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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
RNA, Neoplasm (0):
Recent article
RNA, Neoplasm
Brain research (1411) 2011
Abstract
We show MMP-9 overexpression conferred a poor prognosis in 163 GBM patients. Furthermore, MMP-9 specific miRNA expression profile (14 positively and 31 negatively correlated miRNAs with MMP-9) was established via miRNA microarrays in 60 GBM samples. Among them, two miRNAs: miR-885-5p and miR-491-5p,...
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PMID: 21831363
PDF is available here.
PDF is available here.
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Abstract
We previously showed that microRNA-155 (miR-155) is down-regulated in melanoma cells as compared with normal melanocytes and that its ectopic expression impairs proliferation and induces apoptosis. Here, we investigated whether miR-155 could mediate melanoma growth inhibition via SKI gene silencing....
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PMID: 21466664
PDF is available here.
PDF is available here.
Abstract
We investigated possible cooperative deregulation of microRNAs (miRNAs) and transcription factors (TFs) in glioblastoma, under the hypothesis that miRNAs and TFs might have a combinational regulatory effect on glioblastoma genes. We searched glioblastoma-specific regulatory networks by integrating g...
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PMID: 21712563
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)26 2010
Abstract
We randomly assigned 636 patients with untreated chronic-phase CML to receive imatinib alone at a dose of 400 mg daily, imatinib (400 mg daily) plus cytarabine (20 mg per square meter of body-surface area per day on days 15 through 28 of each 28-day cycle) or pegylated interferon (peginterferon) alf...
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PMID: 21175313
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (50)1 2011
Abstract
We examined Prr15 expression by in situ hybridization (ISH) on mouse intestinal tumors caused by different gene mutations, and on human colorectal cancer (CRC) samples. Prr15/PRR15 expression was consistently observed in mouse gastrointestinal (GI) tumors caused by mutations in the Apc gene, as well...
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PMID: 21061267
PDF is available here.
PDF is available here.
Abstract
We show that the DNA methylation pattern is intimately correlated with MUC5AC expression in ten cancer cell lines (breast, lung, pancreas, and colon).
The CpG methylation status of the MUC5AC promoter from -3855 to +321 was mapped using MassARRAY analysis, which utilizes base-specifi...
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PMID: 20734208
PDF is available here.
PDF is available here.
Abstract
We show that, in many cell types, p53 confers increased survival in the face of chronic starvation. We implicate regulation of autophagy in this effect. In HCT116 human colorectal cancer cells exposed to prolonged nutrient deprivation, the endogenous wt p53 posttranscriptionally down-regulates LC3,...
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PMID: 20937856
PDF is available here.
PDF is available here.
Kidney International (76) 2010
Abstract
Kidney International (78)10 2010
Abstract
Kidney International (78)10 2010
Abstract
Journal of Pathology (222)1 2010
Abstract
We performed whole-genome smRNA-seq analysis using a benign and RCC specimen set and have successfully profiled the miRNA expression. Studies performed on paired frozen and FFPE specimens showed very similar results. Moreover, a comparison study of microarray, deep-sequencing and RT-PCR methodologie...
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PMID: 20593407
PDF is available here.
PDF is available here.
Abstract
In prostate cancer cells, MSA activates the FOXO1 signaling pathway. FOXO1 activation is critical for the anticancer effects of MSA.
(c) 2010 Wiley-Liss, Inc....
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PMID: 20623629
PDF is available here.
PDF is available here.
Abstract
In the present study, we demonstrated the ability of DES to inhibit telomerase in prostate cancer cells. Androgens did not limit the inhibitory effect and even acted synergistically with DES in the LNCaP line. This phenomenon should be considered if telomerase inhibition is part of prostate cancer t...
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PMID: 20623632
PDF is available here.
PDF is available here.
Abstract
The data suggest that WJ9708011 induces transcriptional and translational suppression of cell-cycle regulators that might be through Akt- and AMPK-independent loss of DeltaPsi(m) and inhibition of mTOR signaling pathway, leading to G1 arrest of the cell cycle and subsequent apoptotic cell death.
(c)...
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PMID: 20623631
PDF is available here.
PDF is available here.
Abstract
Hep 3B produces 36 x miRNA 181a compared with Hep G2. Luciferase activity after transfection with miRNA 181a precursor was decreased in both cell lines (P < .01); luciferase activity increased with miRNA 181a inhibitor transfection in both cell lines (P < .01). Hep 3B transfected with mutated OPN 3'...
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PMID: 20576283
PDF is available here.
PDF is available here.
Abstract
Nicotine treatment significantly increased MCP-1 expression in PDA cells. Interestingly, blocking OPN with siRNA or OPN antibody abolished these effects. Transient transfection of the OPNc gene in PDA cells or their treatment with recombinant OPN protein significantly (P < .05) increased MCP-1 mRNA...
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PMID: 20579680
PDF is available here.
PDF is available here.
Abstract
We hypothesized that tumor microRNAs (miRNAs) could serve as predictive biomarkers for chemoresistance and prognostic biomarkers for survival of patients with SCLC treated with systemic chemotherapy.
SCLC samples annotated with clinical characteristics and baseline comorbidities were...
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PMID: 20548249
PDF is available here.
PDF is available here.
Abstract
We demonstrate that a subset of ALL cases bearing 14q32 LOH showed a down-regulation of miRNA 14q32 clusters, which is directly linked to the submicroscopic chromosomal deletion. As a consequence of miRNAs deregulation we reported an inverse correlation with the expression of their target BCL11a, a...
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PMID: 20578197
PDF is available here.
PDF is available here.
Abstract
Transcripts expressed from plasmid both in vitro and in vivo were identified by northern blot analysis. pGensil2-shRNA/FAK effectively down-regulated the expression of FAK as demonstrated in vitro by real time RT-PCR and western blot analysis, whereas by real time RT-PCR and IHC staining of MDA-MB-4...
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PMID: 20140743
PDF is available here.
PDF is available here.
Abstract
In summary, application of HRM analysis to large amount of clinical samples proves to be a fast and high-throughput way to investigate the epigenetic status of GADD45G. And this is the first study to evaluate the prevalence of GADD45G methylation based on large amount of tumor samples, showing that...
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PMID: 20111973
PDF is available here.
PDF is available here.
Abstract
HCA is a very good marker for tumors, especially for HCC. It could play important roles in HCC development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC....
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PMID: 20130911
PDF is available here.
PDF is available here.
Journal of Immunological Methods (359)1-2 2010
Abstract
We present here a simple and fast method for RNA isolation from formalin-fixed paraffin-embedded lymph nodes that can be successfully applied for RT-PCR as well as for quantitative RT-PCR analysis. We tested diverse isolation reagents and combined a range of factors in order to get a high quality RN...
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PMID: 20570676
PDF is available here.
PDF is available here.
Cancer Letters (294)1 2010
Abstract
We found that TWEAK gene expression was down-regulated and Fn14 gene expression was up-regulated in human endometrial cancer specimens compared with that in normal endometrial specimens; TWEAK acting on Fn14 decreased cell viability by inducing apoptosis through caspase pathways in endometrial cance...
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PMID: 20189297
PDF is available here.
PDF is available here.
European Journal of Cancer (46)12 2010
Abstract
We report that the expression of microRNA-101 (miR-101) is down-regulated in gastric cancer tissues and cells, and ectopic expression of miR-101 significantly inhibits cellular proliferation, migration and invasion of gastric cancer cells by targeting EZH2, Cox-2, Mcl-1 and Fos. Our animal study als...
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PMID: 20712078
PDF is available here.
PDF is available here.
Abstract
Acceptable RNA for gene expression analysis was extracted from 72% of lung cancer biopsies. Use of an RNA preservative for storage allowed the extraction of higher quality, more intact RNA from biopsies gathered by both endobronchial forceps and transbronchial needle aspiration. High quality RNA cou...
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PMID: 20512072
PDF is available here.
PDF is available here.
Abstract
We present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis....
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PMID: 20549139
PDF is available here.
PDF is available here.
Abstract
Abstract
Most of the biomarkers were found to be overexpressed in patients with recurrent HCC by quantitative reverse transcription-PCR (qRT-PCR). The HSC/HPC biomarkers cytokeratin 19, ATP-binding cassette subfamily G member 2 (ABCG2), CD133, Nestin and CD44, and the markers of angiogenesis microvessel dens...
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PMID: 20442200
PDF is available here.
PDF is available here.
Experimental Cell Research (316)10 2010
Abstract
We have investigated the relationship between 12-LOX and hypoxia inducible factor-1alpha (HIF-1alpha), a transcription factor involved in the regulation of VEGF expression under hypoxic conditions in solid tumors. Our findings have revealed that HIF-1 is one of the target transcription factors regul...
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PMID: 20303950
PDF is available here.
PDF is available here.
Abstract
We present a meta-analysis and review of gene expression microarray and comparative genome hybridization (CGH) studies performed to date on these tumours, including our own data. Data of whole genome microarray studies from altogether 164 tumours (97 benign, 67 malignant) and 18 normal tissues were...
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PMID: 20305693
PDF is available here.
PDF is available here.
Abstract
Archives of Dermatology (146)6 2010
Abstract
Abstract
We investigated AID-mRNA isoform expression in a series of 195 CLL patients and explored associations with IG gene mutational status and surface immunoglobulin (sIg) isotype expression. Full-length AID transcripts and two splice variants were detected in 110/91/95 cases, respectively. Co-expression...
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PMID: 20117026
PDF is available here.
PDF is available here.
Abstract
Circulating nucleic acids are present in the blood of humans and other vertebrates. During the last 10 years researchers actively studied cell-free nucleic acids present in plasma or serum with great expectations of their use as potential biomarkers for cancer and other pathologic conditions. In the...
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PMID: 20146940
PDF is available here.
PDF is available here.
New England Journal of Medicine (362)10 2010
Abstract
An increased number of tumor-associated macrophages was strongly associated with shortened survival in patients with classic Hodgkin's lymphoma and provides a new biomarker for risk stratification.
2010 Massachusetts Medical Society...
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PMID: 20220182
PDF is available here.
PDF is available here.
Methods in Molecular Biology (624)624 2010
Abstract
Pancreatic cancer is generally detected at later stages with a poor prognosis and a high-mortality rate. Development of theranostic imaging agents that noninvasively target pancreatic cancer by gene expression and deliver therapies directly to malignant cells could greatly improve therapeutic outcom...
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PMID: 20217597
PDF is available here.
PDF is available here.
Methods in Molecular Biology (632)632 2010
Abstract
We have used fluorescence-activated cell sorting (FACS) technology to purify CD133(+) and CD133(-) cellular subsets from mouse melanoma models for high-quality total RNA practical for downstream applications such as expression profiling. Implementation of this strategy can lead to higher resolution...
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PMID: 20217569
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms....
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PMID: 19942715
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We will highlight microRNAs of potential relevance to endocrine tumors and hormone-dependent cancers. Through this overview of how microRNAs regulate multiple targets and entire pathways, we will provide insight into the potential to develop new molecular microRNA-targeted therapies for endocrine tu...
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PMID: 19843580
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
NADPH oxidase 4 (NOX4) belongs to the NOX family that generates reactive oxygen species (ROS). Function and tissue distribution of NOX4 have not yet been entirely clarified. To date, in the thyroid gland, only DUOX1/2 NOX systems have been described. NOX4 mRNA expression, as shown by real-time PCR,...
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PMID: 19779036
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We performed serial deletions of the promoter and chromatin immunoprecipitation assays. The T(3) response element on the spondin 2 promoter was localized in the -1104/-1034 or -984/-925 regions. To explore the effect of spondin 2 on cellular function, spondin 2 knockdown cell lines were established...
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PMID: 19903741
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has docu...
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PMID: 19779034
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We review the current findings about microRNAs focusing on their involvement in the apoptotic process....
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PMID: 19815577
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
The molecular mechanisms involved in epithelial ovarian cancer initiation and progression are just beginning to be elucidated. In particular, it has become evident that microRNAs (miRNAs or miRs), a class of molecules that post-transcriptionally regulate gene expression, play a major role in ovarian...
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PMID: 19903743
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We discuss the role of let-7 in normal development and differentiation, and provide an overview of the relationship between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the relationship between let-7 and drug sensitivity are h...
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PMID: 19779035
PDF is available here.
PDF is available here.
Modern Pathology (23)3 2010
Abstract
We examined the differential expression of 95 miRNAs by RT-PCR using the QuantiMir System in eight matching primary and metastatic carcinoid tumors from the ileum. All miRNAs chosen for the QuantiMir System array were based on their potential functions related to cancer biology, cell development, an...
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PMID: 20037573
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
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PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
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PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.
Veterinary Pathology (47)2 2010
Abstract
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 1...
|
PMID: 20139375
PDF is available here.
PDF is available here.