Abstract
To study the clinicopathologic features of lipomatosis of nerve (NLS).
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PMID: 21575386
PDF is available here.
Abstract
The management of peripheral nerve injury requires a thorough understanding of the complex physiology of nerve regeneration. The ability to perform surgery under magnification has improved our understanding of the anatomy of the peripheral nerves. However, the level of functional imp...
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PMID: 20061198
PDF is available here.
Abstract
We are summarizing evidence pointing to altered glucocorticoid (GC) sensitivity in relevant target tissues for HPA axis hormones. Specifically, we provide a summary of GC effects on cognitive functions, as an emerging marker for central nervous system GC sensitivity, and of GC effects on peripheral...
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PMID: 20005894
PDF is available here.
Abstract
We describe a novel fluorescent dye, 3-(4-aminophenyl)-2H-chromen-2-one (termed case myelin compound or CMC), that can be used for in situ fluorescent imaging of myelin in the vertebrate nervous system. When administered via intravenous injection into the tail vein, CMC selectively stained large bun...
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PMID: 20354147
PDF is available here.
Abstract
Pain is one of the most ubiquitous problems of today's world, its impact being far-reaching. Current conceptualizations of pain medicine adopt a bio-psycho-social perspective. In this model, pain is best described as an interactive, psycho-physiological behavioral pattern that cannot be divided into...
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PMID: 20562750
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Abstract
A simple, safe and efficient system that can specifically transfect peripheral sensorial neurons can bring new answers to address peripheral neuropathies. A multi-component non-viral gene delivery vector targeted to peripheral nervous system cells was developed, using poly(ethylene imine) (PEI) as s...
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PMID: 20093157
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Abstract
Studies in the last two decades have firmly established that nitric oxide (NO) exerts a broad range of effects on bodily functions including muscle contractility, platelet aggregation, metabolism, neuronal activity, and immune responses. The underlying mechanisms rely primarily on elevating guanosin...
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PMID: 20024580
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Abstract
We have first made use of different mouse mutants. We show that depletion of Schwann cells and boundary cap cells or inactivation of Krox20/Egr2, a master regulatory gene for myelination in Schwann cells, results in transgression of the CNS/PNS boundary by astrocytes and oligodendrocytes and in myel...
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PMID: 20427655
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Abstract
We identified the Drosophila Phocein homolog (DMob4) as a regulator of neurite branching in a genome-wide RNA interference screen for neuronal morphology mutants. To further characterize DMob4, we generated null and hypomorphic alleles and performed in vivo cell biological and physiological analysis...
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PMID: 20392941
PDF is available here.
Abstract
We compared the effects of orexin-A, vasoactive intestinal polypeptide (VIP), melatonin, serotonin, uroguanylin, ghrelin and prostaglandin E(2) (PGE(2)) on duodenal bicarbonate secretion in fed and overnight fasted animals. This review is a summary of our findings. Secretagogues were administered by...
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PMID: 20003099
PDF is available here.
Abstract
The scientific evidence is reviewed for the involvement of the brain monoamines serotonin, dopamine and noradrenaline (norepinephrine) in the onset of fatigue, in both normal and high ambient temperatures. The main focus is the pharmacological manipulations used to explore the central fatigue hypoth...
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PMID: 20199121
PDF is available here.
Abstract
Chemotherapy-induced peripheral neuropathy (CIN) is a common toxicity of anticancer treatment and its incidence is growing. It significantly affects quality of life and is a dose-limiting factor that interferes with treatment. Its diagnosis can be established in clinical terms but some complementary...
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PMID: 20156778
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Abstract
We demonstrated a significant weight loss of parotid gland tissue, a marked decrease in 3H-thymidine incorporation, a decreased volume of saliva and amylase activity of the glandular tissue in response to PEF. Animals received intraperitoneal injection of PEF (20 mg/100 g body weight daily) for 3 an...
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PMID: 19937634
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Abstract
We present our optimized protocol for isolation of Drosophila da neurons using the infrared (IR) class of LCM. This method allows for the capture of single, class-specific or multiple da neurons with high specificity and spatial resolution. Age-matched third instar larvae expressing a UAS-mCD8::GFP...
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PMID: 20502436
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Abstract
The studies testifying to the presence of the interrelation between the physiological functions of the organism and physical and chemical processes in nerves are discussed. Changes in some physical and chemical parameters observed both upon elicited rhythmic exaltation of nerves and during the spont...
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PMID: 20429284
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Abstract
We will briefly overview the main investigation lines on plasticity and regeneration in the peripheral nervous system that have been carried out at the Laboratory of Human Anatomy of the Department of Clinical and Biological Sciences at the "San Luigi Gonzaga" Medical Faculty of the University of Tu...
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PMID: 21072996
PDF is available here.
Abstract
We found that while trunk neural crest migration in snakes is very similar to that of other amniotes, the inter-somitic pathway is used more extensively by late-migrating trunk neural crest cells in snake....
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PMID: 20482793
PDF is available here.
Abstract
We concentrate on the manner in which local changes in bone morphogenetic protein (BMP) expression contribute to a cascade of events within the peripheral nerves, both sensory and sympathetic, in the immediate area of HO formation....
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PMID: 21395504
PDF is available here.
Abstract
At the durations studied, Lewis rats showed accelerated loss of both retinal capillaries and ganglion cells in diabetes, whereas diabetic Wistar rats showed degeneration of the capillaries without significant neurodegeneration, and Sprague Dawley rats showed neither lesion. Identification of strains...
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PMID: 20806092
PDF is available here.
Ana Margarida Teixeira,
Patrícia Garrido,
Paulo Santos,
Rui Alves,
Belmiro Parada,
Elísio Costa,
Anabela Almeida,
Edite Teixeira-Lemos,
José Sereno,
Rui Pinto,
Luís Belo,
Alice Santos-Silva,
Frederico Teixeira and
Flávio Reis
Abstract
Chronic kidney disease (CKD) patients develop anemia because of the low kidney erythropoietin (EPO) production, thus promoting cardiovascular complications. The degree of renal insufficiency might determine the moment to start recombinant human erythropoietin (rhEPO) therapy, but the molecular basis...
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PMID: 20863212
PDF is available here.
Abstract
Steroid hormones act in the central and peripheral nervous systems to regulate a variety of functions, including development, cell proliferation, cognition and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the nuclear receptor su...
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PMID: 19541426
PDF is available here.
Abstract
We successfully established human immortalized cell lines originating from BNB using temperature-sensitive SV40 large T antigen and the cellular properties of human cell lines are presented in this paper. Human PnMEC cell line showed high transendothelial electrical resistance and expressed tight ju...
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PMID: 20030260
PDF is available here.
Abstract
Under light condition, all vSM judgments approximately matched the OM. However, in the dark, CRPS patients, but not PHN patients, showed a shifted vSM towards the affected side. CONCLUSION: We demonstrated that chronic pain does not always impair visuospatial perception. The aetiology of PHN is limi...
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PMID: 19956813
PDF is available here.
Abstract
We used a well-established experimental rat model of DPN in which buprenorphine at doses of 1.2 and 2.4 microg/kg/h was administered by implantable Alzet osmotic pumps for 3 weeks. After 6 weeks of diabetes, nerve conduction velocity (NCV) and behavioural responses to noxious mechanical and thermal...
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PMID: 19595641
PDF is available here.
Abstract
We ask if intraneural perineurioma is a pure motor syndrome that remains confined to one nerve and should be treated by surgical resection. We examined the nerve biopsies of cases labelled perineurioma and selected those with diagnostic features. Thirty-two patients were identified; 16 children and...
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PMID: 19567701
PDF is available here.
Abstract
There is no significant relationship between gender and the result of HUTT. The type of VVR is related to HUTT protocol--cardioinhibitory response is more frequent following nitroglycerin administration in comparison to standard protocol and HUTT with isoproterenol provocation....
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PMID: 19784908
PDF is available here.
Abstract
In this article, the authors discuss the pharmacology of sedative-analgesic agents like dexmedetomidine, remifentanil, ketamine, and volatile anesthetics. Dexmedetomidine is a highly selective alpha-2 agonist that provides anxiolysis and cooperative sedation without respiratory depression. It has or...
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PMID: 19576524
PDF is available here.
Abstract
We have engineered a novel model of sympathetic neurons in which the erk5 gene can be deleted in vitro. Our data provide for the first time genetic evidence that ERK5 is required to mediate the survival response of neurons to nerve growth factor. Increased cell death associated with the loss of ERK5...
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PMID: 19148185
PDF is available here.
Abstract
We observed that Aldh1a1 was preferentially expressed in mouse hematopoietic stem cells (HSCs) and expression increased with age. Hematopoietic cells from Aldh1a1-deficient mice exhibited increased sensitivity to cyclophosphamide in a non-cell-autonomous manner, consistent with its role in cyclophos...
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PMID: 18971422
PDF is available here.
Abstract
We introduce an integrated framework for detecting peripheral sympathetic responses through purely imaging means. The measurements are performed on three facial areas of sympathetic importance, that is, periorbital, supraorbital, and maxillary. To the best of our knowledge, this is the first time th...
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PMID: 19272941
PDF is available here.
Abstract
Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from th...
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PMID: 19582408
PDF is available here.
Abstract
The work deals with study of development of central and peripheral serotonin-producing systems in rat ontogenesis before and after formation of the blood-brain barrier. By the method of highly efficient liquid chromatography it has been shown that the serotonin level in peripheral blood before forma...
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PMID: 19370991
PDF is available here.
Abstract
In amphioxus embryos, the early development of the type 1 sensory neurons was followed by Tlx gene expression and scanning electron microscopy. At the early neurula stage, AmphiTlx transcription is first detectable in a ventral zone of epidermis. In later embryos, expression is also seen in differen...
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PMID: 19245546
PDF is available here.
Abstract
Three studies of DLX, six of PGB, two of GBP and none of AMT met the inclusion criteria. In random-effects and fixed-effects analyses of DLX, PGB and GBP, all were superior to placebo for all efficacy parameters, with some tolerability trade-offs. Indirect comparison of DLX with PGB found no differe...
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PMID: 19208243
PDF is available here.
Abstract
The benzene extract of the leaves of Ficus benjamina (variety comosa) afforded a new triterpene, named serrat-3-one (Fc-2), along with the known phytoconstituents pentacontanyl decanoate (Fc-1), friedelin and beta-sitosterol. Their structures were established on the basis of chemical and physical ev...
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PMID: 19418356
PDF is available here.
Abstract
Stimulation and needle electromyography studies covered 102 patients with occupational hands disorders. 87% of the examinees showed tunnel syndromes signs: 44% of those had one tunnel syndrome, 36% - two synromes, and 7% - multiple ones. The results failed to demonstrate reliable difference in tunne...
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PMID: 19382648
PDF is available here.
Abstract
Von Holst (1939/73) proposed relative coordination as a general characteristic of sensorimotor functions like locomotion. Its functionality derives from striking a balance between independence versus interdependence among component activities, e.g., fin or leg oscillations in lipfish and centipede m...
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PMID: 19061545
PDF is available here.
Abstract
Typical NPD cytoplasmic inclusions were observed in DRG neurons and satellite cells, in peripheral nerve Schwann cells, in spinal cord neurons and in endothelial cells. All these inclusions were present from the age of 1 month and increased with aging. By Fluoro-Jade B staining we demonstrated the o...
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PMID: 19642505
PDF is available here.
Abstract
We present the development of a family of biomimetic scaffolds composed of chemically crosslinked, elastin-like proteins designed to support neural regeneration through a combination of cell adhesion and cell-induced degradation and remodeling. Through use of a modular protein-design strategy, a ran...
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PMID: 19964779
PDF is available here.
Abstract
We present the development of a family of biomimetic scaffolds composed of chemically crosslinked, elastin-like proteins designed to support neural regeneration through a combination of cell adhesion and cell-induced degradation and remodeling. Through use of a modular protein-design strategy, a ran...
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PMID: 19964779
PDF is available here.
Abstract
We have developed a strategy for the isolation of a subclass of PNS neurons called dendritic arborization (da) neurons that have been widely used for studying dendrite morphogenesis. These neurons are very difficult to isolate as a pure population, due in part to their extremely low occurrence and t...
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PMID: 19953079
PDF is available here.
Abstract
We investigated the roles of dCtBP during development of the peripheral nervous system (PNS). Our study includes a detailed quantitative analysis of how altered dCtBP activity affects the formation of adult mechanosensory bristles. We found that dCtBP loss-of-function resulted in a series of phenoty...
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PMID: 18992810
PDF is available here.
Abstract
A 28-year-old woman presented with classic signs of measles and subsequently developed bilateral retro-bulbar optic neuritis and Guillain-Barré syndrome. Her radiographic and CSF findings were consistent with acute measles encephalitis. However, encephalopathy, such as behavioral changes and alte...
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PMID: 19252366
PDF is available here.
Abstract
We targeted the individual inactivation of E2f3a or E2f3b in mice and examined their contributions to cell proliferation and development. Chromatin immunoprecipitation and gene expression experiments using mouse embryo fibroblasts deficient in each isoform showed that E2F3a and E2F3b contribute to G...
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PMID: 19015245
PDF is available here.
Abstract
Recovery values of 200, 400, 600, 800, 1000 ms and grades for all groups were significantly different when compared to the control group. The most significant difference observed between the groups was at 200 msn and the smallest at 800 msn interstimuli intervals. The subjects within the group refer...
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PMID: 19280796
PDF is available here.
Abstract
We now know, for instance, that members of the transient receptor potential superfamily of nonselective cation channels function as transducers that convert specific external stimuli into neuronal activation. We also know that certain Na+ and K+ channels play specialized roles in regulating action p...
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PMID: 18825339
PDF is available here.
Abstract
Cough is an indispensable defensive reflex. Although generally beneficial, it is also a common symptom of diseases such as asthma, chronic obstructive pulmonary disease, upper respiratory tract infections, idiopathic pulmonary fibrosis and lung cancer. Cough remains a major unmet medical need and al...
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PMID: 18825340
PDF is available here.
Abstract
We have previously demonstrated that Sox3 is not only expressed in these structures but also marks a larger, earlier domain. Here we demonstrate that neurons are produced from the Sox3-positive ectoderm that lies outside of the classically-defined epibranchial placodes. Our data show that these regi...
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PMID: 19598119
PDF is available here.
Abstract
We discuss the role of IGFs during peripheral nervous system development and the IGF signaling system as the potential therapeutic target for the treatment of nerve injury and motor neuron diseases....
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PMID: 18719018
PDF is available here.
Abstract
Local administration of either morphine or a selective kappa-opioid agonist for three consecutive days from the onset of periodontal disease reduced the loss of periodontal tissues, without changing the number of leukocytes in inflamed periodontium. Nor-binaltorphimine, a selective kappa-antagonist,...
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PMID: 18705652
PDF is available here.
Abstract
All rats survived to the end of the experiment. At 12 and 16 weeks after the operation, group E was significantly different from group B in SFI (P < 0.05). At 20 and 24 weeks after the operation, group E was significantly different from groups B and C in SFI (P < 0.05). At 12 weeks after the operati...
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PMID: 19137896
PDF is available here.
Abstract
We conclude that collagen-blended chitosan nerve guides enhanced motor and sensory nerve recovery assayed through gait and behavioral testing compared to unblended nerve guides....
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PMID: 18817475
PDF is available here.
Abstract
We observed an effect of As on neurofilaments in the sciatic nerve. This study deals with the effects of inorganic As in Wistar rats on the cytoskeletal protein composition of the sciatic nerve after subchronic intoxication. Sodium meta-arsenite (NaAsO2) dissolved in phosphate-buffered saline (PBS)...
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PMID: 18674524
PDF is available here.
Abstract
These results suggest that oral diclofenac achieves effective concentrations producing an antinociceptive effect involving participation of the NO-potassium channel pathway at both, the local and spinal levels. In an additional experimental series, diclofenac was administered either locally (25-200...
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PMID: 18602417
PDF is available here.
Abstract
We found that treatment with GDNF had no effect on wild type neuronal numbers in any of the anatomic locations investigated. However, GDNF rescued the neurons of the facial motor nucleus, the mesencephalic nucleus and the median motor column in the absence of skeletal muscle. The findings of the cur...
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PMID: 18816441
PDF is available here.