Abstract
We present a fast reconstruction algorithm for SENSE in partially parallel MR imaging with arbitrary k-space trajectories. The proposed method is a combination of variable splitting, the classical penalty technique and the optimal gradient method. Variable splitting and the penalty technique reformu...
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PMID: 21356608
PDF is available here.
Abstract
A new, sample independent optimization criterion for minimizing the effect of the imaging gradients, including the directional awareness they create, is defined for diffusion tensor imaging (DTI) experiments. The DTI linear algebraic framework is expanded to a normed space to design...
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PMID: 21356610
PDF is available here.
Abstract
The dramatic increase in use of cellular telephones has generated concern about possible negative effects of radiofrequency signals delivered to the brain. However, whether acute cell phone exposure affects the human brain is unclear.
To evaluate if acute cell phone e...
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PMID: 21343580
PDF is available here.
Abstract
We study temperature coding in Drosophila, and show that temperature is represented by a spatial map of activity in the brain. First, we identify TRP channels that function in the fly antenna to mediate the detection of cold stimuli. Next, we identify the hot-sensing neurons and show that hot and co...
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PMID: 21335241
PDF is available here.
Abstract
We perform an extensive analysis of the developing central nervous system in global p63-/- mice and their wildtype littermates. Brain and spinal cord of embryos and newborn mice were assessed in vivo for neuroanatomy, histology, apoptosis, proliferation, stemness and differentiation, and in vitro fo...
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PMID: 21293190
PDF is available here.
Abstract
We show that Notch is activated in select olfactory receptor neurons (ORNs) in an odorant-specific fashion. This response requires olfactory receptor activity and the Notch ligand Delta. We present evidence that Notch activation depends on synaptic transmission by the ORNs in which the receptors are...
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PMID: 21315258
PDF is available here.
Abstract
We review this approach and its existing and potential applications to Parkinson's disease, Tourette's syndrome, attention-deficit/hyperactivity disorder, addiction, schizophrenia and preclinical animal models used to screen new antipsychotic drugs. The approach's proven explanatory and predictive p...
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PMID: 21270784
PDF is available here.
Abstract
We will show that the primary targets of NSAIDs are involved in a pathological stage that precedes the clinical appearance of AD. The early, preclinical involvement of inflammation in AD explains why patients with clinical signs of AD do not benefit from anti-inflammatory treatment and suggests that...
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PMID: 21143138
PDF is available here.
Abstract
Traumatic brain injury (TBI) generates regional alterations in cerebral metabolism, leading to the potential evolution of persistent metabolic dysfunction. In the case of penetrating, firearm-related TBI, the pathophysiological mechanisms underlying these acute-phase metabolic derang...
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PMID: 21207188
PDF is available here.
Abstract
We measured arterial and jugular levels of ET-1 and its precursor, big endothelin (Big ET), and calculated juguloarterial (JA) gradients for the first 5 days post-TBI.
Arterial levels of both Big ET and ET-1 were maximal on day 1 post-TBI, and decreased thereafter (P < 0.05). Arteria...
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PMID: 20652766
PDF is available here.
Abstract
We will address functional phenotypes of microglia in diverse brain regions and phenotypes associated with neuroinflammation, neurogenesis, brain tumor homeostasis, and aging....
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PMID: 21143141
PDF is available here.
Abstract
Closed-loop experimental testing of single medial temporal lobe neurons in humans reveals top-down effects, opening new possibilities for describing neural representations at the highest level.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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PMID: 21256441
PDF is available here.
Abstract
We evaluate the effects of BP-4 in eleuthero-embryos and in the liver, testis and brain of adult male fish on the transcriptional level by focusing on target genes involved in hormonal pathways to provide a more complete toxicological profile of this important UV-absorber. Eleuthero-embryos and male...
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PMID: 20937294
PDF is available here.
Abstract
We employed SILAM (Stable Isotope Labeling in Mammals) combined with mass spectrometry to quantify the proteome between mammalian tissues. Using (15)N labeled rat tissue, we quantified 3742 phosphorylated peptides in nuclear extracts from liver and brain tissue. Analysis of the phosphorylation sites...
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PMID: 21283754
PDF is available here.
Abstract
We hypothesized that expression of EGF, HGF, VEGF, and their receptors EGFR, c-Met, and Flt-1, respectively, would be altered in TSC. We show by cDNA array and immunohistochemical analysis that EGF, EGFR, HGF, c-Met, and VEGF, but not Flt-1, mRNA, and protein expression was up-regulated in Tsc1 cond...
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PMID: 21224066
PDF is available here.