Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
DNA, Neoplasm (0):
Recent article
DNA, Neoplasm
Rivista Urologia (78)2 2011
Abstract
We present a short review of the literature describing a selection of the most promising alternatives to PSA being studied currently: PCA3, serum kallikreins, serum detectable prostate specific membrane antigen, the nuclear matrix protein EPCA, EPCA-2, prostatic acid phosphatase, urine detectable GS...
|
PMID: 21553390
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
The identification of patients with inherited cancer susceptibility syndromes facilitates early diagnosis, prevention, and treatment. However, in many cases of suspected cancer susceptibility, the family history is unclear and genetic testing of common cancer susceptibility genes is...
|
PMID: 21505135
PDF is available here.
PDF is available here.
Abstract
The BRAF(T1799A) mutation is reported to be associated to aggressive, persistent, and recurrent tumor in papillary thyroid carcinoma (PTC) patients. Association of the BRAF(T1799A) mutation in the primary tumor with the clinicopathological characteristics of PTC patients was analyzed...
|
PMID: 21441079
PDF is available here.
PDF is available here.
Abstract
Specific mutations of the epidermal growth factor receptor (EGFR) gene are predictive for favorable response to tyrosine kinase inhibitors (TKIs) and are associated with a good prognosis. In contrast, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation has been shown to predic...
|
PMID: 21258250
PDF is available here.
PDF is available here.
Abstract
Our objective was to evaluate SNaPshot and the KRAS StripAssay as alternatives to sequencing for KRAS mutation detection in daily practice. KRAS exon 2-specific PCR followed by sequencing or by a SNaPshot reaction was performed. For the StripAssay, a mutant-enriched PCR was followed by hybridization...
|
PMID: 21354055
PDF is available here.
PDF is available here.
Mutation Research (709-710) 2011
Abstract
We intended to explore a strategy to quickly identify somatic mutations in the entire mtDNA genome based on its phylogeny. The principal assumption for this strategy is that somatic mutations, as recently accumulated in cancerous tissue, have younger age and will be located in the terminal branches...
|
PMID: 21419139
PDF is available here.
PDF is available here.
Abstract
Mutation Research (707)1-2 2011
Abstract
Fragile histidine triad (FHIT) gene located at chromosome 3p14.2 is a putative tumor suppressor gene involved in the pathogenesis of breast cancer. Both genetic and epigenetic alterations in FHIT have been implicated in breast carcinoma. In the present study, our main aim was to study the impact of t...
|
PMID: 21095196
PDF is available here.
PDF is available here.
Abstract
Our goal was to identify candidate polymorphisms that could influence overall survival (OS) in advanced non-small cell lung cancer (NSCLC) patients treated with carboplatin (CBDCA) and paclitaxel (PTX).
Chemotherapy-naïve stage IIIB or IV NSCLC patients treated with CBDCA (area unde...
|
PMID: 21079520
PDF is available here.
PDF is available here.
Abstract
We analyzed Kras mutation and Kras copy number in 172 Japanese non-small cell lung cancer (NSCLC) cases and their relation to the survival of patients. We also studied using fluorescence in situ hybridization to provide direct evidence of Kras amplification in 40 clinical specimens....
|
PMID: 21150464
PDF is available here.
PDF is available here.
Abstract
We investigated the single-nucleotide polymorphism C-938A in the apoptotic gene BCL-2 to assess the potential impact as a genetic marker for response to chemotherapy and outcome prediction in small cell lung cancer (SCLC) patients. Such a marker might help optimize lung cancer treatment in a tailore...
|
PMID: 21107291
PDF is available here.
PDF is available here.
Abstract
We report five cases of patients with a never-smoking adenocarcinoma of the lung with such a pattern of metastases. In the tumor cells of all five patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified a deletion in exon 19 of the EGFR gene, and all five patients had a...
|
PMID: 21178715
PDF is available here.
PDF is available here.
Abstract
Identification of somatic mutations in cancer is a major goal for understanding and monitoring the events related to cancer initiation and progression. High resolution melting (HRM) curve analysis represents a fast, post-PCR high-throughput method for scanning somatic sequence altera...
|
PMID: 21264207
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (16)11 2010
Abstract
Breast cancer is the commonest type of malignancy in Iraq. The study was carried out on 721 out of a total of 5044 patients (14.3%) presenting with palpable breast lumps that were diagnosed as cancer. Approximately one third of the breast cancer patients were diagnosed at age 40-49 years; 71.9% came...
|
PMID: 21218740
PDF is available here.
PDF is available here.
Abstract
We believe reflects the intratumoral heterogeneity, should be taken into account when applying DNA ploidy to endometrial carcinoma specimens....
|
PMID: 20881853
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated the effectiveness of a microfluidic device, the CTC-Chip, in capturing these epithelial cell adhesion molecule (EpCAM)-expressing cells using antibody-coated microposts. Here, we describe a high-throughput microfluidic mixing device, the herringbone-chip, or "HB-Chip," whi...
|
PMID: 20930119
PDF is available here.
PDF is available here.
British Journal of Cancer (103)9 2010
Abstract
Oral epithelial dysplasia (OED) is a histologically detectable lesion that may progress to carcinoma but there are no accurate markers that predict progression. This study examined the development of carcinoma from oral dysplastic lesions, and the association between abnormal DNA content and progres...
|
PMID: 20859287
PDF is available here.
PDF is available here.
Epigenetics (5)7 2010
Abstract
Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular...
|
PMID: 20622527
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
We have hypothesized that during tumor development, cancer cells exhibit a mutator phenotype. As a defining feature of cancer, the mutator phenotype remains an as-yet unexplored therapeutic target: by reducing the rate at which mutations accumulate it may be possible to significantly delay tumor dev...
|
PMID: 20840072
PDF is available here.
PDF is available here.
Human Pathology (41)10 2010
Abstract
We observed a strong correlation between high p53 expression and DNA aneuploidy. This relation was also present at the level of a single nucleus, measured by sequential image cytometry of p53 immunohistochemistry followed by DNA image cytometry on formalin-fixed tissue sections. Similarly, we found...
|
PMID: 20656324
PDF is available here.
PDF is available here.
Abstract
We used a highly sensitive patient-specific nested quantitative PCR to look for evidence of genomic BCR-ABL1 DNA in patients who sustained CMR after stopping imatinib therapy. Seven of eight patients who sustained CMR off therapy had BCR-ABL1 DNA detected at least once after stopping imatinib, but n...
|
PMID: 20811403
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Ovarian cancer remains an ongoing challenge because of the occurrence of resistant forms of tumour for which the drugs fail to function. Combination therapy using drugs with different mechanisms of action offer a means of overcoming drug resistance and reducing the side-effects. In this study, binar...
|
PMID: 21036717
PDF is available here.
PDF is available here.
Cancer Research (70)19 2010
Abstract
We assessed NF-κB activation following coculture with endothelial cells. DNA binding of the NF-κB subunit Rel A was significantly increased and strongly correlated with changes in transcription of CD38, CD49d, BCL2, MCL1, and BCLXL, effects that were reversed by a peptide inhibitor of Rel A. These...
|
PMID: 20736369
PDF is available here.
PDF is available here.
Kidney International (76) 2010
Abstract
Kidney International (76) 2010
Abstract
Kidney International (78)10 2010
Abstract
Kidney International (78)10 2010
Abstract
Abstract
We analyzed the EGFR sequence of tumor samples from advanced stage non-small cell lung cancer patients previously participated in treatment clinical trials. Responses to chemotherapy and survival of EGFR mutation-positive or -negative patients were compared.
Tumor samples from 122 pa...
|
PMID: 20631634
PDF is available here.
PDF is available here.
Abstract
We studied expression of c-kit in a large retrospective series of thymic epithelial malignancies and sequenced the whole gene in a subset of patients.
Thymic epithelial tumors from 120 patients (13 thymic carcinomas and 107 thymomas) were examined. Immunohistochemical staining with a...
|
PMID: 20651610
PDF is available here.
PDF is available here.
Abstract
We studied expression of c-kit in a large retrospective series of thymic epithelial malignancies and sequenced the whole gene in a subset of patients.
Thymic epithelial tumors from 120 patients (13 thymic carcinomas and 107 thymomas) were examined. Immunohistochemical staining with a...
|
PMID: 20651610
PDF is available here.
PDF is available here.
Abstract
We analyzed the mutation frequencies of these three genes together with EGFR, and their association with overall survival in 61 Chinese patients with metastatic CRC (mCRC). Gene mutations were examined using pyrosequencing. Kaplan-Meier survival analysis and multivariate Cox proportional hazard anal...
|
PMID: 20652941
PDF is available here.
PDF is available here.
Abstract
These results should be validated in larger prospective studies using pemetrexed....
|
PMID: 20651609
PDF is available here.
PDF is available here.
Abstract
We report a case of primary Epstein Barr virus (EBV) negative peripheral T-cell lymphoma (PTCL) NOS in a 56-year-old female who-after an initially indolent course - simultaneously developed an aggressive, EBV+ cytotoxic large T-cell lymphoma, clonally related to the primary PTCL, and an EBV+, clonal...
|
PMID: 20739840
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to gain a better understanding of cancer genes contributing to oral squamous cell (OSCC) development and progression and correlate genetic changes to clinical parameters. Human papilloma virus (HPV) 16 detection is also included in the study. 60 samples of OSCC were analyse...
|
PMID: 20579853
PDF is available here.
PDF is available here.
Der Urologe (49)9 2010
Abstract
The presence of circulating cell-free DNA was demonstrated already in the 1940s. Improved detection methods have led to increased knowledge on cell-free DNA, and recent studies showed that most cancer patients have increased levels of cell-free DNA. Measurement of cell-free DNA allowed sensitive and...
|
PMID: 20628864
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
DNA content varied over time and different ploidy states were found to coexist at a single timepoint. Non-diploid DNA content was associated with shorter overall survival (median, 19 vs. 84 months, p=0.047). CONCLUSION: We encountered a change and heterogeneity of ploidy state. This implies that scr...
|
PMID: 20944159
PDF is available here.
PDF is available here.
Discovery medicine (10)51 2010
Abstract
There have been several publications recently that reported DNA sequence alterations in human tumors. There are gene deletions, amplifications, point mutations, translocations, and other genome changes in these samples compared to normal controls. There is also considerable variation...
|
PMID: 20807475
PDF is available here.
PDF is available here.
Abstract
Tumor Biology (31)4 2010
Abstract
We determined a methylation profile of tumor-related genes in serum of sporadic breast cancer (SBC). The multigene methylation was examined by methylation-specific polymerase chain reaction assay in serum of 50 SBCs and 50 paired nontumors, and CIMP+ was defined as having three genes that are concor...
|
PMID: 20490964
PDF is available here.
PDF is available here.
Tumor Biology (31)4 2010
Abstract
We analyzed methylation profile by methylation-specific PCR and mutations and polymorphisms by DNA sequencing. Methylation analysis showed that promoter hypermethylation was present in 38 of 50 (76%) patients. In addition, promoter region of WWOX gene of younger patients was more frequently methylat...
|
PMID: 20480411
PDF is available here.
PDF is available here.
Abstract
Cancer Treatment Reviews (36)5 2010
Abstract
We provide a summary of the basic mechanistic role of APE1 in DNA repair and redox regulation and highlight preclinical and clinical data that confirm APE1 as a valid anticancer drug target. Development of small molecule inhibitors of APE1 is an area of intense research and current evidence using AP...
|
PMID: 20056333
PDF is available here.
PDF is available here.
Abstract
Increased expression of HOXA10 was detected in almost all ovarian carcinomas (p < 0.05). Promoter hypomethylation was found in (17 of 29) 58.62% ovarian cancers and (4 of 16) 25% normal ovaries (p < 0.05). The HOXA10 expression is higher when the status of HOXA10 gene promoter is hypomethylated than...
|
PMID: 20151152
PDF is available here.
PDF is available here.
Abstract
Transcripts expressed from plasmid both in vitro and in vivo were identified by northern blot analysis. pGensil2-shRNA/FAK effectively down-regulated the expression of FAK as demonstrated in vitro by real time RT-PCR and western blot analysis, whereas by real time RT-PCR and IHC staining of MDA-MB-4...
|
PMID: 20140743
PDF is available here.
PDF is available here.
Abstract
WIF-1 silencing as a result of its promoter hypermethylation may be a frequent event in HCC....
|
PMID: 20119713
PDF is available here.
PDF is available here.
Abstract
In summary, application of HRM analysis to large amount of clinical samples proves to be a fast and high-throughput way to investigate the epigenetic status of GADD45G. And this is the first study to evaluate the prevalence of GADD45G methylation based on large amount of tumor samples, showing that...
|
PMID: 20111973
PDF is available here.
PDF is available here.
Abstract
We characterized the sterol-response element and NF-Y (nuclear factor Y)-binding site in the human FDPS promoter. Using a luciferase assay, electrophoretic mobility-shift assay and chromatin immunoprecipitation assay, we demonstrated that these elements are responsible for the transcription of the F...
|
PMID: 20450493
PDF is available here.
PDF is available here.
Life Sciences (87)3-4 2010
Abstract
The frequency of tumor hypermethylation was 27% in BRCA1, 32% in MGMT and 25% in GSTP1 and correlated with methylation of these genes in paired serum DNA. Immunohistochemical analysis showed no detectable expression of BRCA1 and MGMT in 51/89 (57%) and 35/89 (39%) tumors, respectively. MGMT promoter...
|
PMID: 20470789
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We provide evidence that the synthetic derivative of benzofuran lignan (Benfur) showed antitumor activities. It induced apoptosis in p53-positive cells. Though it inhibited endotoxin-induced nuclear factor kappaB (NF-kappaB) activation in both p53-positive and -negative cells, the activation of casp...
|
PMID: 20472557
PDF is available here.
PDF is available here.
Abstract
In this prospective study of older women, cigarette smoking was associated with the MSI-high, CIMP-positive, and BRAF mutation-positive colorectal cancer subtypes, which indicates that epigenetic modification may be functionally involved in smoking-related colorectal carcinogenesis....
|
PMID: 20587792
PDF is available here.
PDF is available here.
Journal of Cell Biology (190)1 2010
Abstract
British Journal of Cancer (103)2 2010
Abstract
Malten exposure led to a dose-dependent reduction in cell survival in all the neoplastic models studied. Sublethal concentrations of malten induce profound cell cycle changes, particularly affecting the S and/or G2-M phases, whereas exposure to lethal doses causes the induction of programmed cell de...
|
PMID: 20571494
PDF is available here.
PDF is available here.
Abstract
We sought to determine the clonality and TP53 mutation status of FNH to better characterize the nature of FNH. We analyzed 15 cases of FNH from female patients who underwent surgical resection of their lesions. Genomic DNA was extracted from paraffin-embedded tissue sections using laser-capture micr...
|
PMID: 20551268
PDF is available here.
PDF is available here.
Abstract
We compared IGH VDJ sequences in 4 patients with 2 sequential sites of MALT lymphoma. The specimen pairs were stomach and nasopharynx, stomach and lung, ocular adnexa and nasopharynx, and ocular adnexa and parotid gland. The median interval between biopsies was 4 months (range, 1-32 months). Monoclo...
|
PMID: 20551275
PDF is available here.
PDF is available here.
Abstract
We assessed the standardized BIOMED-2 IGH and IGK PCR primers for the detection of clonality using 50 consecutively diagnosed formalin-fixed, paraffin-embedded (FFPE) classic HL specimens. Without microdissection, clonality was detected in 23 of 47 assessable cases. The IGK assay was significantly m...
|
PMID: 20551274
PDF is available here.
PDF is available here.
Abstract
We compared the Access Genetics (Minneapolis, MN) polymerase chain reaction (PCR) assay (AGPCR), DNA-DNA in situ hybridization (ISH; Ventana, Tucson, AZ), and HPV-16 E7 PCR amplification in consecutively accessioned oropharyngeal cancers. We tested 126 cases by both PCR methods; 102 were positive by...
|
PMID: 20551264
PDF is available here.
PDF is available here.
Abstract
We describe 3 such cases in which we employed fluorescence in-situ hybridization analysis to detect translocation involving the EWS gene and reverse transcription polymerase chain reaction followed by sequencing to detect the fusion transcript EWS-FLI1....
|
PMID: 20495444
PDF is available here.
PDF is available here.
Abstract
We retrospectively investigated 46 well-characterized LCH cases to detect clonal rearrangements of T-cell receptor gamma gene (TRG@) and immunoglobulin heavy chain and kappa light chain genes (IGH@/IGK@). The study included 25 males and 21 females, with ages ranging from <1 to 59 years. None (0/46)...
|
PMID: 20551822
PDF is available here.
PDF is available here.
Abstract
PURPOSE. The purposes of this study were to investigate the frequency of MET activation in uveal melanomas (UMs), to study the potential molecular mechanism for its activation, and to assess the utility of MET inhibition as a potential therapy for UM. METHODS. The frequency of MET activation in UMs...
|
PMID: 20164465
PDF is available here.
PDF is available here.
Clinical Cancer Research (16)13 2010
Abstract
These biomarkers can distinguish between cancerous and noncancerous abnormal CT findings....
|
PMID: 20592015
PDF is available here.
PDF is available here.