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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
DNA (26):
- DNA Adducts
- DNA, Satellite
- DNA, Ribosomal
- DNA, Antisense
- DNA, Circular
- DNA, Protozoan
- DNA, Fungal
- DNA, C-Form
- DNA, Algal
- Isochores
- DNA, Single-Stranded
- DNA, Helminth
- DNA, Catalytic
- DNA, Cruciform
- DNA, Archaeal
- Retroelements
- DNA, Bacterial
- DNA, Z-Form
- DNA, Recombinant
- DNA, Plant
- DNA, Neoplasm
- DNA Transposable Elements
- DNA, Intergenic
- DNA, Concatenated
- DNA, Viral
- DNA, A-Form
Recent article
DNA
Abstract
We present six design rules that can be used to deliberately prepare nine distinct colloidal crystal structures, with control over lattice parameters on the 25- to 150-nanometer length scale. These design rules outline a strategy to independently adjust each of the relevant crystallographic paramete...
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PMID: 21998382
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Abstract
We first conducted 4 association studies (2639 individuals) that showed a protective effect of the -308A allele (odds ratio [OR] = 0.77; P = .005). Next, results of a meta-analysis reinforced this association after inclusion of our new data (OR = 0.74; P = .04). Furthermore, a subgroup analysis incl...
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PMID: 21917899
PDF is available here.
PDF is available here.
FEBS Journal (278)19 2011
Abstract
Chromatin remodelling is the ATP-dependent change in nucleosome organisation driven by Snf2 family ATPases. The biochemistry of this process depends on the behaviours of ATP-dependent motor proteins and their dynamic nucleosome substrates, which brings significant technical and conce...
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PMID: 21810178
PDF is available here.
PDF is available here.
FEBS Journal (278)19 2011
Abstract
Through its capability to transiently pack and unpack our genome, chromatin is a key player in the regulation of gene expression. Single-molecule approaches have recently complemented conventional biochemical and biophysical techniques to decipher the complex mechanisms ruling chroma...
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PMID: 21810177
PDF is available here.
PDF is available here.
FEBS Journal (278)19 2011
Abstract
We discuss nucleosome dynamics from two angles. First, we describe the dynamical modes of nucleosomes in the absence of remodelers that are experimentally fairly well characterized and theoretically understood. Then, we discuss remodelers and describe recent insights about the possible schemes that...
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PMID: 21812931
PDF is available here.
PDF is available here.
Abstract
Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation of tegafur to PEI-CyD via...
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PMID: 21887847
PDF is available here.
PDF is available here.
Molecular BioSystems (7)9 2011
Abstract
PELDOR (pulsed electron-electron double resonance) spectroscopy was applied to determine spin-spin distances in spin-labeled DNA duplexes (13-mer and 17-mer) containing the damaged sites 8-oxoguanine or uncleavable abasic site analogue tetrahydrofuran. The lesions were located in one...
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PMID: 21731955
PDF is available here.
PDF is available here.
Molecular BioSystems (7)9 2011
Abstract
We report a general pH-responsive, DNA-directed assay for the design of a reversible assembly of GO-GO and GO-AuNPs hybrid using human telomeric G-quadruplex and i-motif DNA....
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PMID: 21748191
PDF is available here.
PDF is available here.
Abstract
We describe the potential of estimating melting temperature (T(m)) for nonstandard oligonucleotides by using the correlation of the experimental T(m) with the calculated duplex binding energy (BE) for oligonucleotides of a given length. This method has been automated into a standardized molecular dy...
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PMID: 21702481
PDF is available here.
PDF is available here.
Abstract
Noninvasive prenatal determination of fetal sex using cell-free fetal DNA provides an alternative to invasive techniques for some heritable disorders. In some countries this testing has transitioned to clinical care, despite the absence of a formal assessment of performance....
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PMID: 21828326
PDF is available here.
PDF is available here.
Abstract
Abstract
We tested this hypothesis in mosquito populations in Florida. A new polymerase chain reaction species diagnostic applied to sperm dissected from 304 field-collected females revealed bidirectional cross-mating in five (1.6%) individuals. Cross-injections of females with Acps showed that Ae. albopictu...
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PMID: 21813845
PDF is available here.
PDF is available here.
DNA Repair (10)7 2011
Abstract
Despite detailed knowledge on the genetic network and biochemical properties of most of the nucleotide excision repair (NER) proteins, cell biological analysis has only recently made it possible to investigate the temporal and spatial organization of NER. In contrast to several other...
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PMID: 21550320
PDF is available here.
PDF is available here.
Abstract
Lipoic acid (LA) is an antioxidant with therapeutic potential on several diseases such as diabetes and obesity. Hyperleptinemia and oxidative stress play a major role in the development of obesity-linked diseases. The aim of this study was to examine in vivo and in vitro the effects...
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PMID: 21351249
PDF is available here.
PDF is available here.
Abstract
We examined a genetic marker on the CD86 gene in kidney transplant outcome.
In our retrospective study, 168 kidney allograft recipients were genotyped by direct sequencing. Patients were classified into 2 groups of 29 human leukocyte antigen (HLA)-identical haplotype allograft recipi...
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PMID: 21525579
PDF is available here.
PDF is available here.
Abstract
We synthesize a new cationic water-soluble CP containing fluorene moiety and flexible ethylenic moiety in the backbone (PFV) for label-free DNA detection. The conformational freedom of PFV provides stronger interactions with double-stranded DNA (dsDNA) and optimizes the orientation of transition mom...
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PMID: 21093227
PDF is available here.
PDF is available here.
Biophysics (40)1 2011
Abstract
We provide a brief historical account of how the overriding perception regarding aspects of nucleosome structure has changed over the past thirty years. We discuss recent technical advances regarding nucleosome structure and its physical characterization and review the evidence for alternative nucle...
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PMID: 21332355
PDF is available here.
PDF is available here.
PLoS Biology (9)6 2011
Abstract
We show here that mammalian cells lacking High Mobility Group Box 1 protein (HMGB1) contain a reduced amount of core, linker, and variant histones, and a correspondingly reduced number of nucleosomes, possibly because HMGB1 facilitates nucleosome assembly. Yeast nhp6 mutants lacking Nhp6a and -b pro...
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PMID: 21738444
PDF is available here.
PDF is available here.
Abstract
We report for the first time the use of DNA hybridization for the controllable assembly of a graphene nanosheet. Moreover, with the help of dynamic light scattering technique, we extended the above studies by exploiting the DNA-graphene dispersed sheets as highly ultrasensitive detection of oligonul...
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PMID: 21534537
PDF is available here.
PDF is available here.
Abstract
We are able to conjugate GNP with peptides, drugs, and other molecules to gain astonishing effects. High quality, non-invasive imaging will inevitably lead to astonishing accuracy diagnostic tools with effective use during surgery. The same principles may be used in the future for drug delivery and...
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PMID: 21780364
PDF is available here.
PDF is available here.
DNA Repair (10)5 2011
Abstract
We show that FANCD2 deficient cells have a defective S-phase checkpoint after Hydrogen Peroxide (H(2)O(2)) induced oxidative damage. ATM dependent phosphorylation of FANCD2 at the S222 residue is necessary for normal S-phase checkpoint activation after oxidative stress, while FANCD2 monoubiquitinati...
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PMID: 21466974
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2011)5 2011
Abstract
Protein-DNA interactions (PDIs) are critical for many cellular processes. We present here a protocol for the identification of PDIs in vitro using protein microarray technology. The procedure involves double-stranding synthesized DNA oligonucleotides with a fluorescent-labeled primer, binding the la...
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PMID: 21536762
PDF is available here.
PDF is available here.
DNA Repair (10)5 2011
Abstract
We use two protein footprinting techniques, limited proteolysis and oxidative surface mapping, coupled with mass spectrometry to identify amino acids involved along the DNA-binding surface of the Pms1-NTD. Limited proteolysis experiments elucidated several basic residues that were protected in the p...
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PMID: 21354867
PDF is available here.
PDF is available here.
Abstract
We propose an integrative and practical strategy for optimizing a complex dynamic model by using qualitative and incomplete experimental data. The key technologies are the divide and conquer method for reducing the search space, handling of multiple objective functions representing different types o...
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PMID: 21113727
PDF is available here.
PDF is available here.
Abstract
Obesity in adults is associated with shorter mean leukocyte telomere length (LTL), a marker of biological age that is also associated with age-related conditions including cardiovascular disease and type 2 diabetes. However, studies of childhood obesity and LTL have proved inconclusi...
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PMID: 21349907
PDF is available here.
PDF is available here.
Abstract
Cell Cycle (10)8 2011
Abstract
We show that RNF8 and RNF168 are recruited to DNA damage foci in late mitosis, presumably to prime sites for 53BP1 recruitment in early G1. Interestingly, we show that, although RNF8, RNF168 and 53BP1 are excluded from DSB sites during most of mitosis, they associate with mitotic structures such as...
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PMID: 21412056
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We demonstrate that the absence of E2F1 leads to spontaneous DNA breaks and impaired recovery following exposure to ionizing radiation. E2F1 deficiency results in defective NBS1 phosphorylation and foci formation in response to DSBs but does not affect NBS1 expression levels. Moreover, an increased...
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PMID: 21512314
PDF is available here.
PDF is available here.
Abstract
Total atherosclerotic occlusions often include significant calcium deposits. Current animal models do not mimic the pathology of gradual occlusion of arteries and lack cell-mediated calcium. The primary goal of this project was to establish an animal model incorporating these feature...
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PMID: 20827712
PDF is available here.
PDF is available here.
Abstract
A bio-nanofilm consisting of a tetrad nanomaterial (nanotubes, nanoparticles, DNA, polymer) was fabricated utilizing in situ reduction and noncovalent interactions and it displayed effective antibacterial activity and biocompatibility. This bio-nanofilm was composed of homogenous sil...
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PMID: 21336791
PDF is available here.
PDF is available here.
Abstract
We show that in the human, although there are no differences in expression of NF-κB p65, or IκB-α between upper- or lower-segment myometrium or before or after labour, there is nuclear localization of serine-256-phospho-p65 and serine-536-phospho-p65 in both upper- and lower-segment myometrium bo...
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PMID: 20406326
PDF is available here.
PDF is available here.
Abstract
We conducted here a meta-analysis study in order to evaluate and compare the newly generated antibody levels after golimumab therapy. The examination of original clinical trials revealed that their levels were neither higher nor significant. Moreover, no evident associations between the induced-anti...
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PMID: 21612149
PDF is available here.
PDF is available here.
Mutation Research (712)1-2 2011
Abstract
I in chromosomal DNA replication in E. coli was investigated using the rpoB forward target. These experiments indicated that in a strain carrying a proofreading-exonuclease-defective form of Pol I (polAexo mutant) the frequency of rpoB mutations increased by about 2-fold, consistent with a model tha...
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PMID: 21459099
PDF is available here.
PDF is available here.
Abstract
We identify molecular events particularly likely to produce significant regulatory changes in humans: complete deletion of sequences otherwise highly conserved between chimpanzees and other mammals. We confirm 510 such deletions in humans, which fall almost exclusively in non-coding regions and are...
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PMID: 21390129
PDF is available here.
PDF is available here.
Abstract
We consider the ethical requirements, our hypothesis that genetic susceptibility modifies the risk of cerebral palsy in the presence of perinatal environmental triggers, a priori primary and secondary aims, power calculations, participant recruitment strategies, data linkage, sampling methods of gen...
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PMID: 21091581
PDF is available here.
PDF is available here.
Abstract
We provide a practical guide for design and assembly of scaffolded DNA origami objects. We also introduce a computational tool for predicting the structure of DNA origami objects and provide information on the conditions under which DNA origami objects can be expected to maintain their structure....
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PMID: 21358626
PDF is available here.
PDF is available here.
Abstract
We undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P =...
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PMID: 21040458
PDF is available here.
PDF is available here.
Abstract
We show that TAp63α is kept in an inactive dimeric state. We reveal that relief of inhibition leads to tetramer formation with ∼20-fold higher DNA affinity. In vivo, phosphorylation-triggered tetramerization of TAp63α is not reversible by dephosphorylation. Furthermore, we show that a helix in t...
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PMID: 21335238
PDF is available here.
PDF is available here.
Cell Cycle (10)4 2011
Abstract
Scientific American (304)2 2011
Abstract
Abstract
A family of biodegradable poly(amine-co-esters) was synthesized in one step via enzymatic copolymerization of diesters with amino-substituted diols. Diesters of length C(4) -C(12) (i.e., from succinate to dodecanedioate) were successfully copolymerized with diethanolamines with eithe...
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PMID: 21171165
PDF is available here.
PDF is available here.
Biomedical Materials (6)1 2011
Abstract
Stem cell-based tissue engineering has provided an alternative strategy to treat cartilage lesions, and synovium-derived mesenchymal stem cells (SMSCs) are considered as a promising cell source for cartilage repair. In this study, the SMSCs were isolated from rat synovium, and CD105-...
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PMID: 21205995
PDF is available here.
PDF is available here.
Abstract
We used fluorescence microscopy and 3-dimensional image analysis to compare mESC and differentiated cells, with regard to HR-mediated repair of spontaneous and X-ray-induced double-strand breaks (DSBs). Microscopic analysis of repair foci, flow cytometry, and functional assays of the major DSB repai...
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PMID: 20491544
PDF is available here.
PDF is available here.
Abstract
NFκB is an inducible transcriptional factor controlled by two principal signaling cascades and plays pivotal roles in diverse physiological processes including inflammation, apoptosis, oncogenesis, immunity, and development. Activation of NFκB signaling was detected in skin of SHAP...
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PMID: 21829440
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
The nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins. The dynamics associated with these various components are responsible for making sure that the DNA is properly duplicated, genes are properly trans...
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PMID: 20855937
PDF is available here.
PDF is available here.
Oligonucleotides (21)2 2011
Abstract
We focused on the function of special AT-rich sequence binding protein 1 (SATB1) as a target molecule for the treatment of TN breast cancers. By recruiting chromatin remodeling enzymes and transcriptional factors, SATB1 regulates the expression of >1,000 genes related to cell growth and translocatio...
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PMID: 21500976
PDF is available here.
PDF is available here.
Oligonucleotides (21)2 2011
Abstract
Oligonucleotide- and polynucleotide-based gene modification strategies were developed as an alternative to transgene-based and classical gene targeting-based gene therapy approaches for treatment of genetic disorders. Unlike the transgene-based strategies, oligo/polynucleotide gene t...
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PMID: 21417933
PDF is available here.
PDF is available here.
Abstract
These results demonstrated that mucosal immunization with chitosan-psaA may successfully generate mucosal and systemic immune responses and prevent pneumococcal nasopharyngeal colonization. Hence, a chitosan-DNA nanoparticle vaccine expressing pneumococcal major immunodominant antigens after intrana...
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PMID: 21047997
PDF is available here.
PDF is available here.
Abstract
This study aims to assess the in vivo performance of cell-scaffold constructs composed of goat marrow stromal cells (GBMCs) and SPCL (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. GBMCs from iliac crests w...
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PMID: 20603869
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
A degradable, polar, hydrophobic, ionic polyurethane (D-PHI), with physical properties comparable to those of peripheral arterial vascular tissue, was evaluated for monocyte interactions with two different physical forms: two-dimensional films and three-dimensional porous scaffolds....
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PMID: 20728587
PDF is available here.
PDF is available here.
Abstract
Incorporation of gene into electrospun nanofibers for localized gene transfection of target cells represents a robust platform for tissue regeneration. In this study, a new two-step approach was explored to immobilize DNA onto electrospun nanofibers for effective gene delivery, that...
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PMID: 21105170
PDF is available here.
PDF is available here.
Abstract
We show that direct dsDNA stimulation of endothelial cells induces a potent proinflammatory response as demonstrated by increased expression of ICAM1, E-selectin and VCAM1, and enhanced leukocyte adhesion. This response was dependent on the stress kinases JNK and p38 MAPK, required the activation of...
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PMID: 21611132
PDF is available here.
PDF is available here.
Nature Protocols (6)1 2011
Abstract
We describe a protocol for hiPSC derivation by transfection of a simple, nonviral minicircle DNA construct into human adipose stromal cells (hASCs). Minicircle DNA vectors are free of bacterial DNA and thus capable of high expression in mammalian cells. Their repeated transfection into hASCs, abunda...
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PMID: 21212777
PDF is available here.
PDF is available here.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] (Chapter 3) 2011
Abstract
Reaction conditions for a variety of endonucleases are detailed in this unit along with discussions of potential applications. Enzymes covered include BAL 31 nuclease, S1 nuclease, mung bean nuclease, micrococcal nuclease, and DNase I. A general discussion regarding the use of endonu...
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PMID: 21225639
PDF is available here.
PDF is available here.
Biology Direct (6) 2011
Abstract
We review the history of the terminology and suggest retaining a single sense that is currently the most useful and consistent. PROPOSAL: The Saccharomyces Genome Database defines the Watson strand as the strand which has its 5'-end at the short-arm telomere and the Crick strand as its complement. T...
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PMID: 21303550
PDF is available here.
PDF is available here.
Abstract
Two vital pre-requisites for genetic epidemiology have been fullfiled during the past decade and have led to a virtual explosion of knowledge concerning disease risks. Reliable databases over genetic variation derived from, e.g. the HUGO and HapMap projects, coupled with technological advances make...
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PMID: 20949395
PDF is available here.
PDF is available here.
Abstract
There are several types of bioreactors currently available for the culture of orthopaedic tissue engineered constructs. These vary from the simple to the complex in design and culture. Preparation of samples for bioreactors varies depending on the system being used. This chapter presents data and de...
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PMID: 21042966
PDF is available here.
PDF is available here.
Abstract
In summary, recently developed technologies have begun to draw back the curtain of mystery that obscures some of the basic mechanisms of DNA replication at multiple levels. Studies using extended DNA and chromatin fiber techniques have proven valuable for identifying the location of...
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PMID: 21093474
PDF is available here.
PDF is available here.
Abstract
The self-assembling of cationic liposomes (CLs) and DNA can give rise to a variety of nanostructures and morphologies. Multilamellar complexes are made of DNA intercalated between opposing lipid bilayers, while clusters formed by intact vesicles may exist as 'beads-on-a-string' (i.e. CLs attached to...
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PMID: 20843667
PDF is available here.
PDF is available here.