Abstract
We predicted recruitment of the left-hemispheric VWFA, identically to the sighted. Using functional magnetic resonance imaging, we show that activation during Braille reading in blind individuals peaks in the VWFA, with striking anatomical consistency within and between blind and sighted. Furthermor...
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PMID: 21333539
PDF is available here.
Abstract
To report a patient with a tumor-like corneal keloid.
Retrospective review of clinical features and histopathologic findings.
A 68-year-old woman with a remote history of an orbital tumor treated with radiation developed a corneal tumor. A biopsy of the tumor showed fibrocellular tissue, and her bli...
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PMID: 20856108
PDF is available here.
Abstract
Couching is an ancient treatment for cataract which is still practiced in some of the poorer developing countries, particularly in sub-Saharan Africa. The purpose of this study is to describe risk factors for couching and visual acuity outcomes in a nationally representative sample of adults aged 40...
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PMID: 20868252
PDF is available here.
Abstract
We present the prevalence and determinants of visual disabilities and status of cataract among citizens aged 50 years and older.
Residents of randomly selected houses and clusters participated in the survey. Opticians noted the presenting and the best corrected vision of participants from 49 cluster...
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PMID: 20868255
PDF is available here.
Abstract
To compare the effect of levodopa-carbidopa on the visual outcome of patients with indirect traumatic optic neuropathy (ITON), this randomized, double-blind, placebo-controlled study was conducted on 32 patients with ITON within 6 days after trauma. Patients underwent a complete ocular examination,...
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PMID: 20649490
PDF is available here.
Abstract
Age-related macular degeneration (AMD) is a progressive disease characterized in macula photoreceptors degeneration that leads to loss of central vision in elderly people, especially in developed countries. Many environmental and genetic factors have influence on the occurrence and progression of AM...
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PMID: 19673454
PDF is available here.
Abstract
The causes of blindness in Yemen were determined in people aged 50+ years in both a community- and hospital-based study and documented using WHO/PBL criteria. In the community sample of 707 individuals in a rural area of Taiz governorate the prevalence of bilateral blindness was 7.9% and the main ca...
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PMID: 21218720
PDF is available here.
Abstract
The gene therapy vector tgAAG76 (rAAV 2/2.hRPE65p.hRPE65) is in joint development by Targeted Genetics Corp, Moorfields Eye Hospital and the University of London. The vector is a recombinant adeno-associated virus vector that contains the human RPE65 gene under the control of the human RPE65 promote...
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PMID: 20677098
PDF is available here.
Abstract
Patients with corneal blindness secondary to autoimmune disease often fare poorly with available surgical treatments. Study of existing literature on prosthetic device complications in autoimmune diseases may help uncover common mechanisms of tissue destruction to establish perioperative immunomodul...
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PMID: 20662659
PDF is available here.
Abstract
I to care for German soldiers blinded in that war. Other schools in Germany followed. Observation by an American at one of the schools led to the creation of the first guide dog school in the United States in 1929, "The Seeing Eye." Additional U.S. schools were opened during and after World War II....
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PMID: 20731263
PDF is available here.
Abstract
The study was planned to evaluate the effect of loss of hearing and vision on balance and gait in 60 children, 20 of whom had hearing loss (M age = 9.3 yr., SD = 0.9), 20 who were visually impaired (M age = 12.2 yr., SD = 2.5), and 20 controls with no disability (M age = 9.4 yr., SD = 0.6). Standing...
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PMID: 21058587
PDF is available here.
Abstract
We count diabetes mellitus and the light color of the iris. Equivocal is the negative influence of ultraviolet rays....
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PMID: 21137473
PDF is available here.
Abstract
An initial VA less than LP using a penlight, a history of golf ball injury, and elapsed time more than 12 hours between ocular trauma and hospital arrival were associated with eyeball loss and ambulatory vision loss. Physicians should bear these factors in mind so that they can more effectively coun...
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PMID: 20068482
PDF is available here.
Abstract
In a retrospective survey, researchers identified 100 incidents of attacks on guide dogs by other dogs. These were reviewed in order to determine the number, severity and impact on the handler and dog, and the characteristics of the aggressors and victims. During the study period there were more tha...
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PMID: 20562376
PDF is available here.
Abstract
A 27-year-old man presented with rapid and severe visual loss in both eyes, together with pain behind the eyes. Visual acuities were light perception in both eyes. Pupillary constriction to light was minimal, and ophthalmoscopy results were normal. For a presumptive diagnosis of retrobulbar optic ne...
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PMID: 20414132
PDF is available here.
Abstract
We identified 23 additional cases of NAION during interferon alpha therapy. At least 12 of these patients suffered bilateral NAION. Patients lost vision 1-40 weeks after initiating therapy. Of 21 eyes that had documented initial and follow-up acuities, 8 improved, 1 worsened, and the rest remained s...
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PMID: 20351572
PDF is available here.
Abstract
A 30-year-old woman developed acute visual loss and optic disc elevation in the left eye after breastfeeding her second son. The initial diagnosis was optic neuritis. However, MRI showed a lesion in left intraorbital and intracanalicular optic nerve and several cerebral lesions with imaging features...
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PMID: 20351573
PDF is available here.
Abstract
New estimates show reduction in the number of people who are blind or suffer from vision impairment as a sequel of infectious diseases, while there is an increase in the number of people who are blind due to conditions related to longer life span and diabetes. Diabetic retinopathy is the leading cau...
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PMID: 21086731
PDF is available here.
Abstract
We generated a targeted null mutation Ush1c mouse model in which the first four exons of the Ush1c gene were replaced with a reporter gene. Here, we assessed the expression pattern of the reporter gene under control of Ush1c regulatory elements and characterized the phenotype of mice defective for U...
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PMID: 20211154
PDF is available here.
Abstract
Based on an overview of 186 cases of apoplectic pituitary adenoma presenting with monocular or binocular blindness, we highlight the importance of correct diagnosis and an early, but not necessarily emergency, surgery within the first week of admission to optimize visual outcome of such patients. Th...
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PMID: 20140630
PDF is available here.
Abstract
We describe here a 41-year-old man with profound vision deficit and episodic complete blindness associated with marked optic atrophy, spastic paraparesis, and sensory neuropathy without ataxia whose diagnostic evaluation revealed compound heterozygosity for two frataxin mutations, a 994 GAA repeat i...
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PMID: 20162437
PDF is available here.
Abstract
We show that mice with a Dermo1-Cre-mediated disruption of Lrp5 in osteoblast progenitor cells have normal embryonic skeletogenesis and normal skeletal growth and development postnatally. Histomorphometric analysis of 3-month-old adult mice revealed normal osteoblast numbers, bone formation rate, an...
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PMID: 20333369
PDF is available here.
Abstract
Incidence of visual impairment was high and significantly affected quality of life. Age-related cataract and OAG caused ~ 75% of blindness, indicating the need for public health action to increase appropriate cataract surgery and early OAG detection and treatment. Controlling DM and hypertension wou...
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PMID: 20512228
PDF is available here.
Abstract
Since children may not be able to complain of progressive reduction in optic acuity, visual assessment in infancy may present practical difficulties. The authors report a case of craniopharyngioma, which led a young child to early blindness before the correct diagnosis could be made. Similar to othe...
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PMID: 20367364
PDF is available here.
Abstract
I review my previous work related to understanding the limiting factors on reading, a task that is the primary complaint of many patients with age-related macular degeneration, the leading cause of visual impairment in the elderly. I also review my work related to enhancing visual functions in the n...
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PMID: 20010138
PDF is available here.
Abstract
SD-OCT evaluation of Nd:YAG laser treatment for Valsalva retinopathy confirmed the cleavage plane of the premacular hemorrhage. In addition, it revealed the exact location of the ILM disruptions caused by the laser spots, and the safety of the procedure, with no involvement of the underlying retinal...
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PMID: 19997743
PDF is available here.
Abstract
Between 1991-2006, nine patients below age 18 years, with a microbiologic documentation of Cryptococcus neoformans infection and no evidence of human immunodeficiency virus infection, were identified and treated at Chang Gung Children's Hospital. All exhibited central nervous system involvement. Sev...
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PMID: 20304330
PDF is available here.
Abstract
This case highlights the development of 2 ocular malignancies in the same eye of an HIV-positive patient, at different CD4 counts, allowing the authors to speculate on additional factors involved in the development of the second malignancy....
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PMID: 20370336
PDF is available here.
Abstract
Repeat MRI of the brain and orbits at this time revealed a 0.8 x 2.4-cm lesion of the left choroid plexus. LP revealed rare atypical B cells. The patient rapidly deteriorated and died a month later. CONCLUSION: Recognition of the potential for rapid progression and mortality in patients with PIOL is...
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PMID: 20370335
PDF is available here.
Abstract
We describe the zebrafish mutant bumper (bum), which shows a transient, tumour-like hyperproliferation of the lens epithelium as well as a progressively stronger defect in secondary fibre cell differentiation, which results in a significantly reduced lens size and ectopic location of the lens within...
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PMID: 20117205
PDF is available here.
Abstract
Central retinal vein occlusion (CRVO) remains one of the most common retinal vascular disorders that may lead to blindness. The etiology is unknown, however, predisposing factors such as hypertension, diabetes, atherosclerosis and hypercoagulable states have all been described. Local ophthalmic illn...
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PMID: 20812500
PDF is available here.
Abstract
Five patients were included, all females, ranging from 15 to 50 years of age. Four were emmetropic. One patient had undergone refractive photokeratectomy a few months before. All had risk factors for infectious complications. The fundamental causes of infections were diverse: bacterial abscesses, ke...
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PMID: 20223558
PDF is available here.
Abstract
We report a very rare case of a hydatid cyst in the infratemporal fossa, causing visual loss over a 10-day period, which disappeared with rapid surgical and medical treatment. CASE REPORT: A 14-year-old girl presented with right exophthalmos and visual loss. Over a 10-day period, her visual acuity h...
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PMID: 19941683
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We report the case of bilateral blindness following a bite from a carpet viper. The literature on the subject matter is reviewed and the possible mechanisms of snakebite-induced blindness are discussed....
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PMID: 20305112
PDF is available here.
Abstract
We examined the impact of this absence of sensory input on the development of the primary visual cortex (V1) in early postnatal Crx-/- mice, before wiring of the visual system is complete, and in adulthood. We revealed that Crx-/- mice did not exhibit gross anatomical differences in V1; however, the...
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PMID: 20034544
PDF is available here.
Abstract
Recent research has thrown considerable doubt on the claim that King George III suffered from variegate porphyria, but indicates that he suffered recurrent attacks of mania as part of his bipolar disorder. George III's last episode of ill health occurred during the final decade of his life (1810-20)...
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PMID: 20503691
PDF is available here.
Abstract
Fifty-nine patients with bilateral blindness from corneal disease were included in the study, of which 56 (95%) had bilateral corneal disease resulting from similar etiology and three (5%) of different etiology in both eyes. Twenty-two patients (37%) had simultaneous onset and 37 patients (63%) had...
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PMID: 20118783
PDF is available here.
Abstract
INTRODUCTION AND DEVELOPMENT: Neuroplasticity is a process by which neurons increase their connectivity with other neurons in a stable fashion as a consequence of experience, learning and both sensitive and cognitive stimulation. Different authors have shown a huge process of brain plasticity in bli...
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PMID: 20200843
PDF is available here.
Abstract
We describe two cases of acute vision loss due to giant cell arteritis. In both cases the erythrocyte sedimentation rate (ESR) was below 50 mm/hr and the presenting complaint was foggy vision followed by acute blindness. The cases are to some extent different, for example in the former case the pati...
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PMID: 20197597
PDF is available here.
Abstract
This study in 2005 evaluated the causes and major anatomical site of blindness and severe visual loss at a school for blind children in Isfahan province, Islamic Republic of Iran. All 211 students were examined according to the modified WHO/PBL eye examination record: 70.4% were blind, 24.3% had sev...
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PMID: 20799580
PDF is available here.
Abstract
We found that exacerbation of migraine headache by light is prevalent among blind individuals who maintain non-image-forming photoregulation in the face of massive rod/cone degeneration. Using single-unit recording and neural tract tracing in the rat, we identified dura-sensitive neurons in the post...
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PMID: 20062053
PDF is available here.