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Nervous System Diseases (15):
- Neurotoxicity Syndromes
- Neuromuscular Diseases
- Neurologic Manifestations
- Trauma, Nervous System
- Sleep Disorders
- Nervous System Neoplasms
- Nervous System Malformations
- Demyelinating Diseases
- Cranial Nerve Diseases
- Autoimmune Diseases of the Nervous System
- Neurodegenerative Diseases
- Central Nervous System Diseases
- Autonomic Nervous System Diseases
- Neurocutaneous Syndromes
- Chronobiology Disorders
Recent article
Nervous System Diseases
Annals of Neurology (70 Suppl 15) 2011
Abstract
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European Journal of Neurology (18 Suppl 2) 2011
Abstract
Mayo Clinic Proceedings (86)9 2011
Abstract
Abstract
Neurocritical care bioinformatics is a new field that focuses on the acquisition, storage and analysis of physiological and other data relevant to the bedside care of patients with acute neurological conditions such as traumatic brain injury or stroke. The main focus of neurocritical...
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PMID: 21750522
PDF is available here.
PDF is available here.
Harvard Men's Health Watch (15)10 2011
Abstract
Abstract
We should therefore try to avoid overlooking this treatable disease....
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PMID: 21515923
PDF is available here.
PDF is available here.
Revue Neurologique (167 Suppl 2) 2011
Abstract
Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous add...
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PMID: 21331083
PDF is available here.
PDF is available here.
Nature Neuroscience (14)2 2011
Abstract
We review this approach and its existing and potential applications to Parkinson's disease, Tourette's syndrome, attention-deficit/hyperactivity disorder, addiction, schizophrenia and preclinical animal models used to screen new antipsychotic drugs. The approach's proven explanatory and predictive p...
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PMID: 21270784
PDF is available here.
PDF is available here.
Abstract
A pediatric assessment is now a required component of every New Drug Application in North America or Marketing Authorization Application in Europe, unless a waiver has been granted previously. Nonclinical juvenile toxicity studies are usually required as part of this assessment. The protocols for ju...
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PMID: 20972745
PDF is available here.
PDF is available here.
NeuroRehabilitation (28)1 2011
Abstract
Repetitive task-specific training appears to improve upper extremity function among individuals with neurological injuries. However, treatment options are limited for neurological patients who cannot effectively incorporate their hand consistently for functional grasp and release/pre...
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PMID: 21335678
PDF is available here.
PDF is available here.
Neural plasticity (2011) 2011
Abstract
GABAergic interneurons are critical for the normal function and development of neural circuits, and their dysfunction is implicated in a large number of neurodevelopmental disorders. Experience and activity-dependent mechanisms play an important role in GABAergic circuit development,...
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PMID: 21826279
PDF is available here.
PDF is available here.
Neural plasticity (2011) 2011
Abstract
These results cast new light on dynamics and plasticity of adult neuronal assemblies and their associated functions disclosing new therapeutic opportunities for the near future....
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PMID: 21766042
PDF is available here.
PDF is available here.
World Neurosurgery (76)3-4 2011
Abstract
We must realistically evaluate its disease modeling and therapeutic potential. Recent advances including the use of iPS cells to successfully model spinal muscular atrophy in vitro, as well as new techniques in generating iPS cells with recombinant proteins have accelerated the prospects of iPS cell...
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PMID: 21986423
PDF is available here.
PDF is available here.
Abstract
We focus on Nedd4 and Nedd4-2 ubiquitin ligases and the mechanisms by which they regulate voltage-gated ion channels and describe a novel paradigm on the mechanisms that underpin aberrant ion channel function in neurological disorders....
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PMID: 21057195
PDF is available here.
PDF is available here.
Abstract
We investigated 164 of 180 women with hip fracture admitted consecutively to a rehabilitation hospital. Lateral radiographs of the spine were taken 20.0 ± 5.1 days (mean ± SD) after fracture occurrence. To obtain a summary measure of vertebral fracture burden, we calculated the spinal deformity in...
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PMID: 21169744
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)48 2010
Abstract
We present six cases with different manifestations of neurosarcoidosis. There are no specific diagnostic tests for sarcoidosis. In the presented cases the diagnosis was made by histological proof of noncaseating granulomas. Patients with systemic sarcoidosis and neurological symptoms should be teste...
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PMID: 21118667
PDF is available here.
PDF is available here.
Abstract
Craniopharyngiomas are the third most common pediatric brain tumor and most common pediatric suprasellar tumor. Contemporary treatment of craniopharyngiomas uses limited surgery and radiation in an effort to minimize morbidity, but the long-term health status of patients treated in this fashion has...
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PMID: 21207770
PDF is available here.
PDF is available here.
Abstract
Abstract
The surgical approach and treatment of thoracolumbar osteoporotic vertebral collapse with neurological deficit have not been documented in detail. Anterior surgery provides good decompression and solid fusion, but the surgery-related risk is relatively higher than that associated with the posterior...
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PMID: 21039153
PDF is available here.
PDF is available here.
Abstract
A database search found 5 studies that examined the psychometrics of the NPDS. These supported its validity and reliability. The present study added to these by evaluating the internal consistency, factor structure, discriminatory power and responsiveness to change during rehabilitation. The NPDS wa...
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PMID: 21031290
PDF is available here.
PDF is available here.
Abstract
Vincristine is considered as a backbone of therapy in the induction and consolidation phases of pediatric malignancies. Neurotoxicity is a principal side effect of its use. This study is a randomized single-blinded placebo-controlled clinical trial to evaluate the role of glutamic acid in ameliorati...
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PMID: 20921909
PDF is available here.
PDF is available here.
Abstract
We highlighted the current knowledge on the miRNA pathway field, focusing on how the disruption of the miRNA-mediated silencing pathways could lead to the pathogenesis of neurological disorders. The potential use of miRNAs as diagnostic/prognostic markers and the possibility of reversing the effects...
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PMID: 20937025
PDF is available here.
PDF is available here.
Abstract
G protein-coupled receptors (GPCRs) are expressed throughout the nervous system where they regulate multiple physiological processes, participate in neurological diseases, and are major targets for therapy. Given that many GPCRs respond to neurotransmitters and hormones that are pres...
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PMID: 20632972
PDF is available here.
PDF is available here.
Abstract
Because G protein-coupled receptors (GPCRs) are numerous, widely expressed and involved in major physiological responses, they represent a relevant therapeutic target for drug discovery, particularly regarding pharmacological treatments of neurological disorders. Among the biological...
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PMID: 20632964
PDF is available here.
PDF is available here.
Abstract
We describe the pathology of several major neurological disorders and discuss the potential pharmacotherapeutic role of VIP and its receptors for the treatment of disorders such as Alzheimer's disease, Parkinson's disease, and Autism Spectrum Disorders....
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PMID: 20632962
PDF is available here.
PDF is available here.
Abstract
Hospital practice (1995) (38)4 2010
Abstract
Neurologic complications of cardiac surgery and interventional cardiac procedures may affect the central nervous system or the peripheral nervous system. The most common central nervous system complications are strokes and seizures. This article provides a succinct neuroanatomic and pathophysiologic...
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PMID: 21068531
PDF is available here.
PDF is available here.
Abstract
This article reviews the neurologic conditions associated with a high prevalence of bladder dysfunction and about which significant advances in understanding have occurred in recent years. The importance of the frontal lobes for bladder control has been confirmed through functional brain imaging, an...
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PMID: 20955903
PDF is available here.
PDF is available here.
Abstract
We describe the evolution of neuropathology in Canada, beginning with William Osler who began working in Montréal in 1874 and finishing with the major period of expansion in the 1970s. Organized services began in the 1930s, in Montréal with the neurosurgeons Wilder Penfield and William Cone, and i...
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PMID: 21059534
PDF is available here.
PDF is available here.
Neurological Surgery (38)11 2010
Abstract
We should keep in mind that high MET uptake is frequently observed in nontumorous brain lesions. Although differentiation from tumorous lesions is usually possible by laboratory and morphological examinations, nontumorous lesions should be included in the differential diagnosis when encountering pat...
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PMID: 21081810
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)44 2010
Abstract
Systemic diseases may affect the oral tissues, i.e. oral mucosa, salivary glands, teeth or bone, and oral manifestations will frequently present early, i.e. in association with (non-fulminant) systemic disease. Thus, recognition and proper diagnosis is essential to initiate appropriate treatment sch...
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PMID: 21044560
PDF is available here.
PDF is available here.
Australasian Psychiatry (18)5 2010
Abstract
The aim of this paper is to discuss the restriction of electroconvulsive therapy (ECT) to the treatment of psychiatric disorders and the prohibition of psychosurgery and deep brain stimulation (DBS) in the NSW Mental Health Act 2007 (MHA), and to examine these restrictions from clinical and human ri...
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PMID: 20863180
PDF is available here.
PDF is available here.
Autism Research (3)5 2010
Abstract
We recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis ("exploratory phase"), followed by intra- and inter-component cross-correlati...
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PMID: 20878720
PDF is available here.
PDF is available here.
Abstract
Abstract
This quantitative study was designed to identify the needs of family members of neuroscience patients. An adaptation of the Critical Care Family Needs Inventory was used to identify the top 10 needs of neuroscience families. Results were compared on the basis of whether the admission was planned or...
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PMID: 20968223
PDF is available here.
PDF is available here.
Abstract
Sagopilone is a novel, fully synthetic epothilone that has shown promising preclinical activity in a range of tumor models, including platinum-resistant ovarian cancer and metastatic breast cancer (MBC). This open-label, multicenter, Phase II study investigated the efficacy, safety, and tolerability...
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PMID: 20697802
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)14 2010
Abstract
Kidney International (78)10 2010
Abstract
We recently showed that levels of the soluble form of the chemokine CX3CL1 are elevated in the cerebrospinal fluid of patients with active NPSLE. In this review, we will discuss the involvement of chemokines in the pathogenesis of NPSLE and their significance as a useful laboratory parameter indicat...
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PMID: 17981732
PDF is available here.
PDF is available here.
Abstract
Abstract
The answer to the question, "Is autonomous practice in neurologic physical therapy defined differently based on the type of practice setting?" is no. Autonomous practice is a characteristic of the physical therapist, embodying excellence, communication and collaboration, and advocacy and caring. It...
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PMID: 20716991
PDF is available here.
PDF is available here.
Abstract
The silent information regulator (SIR) genes (sirtuins) comprise a highly conserved family of proteins, with one or more sirtuins present in virtually all species from bacteria to mammals. In mammals seven sirtuin genes - SIRT1 to SIRT7 - have been identified. Emerging from research on the sirtuins...
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PMID: 21155626
PDF is available here.
PDF is available here.
Behavioural Pharmacology (21)5-6 2010
Abstract
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone, secreted from the enteroendocrine K cells, which has insulin-releasing and extra-pancreatic actions. GIP and its receptor present a widespread distribution in the mammalian brain where they have been implicated with synap...
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PMID: 20574409
PDF is available here.
PDF is available here.
Abstract
Mortality and serious long-term sequelae still occur in about 50% of patients with tuberculous meningitis. The frequency and the clinical features of neurological and systemic complications were determined in a retrospective review of 104 patients with tuberculous meningitis. Complications occurred...
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PMID: 20605462
PDF is available here.
PDF is available here.
Abstract
James Ross (1837-1892) was an Aberdeen medical graduate who, after 13 years in rural general practice, mainly in Lancashire, became a pathologist and then physician to the Manchester Royal Infirmary and professor of medicine at Owens College, Manchester. In mid-career he developed a major interest i...
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PMID: 20973438
PDF is available here.
PDF is available here.
Acta Neurologica Belgica (110)3 2010
Abstract
Canadian Journal of Neurological Sciences (37 Suppl 2) 2010
Abstract
We discuss our current understanding of the biological origin of SKPs and specifically the potential therapeutic utility of SKPs as a highly accessible and autologous source of Schwann cells for remyelination and repair of the injured or diseased nervous system....
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PMID: 21246933
PDF is available here.
PDF is available here.
Abstract
Ankle Foot Orthoses (AFOs) to promote walking ability are a common treatment in patients with neurological or muscular diseases. However, guidelines on the prescription of AFOs are currently based on a low level of evidence regarding their efficacy. Recent studies aiming to demonstrate the efficacy...
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PMID: 20738235
PDF is available here.
PDF is available here.
Trends in Neurosciences (33)9 2010
Abstract
Serotonin is an important neuromodulator associated with a wide range of physiological effects in the central nervous system. The exact mechanisms whereby serotonin influences brain development are not well understood, although studies in invertebrate and vertebrate model organisms are beginning to...
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PMID: 20561690
PDF is available here.
PDF is available here.
Abstract
We recently developed a technique for free radical and oxidative stress monitoring using the ex vivo electron spin resonance (ESR) spin trapping method in patients with neuroemergency. Blood samples were collected by catheterization of the internal jugular bulb. The alkoxyl radical level was measure...
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PMID: 19812971
PDF is available here.
PDF is available here.
Abstract
Forty-eight patients (24 men and 24 women) were diagnosed with spinal TB. Their mean age was 64.3 years. The most common presenting symptoms were backache, neurological deficits, and fever. The most common vertebral area involved was lumbar spine (41.7%). The mean number of vertebra involved was 2.4...
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PMID: 20688289
PDF is available here.
PDF is available here.
Abstract
We describe the involvement of mitochondrial (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation.
(c) 2010 Mitochondria Research Society. Published by Elsevier B.V. All rights reserved....
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PMID: 20573557
PDF is available here.
PDF is available here.
Neurotoxicity Research (18)2 2010
Abstract
In neurologic disorders, there are progressive losses in regional brain structural integrity, circuitry, and neuronal process that threaten individuals' ability to express functional capacity at several levels of severity. The classification of (a) patients on the basis of diagnosis, risk prognosis,...
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PMID: 19941173
PDF is available here.
PDF is available here.
Cerebrovascular Diseases (30)3 2010
Abstract
To evaluate the neurological outcome of postoperative neurological deficit (PND) in patients undergoing carotid endarterectomy (CEA).
A total of 3.7% (n = 48) out of 1,290 consecutive patients developed PND and were assessed neurologically after a mid-term follow-up.
After a 4-year follow-up, these...
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PMID: 20664264
PDF is available here.
PDF is available here.
Abstract
We present an overview of these new methods and discuss how they have led to new insights in core aspects of the human brain, providing an overview of these novel imaging techniques and their implication to neuroscience. We discuss the use of spontaneous resting-state fMRI in determining functional...
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PMID: 20471808
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)8 2010
Abstract
Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private fu...
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PMID: 20504161
PDF is available here.
PDF is available here.
Abstract
Abstract
We have shown that it also has the potential to produce degenerate neurons in discrete areas of the brain such as insular and parietal cortex, thalamus, tenia tecta and bed nucleus of stria terminalis (BST). Acute effects of MDMA can result in a constellation of changes including arrthymias, hyperte...
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PMID: 20420572
PDF is available here.
PDF is available here.