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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neurodegenerative Diseases (12):
- Shy-Drager Syndrome
- Heredodegenerative Disorders, Nervous System
- Parkinson Disease
- Olivopontocerebellar Atrophies
- Motor Neuron Disease
- Postpoliomyelitis Syndrome
- Lewy Body Disease
- Multiple System Atrophy
- Subacute Combined Degeneration
- Prion Diseases
- Paraneoplastic Syndromes, Nervous System
- Tauopathies
Recent article
Neurodegenerative Diseases
Proteomics (11)16 2011
Abstract
The HUPO Brain Proteome Project (HUPO BPP) held its 14th workshop during the HUPO 9th Annual World Congress in Sydney, Australia. The principal aim of this project is to discover prognostic and diagnostic biomarkers associated with neurodegenerative diseases and brain aging, with the...
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PMID: 21796782
PDF is available here.
PDF is available here.
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Abstract
We found 35 brains with deposits of 3 proteins (tau, β-amyloid, and α-synuclein). In these two series of brains, the high incidence of deposition of multiple proteins in neurodegenerative disorders is shown. Our results are in agreement with previous findings showing that tau, β-amyloid, and α-s...
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PMID: 21618706
PDF is available here.
PDF is available here.
Abstract
Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies of aging and neurodegenerative diseases suggests that mitochondrial function is defective in aging and neurodegenerative dis...
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PMID: 21470101
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We describe the molecular mechanisms regulating the ubiquitin proteasome system, thereby focussing on Nrf2 as well as on the recently identified transcription factor (TF) TCF11. In response to proteasome inhibition TCF11 plays a central role in upregulating the proteasome system via an ERAD-dependen...
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PMID: 21412055
PDF is available here.
PDF is available here.
Abstract
We identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human P...
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PMID: 21376232
PDF is available here.
PDF is available here.
Abstract
We focus on the recent main contribuitions of natural products chemistry to the discovery of new chemical entities usefull to the control and prevention of AD installation and progression. More than sixteen plant species, including Ginseng, Celastrus paniculatus, Centella asiatica, Curcuma longa, Gi...
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PMID: 20874701
PDF is available here.
PDF is available here.
Abstract
Mesenchymal stromal cells (MSC) are part of the bone marrow stem cells repertoire which also includes the main stem cells population of the bone marrow, the hematopoietic stem cells. The main role of MSCs is to support hematopoiesis but they can also give rise to cells of the mesoder...
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PMID: 20955154
PDF is available here.
PDF is available here.
Abstract
Under pathological conditions microglia (resident CNS immune cells) become activated, and produce reactive oxygen and nitrogen species and pro-inflammatory cytokines: molecules that can contribute to axon demyelination and neuron death. Because some microglia functions can exacerbate...
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PMID: 21143139
PDF is available here.
PDF is available here.
Natural Product Reports (28)1 2011
Abstract
A review with 187 references, describing natural products that exhibit bioactive properties relevant to the treatment of protein aggregation-related neurodegenerative diseases (e.g., Huntington's, Parkinson's, and prion diseases) and comparing the chemical properties of these secondary metabolite le...
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PMID: 20927454
PDF is available here.
PDF is available here.
Abstract
The rising epidemic of obesity is associated with cognitive decline and is considered as one of the major risk factors for neurodegenerative diseases. Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases. Increased metabo...
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PMID: 21639917
PDF is available here.
PDF is available here.
Abstract
We will present the current knowledge of caspase activation and activity pathways, the current tools for examining caspases, and functions of caspases in the nervous system in health and in disease. Alzheimer's Disease, the most common neurodegenerative disorder, and cerebral ischemia, the most comm...
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PMID: 21238939
PDF is available here.
PDF is available here.
BMC Medicine (9) 2011
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
PDF is available here.
BMC Medicine (9)1 2011
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
PDF is available here.
Abstract
The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parki...
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PMID: 21482412
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Nature Medicine (16)12 2010
Abstract
Nature Medicine (16)12 2010
Abstract
Nature Medicine (16)12 2010
Abstract
Nature Medicine (16)12 2010
Abstract
Abstract
Despite the capacity of chaperones and other homeostatic components to restore folding equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer and in metabolic and neurodegenerative diseases. Modulation of endogenous cellular defense mechanisms...
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PMID: 20446769
PDF is available here.
PDF is available here.
Abstract
Neurodegenerative diseases trigger neuronal cell death by a variety of endogenous suicide pathways. Although cell death may occur through highly heterogeneous processes, specific cell organelles and stress sensors have shown promise as potential therapeutic targets. The plasma membra...
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PMID: 20942793
PDF is available here.
PDF is available here.
Abstract
We describe here how conformational preferences of non-polar amino acid residues can affect amyloid formation. The most non-polar residues promote either β-strands (Val, Ile, Phe, and Cys, VIFC) or α-helices (Leu, Ala, and Met, LAM), while the most polar residues promote only α-helices. For 12 pr...
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PMID: 20971069
PDF is available here.
PDF is available here.
Abstract
We hypothesize that secretory factors from the activated astrocytes affect N-methyl-d-aspartate (NMDA) receptor, a major pathway implicated in HIV-1-associated neurodegeneration. To test this hypothesis, we studied effects of IL-1β-stimulated astrocyte conditioned medium (ACM+) for its ability to a...
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PMID: 20933498
PDF is available here.
PDF is available here.
Abstract
We review the molecular mechanisms involved in the neurotoxic action of pesticides, with emphasis on the mechanisms associated with the induction of neuronal cell death by paraquat as a model for Parkinsonian neurodegeneration.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved....
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PMID: 20542017
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (285)45 2010
Abstract
We report cellular models of intracytoplasmic inclusions of α-synuclein, generated by introducing nucleation seeds into SH-SY5Y cells with a transfection reagent. Upon introduction of preformed seeds into cells overexpressing α-synuclein, abundant, highly filamentous α-synuclein-positive inclusio...
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PMID: 20805224
PDF is available here.
PDF is available here.
Abstract
We aim to give an overview of the current literature and patents for inhibitors of inflammatory oxidative enzymes in glia such as NADPH oxidase, myeloperoxidase, COX-2 and 5-lipooxygenase.
Recent literature and patents on natural products or small molecule-based inhibitors of glial oxidative enzymes...
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PMID: 20939683
PDF is available here.
PDF is available here.
Abstract
We discuss this plasticity of the endocannabinoid system during the aforementioned central nervous system disorders, as well as its dysregulation, both of which have opened the way to the use of either direct and indirect activators or blockers of CB₁ and CB₂ receptors for the treatment of the s...
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PMID: 20632970
PDF is available here.
PDF is available here.
Human Vaccines (6)11 2010
Abstract
Neurodegenerative diseases are still an area of unmet medical need. This is in contrast to our increasing knowledge on their pathology (e.g., Alzheimer's- (AD), Parkinson's (PD) disease). They are driven by the cerebral accumulation and aggregation of specific proteins (e.g., β-amyl...
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PMID: 20980801
PDF is available here.
PDF is available here.
Abstract
We review the mechanisms of neurotoxicity associated with chronic microglial activation and discuss the role of neuronal death and microglial ROS driving the chronic and toxic microglial phenotype.
Copyright © 2010 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier...
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PMID: 20880500
PDF is available here.
PDF is available here.
Abstract
The Modern Challenges in Therapeutic Protein Production conference hosted 44 delegates from the UK and Germany and was organized by EuroSciCon. The aim of the meeting was to look at the challenges that currently face the production of therapeutic proteins and to attempt to demystify some of the nove...
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PMID: 20973635
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
We focus in particular on recent findings on sirtuins for prevention of neurodegenerative diseases....
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PMID: 20840070
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
Mitochondrial dysfunction is a common hallmark of ageing-related diseases involving neurodegeneration. Huntington's disease (HD) is one of the most common monogenetic forms of neurodegenerative disorders and shares many salient features with the major sporadic disease of neurodegeneration, such as a...
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PMID: 20840068
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
We review how sirtuins contribute for aging and, in particular, for neurodegeneration and how they are becoming attractive targets for therapeutic intervention....
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PMID: 20840069
PDF is available here.
PDF is available here.
Abstract
The identification of xenobiotic metabolizing enzymes (i.e., CYP) and transporters (i.e., ABC transporters) (XMET) in the human brain, including the BBB, raises the question whether these transporters and enzymes have specific functions in brain physiology, neuropharmacology and toxicology.
Relevant...
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PMID: 20843279
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)38 2010
Abstract
Intrastriatal, foetal neural transplants can ameliorate symptoms in patients with Parkinson's and Huntington's disease, although not stop the primary cell-loss. Several issues must, however, be addressed before general or extended clinical use of cell therapy in neurodegenerative diseases can become...
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PMID: 20920404
PDF is available here.
PDF is available here.
Abstract
We provide a comprehensive search through several key patent collections. We have covered promising small molecule compounds which are being evaluated in different clinical trials as well as drugs currently available in the pharmaceutical market. In addition, readers will gain a deep insight into th...
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PMID: 20716023
PDF is available here.
PDF is available here.
Abstract
We identify an evolutionarily highly conserved modifier of aggregation, MOAG-4, as a positive regulator of aggregate formation in C. elegans models for polyglutamine diseases. Inactivation of MOAG-4 suppresses the formation of compact polyglutamine aggregation intermediates that are required for agg...
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PMID: 20723760
PDF is available here.
PDF is available here.
Ideggyogyaszati szemle (63)7-8 2010
Abstract
During his long practice as head physician of a neurological and psychiatrical department with over 100 beds performed the examination and department of more than a hundred thousand patients. Based on the acquired experience and the data of the most recent literature he treats every aspect of the ap...
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PMID: 20812449
PDF is available here.
PDF is available here.
Abstract
We present here the effects of a low-molecular-mass peptides fraction (Ba-V) from Bothrops atrox snake venom, on rat brain mitochondrial function. Ba-V did not induce the mitochondrial swelling and moreover, was as effective as cyclosporin A (CsA) to inhibit the calcium/phosphate-induced swelling, w...
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PMID: 20338188
PDF is available here.
PDF is available here.
Abstract
Human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people. The majority of the diseases are associated with pathogenic oligomers from misfolded proteins, eventually causing the formation of aggregates and the progressive loss of neurons in the brain and nerv...
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PMID: 20522007
PDF is available here.
PDF is available here.
Abstract
Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases leading to the generation of lipid peroxides, carbonyl proteins and oxidative DNA damage in tissue samples from affected brains. Studies from mouse models that express disease-specific mutant proteins associat...
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PMID: 20522012
PDF is available here.
PDF is available here.
Abstract
Abstract
Individuals with trisomy 21, also known as Down syndrome (DS), develop a clinical syndrome including almost identical neuropathological characteristics of Alzheimer's disease (AD) observed in non-DS individuals. The main difference is the early age of onset of AD pathology in individuals with DS, wi...
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PMID: 20522013
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)8 2010
Abstract
Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private fu...
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PMID: 20504161
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantifica...
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PMID: 20634706
PDF is available here.
PDF is available here.
Abstract
Abstract
We further proposed that the octameric structure (the SH2-ST4 model in this study) is the possible nucleus seed for MVGGVV protofibril formation. Our results also demonstrated that hydrophobic interaction is the principle driving force to stabilize the adjacent B-strands while the steric zipper invo...
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PMID: 20476794
PDF is available here.
PDF is available here.
Abstract
We note that these neurodegenerative disorders all share a common mechanistic theme in that depositions of misfolded protein in the brain is a key molecular feature underlying disease onset and/or progression. While previous studies have identified a number of drugs and nutraceuticals capable of int...
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PMID: 20653511
PDF is available here.
PDF is available here.
Abstract
We review how proteomics has been applied to neurodegenerative diseases in order to characterize the relationship existing between protein aggregation and mitochondrial alterations. Moreover, we highlight recent advances in the use of proteomics to identify protein modifications caused by oxidative...
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PMID: 20653508
PDF is available here.
PDF is available here.
Abstract
We describe our findings of N-terminally truncated tau in the brain in a subgroup of the tauopathies in which tau isoforms containing four microtubule-binding domains predominate. We also discuss the evidence for the involvement of proteases in the generation of tau pathology in neurodegenerative di...
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PMID: 20658996
PDF is available here.
PDF is available here.
Molecular Cell (39)2 2010
Abstract
We report that nitric oxide (NO) reacts with XIAP by S-nitrosylating its RING domain (forming SNO-XIAP), thereby inhibiting E3 ligase and antiapoptotic activity. NO-mediated neurotoxicity and caspase activation have been linked to several neurodegenerative disorders, including Alzheimer's, Parkinson...
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PMID: 20670888
PDF is available here.
PDF is available here.
Abstract
Impairment of olfaction is a characteristic feature of many neurodegenerative diseases. This review summarizes the available information about olfactory function in distinct neurodegenerative conditions and indicates the advantageous use of olfactory testing in the diagnosis of Parkinson's disease a...
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PMID: 20480126
PDF is available here.
PDF is available here.
Abstract
Glycosphingolipids (GSLs) and gangliosides are a group of bioactive glycolipids that include cerebrosides, globosides, and gangliosides. These lipids play major roles in signal transduction, cell adhesion, modulating growth factor/hormone receptor, antigen recognition, and protein tr...
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PMID: 20211931
PDF is available here.
PDF is available here.
Abstract
We have reviewed all the archival cases in the Queen Square Brain Bank for Neurological Disorders over a 20-year period with either a clinical diagnosis of corticobasal syndrome or pathological diagnosis of corticobasal degeneration in an attempt to identify the main diagnostic pitfalls. Of 19 patho...
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PMID: 20584946
PDF is available here.
PDF is available here.
Abstract
Annals of Neurology (68)1 2010
Abstract
Annals of Neurology (68)1 2010
Abstract
Annals of Neurology (68)1 2010
Abstract
Annals of Neurology (68)1 2010
Abstract