Abstract
We have shown that when E₂ was removed from embryonic zebrafish (Danio rerio) system using the aromatase inhibiter (AI) 4-hydroxyandrostenedione (4-OH-A) fish did not developmentally express normal sensory-motor (S-M) functions such as tactile, vestibular, and swimming behaviors, creating a condit...
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PMID: 21255558
PDF is available here.
Abstract
We present a model of creativity captured as exploration and production of novel and functionally efficient behaviors, based on the statistical mechanics of disordered systems. In support of the modelling, we highlight examples of creative behaviors from our research in sports like boxing and rugby...
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PMID: 21382260
PDF is available here.
Abstract
We will present the current knowledge of caspase activation and activity pathways, the current tools for examining caspases, and functions of caspases in the nervous system in health and in disease. Alzheimer's Disease, the most common neurodegenerative disorder, and cerebral ischemia, the most comm...
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PMID: 21238939
PDF is available here.
Abstract
We investigated the hydrolysis of tabun by PON1 with the objective of comparing the hydrolysis potential of human and rabbit serum purified and recombinant human PON1. The hydrolysis potential of PON1 against tabun, sarin, and soman was evaluated by using an acetylcholinesterase (AChE) back-titratio...
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PMID: 21040699
PDF is available here.
Author(s) unavailable
Abstract
We present a special focus on epigenetics in the nervous system, highlighting recent advances in our understanding of epigenetic mechanisms and their regulation in neurons, as well as their role in nervous system function.
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PMID: 20975746
PDF is available here.
Abstract
We report a cell-intrinsic mode of BMP response control executed by the membrane protein Jiraiya. In the Xenopus embryo, zygotic Jiraiya, expressed exclusively in the neuroectoderm, is essential and sufficient for limiting dorsal neural development, which is dependent on BMP signals. In animal cap a...
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PMID: 20951346
PDF is available here.
Abstract
We report that CG10527 is expressed widely in secondary cells in the male accessory glands, in ovarian follicle cells, and in glial cells in the nervous system. Furthermore, CG10527 is expressed abundantly in the corpora allata where JH is synthesized. To understand the physiological functions of CG...
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PMID: 20833126
PDF is available here.
Abstract
The physiological and pathological phenomenon along the running courses of meridians such as enrichment of small charged molecular, low-resistance, isotope migration, electromyography phenomenon, acoustical conductivity, thermal radiation, magnetic phenomenon and optical-electrical characteristics,...
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PMID: 21058482
PDF is available here.
Abstract
Tauopathies are a clinically diverse group of neurodegenerative dementias involving perturbations of the level or phosphorylation state of the microtubule-binding axonal protein tau. Despite intense effort in recent years, the precise role of tau in the pathology of the various behaviourally and neu...
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PMID: 20658983
PDF is available here.
Abstract
We have studied the function of NO and its signaling cascade via cyclic GMP in the locust embryo. Its developing nervous system is well suited for pharmacological manipulations in tissue culture. The components of this signaling pathway are localized by histochemical and immunofluorescence technique...
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PMID: 20361970
PDF is available here.
Abstract
We compared the timing of abnormal prion protein (PrP(Sc)) dissemination and accumulation in the organism of susceptible sheep either orally inoculated or naturally infected with classical scrapie. Both animal groups shared a similar PrP(Sc) dissemination scheme and accumulation dynamics in lymphoid...
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PMID: 20444991
PDF is available here.
Abstract
We present a revision of our previously published model of circadian effects in cancer (Sephton and Spiegel, 2003) based on evaluation of new data from divergent lines of investigation. Human clinical studies show circadian endocrine disruption may be accompanied by suppressed functional cellular im...
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PMID: 20097011
PDF is available here.
Abstract
We summarize basic information on the lipid composition and distribution in zebrafish tissues, including lipoprotein metabolism, intestinal lipid absorption, the yolk lipids and their mobilization, as well as lipids in the nervous system. We also discuss studies in which zebrafish have been employed...
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PMID: 20578994
PDF is available here.
Abstract
We provide an overview of the pathological conditions caused by L1 malfunction. We further discuss how the available data on gene regulation, molecular interactions and posttranslational processing of L1 may contribute to a better understanding of associated neurological and cancerous diseases....
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PMID: 20237819
PDF is available here.
Abstract
Role of developmental exposure to environmental agents in altering the disease process is well known. Exposure to chemical agents at critical periods of development may cause some permanent changes in the functioning of various vital systems including the nervous system in the organisms. It is not s...
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PMID: 20929048
PDF is available here.
Abstract
We examined associations between pediatric blood lead concentrations (PbB), as well as those of mercury (Hg), and aluminum (Al), and performance in four different attention tasks, as well as behavioral ratings from an ICD-10 (hyperactivity) and DSM-IV-coded (attention deficit) German questionnaire (...
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PMID: 20434143
PDF is available here.
Abstract
These results show, for the first time, the general chemical characteristics of the ECM of the snail CNS, indicating differences in the composition of the ganglion neuropil between aquatic and terrestrial species. Hence, a different strategy for retaining water by the neural tissue is suggested in s...
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PMID: 20219380
PDF is available here.
Abstract
We show that neural tube closure in Xenopus depends on orthologs of two proteins: MID1, which is responsible for Opitz G/BBB syndrome in humans, and its paralog MID2. Depletion of the Xenopus MIDs (xMIDs) by morpholino-mediated knockdown disrupted epithelial morphology in the neural plate, leading t...
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PMID: 20534674
PDF is available here.
Abstract
We use mouse embryonic fibroblasts from an Mcm2-deficient strain of mice to show by DNA fiber analysis that origin usage is decreased in Mcm2-deficient cells under conditions of hydroxyurea (HU)-mediated replication stress. DNA damage responses (DDRs) resulting from HU and additional replication-dep...
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PMID: 20440269
PDF is available here.
Abstract
We summarise recent findings related to the interactions between the nervous system and tumour cells and suggest further research into the role of the nervous system in the aetiopathogenesis of cancer. Data showing the transmission of signals between the brain and tumour tissue create a complex view...
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PMID: 20522385
PDF is available here.
Abstract
Over the past decade, it has been increasingly recognized that both chemical and mechanical properties of scaffolds influence neural cell behavior, ranging from growth to differentiation to migration. However, mechanical properties are difficult to control for in the design of scaffo...
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PMID: 20401966
PDF is available here.
Abstract
The results obtained in the present study made it possible to place selected markers responsible for development of the nervous and skeletal systems on the physical map of the donkey genome. Fluorescence in situ hybridization (FISH) was used to localize genes such as GDF5 (15q13), FRZB (4q23.1), TWI...
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PMID: 20626768
PDF is available here.
Abstract
We induced neural differentiation of a human embryonal carcinoma stem cell line, NTERA2/NT2, by retinoic acid (RA) treatment, primarily according to two different methods of adherent cell culture (rosette formation) and suspension cell culture (EB formation) conditions, and histone modifications and...
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PMID: 20555394
PDF is available here.
Abstract
The risk of abnormal aEEG is high in sick neonates with PPHN or complex CHD. Prospective evaluation of the relationship between aEEG recordings in these disorders and acute cardiorespiratory physiology, comprehensive neuroimaging, and long-term patient outcomes is needed.
Crown Copyright (c) 2010....
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PMID: 19327328
PDF is available here.
Abstract
We identify miR-124 targets based on the analysis of the first mir-124 mutant in any organism. We find that miR-124 is expressed in many sensory neurons in Caenorhabditis elegans and onset of expression coincides with neuronal morphogenesis. We analyzed the transcriptome of miR-124 expressing and no...
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PMID: 20176573
PDF is available here.
Abstract
A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four...
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PMID: 20211511
PDF is available here.
Abstract
We review recent progress in understanding both the molecular mechanisms that modulate Slit/Robo expression and their functions in neural and non-neural tissue....
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PMID: 20501589
PDF is available here.
Abstract
We aim at tackling the problem of how the bilaterian anterior-posterior (AP) axis is organized, and how this axis have been established over evolutionary time. To this purpose we have studied the role of some key regulatory genes involved in the control of the AP axis, the Hox family of transcriptio...
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PMID: 20565536
PDF is available here.
Abstract
In a dynamic environment, there is an adaptive value in the ability of animals to acquire and express memories. That both simple and complex animals can learn is therefore not surprising. How animals have solved this problem genetically and anatomically probably lies somewhere in a range between a s...
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PMID: 20418404
PDF is available here.
Donald G Stump,
Melissa J Beck,
Ann Radovsky,
Robert H Garman,
Lester L Freshwater,
Larry P Sheets,
M Sue Marty,
John M Waechter,
Stephen S Dimond,
John P Van Miller,
Ronald N Shiotsuka,
Dieter Beyer,
Anne H Chappelle and
Steven G Hentges
Abstract
This study was conducted to determine the potential of bisphenol A (BPA) to induce functional and/or morphological effects to the nervous system of F(1) offspring from dietary exposure during gestation and lactation according to the Organization for Economic Cooperation and Developme...
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PMID: 20164145
PDF is available here.
Abstract
I and hyaluronic acid. The tissue inside the sponge consisted of nonepithelial cells and hyaluronic acid. Epidermal ingrowth underneath the sponges and neovascularization into the sponges occurred and were significantly increased by the incorporation of basic fibroblast growth factor. Although furth...
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PMID: 19954327
PDF is available here.
Abstract
We have engineered collagen and hyaluronic acid interpenetrating polymer network (IPN) hydrogels with and without laminin as a 3D culture system for Schwann cells in an attempt to devise novel neural regeneration therapies. Encapsulation of Schwann cells in 3D hydrogel constructs did not affect cell...
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PMID: 20136524
PDF is available here.
Abstract
Fetal growth restriction (FGR) due to placental dysfunction has important short- and long-term impacts that may reach into adulthood. Early-onset FGR before 34 weeks' gestation shows a characteristic sequence of responses to placental dysfunction that evolves from the arterial circulation to the ven...
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PMID: 20205623
PDF is available here.
Abstract
This epidemiologic study demonstrates neurodevelopmental effects in relation to cord blood PBDE concentrations. Confirmation is needed in other longitudinal studies....
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PMID: 20056561
PDF is available here.
Abstract
A growing body of literature supports the relationship of maternal inflammation with preterm birth and adverse neonatal outcomes, including infection and central nervous system (CNS) dysfunction. Mediators of inflammation, most notably proinflammatory cytokines, have been implicated as having an ass...
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PMID: 20028689
PDF is available here.
Abstract
OBJECTIVE: To investigate the neuroprotective effects of the constituents in Herba Erigerontis on neuroblastoma SH-SY5Y cells, and find out its possible material foundation in treating Alzheimer's disease (AD). METHOD: Different combinations of the three constituents in Herba Erigerontis were prepar...
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PMID: 20617689
PDF is available here.
Abstract
We performed integrated gene coexpression network analysis on two large microarray-based brain gene expression data sets generated from the prefrontal cortex obtained post-mortem from 101 subjects, 47 subjects with schizophrenia and 54 normal control subjects, ranging in age from 19 to 81 years. Twe...
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PMID: 20197298
PDF is available here.
Abstract
As shown by liquid scintillation counter, the cpm value of NSCs was 16592.8 +/- 2865.3, and that of the hepatic cells was 27815.0 +/- 2416.3 (P<0.01). About (87.55 +/- 3.65)% NSCs expressed neither MHC-I nor MHC-II, but there were only about (27.45 +/- 1.86)% hepatocytes showed both MHC-I and MYC-II...
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PMID: 20564819
PDF is available here.
Abstract
Paraneoplastic neurological syndrome (PNS) may affect any part of the nervous system and muscles. PNS is a rare disorder caused by the remote effects of cancer and is considered to be immune-mediated. Since the 1980s, several specific onco-neural antibodies and T-cell responses against onco-neural m...
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PMID: 20420169
PDF is available here.
Abstract
We observed that the disease model could not be produced using only anti-intracellular antibodies such as anti-Yo or anti-Hu antibodies, but that CTL activity could be induced in CD8+ T cells isolated from the peripheral mononuclear cells obtained from PNS patients with anti-Yo or anti-Hu antibodies...
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PMID: 20420170
PDF is available here.
Abstract
We will review many of these articles, focusing on those that address intracranial hemorrhage, intracranial procedures, carotid endarterectomy, spine surgery, and the determinants of outcome in patients with evolving or new-onset neurologic disease. Additionally, we will review articles addressing n...
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PMID: 20308816
PDF is available here.
Abstract
We provide the first comprehensive analysis of the cellular events shaping the PNT. We observe that this tissue is formed in a stepwise manner, beginning with merging of presumptive neural domains in the tailbud (Stage 1); followed by neural convergence and infolding to shape the neural rod (Stage 2...
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PMID: 20077475
PDF is available here.
Abstract
Sporadic Parkinson's disease is a multisystem disorder that involves predisposed nerve cell types in circumscribed regions of the entire human nervous system (peripheral, enteric, and central nervous systems). A recent staging procedure for the pathological process proposes that, in the brain, the f...
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PMID: 20195936
PDF is available here.
Abstract
To investigate if circulating cytokines are related to growth and neurodevelopmental outcome following necrotizing enterocolitis (NEC).
Pro-inflammatory cytokine levels were measured prospectively in 40 neonates and compared with neurodevelopmental outcome. Cytokine l...
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PMID: 19922507
PDF is available here.
Abstract
Existing multiple options for neuropathology training have facilitated recruitment and allowed development of a mosaic of specialists able to fulfill the diversity of needs in Canadian medical and scientific communities....
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PMID: 20437930
PDF is available here.
Abstract
Heliopsis longipes S.F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and muscle pains. Its biocide effect has already been experimentally demonstrated; however, its analgesic action and its action on the nervous system...
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PMID: 20645840
PDF is available here.