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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Chronobiology Disorders (2):
Recent article
Chronobiology Disorders
Autism Research (3)5 2010
Abstract
We recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis ("exploratory phase"), followed by intra- and inter-component cross-correlati...
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PMID: 20878720
PDF is available here.
PDF is available here.
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Brain research (1348) 2010
Abstract
Circadian disturbances, including a fragmented sleep-wake pattern and sundowning, are commonly reported early in the progression of Alzheimer's disease (AD). These changes are distinctly different from those observed in non-pathological aging. Transgenic models of AD are a promising...
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PMID: 20471965
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (35)7 2010
Abstract
We present a revision of our previously published model of circadian effects in cancer (Sephton and Spiegel, 2003) based on evaluation of new data from divergent lines of investigation. Human clinical studies show circadian endocrine disruption may be accompanied by suppressed functional cellular im...
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PMID: 20097011
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)6 2010
Abstract
We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) an...
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PMID: 20072116
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
We investigate the effects of cadmium on the 24 h changes of aspartate, glutamate, and glutamine content in the pituitary. Adult male Sprague-Dawley rats were treated with 25 or 50 mg/l of cadmium chloride (CdCl(2)) in the drinking water for 30 days. Metal exposure with the lowest dose induced the d...
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PMID: 19636671
PDF is available here.
PDF is available here.
Sleep Medicine (11)4 2010
Abstract
Of 5107 respondents, 3403 (mean age: 51.0years, women: 52.6%) were used for the analysis after exclusion of missing PSQI data. The PSQI global score (mean: 4.9) increased as the number of comorbid conditions increased in a linear and statistically significant manner (p<0.0001). The PSQI global score...
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PMID: 20219425
PDF is available here.
PDF is available here.
Sleep Medicine (11)4 2010
Abstract
Visual inspection of the 293-day plot of the sleep log disclosed a regular 42-day rhythm of insomnia recurrence confirmed by a Discrete Fourier Transform. During the periods of insomnia, lasting 5-7days, only moderate mood symptoms (depressive overlapping hypomaniac symptoms) were present. Treatment...
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PMID: 20133194
PDF is available here.
PDF is available here.
Sleep Medicine (11)4 2010
Abstract
Abstract
This paper summarizes the rationale for, possible mechanisms of, and problems related to risk assessment of the association between shift work and cancer. The mechanisms by which circadian disruption may favor the induction and/or promotion of malignant tumors are complex and multifactorial. The mul...
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PMID: 20126969
PDF is available here.
PDF is available here.
Revista de Neurologia (50 Suppl 2) 2010
Abstract
Subjective or objective sleepiness assessment should routinely be performed by physicians looking after Parkinson's disease patients. Management is difficult and should be targeted to the specific sleep disorder and its likely cause....
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PMID: 20205138
PDF is available here.
PDF is available here.
La Medicina del lavoro (101)6 2010
Abstract
Healthcare workers may be exposed to a variety of biological hazards. Although many studies have shown that some immunological alterations were related to work stress and sleep disorders, few studies investigated effects of shiftwork on the immunological system.
The aim of the study was to compare t...
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PMID: 21141454
PDF is available here.
PDF is available here.
médecine/sciences (26)1 2010
Abstract
Cellular rhythms represent a field of choice for studies in system biology. The examples of circadian rhythms and of the cell cycle show how the experimental and modeling approaches contribute to clarify the conditions in which periodic behavior spontaneously arises in regulatory networks at the cel...
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PMID: 20132775
PDF is available here.
PDF is available here.
Abstract
We review a few recently developed concepts regarding the high incidence of CVD in CKD patients....
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PMID: 20103816
PDF is available here.
PDF is available here.
Abstract
A disruption of the circadian timing system, as identified by monitoring of marker biorhythms, is common in cancer patients. The recording of the rest-activity rhythm with a wrist actigraph has been commonly used. This noninvasive monitoring allows a robust estimation of circadian di...
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PMID: 20050374
PDF is available here.
PDF is available here.
Abstract
Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergo...
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PMID: 19926609
PDF is available here.
PDF is available here.
Abstract
Accumulation of epidemiological evidence has accelerated in recent years, reflected in an International Agency for Research on Cancer (IARC) classification of shift work as a probable human carcinogen (2A). There is also a strong rodent model in support of the light-at-night (LAN) idea. CONCLUSION:...
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PMID: 19380369
PDF is available here.
PDF is available here.
Abstract
We aimed to compare performance on the PVT and on an addition test (ADD) across a 6-week FD study, to determine whether practice effects were present and to analyze the circadian and wake-dependent modulation of the 2 measures....
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PMID: 19639753
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
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PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
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PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
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PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
|
PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
|
PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
|
PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
|
PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
|
PMID: 18842366
PDF is available here.
PDF is available here.
Brain and Development (31)6 2009
Abstract
We examined hypothalamic dysfunctions in a XLAG case with a novel mutation of the ARX gene, and performed immunohistochemical evaluation of the diencephalons in autopsy brain. A 1-year-old boy showed intractable epilepsy, persistent diarrhea and disturbed temperature regulation. This case had abnorm...
|
PMID: 18842366
PDF is available here.
PDF is available here.
Autism Research (2)2 2009
Abstract
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by delayed/abnormal language development, deficits in social interaction, repetitive behaviors and restricted interests. The heterogeneity in clinical presentation of ASD, likely due to different etiologies, complicates g...
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PMID: 19418574
PDF is available here.
PDF is available here.
Toxicology Letters (185)3 2009
Abstract
These results suggest that cadmium exposure affects GABA and taurine daily pattern in the median eminence and anterior pituitary, and those changes explain, at least in part, the modification in the regulatory pattern of prolactin secretion....
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PMID: 19382341
PDF is available here.
PDF is available here.
Abstract
Psychiatria polska (43)5 2009
Abstract
Sleep disturbances are a very sensitive indicator, which allows identifying various psychic illnesses, especially depression. Irrelevant of the very nature of sleep disturbances, their presence can tell us about the onset of depression or its ending. The mechanism of sleep disturbanc...
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PMID: 20214093
PDF is available here.
PDF is available here.
Abstract
We propose a multidimensional approach that includes several symptom domains, namely affective instability, circadian rhythm dysregulation, and cognitive and executive dysfunction, presenting in various combinations that give shape to each individual presentation, and offers potential indicators of...
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PMID: 18828143
PDF is available here.
PDF is available here.
Abstract
In October of 2007, an IARC panel of 24 scientists systematically evaluated epidemiologic, experimental, and mechanistic data and concluded that shift work that involves circadian or chronodisruption is probably carcinogenic in humans. In view of the possible scope of the problem--shift work is wide...
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PMID: 19277435
PDF is available here.
PDF is available here.
Abstract
Abstract
Discoveries in circadian biology have revealed that the biologic clocks, which control sleep/wake rhythms, are present in all cells and exert considerable control over the cell cycle. This has opened new opportunities for improving efficacy, decreasing toxicity, or both of cancer therapy through cir...
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PMID: 19023918
PDF is available here.
PDF is available here.
Abstract
It would be most useful to identify a biomarker of circadian dysregulation that could be used in epidemiologic studies of the effects of circadian disruption in humans. An indicator of circulating melatonin level has been shown to be a good biomarker of circadian dysregulation and has been associate...
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PMID: 19064543
PDF is available here.
PDF is available here.
Abstract
According to the results of HUT, 76 patients (31%) had cardioinhibitory, 62 patients (25%) had vasodepressor, and 108 patients (44%) had mixed type of VVS. During the initial passive phase, 40% of patients (99/246) showed positive response. Time to syncope was 20+/-2 minutes during HUT. The mean num...
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PMID: 19067810
PDF is available here.
PDF is available here.
Abstract
Until recently, sleep has been a mystery even to scientists. Research has defined sleep function and the effects of sleep deprivation. Sleep disorders are interrelated with medical and psychiatric illnesses. This article presents insomnia, jet lag, and shift work sleep disorders and reviews issues r...
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PMID: 18928832
PDF is available here.
PDF is available here.
Abstract
For two decades, research has been suggested and conducted into the causation and development of cancers in seemingly diverse and unrelated populations such as blind individuals, shift-workers, flight personnel, Arctic residents and subsets of sleepers. One common denominator of these investigations...
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PMID: 19112419
PDF is available here.
PDF is available here.
Revue medicale suisse (4)181 2008
Abstract
We review the health disorders that may be generated or aggravated by shift work and illustrate the problem by two case studies of occupational medicine and discuss the appropriate attitude to take....
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PMID: 19066146
PDF is available here.
PDF is available here.
Clinical Journal of Oncology Nursing (12)5 Suppl 2008
Abstract
Cancer-related fatigue (CRF) is influenced and modulated by a number of critical factors, and the mechanism that is both necessary and sufficient to induce development of severe fatigue in patients with cancer has not yet been identified. Specific research efforts to understand the factors that may...
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PMID: 18842520
PDF is available here.
PDF is available here.
Abstract
Recent progress in understanding chronobiological and sleep regulation mechanisms may provide novel insights and avenues into the development of new pharmacological and behavioral treatment strategies for mood disorders....
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PMID: 18680211
PDF is available here.
PDF is available here.
Nature Reviews: Genetics (9)10 2008
Abstract
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the geneti...
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PMID: 18802415
PDF is available here.
PDF is available here.
Abstract
Activation of dopamine D2Rs by B favorably affects impaired nyctohemeral GH secretion in obese women. Reduced dopaminergic neuronal signaling might be involved in the pathogenesis of obesity associated hyposomatotropism....
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PMID: 18559918
PDF is available here.
PDF is available here.
Abstract
We studied the relationship between circadian rhythm and Pai-1, t-PA, TF and ET-1 in normal and atherosclerotic mice. Atherosclerosis was developed in apoE-/- mice fed a normal diet or a high cholesterol diet. The expression of Pai-1, t-PA, TF and ET-1 in the hearts of control C57BL/6J mice and athe...
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PMID: 18636167
PDF is available here.
PDF is available here.
Abstract
Abstract
Clock genes regulate mammalian circadian rhythms, and dysfunction of clock genes can contribute to various disorders. To investigate whether obstructive sleep apnoea syndrome (OSAS) influences clock gene function, the present authors examined Period1 (Per1) mRNA expression in vitro and in vivo. In e...
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PMID: 18321934
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (269)1-2 2008
Abstract
Tuberculous meningitis is associated with significant alteration of sleep-wake circadian cycles. This needs to be further characterized through studies involving polysomnography. There is a need to address these specific sleep difficulties to improve the quality of life of the patient as well as the...
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PMID: 18294655
PDF is available here.
PDF is available here.
Abstract
Biological rhythms are periodic phenomena entrained to environmental changes by exogenous factors called synchronizers or entraining agents namely the light-dark cycle, the rest-activity cycle and the seasons, among others. In humans the major synchronizers are the light-dark and rest activity cycle...
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PMID: 18706343
PDF is available here.
PDF is available here.
Abstract
IG and KG had significant lower pain intensities compared to the NG. The NG even experienced an increase in pain intensity. The results of the MDBF suggest an unspecific relaxing effect of the intervention in IG and KG. Twice during the treatment a significant decrease of the pulse rate could be obs...
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PMID: 18622133
PDF is available here.
PDF is available here.
Neuroscience Letters (437)2 2008
Abstract
Narcolepsy is characterized, beside other features, by excessive daytime sleepiness and disturbed sleep at night. The pineal hormone melatonin may affect the sleep characteristics. The aim of the study was to compare the circadian rhythm in salivary melatonin in narcoleptic patients with that in con...
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PMID: 18436380
PDF is available here.
PDF is available here.
Abstract
Neurotoxicity Research (13)2 2008
Abstract
While certain circadian hormonal changes are prominent, their predictable assessment requires a standardization of conditions of sampling. The 24-hour rhythm in circulating corticosterone of rodents, known since the 1950s, was studied as a presumed proxy for stress on 108 rats divided into 9 groups...
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PMID: 18515211
PDF is available here.
PDF is available here.
Abstract
Recently, two mouse strains carrying mutant alleles of the alpha4 subunit of the nicotinic acetylcholine receptor that are associated with autosomal dominant nocturnal frontal lobe epilepsy have been found to show spontaneous seizures. Recordings from neocortical pyramidal neurons in vitro show that...
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PMID: 18317273
PDF is available here.
PDF is available here.
Neuroscience (152)3 2008
Abstract
We investigated the effects of acute ethanol on both glutamatergic and serotoninergic resetting of the mouse SCN clock in vitro. We show that ethanol dose-dependently inhibits glutamate-induced phase shifts and enhances serotonergic phase shifts. The inhibition of glutamate-induced phase shifts is n...
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PMID: 18313227
PDF is available here.
PDF is available here.
Circulation Research (102)5 2008
Abstract
We show here that impaired circadian rhythmicity is related to a decrease of NO production with aging. Treatment with an NO donor significantly upregulated the promoter activity of the clock gene Period via the cAMP response element-dependent and the E-box enhancer element-dependent pathways. Both p...
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PMID: 18218984
PDF is available here.
PDF is available here.
Abstract
When PSG was performed early (before the end of the first half of the symptomatic period), an important reduction in slow wave sleep (SWS) was always present with progressive return to normal during the second half (with percentages very similar to those monitored during the asymptomatic period) des...
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PMID: 18316691
PDF is available here.
PDF is available here.
médecine/sciences (24)3 2008
Abstract
A network of feedback loops constitutes the basis for circadian timing in mammals. Complex transcriptional, post-transcriptional and post-translational events are also involved in the ticking of circadian clocks, allowing them to run autonomously with their characteristic, near-24h period. Central t...
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PMID: 18334175
PDF is available here.
PDF is available here.
Abstract
A comprehensive psychological account of the development of manic symptoms is needed to improve interventions for bipolar disorder. This review aims to develop the basis for such an account by covering three domains of evidence: (1) the multiple symptoms of mania; (2) the signs and symptoms leading...
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PMID: 17825463
PDF is available here.
PDF is available here.
Bipolar Disorders (10)2 2008
Abstract
In this Korean sample, patients with BDI showed a significantly greater preference for 'eveningness' (including delayed sleep timing) than control individuals. The influences of pharmacotherapy or clinical status on CSM scores need to be clarified....
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PMID: 18271906
PDF is available here.
PDF is available here.
Bipolar Disorders (10)2 2008
Abstract
These findings suggest that abnormal activity rhythms, including sustained phase advances, may represent enduring (trait) characteristics of BPD patients even during clinical recovery. If verified, such indices may be useful in supporting diagnoses and as an objective phenotype for genetic or other...
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PMID: 18271904
PDF is available here.
PDF is available here.