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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Limbic System (10):
Recent article
Limbic System
Biological Psychiatry (69)12 2011
Abstract
Attention-deficit/hyperactivity disorder (ADHD) and conduct disorder overlap behaviorally, clinically, and cognitively. An important question of potential future clinical relevance is whether these two overlapping disorders are mediated by similar or distinct underlying brain substra...
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PMID: 21094938
PDF is available here.
PDF is available here.
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Anesthesiology (114)1 2011
Abstract
Psychoneuroendocrinology (35)7 2010
Abstract
Glucocorticoid dyshomeostasis is observed in a proportion of depressed individuals. As a result, glucocorticoid receptor (GR) antagonists are currently being tested as potential anti-depressants. The current study was designed to test the efficacy of mifepristone, a GR antagonist, in mitigating beha...
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PMID: 20149549
PDF is available here.
PDF is available here.
Abstract
We will examine how these long-lasting neuroadaptations may drive the pathology of psychostimulant addiction. Finally, we review clinical trials that highlight antagonists at excitatory AMPA receptors as promising targets against cocaine abuse....
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PMID: 20624588
PDF is available here.
PDF is available here.
Postgraduate Medicine (122)4 2010
Abstract
We discuss the affective, behavioral, cognitive, and neurological functioning of youth with BD when processing emotional stimuli. We focus on studies that have employed paradigms involving pictures and words with emotional valence, faces with emotional expressions, and responses to reward and punish...
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PMID: 20675973
PDF is available here.
PDF is available here.
Abstract
Endocannabinoids and their receptors, mainly the CB(1) receptor type, function as a retrograde signaling system in many synapses within the CNS, particularly in GABAergic and glutamatergic synapses. They also play a modulatory function on dopamine (DA) transmission, although CB(1) re...
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PMID: 20406253
PDF is available here.
PDF is available here.
Abstract
Alcoholism remains a serious cause of morbidity and mortality despite progress through neurobiological research in identifying new pharmacological strategies for its treatment. Drugs that affect neural pathways that modulate the activity of the cortico-mesolimbic dopamine system have been shown to a...
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PMID: 20516163
PDF is available here.
PDF is available here.
Psychiatria Danubina (22)2 2010
Abstract
Violence is an important social problem. Violence in the community has important social relevance for the political, criminal justice, and health care systems. Studies of homicide offenders have suggested a high prevalence of neurologic dysfunction due to organic brain damage such as traumatic brain...
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PMID: 20562756
PDF is available here.
PDF is available here.
Pharmacological Research (61)5 2010
Abstract
We examined the role of the endocannabinoid system in regulating this locomotor response in OBX and sham-operated rats. In our study, OBX-induced hyperactivity was restricted to the first 3 min of the open field test, demonstrating the presence of novelty (0-3 min) and habituation (3-30 min) phases...
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PMID: 20044005
PDF is available here.
PDF is available here.
Psychopharmacology (209)4 2010
Abstract
Intra-IL DHbetaE infusions dose-dependently blocked nicotine-induced impulsive-like action, while infusions of DHbetaE into the PL failed to block the effects of nicotine on impulsive-like action. CONCLUSION: The present results suggest a critical role for alpha4beta2 nAChRs in the IL in mediating t...
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PMID: 20238211
PDF is available here.
PDF is available here.
Abstract
There is converging evidence of gray matter (GM) structural alterations in different limbic structures in Post-Traumatic Stress Disorder (PTSD) patients. The aim of this study was to evaluate GM density in PTSD in relation to trauma load, and to assess the GM differences between responders (R) and n...
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PMID: 19942229
PDF is available here.
PDF is available here.
Biological Psychiatry (67)9 2010
Neuroplasticity in the mesolimbic system induced by natural reward and subsequent reward abstinence.
Abstract
Sexual experience induces functional and morphological alterations in the mesolimbic system similar to repeated exposure to psychostimulants. Moreover, abstinence from sexual behavior after repeated mating was essential for increased reward for drugs and dendritic arbors of NAc neurons, suggesting t...
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PMID: 20015481
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)16 2010
Abstract
We conditionally inactivated Fgfr2 or both Fgfr1 and Fgfr2 [Fgfr2 conditional knock-out (cKO) or double knock-out mice, respectively] in radial glial cells of the dorsal telencephalon. Fgfr1 and Fgfr2 are necessary for the attainment of a normal number of excitatory neurons in the cerebral cortex. T...
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PMID: 20410112
PDF is available here.
PDF is available here.
Abstract
We examined the association between bone mineral density (BMD) and neuroimaging markers of neurodegeneration (i.e., global and regional measures of brain volume) in early AD and non-demented aging. Fifty-five non-demented and 63 early AD participants underwent standard neurological and neuropsycholo...
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PMID: 20164583
PDF is available here.
PDF is available here.
Abstract
Psychopharmacology (209)3 2010
Abstract
Statistical parametric mapping analysis showed that both LTG and VPA, compared to placebo, inhibited TMS-induced activation of the motor cortex. In contrast, when TMS was applied over prefrontal cortex, LTG increased the activation of limbic regions, confirming previous results; VPA had no effect. C...
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PMID: 20195575
PDF is available here.
PDF is available here.
Der Nervenarzt (81)4 2010
Abstract
Anti-NMDA-receptor encephalitis is a severe and considerably underdiagnosed form of encephalitis with characteristic clinical features including psychiatric symptoms, decreased levels of consciousness, hypoventilation, epileptic seizures, autonomic dysfunction and dyskinesias. Most patients are prim...
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PMID: 20119656
PDF is available here.
PDF is available here.
Abstract
Music is capable of evoking exceptionally strong emotions and of reliably affecting the mood of individuals. Functional neuroimaging and lesion studies show that music-evoked emotions can modulate activity in virtually all limbic and paralimbic brain structures. These structures are crucially involv...
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PMID: 20153242
PDF is available here.
PDF is available here.
Epilepsy Research (89)1 2010
Abstract
While different hypotheses have been proposed to explain the mechanism of onset of temporal lobe epilepsy (TLE), most of them are based on structural, electrophysiological, cellular or molecular changes in one particular area. Extensive neuronal loss, axon reorganization, dendrite and dendritic spin...
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PMID: 19945824
PDF is available here.
PDF is available here.
Psychological Medicine (40)3 2010
Abstract
Our findings indicate that clinical recovery from depression is associated with increased activity in the DLPFC to negative emotional stimuli. We suggest that this increase may reflect a compensatory cortical control mechanism with the effect of limiting emotional dysregulation in limbic regions suc...
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PMID: 19627640
PDF is available here.
PDF is available here.
Neuropharmacology (58)3 2010
Abstract
We demonstrated that ketamine, an NMDA antagonist and possible psychotomimetic, increases extracellular histamine (HA) in the rat brain. We then examined the ability of the group II mGlu receptor agonist LY379268 to modulate the ketamine evoked increases in HA release in three limbic brain regions....
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PMID: 19951716
PDF is available here.
PDF is available here.
Abstract
We also measured levels of androgen receptor mRNA in a limbic nucleus, the lateral division of the bed nucleus of the stria terminalis (the lateral division of the bed nucleus of the stria terminalis). We found that levels of androgen receptor mRNA were higher in HVC and the lateral division of the...
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PMID: 19686750
PDF is available here.
PDF is available here.
Abstract
We studied normal young adults (n = 27) who completed measures of dispositional mindfulness and depressive symptomatology, which were then correlated with (a) rest: resting neural activity during passive viewing of a fixation cross, relative to a simple goal-directed task (shape-matching); and (b) r...
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PMID: 20141298
PDF is available here.
PDF is available here.
Behavioral Neuroscience (124)1 2010
Abstract
We report the development of such a task in rats: by slowly rotating rats before their return to a trial-unique home base, we could show subjects relied on internal cues only to navigate. To illustrate how this task can be combined with recording, we show examples of simultaneously recorded head dir...
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PMID: 20141292
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)4 2010
Abstract
We examined age differences in financial decisions across the adult life span by combining functional neuroimaging with a dynamic financial investment task. During the task, older adults made more suboptimal choices than younger adults when choosing risky assets. This age-related effect was mediated...
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PMID: 20107069
PDF is available here.
PDF is available here.
Abstract
We review evidence that drugs of abuse are powerful modulators of synaptic plasticity. Both the dopaminergic neurons of the ventral tegmental area as well medium spiny neurons in nucleus accumbens show enhanced excitatory synaptic strength following passive or active exposure to drugs such as cocain...
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PMID: 21161748
PDF is available here.
PDF is available here.
Nature Neuroscience (13)1 2010
Abstract
We characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development. Consistent with the NMDAR hypofunction theory of schizophrenia, distinct schizophrenia-related...
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PMID: 19915563
PDF is available here.
PDF is available here.
[Pathologic changes of neurons of mesocorticolimbic dopaminergic system in healthy humans and rats].
Abstract
The purpose of the present study was to demonstrate pathologically changed forms of neurons and intensity of the neuronoglial interactions which represented the normal standard for the interconnected parts of mesocorticolimbic dopaminergic system (MDS) in 6 intact adult female Wistar rats and in 5 he...
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PMID: 20960707
PDF is available here.
PDF is available here.
Cerebral Cortex (20)1 2010
Abstract
We investigate mechanisms of bundle formation, focusing on layer (L) 2 bundles in rat granular retrosplenial cortex (GRS), a limbic area implicated in spatial memory. By using microarrays, we first searched for genes highly and specifically expressed in GRS L2 at postnatal day (P) 3 versus GRS L2 at...
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PMID: 19447860
PDF is available here.
PDF is available here.
Abstract
A significant proportion of severe psychological problems in recent large-scale peacekeeping operations underscores the importance of effective methods for strengthening the stress resilience. Virtual reality (VR) adaptive stimulation, based on the estimation of the participant's emotional state fro...
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PMID: 20543262
PDF is available here.
PDF is available here.
Hypertension Research (33)1 2010
Abstract
We studied asymptomatic hypertensive subjects using brain magnetic resonance (MR) spectroscopy to evaluate metabolite impairments before the appearance of symptoms in patients with different treatment outcomes. In all, 14 healthy controls and 37 asymptomatic hypertensive patients (17 controlled and...
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PMID: 19876064
PDF is available here.
PDF is available here.
Abstract
We compare the effect of PCP (5mg/kg/day for 5 days) on activity-regulated cytoskeleton-associated protein (Arc) and parvalbumin mRNA expression in juvenile and adult rats. Arc is a marker for excitatory neurotransmission. Parvalbumin is a marker for GABAergic neurotransmission, known to be reduced...
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PMID: 19897002
PDF is available here.
PDF is available here.
Neuroreport (20)16 2009
Abstract
We investigated the brain activities of healthy individuals during a novel tool use (turning a screwdriver) to elucidate the relationship between the brain mechanism relevant to goal-directed non-rewarded behavior and motivation. We found that our designed behavioral task evoked activities in the or...
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PMID: 19786925
PDF is available here.
PDF is available here.
Abstract
Our patient had repetitive occurrence of episodes and remission of the symptomatology after the administration of oxcarbazepine, facts that support the epileptic origin of the disorder....
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PMID: 19484656
PDF is available here.
PDF is available here.
Abstract
Alterations in multiple biological functions, such as transcription factor activity, are implicated in the neurobiology of depression, based primarily on the characterization of antidepressant efficacy in naïve rodents rather than on models that capture the protracted feelings of anhedonia and help...
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PMID: 19802817
PDF is available here.
PDF is available here.
Biological Psychiatry (66)5 2009
Abstract
Inflammation-associated mood deterioration is reflected in changes in sACC activity and functional connectivity during evoked responses to emotional stimuli. Peripheral cytokines modulate this mood-dependent sACC connectivity, suggesting a common pathophysiological basis for major depressive disorde...
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PMID: 19423079
PDF is available here.
PDF is available here.
Canadian Journal of Neurological Sciences (36 Suppl 2) 2009
Abstract
Canadian Journal of Neurological Sciences (36 Suppl 2) 2009
Abstract
The limbic system as described by Broca, Papez and MacLean is an important concept for clinicians and basic researchers but remains controversial. Part anatomy and part physiology, it is hypothesized to be the primary brain mechanism responsible for the well being of the animal. The limbic system pr...
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PMID: 19760912
PDF is available here.
PDF is available here.
Abstract
In order to explore neural activity that accompanies cognitive bias in mood disorders, the authors had clinically depressed and nondepressed controls complete a self-evaluation procedure in which they indicated whether trait words were self-descriptive. Dense-array (256-channel) electroencephalograp...
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PMID: 19685947
PDF is available here.
PDF is available here.
Abstract
Abstract
We discuss the possibility of multiple underlying etiologies of the condition currently labeled as schizophrenia. We support this hypothesis with a theoretical model of the prefrontal-limbic system. We show how the dynamical behavior of this model depends on an entire set of physiological parameters...
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PMID: 19328814
PDF is available here.
PDF is available here.
Behavioural Brain Research (201)1 2009
Abstract
We have shown that repeated intracerebral injections of synthetic TCAP-1 modulate anxiety-like behaviors in three tests of anxiety, although the neural substrates responsible for these effects were previously unknown. In the current study, we examined both c-Fos induction and behavioral responses in...
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PMID: 19428634
PDF is available here.
PDF is available here.
Abstract
Neurologist (15)4 2009
Abstract
This case highlights the need to consider the possibility of infiltrative gliomatosis in patients presenting with features of paraneoplastic limbic encephalitis....
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PMID: 19590380
PDF is available here.
PDF is available here.
Psychological Medicine (39)7 2009
Abstract
Relevant interactions among the emotional face-processing stages exist in the non-clinical range of social anxiety that may ultimately attenuate amygdala responses. Future research will help to establish the role of this effect in a clinical context....
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PMID: 19154647
PDF is available here.
PDF is available here.
Psychological Medicine (39)7 2009
Abstract
Specific structural abnormalities in depression are associated with their attention biases towards mood-congruent information....
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PMID: 18945378
PDF is available here.
PDF is available here.
Drug and Alcohol Dependence (103)1-2 2009
Abstract
BACKGROUND: Cocaine dependence is a major public health problem for which there is no FDA-approved pharmacological treatment. Baclofen is a GABA(B) receptor agonist that in preclinical and early pilot clinical trials has shown promise for the treatment of cocaine dependence. The purpose of this mult...
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PMID: 19414226
PDF is available here.
PDF is available here.
Behavioral Neuroscience (123)3 2009
Abstract
Our results suggest that adolescent social defeat produces both deficits in anxiety responses and altered monoaminergic function in adulthood. This model offers potential for identifying specific mechanisms induced by severe adolescent social stress that may contribute to increased adult male vulner...
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PMID: 19485563
PDF is available here.
PDF is available here.
International Journal of Obesity (33 Suppl 2) 2009
Abstract
Powerful biological mechanisms evolved to defend adequate nutrient supply and optimal levels of body weight/adiposity. Low levels of leptin indicating food deprivation and depleted fat stores have been identified as the strongest signals to induce adaptive biological actions such as increased energy...
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PMID: 19528982
PDF is available here.
PDF is available here.
Psychiatry Research (172)2 2009
Abstract
We aimed to investigate ACC volume in a first-presentation teenage BPD sample with minimal exposure to treatment. Fifteen female BPD patients and 15 healthy female control participants underwent magnetic resonance imaging (MRI) scanning. ACC volumes were estimated using a reliable method that accoun...
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PMID: 19299113
PDF is available here.
PDF is available here.
Pharmacopsychiatry (42)S 01 2009
Abstract
We have investigated the tentative involvement of cys-loop ligand-gated ion-channels, which ethanol is known to interact with in relevant concentrations. Our data indicate that a neuronal circuitry involving glycine receptors in the nucleus accumbens, and, secondarily, nicotinic acetylcholine recept...
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PMID: 19434560
PDF is available here.
PDF is available here.
Abstract
sMRI research indicates that schizophrenia is associated with volumetric reductions in a network of frontal, temporal, limbic, striatal, and thalamic regions. Some of these abnormalities are apparent prior to psychosis onset and may progress with ongoing illness. sMRI findings in bipolar disorder ha...
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PMID: 19365187
PDF is available here.
PDF is available here.
Abstract
We previously found a functional promoter variant of the MET gene to be associated with autism spectrum disorder, suggesting that forebrain circuits governing social and emotional function may be especially vulnerable to developmental disruptions in HGF/Met signaling. However, little is known about...
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PMID: 19226509
PDF is available here.
PDF is available here.
Abstract
The basal ganglia consist of the striatum, which includes the caudate-putamen and the core of the nucleus accumbens, the external segment of the globus pallidus (GPe), the subthalamic nucleus, the internal segment of the globus pallidus (GPi), and the substantia nigra (SN). The major...
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PMID: 19378803
PDF is available here.
PDF is available here.
Abstract
The basal ganglia consist of the striatum, which includes the caudate-putamen and the core of the nucleus accumbens, the external segment of the globus pallidus (GPe), the subthalamic nucleus, the internal segment of the globus pallidus (GPi), and the substantia nigra (SN). The major input to the ba...
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PMID: 19378803
PDF is available here.
PDF is available here.
Human Brain Mapping (30)4 2009
Abstract
We hypothesize that acupuncture may mediate its antipain, antianxiety, and other therapeutic effects via this intrinsic neural circuit that plays a central role in the affective and cognitive dimensions of pain as well as in the regulation and integration of emotion, memory processing, autonomic, en...
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PMID: 18571795
PDF is available here.
PDF is available here.
Abstract
Guided by the affective spillover hypothesis, the present study examined the mediational role of parental adrenocortical reactivity to interparental conflict in explaining associations between interparental conflict and subsequent changes in mothers' and fathers' parenting practices...
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PMID: 19364215
PDF is available here.
PDF is available here.
Abstract
This study for the first time investigated resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder (BD) and compared them with findings in healthy controls and unipolar major depressive disorder (MDD) patient groups. Resting state correlations of low frequency BOLD flu...
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PMID: 19230623
PDF is available here.
PDF is available here.
Neuroreport (20)4 2009
Abstract
Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the con...
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PMID: 19225430
PDF is available here.
PDF is available here.
Brain Research (1259) 2009
Abstract
We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar and as a result show a latent inhibition-like retardation of learning. This ac...
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PMID: 19150440
PDF is available here.
PDF is available here.