Abstract
We found no differences between students in engineering college versus medical college, or between schools and universities in different geographical locations within Pakistan....
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PMID: 20714688
PDF is available here.
Abstract
We identified three novel mutations in the pore-forming region of CNGA3 (L363P, G367V, and E376K) in patients diagnosed with achromatopsia. We assessed the expression and function of channels with these three new and two previously described mutations (S341P and P372S) in a heterologous HEK293 cell...
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PMID: 20506298
PDF is available here.
Abstract
The customized booth demonstrated illumination meeting CIE standards. The total error scores were overestimated by the classical and moment of inertia methods in all groups for room illumination compared with booth illumination, however overestimation was more significant in the diabetes group....
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PMID: 20532142
PDF is available here.
Abstract
We detected impaired responses using S-cone ERG and blue-on-yellow perimetry OS. We diagnosed this case as acute damage of the blue cone. CONCLUSION: S-cone damage can be determined by electro-physiological and psychophysical examinations in cases of unilateral color abnormality....
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PMID: 20593658
PDF is available here.
Abstract
Purpose. Color-vision deficiency is associated with abnormalities in color matching and color discrimination, but its impact on the ability of people to judge the constancy of surface colors under different lights (color constancy) is less clear. This work had two aims: first, to quantify the degree...
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PMID: 19892868
PDF is available here.
Abstract
We present three patients in whom the initial diagnosis of NTG was eventually revealed to be chiasmal compression secondary to a pituitary tumour. Case 1: a 79-year-old woman was treated for NTG for several months before a bitemporal haemianopia developed and imaging showed a pituitary tumour. Case...
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PMID: 19352595
PDF is available here.
Abstract
The control group had no difficulties in selecting the appropriate beads, while the experimental group had significantly more mistakes, particularly with colors in the blue-violet spectrum. Average scores for the total number correct for the control and experimental groups were 36 (100%) and 27 (74....
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PMID: 20363710
PDF is available here.
Maleeha Azam,
Rob W J Collin,
Syed Tahir Abbas Shah,
Aftab Ali Shah,
Muhammad Imran Khan,
Alamdar Hussain,
Ahmed Sadeque,
Tim M Strom,
Alberta A H J Thiadens,
Susanne Roosing,
Anneke I den Hollander,
Frans P M Cremers and
Raheel Qamar
Abstract
Genetic analysis of two Pakistani families with retinal disease enabled the establishment of the correct diagnosis of achromatopsia. Two novel mutations were identified in CNGA3 and CNGB3 that are both specifically expressed in cone photoreceptors. Re-evaluation of the clinical status revealed that...
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PMID: 20454696
PDF is available here.
Abstract
To develop a quantifiable behavioral test for identification of achromatopsic dogs based on visual performance.
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PMID: 20043788
PDF is available here.
Abstract
The aim of this study was to evaluate whether simulated severe red and green color vision deficiency (CVD) influenced color matching results and to investigate whether training with Toothguide Trainer (TT) computer program enabled better color matching results.
A total of 31 color normal dental stud...
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PMID: 20659524
PDF is available here.
Abstract
We suggest color blindness as a medical conditions should restrict employment choices for medical laboratory technicians and technologists job in Iran....
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PMID: 21137654
PDF is available here.
Abstract
Complications from shoulder corticosteroid injections are uncommon. This article presents a case of altered color perception and visual disturbances in a 29-year-old male active duty Navy SEAL following an intra-articular glenohumeral corticosteroid injection, previously unreported in the orthopedic...
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PMID: 19708628
PDF is available here.
Abstract
Genetic analyses provided direct confirmation of compound heterozygosity. The compound heterozygote showed Schmidt's sign, consistent with an extreme skew in her L : M cone ratio and usually associated with protan carrier status. CONCLUSION: Apart from Schmidt's sign, we found the colour vision of t...
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PMID: 19473349
PDF is available here.
Abstract
The developed set-up presents freely adjustable colours in the form of continuous light spectra to examine the influence of filter materials on colour discrimination. A colour space can be generated which corresponds to that of human perception. The saturation and brightness of the light is adjustab...
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PMID: 19548186
PDF is available here.
Abstract
There was no evidence of significant associations between exposure parameters and CCI. This is true for the analyses with all participants as well as for those with the subgroups with high-long versus low-short exposure. Thus, no exposure related changes in the relevant variables were found during t...
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PMID: 19330514
PDF is available here.
Abstract
Many sunglass tints currently permitted for drivers and riders cause a measurable decrement in the ability of color deficient observers to detect and recognize traffic signals. In general, combinations of signals and sunglasses of similar colors are of particular concern. This is prima facie evidenc...
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PMID: 19225432
PDF is available here.
Abstract
The authors propose that the content of certain sociopolitical ideologies can be shaped by individuals in ways that satisfy their social motivations. This notion was tested in the context of color-blind ideology. Color blindness, when construed as a principle of distributive justice, is an egalitari...
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PMID: 19309207
PDF is available here.
Abstract
Cone and cone-rod dystrophies can be divided according to the disease course into stationary and progressive disorders or by the genetic mode of inheritance into autosomal-recessive, autosomal-dominant, and X-linked traits. To date, seven genes for autosomal-recessive and nine for autosomal-dominant...
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PMID: 19184602
PDF is available here.
Abstract
Ocular complications from topical cocaine abuse are rare. Impaired color vision, as in our patient, has been reported in cocaine-withdrawn patients. To our knowledge, this is the first described case of a bilateral and symmetric maculopathy associated with long-term intranasal cocaine use. To avoid...
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PMID: 19787615
PDF is available here.
Abstract
Two of the BCM-causing family genotypes identified in this study comprised different hybrid genes, each of which contained the commonly described C203R inactivating mutation. The genotype in the family with evidence of a slowly progressive phenotype represents a novel BCM mutation. The deleted exon...
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PMID: 19421413
PDF is available here.
Abstract
We compared McCollough adaptation in controls to adaptation in two patients with damage to ventrotemporal cortex, resulting in achromatopsia, but who have spared V1. Each of these patients has some residual colour abilities of which he is unaware. Participants performed a 2AFC orientation-discrimina...
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PMID: 20192125
PDF is available here.
Abstract
Colour-blind patients who develop bladder cancer present with less favourable histology compared with non-colour-blind (p = 0.01). CONCLUSION: Colour blindness was associated with presentation with more advanced bladder tumours....
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PMID: 19829027
PDF is available here.
Abstract
John Dalton was born in the 18th century and was recognized mainly for his work on the chemical atomic theory and “Dalton's Law” for the partial pressure of gases. However, during his lifetime he was already recognized for his theories on “colorblindness,” with which he was afflicted. He was...
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PMID: 19005986
PDF is available here.
Abstract
The mild clinical phenotype observed is consistent with the residual activity of a severely hypomorphic mutant RPE65. Reduction to <10% of wild-type RPE65 activity by homozygous P25L correlates with almost complete rod function loss and cone amplitude reduction. Functional survival of cones is possi...
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PMID: 18599565
PDF is available here.
Abstract
Four pairs of IOF standard colours are likely to be confused by protan observers and four pairs by deutan observers. There were three pairs of colours likely to be confused by both deutan and protan observers on one of the competition maps and one pair likely to be confused by protan observers on th...
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PMID: 18637110
PDF is available here.
Abstract
Stopping the test after a perfect performance on the first run should be abandoned. Presenting three runs of the nine test lights and allowing no more than two errors is repeatable, passes all the NCV, and minimizes the number of individuals who pass the lantern at the first session and fail at a la...
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PMID: 18998483
PDF is available here.
Abstract
We used an adaptive optics ophthalmoscope to obtain in vivo retinal images from a rod monochromat for whom the genetic basis of the disorder consists of a homozygous mutation in the CNGB3 gene. Behavioral data from the patient were consistent with an absence of cone function. Retinal images revealed...
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PMID: 18499214
PDF is available here.
Abstract
We are aware of only one other report of a similar observer [Pokorny, J., & Smith, V. C. (1981). A variant of red-green color defect. Vision Research, 21, 311-317]; this study predated modern genetic techniques that can reveal the cone photopigment(s) in the red-green range. We recently had the oppo...
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PMID: 18423511
PDF is available here.
Abstract
We measured functional input from short-wavelength selective (S) cones to neurons in the dorsal lateral geniculate nucleus (LGN) and striate cortex (area V1) in anaesthetized marmosets. We found that most magnocellular (MC) and parvocellular (PC) cells receive very little (<5%) functional input from...
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PMID: 18397798
PDF is available here.
Abstract
These results suggest that L/M cones, the predominant class of cone photoreceptors in the retinas of dogs and most mammalian species can be successfully targeted using the human red cone opsin promoter....
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PMID: 18337838
PDF is available here.
Abstract
We were able to demonstrate recovery of normal cone function and visual acuity after a single subretinal treatment of vector that supplied wild-type Gnat2 protein to cones. This validates the overall strategy of targeting cones using recombinant viral vectors and justifies a more complete examinatio...
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PMID: 18596991
PDF is available here.
Abstract
The three novel truncative mutations are likely to be null mutations leading to loss of function, with no difference in the phenotype presentation. Amino acid changes are found exclusively in the N-terminal fragment of the protein and in the P-loop, indicating the importance of those regions for the...
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PMID: 18400204
PDF is available here.
Abstract
Most tamoxifen patients who complained of visual disturbances showed electrophysiological changes, particularly in the multifocal electroretinogram and often without a certain morphological correlate. We recommend electrophysiological examination for patients with unclear visual deterioration who ar...
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PMID: 18415107
PDF is available here.
Abstract
Passing the Farnsworth lantern test does not ensure that DCV pilots can distinguish PAPI signal colors. The criterion for passing the lantern test should be made more stringent. In addition the design of PAPI signals can be improved by a better choice of the white color and by providing a redundant...
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PMID: 18581942
PDF is available here.
Abstract
Forty-six per cent of subjects were successful when the pass criterion was a circular results diagram (one single transformation of adjacent hues was accepted as a pass), 53% passed when one red-green isochromatic error was allowed and 60% passed when two red-green isochromatic errors were permitted...
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PMID: 18426425
PDF is available here.
Abstract
The staged pass criteria used by the CAA and the CIE lack internal consistency when applied to the H-W A. Colour-deficient people who pass to a standard at the first stage of the examination are unlikely to be successful if the examination is continued. The staged pass criteria do not identify indiv...
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PMID: 18426424
PDF is available here.
Abstract
We report the identification of three new CNGA3 mutations in patients with achromatopsia. To assess the pathogenicity of these newly identified and four previously reported mutations, mutant CNGA3 channels were heterologously expressed in a human embryonic kidney cell line (HEK293 cells) and functio...
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PMID: 18445228
PDF is available here.
Abstract
L- and M- cone ERG contrast gains and psychophysical estimates of color contrast thresholds were not significantly different. These results do not support the noisy visual system hypothesis of reading discomfort....
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PMID: 18317333
PDF is available here.
Abstract
Out of 249 normal trichromats, 111 individuals (45 per cent) misread at least one plate. Females made up to six total errors and males up to five total errors. When only typical errors were counted, all the normal trichromats made two or fewer errors. There was no significant gender difference for e...
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PMID: 18271779
PDF is available here.
Abstract
CS function is impaired in patients with STGD at distinct spatial-temporal frequencies, which, in addition to the color vision deficits, suggests dual impairment of the magno- parvocellular pathways. STGD morphologically unaffected carriers may show patterns of psychophysical dysfunction that are mi...
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PMID: 18326749
PDF is available here.
Abstract
The red test measures red light increment threshold, a characteristic of color vision not assessed by conventional tests of color vision which are based upon measuring loss of color discrimination. All CD observers have raised red light increment thresholds and the test clearly differentiates CD obs...
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PMID: 18296927
PDF is available here.
Bernd B Wissinger,
Susann S Dangel,
Herbert H Jägle,
Lars L Hansen,
Britta B Baumann,
Günther G Rudolph,
Christiane C Wolf,
Michael M Bonin,
Katja K Koeppen,
Thomas T Ladewig,
Susanne S Kohl,
Eberhart E Zrenner and
Thomas T Rosenberg
Abstract
The phenotype of cone dystrophy with supernormal rod response is tightly linked with mutations in KCNV2....
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PMID: 18235024
PDF is available here.
Abstract
In the mesopic range, mild hypoxia impairs chromatic sensitivity progressively with reducing luminance. Binocular summation of chromatic signals is consistent and independent of the luminance channel. The CAD test is highly sensitive to mild congenital and acquired color vision deficiencies....
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PMID: 18235033
PDF is available here.
Abstract
This is the first report suggesting normal thickness of the RNFL in subjects with congenital red-green CVD....
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PMID: 18850573
PDF is available here.
Abstract
Female teachers constituted 84.6% and males 15.4% of the study population. Seventy three teachers (53.8%) were from public schools while 46.2% were from private schools. Prior to the training workshop, only 6.2% of teachers had heard of the Ishihara color vision chart and none of the teachers could...
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PMID: 19048761
PDF is available here.
Abstract
Achromatopsia in these two United Arab Emirates families results from two different mutations in CNGA3. Two branches of the same pedigree had individuals with both homozygous and compound heterozygous disease, demonstrating a complex molecular pathology in this large family....
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PMID: 18636117
PDF is available here.
Abstract
We assess the colour perception of 8 Saimiri ustus by a behavioural paradigm using Munsell colour chips as discriminating stimuli. A random variation in brightness assured that discriminations were based on colour rather than brightness cues. Results indicate that all males showed random performance...
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PMID: 18212502
PDF is available here.