F David FD Carmona,
Luis L Rodríguez-Rodríguez,
Santos S Castañeda,
José A JA Miranda-Filloy,
Inmaculada C IC Morado,
Javier J Narváez,
Beatriz B Marí-Alfonso,
Ainhoa A Unzurrunzaga,
Raquel R Ríos-Fernández,
Ricardo R Blanco,
Eugenio E de Miguel,
Javier J Martín and
Miguel A MA González-Gay
Abstract
We have studied whether the CCR5/Δ32CCR5 polymorphism is implicated in the susceptibility to the disease and its specific features. A total of 352 Spanish patients with biopsy-proven GCA and 479 matched controls were assessed. DNA was obtained from peripheral blood. Samples were genotyped by PCR wi...
|
PMID: 21354457
PDF is available here.
Abstract
We have discussed the role of APO E polymorphisms in cerebrovascular and coronary heart diseases. The status of APO E polymorphisms and their disease associations in Asian Indians besides, other populations has also been discussed. Further, studies elucidating the pathophysiology of apo E deficiency...
|
PMID: 20966513
PDF is available here.
Abstract
A majority of patients with major depression do not remit or adequately respond to initial antidepressant therapy. When response is insufficient, a diagnosis of depression and any comorbidities should be confirmed, treatment adherence should be established, and antidepressant dosages should be optim...
|
PMID: 20977872
PDF is available here.
Abstract
In a translational model of chronic hypertension, clinically relevant levels of acute anemia were associated with an age-dependent visuospatial working memory and learning impairment that was matched by an age-dependent cellular sensitivity to anemic hypoxia. These data offer support for a possible...
|
PMID: 20808217
PDF is available here.
Abhinav Goyal,
Deepak L Bhatt,
P Gabriel Steg,
Bernard J Gersh,
Mark J Alberts,
E Magnus Ohman,
Ramón Corbalán,
Kim A Eagle,
Efrain Gaxiola,
Runlin Gao,
Shinya Goto,
Ralph B D'Agostino,
Robert M Califf,
Sidney C Smith,
Peter W F Wilson and
Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators
Abstract
The Reduction of Atherothrombosis for Continued Health (REACH) Registry is a prospective study of 67 888 subjects with either established atherothrombotic (coronary, cerebrovascular, and/or peripheral arterial) disease or multiple atherothrombotic risk factors enrolled from 5587 physician practices...
|
PMID: 20823388
PDF is available here.
Abstract
Cardiovascular and cerebrovascular diseases share many pathophysiological traits, often impact one another and share several risk factors, though not always to the same magnitude. Therefore, it is not surprising that many classes of cardiovascular drugs have demonstrated effectiveness in the primary...
|
PMID: 20730696
PDF is available here.
Abstract
Our results indicate that low HDL levels are also associated with more severe WMC lesions on MRI. Dietary or medical adjustment of HDL levels could have important implications for treatment and prevention of cerebral WMC, cerebrovascular and neurodegenerative diseases such as stroke and dementia....
|
PMID: 20455859
PDF is available here.
Abstract
To investigate adipocytokines in patients with ischemic cerebrovascular disease and to develop an association between them.
In this study plasma adiponectin, leptin and Interleukin 6 (IL 6) concentration were measured by ELISA. Blood glucose and lipid profile was done by standard kit methods.
A tota...
|
PMID: 21114131
PDF is available here.
Abstract
Vascular risk factors and outcome events of 3563 patients from a university hospital presenting with nondisabling CAD, CVD or PAOD were compared with regression analyses, adjusted for age and sex (median follow-up, 3.9 years). The primary outcome was the composite of myocardial infarction, stroke an...
|
PMID: 20555265
PDF is available here.
Abstract
Epidemiologic evidence remains limited, and to date data are insufficient to draw firm conclusions regarding the role of PFOA for any of the diseases of concern....
|
PMID: 20423814
PDF is available here.
Abstract
We report a 64-year-old patient who complained of right testicular pain. Right-sided orchiectomy was performed, and metastatic signet ring cell carcinoma of spermatic cord and testis was diagnosed through histological examination and immunohistochemistry. The following stomach biopsy confirmed the p...
|
PMID: 20399569
PDF is available here.
Abstract
The term cerebral small vessel disease refers to a group of pathological processes with various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most commo...
|
PMID: 20610345
PDF is available here.
Abstract
We have described preoperative evaluation and prognosis of patients with cerebrovascular disease. Cerebral infarction accounts for more than 60% of stroke. In patients with recently developed ischemic stroke, a surgery should be delayed at least for a month. Carotid artery stenosis accounts for 15 t...
|
PMID: 20662286
PDF is available here.
Abstract
The above approach to quantitative CT angiography provides a method of evaluating dynamic CTA data by means of intravascular functional maps. The techniques are broadly applicable in the clinical assessment of a variety of vascular diseases....
|
PMID: 20479649
PDF is available here.
Abstract
We report the case of a man who presented a jugular vein thrombosis responsible for severe intracranial hypertension. Because of clinical worsening despite intravenous heparin and symptomatic treatment, endovascular procedure including the placement of five venous stents, thrombolysis and balloon an...
|
PMID: 19782403
PDF is available here.
Abstract
In patients with symptomatic stenosis of the ICA, the flow territory of the symptomatic ICA was smaller than that of the asymptomatic ICA. After administration of acetazolamide, a significant increase in cerebral blood flow at the brain tissue level was measured in both control subjects and patients...
|
PMID: 20574097
PDF is available here.
Abstract
The postcardiac arrest syndrome comprises postcardiac arrest brain injury, postcardiac arrest myocardial dysfunction, the systemic ischaemia/reperfusion response, and the persistent precipitating disease. Primary percutaneous coronary intervention is the preferred method for restoring coronary perfu...
|
PMID: 20216308
PDF is available here.
Abstract
The use of second-generation antipsychotic agents was found not to be associated with increased risk of cerebrovascular adverse events compared to first-generation agents in older adults. However, long-term use of second- and first-generation antipsychotic agents is associated with increased risk of...
|
PMID: 20573328
PDF is available here.
Jiann-Der Lee,
Ya-Hui Lin,
Huan-Lin Hsu,
Yen-Chu Huang,
Chih-Ying Wu,
Shan-Jin Ryu,
Meng Lee,
Ying-Chih Huang,
Ming-Chang Hsiao,
Yeu-Jhy Chang,
Chien-Hung Chang and
Tsong-Hai Lee
Abstract
Low density lipoprotein is transcytosed across the blood-brain barrier mediated by low density lipoprotein receptor (LDLR). LDLR in the brain is mainly expressed on capillary endothelial cells and is therefore considered to be an important susceptibility gene in modifying the stroke presentation. A...
|
PMID: 19589204
PDF is available here.
Abstract
In 88 cases, image analysis showed NVC features that coincided with surgical findings. There were no false-positive results. Among 12 patients that did not show NVC at image analysis, nine did not have NVC at intraoperative observation, resulting in three false-negative cases. MRI sensitivity was 96...
|
PMID: 20108106
PDF is available here.
Abstract
Tumor size ranged from 1 to 6 cm in diameter, with a median at 2.5 cm. The presenting symptoms of the patients were anisocoria (six cases), diplopia (six cases), ptosis (five cases), hemianopia (four cases), and ataxia (two cases). Extent of tumor resection was Simpson grade II in 19 patients, grade...
|
PMID: 20148271
PDF is available here.
Abstract
Navigation using anatomical landmarks for registration is a reliable method in the localization of the TSSJ for retrosigmoid craniotomies and thereby avoiding unnecessary sinus exposure. In addition, the method proved to be fast and accurate. The asterion was found to be a less accurate landmark for...
|
PMID: 19902141
PDF is available here.
Abstract
Our data showed no evidence of an association between retinal vascular calibers and incident late-life depression....
|
PMID: 20429085
PDF is available here.
Abstract
During the follow-up (mean duration=30+/-10 months), group A showed a significantly lower TVR (6%) and MACCE rate (14%), compared with group B (TVR: 12%, P=0.032; MACCE: 24%, P=0.002). However, there was no difference in the rate of death, myocardial infarction, or cerebrovascular accidents between...
|
PMID: 20168221
PDF is available here.
Abstract
Mean aortic PWV was 7.1 +/- 2.5 m/s. Aortic PWV was independently associated with LV ejection fraction (ss = -0.406, P = 0.006), LV stroke volume (ss = -0.407, P = 0.001), LV cardiac output (ss = -0.458, P = 0.001), and with cerebral WMHs (P < 0.05). There were no independent associations between ao...
|
PMID: 19915847
PDF is available here.
Abstract
The aim of this study was to perform perfusion CT imaging in the acute phase of myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), to assess whether these patients had cerebral perfusion abnormalities. Furthermore, the pathology of muscle vessel was evaluated, to explore the...
|
PMID: 20483008
PDF is available here.
Abstract
We aimed to determine the prevalence and severity of cerebrovascular pathologies in DLB and PD and to analyze their relationship to LB pathology. The prevalence and severity of atherosclerosis in the circle of Willis, cerebral amyloid angiopathy, cerebral infarcts, hemorrhages, small-vessel disease,...
|
PMID: 20418782
PDF is available here.
Abstract
Recent research revealed that patients with spatial hemineglect show deficits in the judgment of the subjective vertical and horizontal. Systematic deviations in the subjective axes have been demonstrated in the visual and tactile modality, indicating a supramodal spatial orientation deficit. Furthe...
|
PMID: 20138897
PDF is available here.
Abstract
We have demonstrated that tissue kallikrein through kinin B2 receptor signaling exhibits a wide spectrum of beneficial effects by reducing cardiac and renal injuries, restenosis and ischemic stroke, and by promoting angiogenesis and skin wound healing, independent of blood pressure reduction. Protec...
|
PMID: 20180644
PDF is available here.
Abstract
Intravascular sonography is a valuable tool for the morphologic assessment of coronary atherosclerosis and the effect of pharmacologic and nonpharmacologic interventions on the progression or stabilization of atherosclerosis. An analysis of the different modes, applications, and limi...
|
PMID: 20133387
PDF is available here.
Abstract
The total number of residents died of CVD between 2004 and 2005 was 194 932 (male 108 414, female 86 518, urban 63 397, rural 131 535) in survey districts. The crude death rates of CVD were 136.6 per 100 000 and the standardized death rate was 120.1 per 100 000. The crude death rates of CVD were 148...
|
PMID: 20654139
PDF is available here.
Abstract
Superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass is a well-established, indispensable neurosurgical procedure. It is technically challenging, and surgeons must be prepared for unexpected problems. The present report describes four cases where problems arose that resulted in gra...
|
PMID: 20210534
PDF is available here.
Abstract
A 14-year-old girl was diagnosed with macrophage activation syndrome, based on clinical presentation, laboratory tests, and bone marrow aspirate findings. She developed severe central nervous system involvement in the form of seizure disorder and severe diffuse occlusive cerebral vasculopathy, with...
|
PMID: 20304334
PDF is available here.
Abstract
Of the 20 patients studied, 10 had improvements on their tinnitus visual analogue score intensity postoperatively, 8 were unchanged, and 2 worsened. On the Tinnitus Questionnaire scores, 7 of 13 patients improved and 6 of the 13 patients worsened. If decompression is performed before the end of the...
|
PMID: 20305490
PDF is available here.
Abstract
We identified 156 CLH cases published from 1975 to 2008. The more frequent pathologies in association with CLH were the vascular ones (38.5%, n = 57), followed by tumours (25.7%, n = 38) and inflammatory infectious diseases (13.5%, n = 20). Eighty were excluded from further analysis, because of inad...
|
PMID: 19735480
PDF is available here.
Abstract
We investigated associations among BP, brain structure, and neuropsychological functioning in 52 middle-older-age African Americans without diagnosed history of CVD. All participants underwent diffusion tensor imaging for examination of white matter integrity, indexed by fractional anisotropy (FA)....
|
PMID: 20230114
PDF is available here.
Abstract
Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs. Treatment aimed at vascular risk factors in patients with early Alzheimer disease may be beneficial, possibly in an even earlier stage of the disease....
|
PMID: 20056923
PDF is available here.
Abstract
Although prevalent in patients with vascular risk factors and stroke, enlarged perivascular spaces are specifically associated with lacunar ischemic stroke and white matter hyperintensities. Further studies should determine the mechanism of this association while including adequate controls to accou...
|
PMID: 20056930
PDF is available here.
Abstract
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether pH-stat or alpha-stat is the best technique to follow in patients undergoing deep hypothermic circulatory arrest. Altogether 206 papers were found using the rep...
|
PMID: 19914925
PDF is available here.
Abstract
We aimed to review the literature regarding the current most promising advanced imaging techniques in carotid artery disease. Various advanced imaging methods are available, such as high-resolution magnetic resonance imaging (HR-MRI), single photon emission computed tomography (SPECT), positron emis...
|
PMID: 20031452
PDF is available here.
Abstract
We demonstrated a significant relationship between arterial stiffness and prevalence of electrocardiographically determined LVH and atrial remodeling, independent of 24-h blood pressure. Individuals belonging to the highest quartile of arterial stiffness (QKD100-60 <195 ms) had double the risk of EC...
|
PMID: 19881389
PDF is available here.
Abstract
BP lowering reduces the risk of major vascular events, with separately significant reductions, in both Asia and the West....
|
PMID: 19864958
PDF is available here.
Abstract
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty-six n...
|
PMID: 20014112
PDF is available here.
Abstract
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty-six n...
|
PMID: 20014112
PDF is available here.
Abstract
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty-six n...
|
PMID: 20014112
PDF is available here.
Abstract
Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs. Treatment aimed at vascular risk factors in patients with early Alzheimer disease may be beneficial, possibly in an even earlier stage of the disease....
PDF is available here.
Abstract
Cardiovascular disease (CVD) remains the top cause of global mortality. There is considerable evidence that supports the mortality and morbidity benefit of statin therapy in coronary heart disease (CHD) and stroke, both in primary and secondary prevention settings. Data also exist pointing to the ad...
|
PMID: 20957130
PDF is available here.