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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
RNA, Messenger (5):
Recent article
RNA, Messenger
Nature Genetics (43)5 2011
Abstract
We identify an association between variants in GPC5, encoding glypican-5, and acquired nephrotic syndrome through a genome-wide association study and replication analysis (P value under a recessive model (P(rec)) = 6.0 × 10(-11), odds ratio = 2.54). We show that GPC5 is expressed in podocytes and t...
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PMID: 21441931
PDF is available here.
PDF is available here.
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Transplantation (91)8 2011
Abstract
We studied early transcriptional changes of inflammatory mediators in the grafts during combined auxiliary liver-kidney transplantation using microarrays and real-time polymerase chain reaction. The results were correlated to clinical data.
Liver and kidney grafts both exhibited an u...
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PMID: 21494202
PDF is available here.
PDF is available here.
Abstract
We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for MD. Risk allele carrier status in humans and chronic stress in mice were associated with a downregulation of the expression of this gene in the hippo...
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PMID: 21521612
PDF is available here.
PDF is available here.
Abstract
We review modern developments in genomics and systems biology that have revolutionized our understanding of the multiple means by which translation is regulated. We suggest new means to model the process of translation in a richer framework that will incorporate information about gene sequences, the...
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PMID: 21487400
PDF is available here.
PDF is available here.
Abstract
Ritonavir is a potential therapeutic agent in lung cancer, but its targets in lung adenocarcinoma are unknown, as are candidate biomarkers for its activity.
RNAi was used to identify genes whose expression affects ritonavir sensitivity. Synergy between ritonavir, gemc...
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PMID: 21270666
PDF is available here.
PDF is available here.
Abstract
To investigate the therapeutic effects and mechanisms of using artemisinin (Art) combined with glucocorticoid (GC) to treat lupus nephritis (LN) mice.
Forty hybrid female mice were randomly and equally divided into four groups with the method of random number table: c...
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PMID: 21509671
PDF is available here.
PDF is available here.
Abstract
We hypothesize that the positive effects of adiponectin against atherosclerosis are explained in part by its interactions with EPCs. Cells were obtained from healthy volunteers' blood by mononuclear cell isolation and plating on collagen-coated dishes. Three sub-populations of EPCs were identified a...
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PMID: 20814418
PDF is available here.
PDF is available here.
Abstract
Detection of osteogenic differentiation is crucial for bone tissue engineering. Despite established standard end point assays, there is increasing demand for methods allowing noninvasive kinetic differentiation monitoring. Reporter gene assays employing tissue-specific promoters and...
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PMID: 21043997
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We analyzed proteome dynamics during plasma cell differentiation with combined 2-DE/MS. Thirty-two identified protein spots changed in relative abundance when lipopolysaccharide (LPS)-stimulated primary B cells differentiated into antibody-secreting plasma cells. A correlative analysis of protein an...
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PMID: 21319304
PDF is available here.
PDF is available here.
PLoS Biology (9)4 2011
Abstract
We report a yeast model of human FUS/TLS expression that recapitulates multiple salient features of the pathology of the disease-causing mutant proteins, including nuclear to cytoplasmic translocation, inclusion formation, and cytotoxicity. Protein domain analysis indicates that the carboxyl-terminu...
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PMID: 21541368
PDF is available here.
PDF is available here.
Experimental Gerontology (46)4 2011
Abstract
With the advancement of age, skeletal muscle undergoes a progressive decline in mass, function, and regenerative capacity. Previously, our laboratory has reported an age-reduction in recovery and local induction of IGF-I gene expression with age following tourniquet (TK)-induced skel...
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PMID: 21094246
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)4 2011
Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.
Abstract
We test our hypothesis that the Hypocretin system is regulated by TNF-α. Prepro-Hypocretin and Hypocretin receptor 2 (HcrtR2) can be detected at a very low level in rat B35 neuroblastoma cells. In response to TNF-α, Prepro-Hypocretin mRNA and protein levels are down-regulated, and also HcrtR2 prot...
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PMID: 21094253
PDF is available here.
PDF is available here.
Abstract
miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer.
Abstract
The ability to diagnose non-small cell lung cancer (NSCLC) at an early stage may lead to improved survival. The aim of this study was to identify differentially expressed serum-based microRNAs (miRNAs) between patients with early-stage NSCLC and controls. These miRNAs may serve as bi...
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PMID: 21258252
PDF is available here.
PDF is available here.
Abstract
To test the hypothesis that combinatorial interference of toll-like receptor 2 (TLR2) and TLR4 is superior to isolated interference of TLR2 or TLR4 in stabilizing atherosclerotic plaques, lentiviruses carrying small interfering RNA of TLR2 or TLR4 were constructed and proved efficaci...
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PMID: 20132416
PDF is available here.
PDF is available here.
Abstract
We analyzed the B-cell response in a rat model of long-term cardiac allograft tolerance induced by a short-term immunosuppression. We observed that tolerated allografts are infiltrated by numerous B cells organized in germinal centers that are strongly regulated in their IgG alloantibody response. M...
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PMID: 21114655
PDF is available here.
PDF is available here.
Journal of Hepatology (54)3 2011
Abstract
Hyperoxaluria is a major problem causing nephrolithiasis. Little is known about the regulation of oxalate transport from the liver, the main organ for oxalate synthesis, into the circulation. Since the sulfate anion transporter-1(sat-1) is present in the sinusoidal membrane of hepato...
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PMID: 21093948
PDF is available here.
PDF is available here.
Abstract
We report mutants of a novel Drosophila gene twenty-four (tyf) that show weak behavioural rhythms. Weak rhythms are accompanied by marked reductions in the levels of the clock protein Period (PER) as well as more modest effects on Timeless (TIM). Nonetheless, PER induction in pacemaker neurons can r...
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PMID: 21331043
PDF is available here.
PDF is available here.
Abstract
We show that hypoxia induces the expression of Snail via HIF. In silico analysis identified a potential hypoxia-response element (HRE) close to the minimal promoter of the human and mouse genome of the snail gene. Gel shift assays demonstrated that a specific hypoxia-inducible complex is formed with...
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PMID: 21257819
PDF is available here.
PDF is available here.
Oligonucleotides (21)1 2011
Abstract
Recently, it has been reported that, in several tumor cell lines, short double-stranded RNAs tailored for promoter regions of specific genes are able to activate their transcription. Such molecules (named RNA activators) act opposite to other double-stranded RNA molecules (named RNA...
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PMID: 21241187
PDF is available here.
PDF is available here.
Abstract
To investigate whether EphrinB2 (EfnB2) or EphB4 influence retinal angiogenesis under physiological or pathological conditions.
Using the mouse model of oxygen-induced proliferative retinopathy (OIR), the expression of EfnB2, EphB4, vascular endothelial growth factor...
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PMID: 19764912
PDF is available here.
PDF is available here.
Abstract
Our recent in vitro study demonstrated that endothelial cells (ECs) might influence the differentiation of bone marrow stromal cells (BMSCs). Therefore, the aim of this study was to describe this effect in vivo, using a rat calvarial bone defect model. BMSCs were isolated from femurs of two-donor Le...
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PMID: 21171154
PDF is available here.
PDF is available here.
Journal of Proteomics (74)2 2011
Abstract
We used a mouse hippocampal cell line (HT22) that expresses B-Raf at high levels, to identify B-Raf associated proteins under endogenous expression conditions, avoiding artificial interactions from overexpression studies. We used stringent procedures to co-immunoprecipitate proteins that specificall...
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PMID: 21055488
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
We have shown previously that the scaffold protein MEK1 partner (MP1) is localized to late endosomes by the adaptor protein p14. Using conditional gene disruption of p14 in livers of mice (p14(Δhep) ) we analyzed protein and transcript signatures in tissue samples. Further biological network analys...
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PMID: 21268275
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
We hypothesized that the RCN rice might fail to maintain sugar nutrient homeostasis. This was confirmed with the observation that the sucrose concentration was increased significantly in the RCN rice compared with the wild-type rice. Also, the RCN rice showed a hypersensitive response to exogenous s...
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PMID: 21268274
PDF is available here.
PDF is available here.