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All › Nucleic Acids, Nucleotides, and Nucleosides

Nucleic Acids, Nucleotides, and Nucleosides (5)

Articles on Nucleic Acids, Nucleotides, and Nucleosides

  1. Oral Nucleoside/Nucleotide Analogs Without Hepatitis B Immune Globulin After Liver Transplantation for Hepatitis B.
    James Fung, See-Ching Chan, ... Chung-Mau Lo

    Am J Gastroenterol (2013) PMID 23629601

    Oral nucleoside/nucleotide analogs without HBIG are effective in preventing graft loss secondary to hepatitis B recurrence after liver transplantation. However, new agents with a high barrier to resistance should be used to minimize drug resistance and to prevent virological rebound.Am J Gastroentero...
  2. Prolonged Lifespan with Enhanced Exploratory Behavior in Mice Overexpressing the Oxidized Nucleoside Triphosphatase hMTH1.
    Gabriele De Luca, Ilenia Ventura, ... Gemma Calamandrei

    Aging Cell (2013) PMID 23648059

    We used the hMTH1-Tg mouse model to investigate how oxidative damage to nucleic acids affects aging. hMTH1-Tg mice express high levels of the hMTH1 hydrolase that degrades 8-oxodGTP and 8-oxoGTP and excludes 8-oxoguanine from both DNA and RNA. Compared to wild-type animals, hMTH1-overexpressing mice...
  3. New synthetic substrates of mammalian nucleotide excision repair system.
    Alexey Evdokimov, Irina Petruseva, ... Olga Lavrik

    Nucleic Acids Res (2013) PMID 23609543

    DNA probes for the studies of damaged strand excision during the nucleotide excision repair (NER) have been designed using the novel non-nucleosidic phosphoramidite reagents that contain N-[6-(9-antracenylcarbamoyl)hexanoyl]-3-amino-1,2-propandiol (nAnt) and N-[6-(5(6)-fluoresceinylc...
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  4. Intrinsic Acid-Base Properties of a Hexa-2'-deoxynucleoside Pentaphosphate, d(ApGpGpCpCpT): Neighboring Effects and Isomeric Equilibria.
    Alicia Domínguez-Martín, Silke Johannsen, ... Roland K O Sigel

    Chemistry (2013) PMID 23595830

    These results quantify the release of H(+) from the two (N7)H(+) (G⋅G), the two (N3)H(+) (C⋅C), and the (N1)H(+) (A) units, as well as from the two (N1)H (G⋅G) and the (N3)H (T) sites. Based on measurements with 2'-deoxynucleosides at 25 °C and 47 °C, they were transferred to pKa values...
  5. Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy.
    Yuan Y Zhang, William Y WY Kim, and Leaf L Huang

    Biomaterials 34(13):3447-58 (2013) PMID 23380359

    We have encapsulated a biologically activate nucleotide analog (i.e. gemcitabine triphosphate (GTP)), instead of the nucleoside (i.e. gemcitabine) derivative, into a novel Lipid/Calcium/Phosphate nanoparticle (LCP) platform. The therapeutic efficacy of LCP-formulated GTP was evaluated in a panel of...
  6. Modeling the Conformational Preference of the Carbon-bonded Covalent Adduct Formed Upon Exposure of 2´-deoxyguanosine to Ochratoxin A.
    Purshotam Sharma, Richard Arnold Manderville, and Stacey D Wetmore

    Chem Res Toxicol (2013) PMID 23560542

    These results indicate that the adduct will likely adopt a syn conformation in an isolated nucleoside and nucleotide, while a mixture of syn and anti conformations will be observed in DNA duplexes. Since the syn conformation could stabilize base mismatches upon DNA replication or Z-DNA structures wi...
  7. Efficacy of tenofovir in patients with Lamivudine failure is not different from that in nucleoside/nucleotide analogue-naive patients with c...
    Bulent B Baran, Ozlem Mutluay OM Soyer, ... Sabahattin S Kaymakoglu

    Antimicrob Agents Chemother 57(4):1790-6 (2013) PMID 23380725

    We evaluated the efficacy of tenofovir disoproxil fumarate (TDF) in patients with lamivudine failure (LAM-F) in comparison with that in nucleoside/nucleotide analogue (NA)-naïve patients with chronic hepatitis B (CHB). The criteria for inclusion were being NA naïve or having previous LAM-F and rece...
  8. The solvent effect and identification of a weakly emissive state in nonradiative dynamics of guanine nucleosides and nucleotides - a combine...
    Chopen Chan-Wut Cheng, Chensheng Ma, ... Wai-Ming Kwok

    Photochem Photobiol Sci (2013) PMID 23538894

    A combined method of femtosecond broadband time-resolved fluorescence (fs-TRF) and transient absorption (fs-TA) was employed to investigate the excited state dynamics of 2'-deoxyguanosine (dG) and 2'-deoxyguanosine 5'-monophosphate (dGMP). Comparative fs-TRF and fs-TA measurements we...
  9. Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of HCV genotype 1-infected patients.
    Julia Dietz, Sven-Eric Schelhorn, ... Christoph Sarrazin

    J Virol (2013) PMID 23536652

    We applied ultradeep sequencing to determine ribavirin-induced sequence changes in the HCV coding region (nt 330-9351) of patients treated with six-week ribavirin monotherapy (n = 6) in comparison to placebo (n = 6). HCV RNA levels declined on average by -0.8 or increased by +0.1 log10 IU/mL in riba...
  10. Dynamics of hepatitis B virus quasispecies heterogeneity and virologic response in patients receiving low-to-moderate genetic barrier nucleo...
    J J Peveling-Oberhag, E E Herrmann, ... W-P WP Hofmann

    J Viral Hepat 20(4):234-9 (2013) PMID 23490367

    We characterized the early dynamics of hepatitis B virus (HBV) quasispecies evolution during the first weeks of antiviral therapy with low-to-moderate genetic barrier antiviral drugs and associated these data with antiviral response patterns. Fifteen chronic hepatitis B patients (men, 10; mean age,...