crucially dependent on this rate, its clarification is essential.
To estimate the rate of malignant progression in patients with BO, all patients with a f...
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PMID: 20639249
PDF is available here.
PDF is available here.
Abstract
We report the case of a patient who developed an AVL, vascular type, 4 years after lumpectomy and radiation therapy for ductal carcinoma in situ of the breast. The patient underwent wide local excision with 1-cm margins with subsequent pathologic examination confirming complete excision of the resid...
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PMID: 20138394
PDF is available here.
PDF is available here.
Cancer Research (70)15 2010
Abstract
We examined loss of PAX2 expression, a gene required for embryonic uterine development, during endometrial carcinogenesis. Normal proliferative, EIN, and malignant (endometrial adenocarcinoma) endometrial tissues were immunostained for PTEN and PAX2. Proliferative samples with loss of protein in at...
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PMID: 20631067
PDF is available here.
PDF is available here.
Abstract
Abstract
High frequency and similar incidence of EGFR mutation in AAH, BAC, and ADC support that EGFR gene mutation occurs in the early stage of pulmonary ADC development and tumor initiation from the preneoplastic lung parenchyma to neoplastic conditions. On the contrary, p53 overexpression is a late event...
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PMID: 20512074
PDF is available here.
PDF is available here.
Abstract
This study represents a multiplex cytokine analysis of serum from a 10-month randomized, controlled trial of 238 subjects that investigated the effects of selenomethionine and/or celecoxib in subjects with mild or moderate esophageal squamous dysplasia. The original chemoprevention s...
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PMID: 20587703
PDF is available here.
PDF is available here.
Abstract
Evidence of effectiveness was found for PDT in the treatment of AK and nodular BCC in relation to placebo, and possibly for treating Barrett's oesophagus. However, the effectiveness of PDT in relation to other treatments is not yet apparent. High-quality trials are needed to compare PDT with relevan...
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PMID: 20663420
PDF is available here.
PDF is available here.
Abstract
We propose that one such restriction is the exclusion of blood donors with a history of a malignancy. Most blood services apart from the United States and Australia continue the historical precaution of permanently excluding donors with a history of cancer, despite the absence of any convincing repo...
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PMID: 20656190
PDF is available here.
PDF is available here.
Abstract
We studied the natural history of SSA by analyzing the outcome of previously undiagnosed SSAs and comparing it with that of hyperplastic polyps (HPs) and APs. All colorectal polyps diagnosed between 1980 and 2001 as HP were selected for study. Polyps identified as possible SSAs were reviewed by 3 pa...
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PMID: 20551824
PDF is available here.
PDF is available here.
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging (65)6 2010
Abstract
Host immune responses to HPV are generally low-level because the virus, being confined to basal epithelial cells is shielded from the circulating immune cells during initial stages of infection. In this location there is only a limited expression of viral proteins. Other factors contributing to the...
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PMID: 20879650
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (116)1 2010
Abstract
High-grade squamous intraepithelial lesions (HSIL), atypical squamous cells, cannot exclude HSIL (ASC-H), and atypical glandular cells were more strongly associated with cervical intraepithelial neoplasia grade 3 while low-grade squamous intraepithelial lesions (LSIL) and HPV-positive atypical squam...
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PMID: 20567171
PDF is available here.
PDF is available here.
Clinical Chemistry (56)7 2010
Abstract
We show that the hypermethylation of the DNA region encoding miR-148a is responsible for its repression in PDAC precursor lesions and can be a useful tool for the differential diagnosis of PDAC and CP....
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PMID: 20431052
PDF is available here.
PDF is available here.
Abstract
We identified 197 cases of CAH diagnosed on preoperative endometrial sampling. Carcinoma was subsequently diagnosed in the hysterectomy specimen in 67 subjects (34%). The risk of underlying carcinoma if assigning subjects as CAH suspicious, CAH NOS, or CAH polypoid and/or focal was 56%, 36%, and 20%...
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PMID: 20576254
PDF is available here.
PDF is available here.
Orvosi Hetilap (151)24 2010
Abstract
Hepatocellular carcinoma (HCC) is a tumor with rather bad prognosis. Recent years, however, have seen considerable progress in the diagnostics and treatment of this disease, contributing to better understanding of its molecular pathogenesis. Large regenerative nodules, low and high grade dysplastic...
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PMID: 20519181
PDF is available here.
PDF is available here.
Abstract
ER alters histological grade or local T stage in 48% of patients and dramatically reduces esophagectomy rates by providing safe and effective therapy. ER has a high success rate (94%) for CBE in short segment Barrett's esophagus....
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PMID: 20179694
PDF is available here.
PDF is available here.
Abstract
Many types of lesions throughout the tubal gut fulfill the most basic and classic principles of a neoplastic precursor lesion but lack conventional morphologic evidence of dysplasia and/or maintain the capacity for cell differentiation and maturation. All of these lesions, such as squamous dysplasia...
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PMID: 20524867
PDF is available here.
PDF is available here.
Abstract
The diagnosis and grading of dysplasia in endoscopic surveillance biopsies play a decisive role in the management of patients with IBD. Although interpathologist variation, endoscopic sampling problems, and incomplete information regarding the natural history of dysplastic lesions are important limi...
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PMID: 20524866
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We use fluorescence spectroscopy to detect cervical precancer. In this article, we propose a Bayesian hierarchical model that takes into account random batch effects and selects effective functions among multiple functional predictors. Fixed effects or predictors in nonfunctional form are also inclu...
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PMID: 19508236
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We use fluorescence spectroscopy to detect cervical precancer. In this article, we propose a Bayesian hierarchical model that takes into account random batch effects and selects effective functions among multiple functional predictors. Fixed effects or predictors in nonfunctional form are also inclu...
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PMID: 19508236
PDF is available here.
PDF is available here.