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Blood-Brain Barrier (0):
Recent article
Blood-Brain Barrier
médecine/sciences (27)4 2011
Abstract
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Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous add...
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PMID: 21331083
PDF is available here.
PDF is available here.
Abstract
The rising epidemic of obesity is associated with cognitive decline and is considered as one of the major risk factors for neurodegenerative diseases. Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases. Increased metabo...
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PMID: 21639917
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Abstract
Hypothermic circulatory arrest increases permeability of the blood brain barrier in watershed areas.
Abstract
We tested the hypothesis that the BBB is disrupted by HCA.
Forty-one piglets (mean weight 11 kg) were randomly allocated to acute and survival experiments. Five groups (25 piglets, 5 per group) underwent acute studies: anesthesia alone (control); CPB at 37°C with full-flow (FF); CPB at 25°C with v...
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PMID: 21095352
PDF is available here.
PDF is available here.
Abstract
During development, microvessels acquire specialized functions to meet the requirements of different tissues and organs. The vasculature of the brain constitutes one of the best examples of an organ-specific and highly specialized microvasculature, in which the endothelial cells that...
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PMID: 21084718
PDF is available here.
PDF is available here.
Brain research (1359) 2010
Abstract
Treatment strategies in acute ischemic stroke are still limited. Considering numerous translation failures, research is tending to a preferred use of human-like animal models, and a more-complex perspective of tissue salvaging involving endothelial, glial and neuronal components according to the neu...
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PMID: 20732314
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether the treatment of mice with Salp15 during EAE induction would prevent the generation of proinflammatory T cell responses and the development of the disease. Surprisingly, Salp15-treated mice developed more severe EAE than control animals. The treatment of EAE-induced mi...
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PMID: 20920474
PDF is available here.
PDF is available here.
Abstract
We summarize recent evidence of receptor- and transporter-mediated Aβ clearance across the BBB. Furthermore, we discuss the models used to identify and characterize Aβ transport across the BBB in regard to barrier properties and suitability of the models for the experimental investigation of trans...
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PMID: 20704558
PDF is available here.
PDF is available here.
Abstract
We examined the role of protein kinase C (PKC) isozymes in modifying TJ protein expression in a rat model of global Hx. The Hx (6% O(2)) induced increased hippocampal and cortical vascular permeability to 4 and 10 kDa dextran fluorescein isothiocyanate (FITC) and endogenous rat-IgG. Cortical microve...
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PMID: 20700133
PDF is available here.
PDF is available here.
Abstract
We determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89 ± 0.03 mL/g, with little regional variation within the mouse brain....
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PMID: 20842161
PDF is available here.
PDF is available here.
Abstract
Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) and targeting specific types of brain cells with drug release into the cell cytopl...
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PMID: 20921419
PDF is available here.
PDF is available here.
Neuro-Oncology (12)10 2010
Abstract
We combine 2 methods to increase drug delivery to brain tumors. Focused ultrasound transiently permeabilizes the blood-brain barrier, increasing passive diffusion. Subsequent application of an external magnetic field then actively enhances localization of a chemotherapeutic agent immobilized on a no...
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PMID: 20663792
PDF is available here.
PDF is available here.
Abstract
The identification of xenobiotic metabolizing enzymes (i.e., CYP) and transporters (i.e., ABC transporters) (XMET) in the human brain, including the BBB, raises the question whether these transporters and enzymes have specific functions in brain physiology, neuropharmacology and toxicology.
Relevant...
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PMID: 20843279
PDF is available here.
PDF is available here.
Abstract
To explore permeability of artificial blood-brain barrier (aBBB) by oxygen-glucose deprivation combined (OGD)-induced using tetramethylpyrazine combined with puerarin in vitro.
Rats were divided into normal control group, model group, tetramethylpyrazine group, puerarin group, tetramethylpyrazine-pu...
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PMID: 21246832
PDF is available here.
PDF is available here.
Brain research (1354) 2010
Abstract
We have found that H(2) inhalation significantly improved the survival rate and organ damage of septic mice. In the present study, we investigated the effectiveness of H(2) therapy on brain edema, blood-brain barrier (BBB) breakdown, neurological dysfunction and injury volume in TBI-challenged rats....
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PMID: 20654594
PDF is available here.
PDF is available here.
Neuroscience Letters (482)3 2010
Abstract
Our results indicate that the integrity of the BBB could be impaired in the inflammatory pathophysiology of RA.
(c) 2010 Elsevier Ireland Ltd. All rights reserved....
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PMID: 20654699
PDF is available here.
PDF is available here.
Revue Neurologique (167)3 2011
Abstract
The sepsis associated encephalopathy (SAE) is a common cause of delirium, accompanied by hyperthermia or not. It is defined as a diffuse cerebral dysfunction induced by the systemic response to the infection without clinical or laboratory evidence of direct infectious involvement of...
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PMID: 20888023
PDF is available here.
PDF is available here.
Psychiatry Research (183)2 2010
Abstract
We hypothesized that P-gp function in the BBB is changed in patients with schizophrenia. Positron-emission tomography was used to measure brain uptake of [(11)C]verapamil, which is normally extruded from the brain by P-gp. We found that patients with chronic schizophrenia under treatment with antips...
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PMID: 20620031
PDF is available here.
PDF is available here.
Infection and Immunity (78)9 2010
Abstract
We show that mice protected from cerebral malaria by CD8+ T-cell depletion have significantly fewer parasites in the brain. Treatment of infected mice with an antimalarial drug 15 to 20 h prior to the estimated time of death also protected mice from cerebral malaria without altering the number of CD...
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PMID: 20605973
PDF is available here.
PDF is available here.
Abstract
The possibility that a combination of neurotrophins induces long-lasting neuroprotection of the cord following spinal cord injury (SCI) was examined in a rat model. The SCI was performed by making a unilateral incision into the right dorsal horn of the T10-11 segments and the animals were allowed to...
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PMID: 19812967
PDF is available here.
PDF is available here.
Abstract
Radical ultrastructural changes were seen by TEM in CEC in injured animals. At 5 h post-injury cell swelling and incipient cytoplasmic vacuoles were seen. At 24 h most severe changes were noted with extensive widening of intercellular clefts. At 7 day and 14 day post-injury, increased cytoplasmic el...
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PMID: 19812957
PDF is available here.
PDF is available here.
Abstract
The blood-brain barrier (BBB) functions to protect the environment of the brain through endothelial cells and their interactions with other cells and components of the cerebral vasculature and the brain parenchyma. Alterations in the BBB as a result of injuries (i.e., brain ischemia and traumatic br...
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PMID: 19812915
PDF is available here.
PDF is available here.
Abstract
This report presents that Deferiprone, the only clinically used 3-hydroxypyridin-4-one (HPO), is able to penetrate the blood-brain barrier (BBB) in guinea pigs, whereas its glucosylated analogue is unable to do so. This finding is contrary to published information suggesting that the glucosylation o...
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PMID: 20684616
PDF is available here.
PDF is available here.
Abstract
Although nanoparticles have tremendous potential for a host of applications, their adverse effects on living cells have raised serious concerns recently for their use in the healthcare and consumer sectors. As regards the central nervous system (CNS), research data on nanoparticle interaction with n...
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PMID: 20519209
PDF is available here.
PDF is available here.
Abstract
During sepsis, the dysfunction of blood-brain barrier (BBB) was mediated by inflammation and subsequently caused sepsis-associated encephalopathy. Hydroxyethyl starch (HES, 130/0.4) is most widely used for volume replacement to maintain or improve tissue perfusion in patients with se...
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PMID: 20451670
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)8 2010
Abstract
We attempted to use a cold injury-induced brain trauma (CIBT) model in mice, which provides for a well-established approach for assessing brain edema and blood-brain barrier breakdown. Additionally, we explored cultured mouse brain endothelial cells (bEnd.3) to investigate the protective effects of...
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PMID: 20486808
PDF is available here.
PDF is available here.
Abstract
There is a long-term discussion in the literature concerning the possible link between the improved efficacy of clozapine treatment and elevated plasma triglyceride levels, but no mechanistic studies have been performed to date. The aim of this work was to investigate whether the postprandial hypert...
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PMID: 20163937
PDF is available here.
PDF is available here.
Infection and Immunity (78)8 2010
Abstract
We have shown that E. coli penetration into the brain requires E. coli invasion of human brain microvascular endothelial cells (HBMEC), which constitute the blood-brain barrier. E. coli invasion of HBMEC involves its interaction with HBMEC receptors, such as E. coli cytotoxic necrotizing factor 1 (C...
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PMID: 20515928
PDF is available here.
PDF is available here.
Abstract
We have shown that masking the carboxyl group of 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (nitroxide 1) as an esterase-labile acetoxymethyl ester yields 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (nitroxide 2). Nitroxide 2 can cross the blood-brain barrier and is then hy...
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PMID: 20201101
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We explored the molecular mechanisms of how statins influence Abeta metabolism. Fluvastatin at clinical doses significantly reduced Abeta and amyloid precursor protein C-terminal fragment (APP-CTF) levels among APP metabolites in the brain of C57BL/6 mice. Chronic intracerebroventricular infusion of...
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PMID: 20472556
PDF is available here.
PDF is available here.
Abstract
We infected Epstein-Barr virus-transformed B cells with JCV and found that the viral genome decreased >1000-fold from days 0 to 20 after infection, which concurred with the absence of viral early and late messenger RNA transcripts and proteins. However, immunofluorescent images of B cells infected w...
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PMID: 20550458
PDF is available here.
PDF is available here.
Neuroreport (21)10 2010
Abstract
We have shown that localization of the scaffolding proteins gamma2-syntrophin, alpha-dystrobrevin-2, and dystrophin to glial endfeet is also dependent on the presence of alpha-syntrophin. In this study, we show that the expression levels of alpha-syntrophin, gamma2-syntrophin, and dystrophin at the...
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PMID: 20508543
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)28 2010
Abstract
We detected high levels of soluble CD40 ligand (CD40L) in CSF and plasma of HIV-infected patients with cognitive impairment. We now show that CD40, a receptor for CD40L, is highly expressed in brain endothelial cells of patients affected by HIV-1 encephalitis (HIVE), suggesting an important role for...
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PMID: 20631174
PDF is available here.
PDF is available here.
Abstract
Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated a...
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PMID: 20545360
PDF is available here.
PDF is available here.
Abstract
Intrauterine infection can cause fetal rats' neural cell apoptosis and affect adversely long-term brain development of neonatal rats....
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PMID: 20637158
PDF is available here.
PDF is available here.
Neurological Research (32)6 2010
Abstract
The neurological examination scores mildly increased in trauma groups 48 hours after the induction of trauma. Meloxicam treatment improved the altered neurological status. The trauma caused a significant increase in brain water content that was partially reversed by meloxicam. Meloxicam also reduced...
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PMID: 19660237
PDF is available here.
PDF is available here.
Pediatric Research (68)1 2010
Abstract
We investigated whether low-dose lipopolysaccharide (LPS) sensitizes HI-induced WM injury in postpartum (P) day 2 rat pups by selectively increasing neuroinflammation and BBB damage in the WM. Pups received LPS (0.05 mg/kg) (LPS + HI) or normal saline (NS + HI) followed by 90-min HI. LPS and NS grou...
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PMID: 20351655
PDF is available here.
PDF is available here.
Abstract
We summarize the current understanding of protozoa penetration across the blood-brain barrier, focusing on Plasmodium, Babesia, Trypanosoma, Toxoplasma, Acanthamoeba and Balamuthia. Advances in understanding the molecular pathways will offer opportunities for the rational development of novel therap...
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PMID: 20337721
PDF is available here.
PDF is available here.
Abstract
Increases of cytokine in the blood play important roles in the pathogenesis of influenza-associated encephalopathy. TNF-alpha was administered intravenously to wild-type mice, after which blood, CSF and brain tissue were obtained, and changes in BBB permeability, the amounts of MMP-9 and TIMP-1, and...
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PMID: 20618688
PDF is available here.
PDF is available here.
Abstract
We investigated the influence of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) on distribution of gefitinib to the central nervous system. In vitro studies conducted in Madin-Darby canine kidney II cells indicate that both P-gp and BCRP effectively transport gefitinib, limiting i...
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PMID: 20421331
PDF is available here.
PDF is available here.
Abstract
We extend the application of the Gaussian processes technique to classification quantitative structure-activity relationship modeling problems. We explore two approaches, an intrinsic Gaussian processes classification technique and a probit treatment of the Gaussian processes regression method. Here...
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PMID: 20433177
PDF is available here.
PDF is available here.
Abstract
We report a new classification method based on substructure pattern recognition, in which each molecule is represented as a substructure pattern fingerprint based on a predefined substructure dictionary, and then a support vector machine (SVM) algorithm is applied to build the prediction model. Ther...
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PMID: 20578727
PDF is available here.
PDF is available here.
Abstract
In the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors, the T315I gatekeeper mutant has emerged as resistant to all currently approved agents. This report describes the structure-guided design of a novel series of potent pan-inhibitors of BCR-ABL, including the T315I mutat...
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PMID: 20513156
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)23 2010
Abstract
These results indicate Hcy could increase the permeability of blood-brain barrier, the mechanism may be activating the transcription of MMP-2 in rats. The compounded vitamin has a protective effect on blood-brain barrier via lowering the level of plasma Hcy....
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PMID: 20979757
PDF is available here.
PDF is available here.
Journal of Immunology (184)12 2010
Abstract
We demonstrate that a dense population of resident mast cells in the meninges, structures surrounding the brain and spinal cord, regulate basal CNS barrier function, facilitating initial T cell CNS entry. Through the expression of TNF, mast cells recruit an early wave of neutrophils to the CNS. We p...
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PMID: 20488789
PDF is available here.
PDF is available here.
Abstract
There is a growing interest in dietary therapeutic strategies to combat oxidative stress-induced damage to the Central Nervous System (CNS), which is associated with a number of pathophysiological processes, including Alzheimer's and Parkinson's diseases and cerebrovascular diseases. Identifying the...
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PMID: 20140760
PDF is available here.
PDF is available here.
Abstract
Bend.3 cells have similar barrier characteristics to BEMC, and their barrier function may reach to the best effect 10 days after culture....
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PMID: 20540860
PDF is available here.
PDF is available here.
Abstract
Abstract
The spin-echo T1W images at 10 minutes post-contrast enhancement showed the best correlation with EB staining in both quantity of EB extravasation (r = 0.812; P < 0.01) and spatial distribution (r = 0.528, P < 0.01). This capability was more robust than the gradient-echo sequence. CONCLUSION: Our re...
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PMID: 20512883
PDF is available here.
PDF is available here.
Abstract
We demonstrate for the first time that S. aureus efficiently adheres to and invades human brain microvascular endothelial cells (hBMEC), the single-cell layer which constitutes the blood-brain barrier (BBB). The addition of cytochalasin D, an actin microfilament aggregation inhibitor, strongly reduc...
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PMID: 20419283
PDF is available here.
PDF is available here.
Progress in Neurobiology (91)2 2010
Abstract
The blood-cerebrospinal fluid (CSF) barrier physiologically protects the meningeal spaces from bloodborne bacterial pathogens, due to the existence of specialized junctional interendothelial complexes. A few bacterial pathogens are able to reach the subarachnoidal space and cause bacterial meningiti...
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PMID: 20026234
PDF is available here.
PDF is available here.
Progress in Neurobiology (91)2 2010
Abstract
We focus here on the neurovascular aspects of CM. We specifically address the central role of endothelial activation and alteration in disease pathogenesis. We discuss the respective roles of "mediator-induced" versus "host cell-induced" mechanisms of endothelial alteration. The former include cytok...
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PMID: 20117166
PDF is available here.
PDF is available here.
Abstract
A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in mice. The compounds 11 and 12 have emerged as important lead compounds showing potential...
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PMID: 20207451
PDF is available here.
PDF is available here.
Neurochemical Research (35)6 2010
Abstract
We hypothesized that it operates as the multipotent endocrine gland secreting SM to the general circulation and thereby providing the endocrine regulation of peripheral organs and the brain. The term "multipotent" means that the spectrum of the brain-derived circulating SM and their occupancy at the...
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PMID: 20135220
PDF is available here.
PDF is available here.
Cancer Investigation (28)5 2010
Abstract
We tested the hypothesis that chemotherapeutic agents readily able to cross the blood-brain barrier (cyclophosphamide and fluorouracil), as opposed to those not known to readily cross the barrier (paclitaxel and doxorubicin), reduce neural cell proliferation following chemotherapy. We found that 5-b...
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PMID: 20014946
PDF is available here.
PDF is available here.
Abstract
We synthesized several short polyamines with reducible disulfide backbones for pDNA packaging, internalization and consequent release from endosomal compartments. The synthetic cationic polymers prepared from short linear PEI (pLPEI), triethylenetetramine (pTETA), and spermine (pSPE), demonstrated v...
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PMID: 20093156
PDF is available here.
PDF is available here.
Abstract
Inhibitor administration resulted in an up to 11-fold increase in VPM brain distribution volumes (DV) with half-maximum effective dose (ED(50)) values of 3.0 +/- 0.2 and 1.2 +/- 0.1 mg/kg for tariquidar and elacridar, respectively. In paired PET scans, 3 mg/kg tariquidar resulted in regionally diffe...
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PMID: 20016890
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)5 2010
Abstract
Our findings provide new insights into the short-term interaction of SJW with P-glycoprotein at the blood-brain barrier. They are of potential relevance given the wide use of SJW as OTC medication and the importance P-glycoprotein has for CNS therapy....
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PMID: 20229133
PDF is available here.
PDF is available here.