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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Central Nervous System Diseases (9):
Recent article
Central Nervous System Diseases
New England Journal of Medicine (365)14 2011
Abstract
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New England Journal of Medicine (365)14 2011
Abstract
We enrolled neonates with HSV disease in two parallel, identical, double-blind, placebo-controlled studies. Neonates with central nervous system (CNS) involvement were enrolled in one study, and neonates with skin, eye, and mouth involvement only were enrolled in the other. After completing a regime...
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PMID: 21991950
PDF is available here.
PDF is available here.
Abstract
Tuberculosis of the spine (Pott's disease) is the most common skeletal involvement in tuberculosis, and is often accompanied with neurological deficiency. Surgical treatment was previously the mainstay of therapy in cases of Pott's disease with neurological deficiency, but since clin...
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PMID: 21678648
PDF is available here.
PDF is available here.
Abstract
Ugeskrift for laeger (172)48 2010
Abstract
We present six cases with different manifestations of neurosarcoidosis. There are no specific diagnostic tests for sarcoidosis. In the presented cases the diagnosis was made by histological proof of noncaseating granulomas. Patients with systemic sarcoidosis and neurological symptoms should be teste...
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PMID: 21118667
PDF is available here.
PDF is available here.
Abstract
The human brain contains more than 100 trillion (10(14)) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies hav...
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PMID: 21068831
PDF is available here.
PDF is available here.
Abstract
Systemic toxicity, usually from overdose or intravascular dose, is feared because it mainly affects the heart and brain, and may be acutely life-threatening.
Pharmacological studies of local anesthetic toxicity have largely been reviewed primarily relating to the evaluation of ropivacaine and levobu...
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PMID: 20738226
PDF is available here.
PDF is available here.
Cellular Signalling (22)11 2010
Abstract
We review the cell and molecular biology as well as the prominent pathophysiological aspects of the endothelin system.
Copyright (c) 2010. Published by Elsevier Inc....
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PMID: 20466059
PDF is available here.
PDF is available here.
Abstract
The 5-HT(2C) receptor is a GPCR and is one of the 14 subtypes that constitute the serotonin receptor family. The 5-HT₂(C) receptor is exclusively expressed in the CNS where it demonstrates a wide distribution and displays high-affinity interactions with a wide variety of psychiatric medications. M...
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PMID: 20849206
PDF is available here.
PDF is available here.
Abstract
A number of G-protein-coupled receptors (GPCRs) are currently under consideration as potential therapeutic targets for drugs acting in the central nervous system (CNS). Attempts to discover new medications have operated under the assumption that GPCRs are monomers and that a specific...
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PMID: 20632968
PDF is available here.
PDF is available here.
Abstract
We discuss this plasticity of the endocannabinoid system during the aforementioned central nervous system disorders, as well as its dysregulation, both of which have opened the way to the use of either direct and indirect activators or blockers of CB₁ and CB₂ receptors for the treatment of the s...
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PMID: 20632970
PDF is available here.
PDF is available here.
Abstract
Our understanding of the complex signaling neurophysiology of the central nervous system has facilitated the exploration of potential novel receptor-ligand system targets for disorders of this most complex organ. In recent years, many relatively neglected receptor-ligand systems have been re-evaluat...
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PMID: 20632965
PDF is available here.
PDF is available here.
Abstract
Astrocytes are often referred to, and historically have been regarded as, support cells of the mammalian CNS. Work over the last decade suggests otherwise-that astrocytes may in fact play a more active role in higher neural processing than previously recognized. Because astrocytes can potentially se...
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PMID: 20880499
PDF is available here.
PDF is available here.
Abstract
Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies. Although its roles in CNS pathology are only beginning to be defined, genetic tools are enabling molecular dissection of the functions and mechanisms of reactive astrogliosis in vivo. It is now clear that reac...
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PMID: 20880511
PDF is available here.
PDF is available here.
Abstract
Neurosarcoidosis may be a serious complication of sarcoidosis. As the presentation of neurosarcoidosis is manifold, solitary nervous system sarcoidosis without systemic activity remains a difficult diagnosis. Appropriate treatment may be a dilemma.
Most neurosarcoidosis patients present with neurolo...
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PMID: 20671516
PDF is available here.
PDF is available here.
Chemmedchem (5)8 2010
Abstract
Abstract
Abstract
Abstract
The use of MRI-based imaging in drug development has received increased interest recently because of the difficulties associated with the development of CNS pharmacotherapies. While not yet routine, there have been significant advances in imaging that allow this technology to be used for evaluating...
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PMID: 20571972
PDF is available here.
PDF is available here.
Abstract
We sought to translate and validate the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG), a multidimensional cognitive screening tool.
We used multiple language specialists to translate and then back-translate the NUCOG, and administered the Persian language NUCOG and Mini-Mental State Examina...
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PMID: 20523051
PDF is available here.
PDF is available here.
Abstract
The incidence of specific intracranial parenchymal lesions of HIV-infected patients varies considerably between countries. In the Republic of Korea, the number of HIV-infected patients is increasing, but little is known regarding the spectrum of intracranial parenchymal lesions in these patients. Th...
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PMID: 20592890
PDF is available here.
PDF is available here.
Abstract
Neurological Research (32)6 2010
Abstract
Rosai-Dorfman disease involving the central nervous system appears to be more common than previously thought and may well assume a more prominent place in the differential diagnoses of dural-based lesions. Expert awareness of the characteristic histopathology and immunohistochemistry of the disease...
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PMID: 20350368
PDF is available here.
PDF is available here.
Abstract
The risk of thromboembolic events in patients who received recombinant Factor VIIa for anticoagulation-associated ICH was not higher than that seen in patients treated for spontaneous ICH in the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial. Spontaneous deep vein thrombosis was the most com...
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PMID: 20522813
PDF is available here.
PDF is available here.
Abstract
Etanercept is a potent antagonist of TNF, a pleotropic immune signaling molecule that is also a pivotal regulator of synaptic function. Excess TNF is centrally involved in the pathogenesis of a variety of inflammatory neurological disorders, including Alzheimer's disease, sciatica, traumatic brain i...
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PMID: 20518613
PDF is available here.
PDF is available here.
Biomedical Papers (154)2 2010
Abstract
The cerebellum is a very complex structure with many motor/non-motor functions and direct and indirect connections with almost the entire central nervous system. Transcranial magnetic stimulation (TMS) is a non-invasive electrophysiological method for studying, diagnosing, and treating disorders of...
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PMID: 20668494
PDF is available here.
PDF is available here.
Abstract
Adenosine-dopamine interactions in the central nervous system (CNS) have been studied for many years in view of their relevance for disorders of the CNS and their treatments. The discovery of adenosine and dopamine receptor containing receptor mosaics (RM, higher-order receptor heter...
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PMID: 20345970
PDF is available here.
PDF is available here.
Abstract
We examine neurological and psychopathological conditions associated with dysfunctions in the interaction of acetylcholine and dopamine and conventional and new pharmacological approaches to treat these disorders....
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PMID: 20370804
PDF is available here.
PDF is available here.
Abstract
Endocannabinoids and their receptors, mainly the CB(1) receptor type, function as a retrograde signaling system in many synapses within the CNS, particularly in GABAergic and glutamatergic synapses. They also play a modulatory function on dopamine (DA) transmission, although CB(1) re...
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PMID: 20406253
PDF is available here.
PDF is available here.
Neuromolecular Medicine (12)2 2010
Abstract
Neurologic disease promoted by microbial pathogens, sterile injury, or neurodegeneration rapidly induces innate immunity in adjacent healthy tissue, which in turn contributes extensively to neurologic injury. With more recent focus on innate immune processes, it appears that necrotic...
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PMID: 19830599
PDF is available here.
PDF is available here.
Neuromolecular Medicine (12)2 2010
Abstract
We review the role of cytokines as mediators and regulators of microglial activity in inflammatory demyelination, highlighting their importance in potentiating cell damage, promoting neuroprotection and enhancing cellular repair in a context-dependent manner....
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PMID: 20411441
PDF is available here.
PDF is available here.
Ideggyogyaszati szemle (63)5-6 2010
Abstract
Abstract
Acute kidney injury (AKI) is frequently encountered in the intensive care unit, and from its inception, morbidity and mortality increase in these patients compared to those without AKI. Despite numerous clinical trials and newer pharmacological agents, very little progress has been made to reduce th...
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PMID: 20427965
PDF is available here.
PDF is available here.
Deutsche Medizinische Wochenschrift (135)25-26 2010
Abstract
Abstract
Nippon Ganka Gakkai zasshi (114)6 2010
Abstract
We report a case of Fisher syndrome accompanied by ocular flutter. A 19-year-old man presented with diplopia and vertigo, associated with preceding symptoms of common cold. Since symmetric weakness of abduction in both eyes, truncal ataxia, diminution of tendon reflexes, and gaze nystagmus were note...
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PMID: 20593660
PDF is available here.
PDF is available here.
Abstract
We show that this radiotracer has a high in vitro specificity for PBR/TSPO versus central benzodiazepine receptors, as reflected by the drastic reduction of its binding to target tissue by addition of PK11195 or PBR111, while addition of flumazenil does not affect binding. Only intact [(18)F]PBR111...
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PMID: 20069292
PDF is available here.
PDF is available here.
Abstract
The theoretical risk of local anaesthesia toxicity when these systems are used together is negligible and we conclude that peri-articular multimodal drug infiltration is safe in conjunction with the use of autotransfusion drains....
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PMID: 20501020
PDF is available here.
PDF is available here.
Medicine (Baltimore) (89)3 2010
Abstract
We conducted this study to analyze the frequency of these complications, before and after the use of daclizumab induction therapy. We reviewed all neurologic complications in our HT cohort, comparing infectious with non-infectious complications over 2 periods of time in which different induction the...
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PMID: 20453603
PDF is available here.
PDF is available here.
Abstract
Children with injury to the central nervous system (CNS) exhibit a variety of language disorders that have been described by members of different disciplines, in different journals, using different descriptors and taxonomies. This paper is an overview of language deficits in children with CNS injury...
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PMID: 20397297
PDF is available here.
PDF is available here.
Abstract
Glial cells in the CNS are likely to communicate with other glial cells and neurons through secreted proteins. Glia-derived proteins also participate in neuroinflammation, which is a major component of neurodegenerative disease. Cerebrospinal fluid (CSF) is the biological fluid that best reflects th...
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PMID: 20377392
PDF is available here.
PDF is available here.
Abstract
Damage to the nervous system is a common side effect of antineoplastic therapy. The improvements in treating systemic malignancies have been accompanied by the reports of neurological toxicity that has important impact on quality of life and may even limit the use of the treatment. Neurotoxicity can...
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PMID: 20167398
PDF is available here.
PDF is available here.
Revista de Neurologia (50)7 2010
Abstract
INTRODUCTION: One of the main matters of drug administration into the central nervous system (CNS) is to cross the blood/brain barrier. For this reason, in some cases the drug does not reach the therapeutic level or is necessary to use some special systems to get a right administration. AIM: To pres...
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PMID: 20387211
PDF is available here.
PDF is available here.
Neurological Research (32)3 2010
Abstract
The incidence of congenital cytomegalovirus infection reported from Latin American countries ranges from 0 to 6.8% in different settings. Congenital cytomegalovirus infection is a common cause of hearing deficits and mental impairment in children. However, the impact of this infection as a cause of...
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PMID: 20406606
PDF is available here.
PDF is available here.
Psychological Medicine (40)4 2010
Abstract
Of the patients, two-thirds had a poor outcome at 1 year. Illness beliefs and financial benefits are more useful in predicting poor outcome than the number of symptoms, disability and distress....
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PMID: 19627646
PDF is available here.
PDF is available here.
Abstract
We report our clinical experience with the use of intravenous colistin sulfate in critically ill patients hospitalized from January 2006 to October 2008, as a last treatment resort in China, and assess its effectiveness and adverse effects. Fifteen patients who suffered from severe infections caused...
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PMID: 20085424
PDF is available here.
PDF is available here.
Abstract
We have used cytosine arabinoside (ARA-C) with or without vincristine to treat eight patients with ND-CNS LCH. Patients: Seven male children and one young adult male with clinical and radiologic ND-CNS-LCH were treated with a regimen of vincristine 1.5 mg/m(2) on day 1 and ARA-C 100 mg/m(2) daily fo...
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PMID: 19908293
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Our data show that a part of the steroids may be synthesized de novo in the CNS. However, substantial part of the steroid metabolites may be synthesized in the CNS from the steroid precursors or directly transported from the periphery. The CNS in situ synthesis and transport from periphery might be...
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PMID: 20036740
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
Berberine, an isoquinoline alkaloid of the protoberberine type found in an array of plants, has been used in Indian and Chinese medicines as an antimicrobial, stomachic, bitter tonic and in the treatment of oriental sores. Although pharmacological investigations of berberine have bee...
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PMID: 19998323
PDF is available here.
PDF is available here.
Neurologist (16)2 2010
Abstract
: POLG1 mutations result in extremely heterogenous phenotypes which often have overlapping clinical findings, making it difficult to categorize patients into syndromes. The lack of signs of mitochondrial dysfunction in the muscle biopsy does not exclude a POLG1-related disease. Analysis of mtDNA of c...
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PMID: 20220442
PDF is available here.
PDF is available here.
Abstract
Glial cells in the central nervous system (CNS) consist of a heterogeneous population of cell types, each characterized by distinct morphological features, physiological properties, and specific markers. In contrast to the previous view that glial cells were passive elements in the b...
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PMID: 20596927
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
Borna disease is a severe viral-induced disorder of the central nervous system of horses, sheep, and a few other animal species, occurring in certain areas of central Europe. Pathogenesis and epidemiology of natural Borna disease virus (BDV) infections are still not fully understood;...
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PMID: 20133953
PDF is available here.
PDF is available here.
Abstract
The identification of tumor mimics may be difficult under the best of circumstances, and maintaining a broad differential diagnosis as well as application of a variety of immunocytochemical and occasionally ultrastructural and/or molecular genetic methods is essential to arrive at a correct diagnosi...
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PMID: 20196668
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)8 2010
Abstract
We present an exceptional case of neuro-Behçet in a 38-year-old Caucasian Danish woman. On account of the risk of serious complication, it is important to make the diagnosis as soon as possible....
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PMID: 20184824
PDF is available here.
PDF is available here.
Abstract
There is an increasing interest in nootropic drugs for the treatment of CNS disorders. Since the last meta-analysis of the clinical efficacy of piracetam, more information has accumulated. The primary objective of this systematic survey is to evaluate the clinical outcomes as well as the scientific...
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PMID: 20166767
PDF is available here.
PDF is available here.
Abstract
To understand the cause of death of 405 marine mammals stranded on Cape Cod and southeastern Massachusetts between 2000 and 2006, a system for coding final diagnosis was developed and categorized as (1) disease, (2) human interaction, (3) mass-stranded with no significant findings, (4) single-strand...
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PMID: 20225675
PDF is available here.
PDF is available here.
Abstract
We demonstrate proper technique for three routes of systemic drug delivery: intravenous injection, intraperitoneal injection, and oral gavage. In addition, we show a method for local delivery to the brain: convection-enhanced delivery (CED). The use of fluorescently-labeled compounds is included for...
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PMID: 20736920
PDF is available here.
PDF is available here.
Abstract
The annual meeting of the American Society for Neural Therapy and Repair (ASNTR) has always introduced us to top-notch and up-to-date approaches for regenerative medicine related to neuroscience, ranging from stem cell-based therapy to novel drugs. The 16th ASNTR meeting focused on a variety of diff...
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PMID: 20305989
PDF is available here.
PDF is available here.