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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Codon (2):
Recent article
Codon
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Biochimica et Biophysica Acta (1808)10 2011
Abstract
We analysed the importance of signal sequence non-optimal codons of TolB, a signal recognition particle (SRP) dependent exported protein. The protein production levels of wild type TolB (TolB-wt) and a mutant allele of TolB in which all signal sequence non-optimal codons were changed to a synonymous...
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PMID: 21699884
PDF is available here.
PDF is available here.
Abstract
We analyzed the possible relationship between the protein folding rates and the corresponding mRNA sequences. The content of guanine and cytosine (GC content) of palindromes in protein coding sequence was introduced as a new parameter and added in the Gromiha's model of predicting protein folding ra...
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PMID: 21613670
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe a targeted approach for affinity improvement of therapeutic antibodies. Sets of CDR residues that are solvent accessible and relatively diverse in natural antibodies are targeted for diversification. Degenerate oligonucleotides are used to generate combinatorial phage-displayed antibody...
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PMID: 19252851
PDF is available here.
PDF is available here.
Abstract
These results are in concordance with modern series conducted worldwide....
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PMID: 21678640
PDF is available here.
PDF is available here.
Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] (27)3 2011
Abstract
Abstract
We review modern developments in genomics and systems biology that have revolutionized our understanding of the multiple means by which translation is regulated. We suggest new means to model the process of translation in a richer framework that will incorporate information about gene sequences, the...
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PMID: 21487400
PDF is available here.
PDF is available here.
Abstract
I ovarian tumors (9.1%) including low-grade serous, low-grade endometrioid, clear-cell, and mucinous carcinomas. In contrast, none of 71 type II ovarian (high-grade serous) carcinomas exhibited PPP2R1A mutations. Moreover, PPP2R1A mutations were observed in 2 of 30 type I uterine (endometrioid) carc...
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PMID: 21435433
PDF is available here.
PDF is available here.
Biopolymers (95)9 2011
Abstract
We applied Brownian dynamics methodology to study bimolecular association in the bacterial EF-G/70S ribosome system. We estimated the EF-G association rate constants at 150 and 300 mM monovalent ionic strengths and obtained reasonable agreement with kinetic experiments. We have also elucidated the d...
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PMID: 21394717
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of genetic polymorphisms at codon 10 on the development of alcoholic liver cirrhosis (ALC)....
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PMID: 21494076
PDF is available here.
PDF is available here.
Abstract
The aim of our study was to increase the clinical meaningfulness of the virological data through mRNA E6/E7 oncoprotein identification, and to find a correlation between codon 72 polymorphism of the p53 gene and integration of HPV in host cell genomes.
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PMID: 21446327
PDF is available here.
PDF is available here.
Abstract
We think that the test of Theobald is not sufficient enough to reject the alternative hypothesis of the separate origins of life, despite the Akaike information criterion (AIC) of model selection giving a clear distinction between the competing hypotheses....
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PMID: 21164432
PDF is available here.
PDF is available here.
Abstract
The RET proto-oncogene (REarranged during Transfection; RET) plays an important role in the causation of many thyroid tumours. Germline RET proto-oncogene missense mutations have been clearly linked to medullary thyroid carcinoma (MTC) and the inherited cancer syndrome multiple endocrine neoplasia ty...
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PMID: 21542403
PDF is available here.
PDF is available here.
Abstract
Recent progress in understanding the production, processing, and function of the cystic fibrosis gene product, the cystic fibrosis transmembrane conductance regulator (CFTR), has revealed new therapeutic targets to repair the mutant protein. Classification of CFTR mutations and new treatment strateg...
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PMID: 20829696
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We analyse the speed and accuracy of the decoding step under conditions reproducing the high speed of translation in vivo. We show that error frequency is close to 10⁻³, consistent with the values measured in vivo. Selectivity is predominantly due to the differences in k(cat) values for cognate a...
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PMID: 20842102
PDF is available here.
PDF is available here.
Abstract
We studied the association between KRAS mutation status (p.G13D vs other KRAS mutations) and response and survival in a pooled data set of 579 patients with chemotherapy-refractory colorectal cancer treated with cetuximab between 2001 and 2008. Patients were included in the CO.17, BOND, MABEL, EMR20...
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PMID: 20978259
PDF is available here.
PDF is available here.
Abstract
We show that Dom34:Hbs1 interacts with the ribosome to promote subunit dissociation and peptidyl-tRNA drop-off. Our data further indicate that these recycling activities are shared by the homologous translation termination factor complex eRF1:eRF3, suggesting a common ancestral function. Because Dom...
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PMID: 20947765
PDF is available here.
PDF is available here.