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Peripheral Nerves (5)
Articles on Peripheral Nerves
Applications of 'TissueQuant'- A color intensity quantification tool for medical research
We describe two studies in medical research which use TissueQuant for quantification. The first study evaluated the effect of petroleum-ether extract of Cissus quadrangularis (CQ) on osteoporotic rats. It was found that the analysis results correlated well with the manual evaluation, p < 0.001. The...
Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats.
We next studied the effects of the selective MR antagonist eplerenone and the angiotensin II receptor blocker candesartan on motor and sensory nerve conduction velocity (NCV), morphometric changes and cyclooxygenase-2 (COX-2) gene and NF-κB protein expression in the peripheral nerves of STZ-induced...
Magnetic resonance imaging of peripheral nerves: differences in magnetization transfer.
We demonstrate the feasibility of measuring the MTR of foot nerves. The difference of MTR between median and foot nerves indicates a difference in structure/composition. The MTR of peripheral nerves may serve as a biomarker of nerve damage, collagen integrity, and demyelination. Copy...
Targeted reinnervation in the transfemoral amputee: a preliminary study of surgical technique.
Lower limb amputation is a common and growing problem in the United States. Current prosthetic technology is insufficient for transfemoral amputees to safely control their prostheses for demanding exercise such as stair climbing. Using a technique called targeted reinnervation, intui...
Interposition of autogenous venous nerve conduit: the transluminal stay stitch.
Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy.
We recently identified denervation at the neuromuscular junction in mice lacking the antioxidant enzyme, Cu,Zn-superoxide dismutase (SOD1) (Fischer et al., 2011). These mice show a phenotype of progressive muscle atrophy and weakness in the setting of chronic oxidative stress. Here, we investigated...
Perineural infiltration of cutaneous squamous cell carcinoma and basal cell carcinoma without clinical features.
To review the factors that influence outcome and patterns of relapse in patients with cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) with perineural infiltration (PNI) without clinical or radiologic features, treated with surgery and radiotherapy....
Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions.
Several studies have suggested that 5-HT(7) receptors are involved in nociceptive processing but the exact contribution of peripheral versus central 5-HT(7) receptors still needs to be elucidated. In the present study, the respective roles of peripheral and spinal 5-HT(7) receptors i...
[DNA microarray analysis in nerve biopsies of patients with vasculitic neuropathy].
We used this technique to identify differentially expressed genes (DEGs) in nerve biopsy samples of vasculitic neuropathy (VAS) patients. We find novel previously uncharacterized genes of relevance to VAS pathogenesis. Genes upregulated in VAS include IGLJ3, IGHG3, IGKC, and IGL, which all function...
Blocks for pain management in children undergoing ambulatory surgery.
Data from the USA show that the number of paediatric outpatient procedures has increased by almost 50% during the time period 1996-2006. Despite this increasing trend with regards to ambulatory surgery in children postoperative analgesia is still often suboptimal. The aim of this rev...