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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Brain (7):
Recent article
Brain
Abstract
Prion replication in the periphery precedes neuroinvasion in many experimental rodent scrapie models, and in natural sheep scrapie and chronic wasting disease (CWD) in cervids. Prions propagate in the germinal centers of secondary lymphoid organs and are strongly associated with foll...
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PMID: 22043911
PDF is available here.
PDF is available here.
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Toxicology (289)1 2011
Abstract
We hypothesized that the effects of these compounds could be reflected by changes in biochemical substrates and cholinergic receptors and have examined the levels of four proteins involved in maturation of the brain, neuronal growth and synaptogenesis and the densities of both muscarinic and nicotin...
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PMID: 21820030
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of s...
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PMID: 21944720
PDF is available here.
PDF is available here.
Abstract
We find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited win...
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PMID: 21964341
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)14 2011
Abstract
We concluded a randomized trial involving 1088 patients with multiple sclerosis, 18 to 55 years of age, with a score of 0 to 5.5 on the Expanded Disability Status Scale and at least one relapse in the previous year or at least two relapses in the previous 2 years. Patients were randomly assigned (in...
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PMID: 21991951
PDF is available here.
PDF is available here.
The Lancet (378)9797 2011
Abstract
Abstract
We show that the proteoglycan NG2 segregates asymmetrically during mitosis to generate OPC cells of distinct fate. NG2 is required for asymmetric segregation of EGFR to the NG2(+) progeny, which consequently activates EGFR and undergoes EGF-dependent proliferation and self-renewal. In contrast, the...
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PMID: 21907924
PDF is available here.
PDF is available here.
Brain research (1410) 2011
Abstract
We attempted to characterize protein expression profiles in P301S tau-Tg mouse by using two-dimensional differential in-gel electrophoresis (2D-DIGE) coupled by peptide mass fingerprinting (PMF). As a result, we identified four upregulated proteins; heat shock protein 27 (Hsp27), peroxiredoxin 6 (Pr...
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PMID: 21803337
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)33 2011
Abstract
We observed that small heat shock proteins (sHsps) are associated with Aβ deposits in AD. In this study the molecular chaperones Hsp20, HspB8 and HspB2B3 were found to colocalize with CAA and capCAA in AD brains. In addition, Hsp20, HspB8 and HspB2B3 colocalized with intercellular adhesion molecule...
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PMID: 21849559
PDF is available here.
PDF is available here.
Abstract
We use Drosophila to explore the as yet unknown mechanisms regulating this privileged tissue growth. As in mammals, we observe in Drosophila that the CNS is more highly spared than other tissues during nutrient restriction (NR). We demonstrate that anaplastic lymphoma kinase (Alk) efficiently protec...
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PMID: 21816278
PDF is available here.
PDF is available here.
Abstract
We show here a study on the pathogenesis and the physiopathology of ROCV disease in the central nervous system of a Balb/C young adult mice experimental model. The animals were intraperitoneally infected by ROCV and followed from 0 to 9 days after infection, when all of them died. Nervous tissue sam...
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PMID: 21813860
PDF is available here.
PDF is available here.
Abstract
We begin with a brief history of tau, then provide an overview of pathological forms of tau, followed by a discussion of the differential degradation of tau by either the proteasome or autophagy and possible mechanisms by which pathological forms of tau may exert their toxicity. We conclude by discu...
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PMID: 21348938
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
The HUPO Brain Proteome Project (HUPO BPP) held its 14th workshop during the HUPO 9th Annual World Congress in Sydney, Australia. The principal aim of this project is to discover prognostic and diagnostic biomarkers associated with neurodegenerative diseases and brain aging, with the...
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PMID: 21796782
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (27)8 2011
Abstract
To explore the mechanisms of adipose-derived stem cells (ADSCs) transplanting induced angiogenesis in rat brain after focal cerebral ischemia.
108 male adult Sprague-Dawley rats were randomly assigned into 4 groups: sham-operated group, middle cerebral artery occlusio...
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PMID: 21806884
PDF is available here.
PDF is available here.
Abstract
Experimental data indicate that moderate uncoupling oxidative phosphorylation induces reduction in production of reactive oxygen species (ROS) and promotes an increase in survival of neurons and cardiomyocytes under hypoxia and re-oxygenation conditions. Uncoupling proteins (UCP) are...
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PMID: 21961301
PDF is available here.
PDF is available here.
PLoS Genetics (7)7 2011
Abstract
We used an integrated functional genomics strategy to robustly define Foxp2-dependent pathways, both direct and indirect targets, in the embryonic brain. Specifically, we performed genome-wide in vivo ChIP-chip screens for Foxp2-binding and thereby identified a set of 264 high-confidence neural targ...
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PMID: 21765815
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that brain and cognitive changes suggestive of presymptomatic LOAD may be associated with this TOMM40 polymorphism.
Among healthy APOE ε3 homozygous adults (N = 117; mean age, 55 years), we compared those who were homozygous for VL/VL (n = 35) TOMM40 poly-T...
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PMID: 21784354
PDF is available here.
PDF is available here.
Abstract
We found 35 brains with deposits of 3 proteins (tau, β-amyloid, and α-synuclein). In these two series of brains, the high incidence of deposition of multiple proteins in neurodegenerative disorders is shown. Our results are in agreement with previous findings showing that tau, β-amyloid, and α-s...
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PMID: 21618706
PDF is available here.
PDF is available here.
Nature Genetics (43)7 2011
Abstract
New England Journal of Medicine (364)23 2011
Abstract
Abstract
Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies of aging and neurodegenerative diseases suggests that mitochondrial function is defective in aging and neurodegenerative dis...
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PMID: 21470101
PDF is available here.
PDF is available here.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... (55)3 2011
Abstract
We will outline studies that support the dynamic hypothesis by: 1) testing slope differences among biomarkers; 2) describing how biomarkers map all neuropathological and clinical changes starting from the detection of amyloid burden, to neurodegeneration, and symptoms; and finally 3) identifying the...
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PMID: 21532538
PDF is available here.
PDF is available here.
Abstract
Multiple length scales are involved in the development of traumatic brain injury, where the global mechanics of the head level are responsible for local physiological impairment of brain cells. In this study, a relation between the mechanical state at the tissue level and the cellula...
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PMID: 20635116
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)22 2011
Abstract
We tested the hypothesis that blast-related traumatic brain injury causes traumatic axonal injury, using diffusion tensor imaging (DTI), an advanced form of magnetic resonance imaging that is sensitive to axonal injury. The subjects were 63 U.S. military personnel who had a clinical diagnosis of mil...
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PMID: 21631321
PDF is available here.
PDF is available here.
Abstract
In the context of increasing extinction rates and the potential loss of essential evolutionary biological and anthropological information, it is an important task to support efforts to prepare, preserve, and curate collections of histological brain sections; to disseminate informatio...
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PMID: 21599701
PDF is available here.
PDF is available here.
Abstract
The scientific investigation of brains of different vertebrates, both extant and extinct, is of interest for several reasons: for translating medical research on rodent models into practice, for understanding the animals investigated in order to improve conservation and management st...
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PMID: 21599700
PDF is available here.
PDF is available here.
Abstract
We describe here the history and contents of each of these five collections, to inform the scientific field of the extent and details of these remarkable resources.
© 2011 New York Academy of Sciences....
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PMID: 21599697
PDF is available here.
PDF is available here.
Abstract
We demonstrate the potential for using virtual endocasts (VEs) to examine inter- and intraspecific variation in brain volume in members of the family Hyaenidae. Total endocranial volume (adjusted for body size) and anterior cerebrum volume (adjusted for endocranial volume) were greater in the spotte...
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PMID: 21599694
PDF is available here.
PDF is available here.
Abstract
The comparative study of vertebrate brains is inherently dependent upon access to a sufficient number of species and specimens to perform meaningful comparisons. Although many studies rely on compiling published information, continued specimen collection, in addition to more extensiv...
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PMID: 21599690
PDF is available here.
PDF is available here.
Abstract
We present here accounts of the history and contents of this treasure trove of research materials.
© 2011 New York Academy of Sciences....
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PMID: 21599699
PDF is available here.
PDF is available here.
Abstract
We conducted a comparative survey of the visible gross morphology of the insular cortex and the claustrum in 26 mammalian species, representing most of the major mammalian radiations. We observed several features that are conserved in the mammals that we examined, including the absence of expansion...
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PMID: 21599698
PDF is available here.
PDF is available here.
Abstract
The past two decades have witnessed tremendous advances in noninvasive and postmortem neuroscientific techniques, advances that have made it possible, for the first time, to compare in detail the organization of the human brain to that of other primates. Studies comparing humans to c...
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PMID: 21599696
PDF is available here.
PDF is available here.
Abstract
We use in vivo magnetic resonance imaging (MRI) and advanced image processing using surface rendering to visualize and characterize myeloarchitecture in a small nonhuman primate, the common marmoset (Callithrix jacchus). Through images made in four female adult marmosets, we produce a representative...
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PMID: 21599695
PDF is available here.
PDF is available here.
Abstract
We describe implementation of a method for digitizing at microscopic resolution brain tissue sections containing normal and experimental data and for making the content readily accessible online. Web-accessible brain atlases and virtual microscopes for online examination can be developed using exist...
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PMID: 21599693
PDF is available here.
PDF is available here.
Abstract
The University of Geneva brain collection was founded at the beginning of the 20th century. Today, it consists of 10,154 formaldehyde- or buffered formaldehyde-fixed brains obtained from the autopsies of the Department of Psychiatry and, since 1971, from the Department of Geriatrics....
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PMID: 21599692
PDF is available here.
PDF is available here.
Abstract
The Zagreb Collection of developing and adult human brains was founded in 1974 by Ivica Kostović and consists of 1,278 developing and adult human brains, including 610 fetal, 317 children, and 359 adult brains. It is one of the largest collections of developing human brains. The col...
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PMID: 21599691
PDF is available here.
PDF is available here.
Abstract
We will review the data about the connections of POP with conventional neurotransmitter systems and provide an overview of the role of POP in neurotransmission....
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PMID: 21222629
PDF is available here.
PDF is available here.
Abstract
Annals of the New York Academy of Sciences (1225 Suppl 1) 2011
Abstract
Abstract
We think about iGluR function. Recently, a number of novel transmembrane proteins have been uncovered that may also serve as iGluR auxiliary proteins. Here we review pivotal developments in our understanding of the role of TARPs in AMPA receptor trafficking and gating, and provide an overview of how...
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PMID: 21521608
PDF is available here.
PDF is available here.
Human Molecular Genetics (20)8 2011
Abstract
We generated transgenic mice expressing cDNA that encodes htt N118-82Q with the mouse prion promoter vector. In mice generated in this manner, we demonstrate robust inclusion pathology accompanied by early death and failure to gain weight. These phenotypes are the most robust abnormalities identifie...
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PMID: 21307087
PDF is available here.
PDF is available here.
Abstract
Journal of Proteomics (74)4 2011
Abstract
A large series of protein pathway components have been shown to be dysregulated in Down syndrome (DS) brain. No information about pathomechanisms linked to the trisomic state can be obtained from adult DS brain, however, as neurodegeneration occurs from the fourth decade. The aim of...
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PMID: 21262400
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We analyzed altered protein expressions in various tissues, namely, brain, lung, spleen, and intestine, from 1 Gy-irradiated mice by employing 2-DE analysis. MALDI-TOF MS and peptide mapping identified 25 proteins that showed greater than twofold expressional changes. In order to confirm signific...
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PMID: 21319302
PDF is available here.
PDF is available here.
Journal of Gastroenterology and Hepatology (26 Suppl 3) 2011
Abstract
The placebo effect has evolved from being considered a nuisance factor in clinical research to a hot topic of scientific investigation. New research findings show that a placebo has real psychobiological and biological effects that are attributable to the overall therapeutic context....
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PMID: 21751434
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)14 2011
Abstract
Physiological Reviews (91)2 2011
Abstract
Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed "...
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PMID: 21527731
PDF is available here.
PDF is available here.
Current Eye Research (36)4 2011
Abstract
We examined mouse and rat lenses to determine if alternative splicing of neuronal nPTB and Fox-1/Fox-2 isoforms also occurs in lenses.
Immunoblot, immunofluorescence, and RT-PCR were used to examine expression and alternative splicing of transcripts in lens and brain....
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PMID: 21714144
PDF is available here.
PDF is available here.
Brain research (1379) 2011
Abstract
Abstract
We identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human P...
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PMID: 21376232
PDF is available here.
PDF is available here.
Abstract
We identify molecular events particularly likely to produce significant regulatory changes in humans: complete deletion of sequences otherwise highly conserved between chimpanzees and other mammals. We confirm 510 such deletions in humans, which fall almost exclusively in non-coding regions and are...
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PMID: 21390129
PDF is available here.
PDF is available here.
Abstract
Abstract
We present novel methods for regularized MRI reconstruction from undersampled sensitivity encoded data--SENSE-reconstruction--using the augmented Lagrangian (AL) framework for solving large-scale constrained optimization problems. We first formulate regularized SENSE-reconstruction as an unconstrain...
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PMID: 21095861
PDF is available here.
PDF is available here.
Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous add...
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PMID: 21331083
PDF is available here.
PDF is available here.
Circulation (123)8 2011
Abstract
We found that 498 (11%) subjects had concurrent impairments and 3086 (66%) were intact on all 3 measures. Between 1992 and 1999, 651 (21%) became impaired in all 3 domains. Hypertensive individuals were more likely to be impaired at baseline (odds ratio 1.23, 95% confidence interval 1.04 to 1.42, P=...
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PMID: 21321150
PDF is available here.
PDF is available here.
DukeMedicine healthnews (17)3 2011
Abstract
Abstract
We systematically investigate efficacy of using several different image features such as intensity, fractal texture, and level-set shape in segmentation of posterior-fossa (PF) tumor for pediatric patients. We explore effectiveness of using four different feature selection and three different segmen...
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PMID: 21216716
PDF is available here.
PDF is available here.
Abstract
We detected and characterized axonal injury directly by DTI at each time point. These results demonstrate that DTI has significant potential as a non-invasive tool with which to quantitatively diagnose and evaluate microstructural injury in the experimental and clinical assessment of DAI. This metho...
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PMID: 21385236
PDF is available here.
PDF is available here.
Abstract
We propose a fusion method comprising innovation approach in time series analysis and statistical test. Autoregressive (AR) models were fitted to time series data of each pixel for the range sufficiently before or after the state transition. Then, the remaining time series data were filtered using t...
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PMID: 21224173
PDF is available here.
PDF is available here.